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Liver fluke granulin promotes extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma.

Arunsan P, Chaidee A, Cochran CJ, Mann VH, Tanno T, Kumkhaek C, Smout MJ, Karinshak SE, Rodpai R, Sotillo J, Loukas A, Laha T, Brindley PJ, Ittiprasert W.

Neoplasia. 2020 Mar 31;22(5):203-216. doi: 10.1016/j.neo.2020.02.004. [Epub ahead of print]


Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species.

Vale N, Gouveia MJ, Gärtner F, Brindley PJ.

Parasitol Res. 2020 Mar 23. doi: 10.1007/s00436-020-06640-4. [Epub ahead of print] Review.


What constitutes a neglected tropical disease?

Hotez PJ, Aksoy S, Brindley PJ, Kamhawi S.

PLoS Negl Trop Dis. 2020 Jan 30;14(1):e0008001. doi: 10.1371/journal.pntd.0008001. eCollection 2020 Jan.


World neglected tropical diseases day.

Hotez PJ, Aksoy S, Brindley PJ, Kamhawi S.

PLoS Negl Trop Dis. 2020 Jan 29;14(1):e0007999. doi: 10.1371/journal.pntd.0007999. eCollection 2020 Jan.


Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters.

Thi Phung L, Chaiyadet S, Hongsrichan N, Sotillo J, Dinh Thi Dieu H, Quang Tran C, Brindley PJ, Loukas A, Laha T.

Acta Trop. 2020 Apr;204:105355. doi: 10.1016/j.actatropica.2020.105355. Epub 2020 Jan 25.


Functional analysis of vasa/PL10-like genes in the ovary of Schistosoma mansoni.

Skinner DE, Popratiloff A, Alrefaei YN, Mann VH, Rinaldi G, Brindley PJ.

Mol Biochem Parasitol. 2020 Mar;236:111259. doi: 10.1016/j.molbiopara.2020.111259. Epub 2020 Jan 17.


Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.

Gouveia MJ, Brindley PJ, Rinaldi G, Gärtner F, da Costa JMC, Vale N.

Infect Agent Cancer. 2019 Nov 29;14:41. doi: 10.1186/s13027-019-0257-2. eCollection 2019.


Hemozoin From the Liver Fluke, Opisthorchis felineus, Modulates Dendritic Cell Responses in Bronchial Asthma Patients.

Saltykova IV, Ittiprasert W, Nevskaya KV, Dorofeeva YB, Kirillova NA, Kulikov ES, Ivanov VV, Mann VH, Pershina AG, Brindley PJ.

Front Vet Sci. 2019 Oct 16;6:332. doi: 10.3389/fvets.2019.00332. eCollection 2019.


Recombinant Opisthorchis viverrini tetraspanin expressed in Pichia pastoris as a potential vaccine candidate for opisthorchiasis.

Phung LT, Chaiyadet S, Hongsrichan N, Sotillo J, Dieu HDT, Tran CQ, Brindley PJ, Loukas A, Laha T.

Parasitol Res. 2019 Dec;118(12):3419-3427. doi: 10.1007/s00436-019-06488-3. Epub 2019 Nov 14.


Parasite microbiome project: Grand challenges.

Dheilly NM, Martínez Martínez J, Rosario K, Brindley PJ, Fichorova RN, Kaye JZ, Kohl KD, Knoll LJ, Lukeš J, Perkins SL, Poulin R, Schriml L, Thompson LR.

PLoS Pathog. 2019 Oct 10;15(10):e1008028. doi: 10.1371/journal.ppat.1008028. eCollection 2019 Oct. No abstract available.


Adaptive Radiation of the Flukes of the Family Fasciolidae Inferred from Genome-Wide Comparisons of Key Species.

Choi YJ, Fontenla S, Fischer PU, Le TH, Costábile A, Blair D, Brindley PJ, Tort JF, Cabada MM, Mitreva M.

Mol Biol Evol. 2020 Jan 1;37(1):84-99. doi: 10.1093/molbev/msz204.


High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing.

Stroehlein AJ, Korhonen PK, Chong TM, Lim YL, Chan KG, Webster B, Rollinson D, Brindley PJ, Gasser RB, Young ND.

Gigascience. 2019 Sep 1;8(9). pii: giz108. doi: 10.1093/gigascience/giz108.


Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis.

Sadaow L, Sanpool O, Rodpai R, Yamasaki H, Ittiprasert W, Mann VH, Brindley PJ, Maleewong W, Intapan PM.

Am J Trop Med Hyg. 2019 Nov;101(5):1156-1160. doi: 10.4269/ajtmh.19-0446.


Opisthorchis viverrini Infection Augments the Severity of Nonalcoholic Fatty Liver Disease in High-Fat/High-Fructose Diet-Fed Hamsters.

Chaidee A, Onsurathum S, Intuyod K, Haonon O, Pannangpetch P, Pongchaiyakul C, Pinlaor P, Pairojkul C, Welbat JU, Ittiprasert W, Cochran CJ, Mann VH, Brindley PJ, Pinlaor S.

Am J Trop Med Hyg. 2019 Nov;101(5):1161-1169. doi: 10.4269/ajtmh.19-0442.


Parasite-microbe-host interactions and cancer risk.

Dheilly NM, Ewald PW, Brindley PJ, Fichorova RN, Thomas F.

PLoS Pathog. 2019 Aug 15;15(8):e1007912. doi: 10.1371/journal.ppat.1007912. eCollection 2019 Aug. No abstract available.


Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni.

Nacif-Pimenta R, da Silva Orfanó A, Mosley IA, Karinshak SE, Ishida K, Mann VH, Coelho PMZ, da Costa JMC, Hsieh MH, Brindley PJ, Rinaldi G.

Sci Rep. 2019 Jul 24;9(1):10731. doi: 10.1038/s41598-019-46917-y.


Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.

Tyagi R, Elfawal MA, Wildman SA, Helander J, Bulman CA, Sakanari J, Rosa BA, Brindley PJ, Janetka JW, Aroian RV, Mitreva M.

Sci Rep. 2019 Jun 24;9(1):9085. doi: 10.1038/s41598-019-45548-7.


The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni.

Gouveia MJ, Brindley PJ, Azevedo C, Gärtner F, da Costa JMC, Vale N.

Parasit Vectors. 2019 Jun 20;12(1):309. doi: 10.1186/s13071-019-3566-9.


Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection.

Chaiyadet S, Sotillo J, Krueajampa W, Thongsen S, Brindley PJ, Sripa B, Loukas A, Laha T.

PLoS Negl Trop Dis. 2019 May 28;13(5):e0007450. doi: 10.1371/journal.pntd.0007450. eCollection 2019 May.


Diagnosis of feline filariasis assisted by a novel semi-automated microfluidic device in combination with high resolution melting real-time PCR.

Phuakrod A, Sripumkhai W, Jeamsaksiri W, Pattamang P, Juntasaro E, Thienthong T, Foongladda S, Brindley PJ, Wongkamchai S.

Parasit Vectors. 2019 Apr 8;12(1):159. doi: 10.1186/s13071-019-3421-z.


Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni.

Gouveia MJ, Brindley PJ, Rinaldi G, Gärtner F, Correia da Costa JM, Vale N.

Biomolecules. 2019 Feb 5;9(2). pii: E54. doi: 10.3390/biom9020054.


Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity.

Arunsan P, Ittiprasert W, Smout MJ, Cochran CJ, Mann VH, Chaiyadet S, Karinshak SE, Sripa B, Young ND, Sotillo J, Loukas A, Brindley PJ, Laha T.

Elife. 2019 Jan 15;8. pii: e41463. doi: 10.7554/eLife.41463.


Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni.

Ittiprasert W, Mann VH, Karinshak SE, Coghlan A, Rinaldi G, Sankaranarayanan G, Chaidee A, Tanno T, Kumkhaek C, Prangtaworn P, Mentink-Kane MM, Cochran CJ, Driguez P, Holroyd N, Tracey A, Rodpai R, Everts B, Hokke CH, Hoffmann KF, Berriman M, Brindley PJ.

Elife. 2019 Jan 15;8. pii: e41337. doi: 10.7554/eLife.41337.


Helminth Microbiomes - A Hidden Treasure Trove?

Jenkins TP, Brindley PJ, Gasser RB, Cantacessi C.

Trends Parasitol. 2019 Jan;35(1):13-22. doi: 10.1016/ Epub 2018 Nov 29. Review.


Update on Pathogenesis of Opisthorchiasis and Cholangiocarcinoma.

Sripa B, Tangkawattana S, Brindley PJ.

Adv Parasitol. 2018;102:97-113. doi: 10.1016/bs.apar.2018.10.001. Epub 2018 Oct 22. Review.


RNA Interference as an Approach to Functional Genomics Genetic Manipulation of Opisthorchis viverrini.

Laha T, Brindley PJ, Suyapoh W, Suttiprapa S.

Adv Parasitol. 2018;102:25-43. doi: 10.1016/bs.apar.2018.06.001. Epub 2018 Jul 18. Review.


Opisthorchiasis and the Microbiome.

Saltykova IV, Petrov VA, Brindley PJ.

Adv Parasitol. 2018;102:1-23. doi: 10.1016/bs.apar.2018.07.001. Epub 2018 Aug 17. Review.


Granulin Expression in Hamsters during Opisthorchis viverrini Infection-Induced Cholangiocarcinogenesis

Upontain S, Sereerak P, Laha T, Sripa B, Tangkawatana P, Brindley PJ, Tangkawatana S.

Asian Pac J Cancer Prev. 2018 Sep 26;19(9):2437-2445.


Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing.

Dastpeyman M, Bansal PS, Wilson D, Sotillo J, Brindley PJ, Loukas A, Smout MJ, Daly NL.

J Med Chem. 2018 Oct 11;61(19):8746-8753. doi: 10.1021/acs.jmedchem.8b00898. Epub 2018 Sep 24.


Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota.

Jenkins TP, Peachey LE, Ajami NJ, MacDonald AS, Hsieh MH, Brindley PJ, Cantacessi C, Rinaldi G.

Sci Rep. 2018 Aug 13;8(1):12072. doi: 10.1038/s41598-018-30412-x.


The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases.

Bridger JM, Brindley PJ, Knight M.

PLoS Negl Trop Dis. 2018 Aug 9;12(8):e0006552. doi: 10.1371/journal.pntd.0006552. eCollection 2018 Aug. No abstract available.


Co-occurrence of opisthorchiasis and diabetes exacerbates morbidity of the hepatobiliary tract disease.

Chaidee A, Onsurathum S, Intuyod K, Pannangpetch P, Pongchaiyakul C, Pinlaor P, Pairojkul C, Ittiprasert W, Cochran CJ, Mann VH, Brindley PJ, Pinlaor S.

PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006611. doi: 10.1371/journal.pntd.0006611. eCollection 2018 Jun.


The small RNA complement of adult Schistosoma haematobium.

Stroehlein AJ, Young ND, Korhonen PK, Hall RS, Jex AR, Webster BL, Rollinson D, Brindley PJ, Gasser RB.

PLoS Negl Trop Dis. 2018 May 29;12(5):e0006535. doi: 10.1371/journal.pntd.0006535. eCollection 2018 May.


Developmental Sensitivity in Schistosoma mansoni to Puromycin To Establish Drug Selection of Transgenic Schistosomes.

Yan HB, Smout MJ, Ju C, Folley AE, Skinner DE, Mann VH, Loukas A, Hu W, Brindley PJ, Rinaldi G.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02568-17. doi: 10.1128/AAC.02568-17. Print 2018 Aug.


Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics.

Tyagi R, Maddirala AR, Elfawal M, Fischer C, Bulman CA, Rosa BA, Gao X, Chugani R, Zhou M, Helander J, Brindley PJ, Tseng CC, Greig IR, Sakanari J, Wildman SA, Aroian R, Janetka JW, Mitreva M.

ACS Infect Dis. 2018 Jul 13;4(7):1130-1145. doi: 10.1021/acsinfecdis.8b00090. Epub 2018 May 14.


Granulin Secreted by the Food-Borne Liver Fluke Opisthorchis viverrini Promotes Angiogenesis in Human Endothelial Cells.

Haugen B, Karinshak SE, Mann VH, Popratiloff A, Loukas A, Brindley PJ, Smout MJ.

Front Med (Lausanne). 2018 Feb 16;5:30. doi: 10.3389/fmed.2018.00030. eCollection 2018.


Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.

Gouveia MJ, Brindley PJ, Gärtner F, Costa JMCD, Vale N.

Pharmaceuticals (Basel). 2018 Feb 5;11(1). pii: E15. doi: 10.3390/ph11010015. Review.


Expression, purification and characterization of two leucine aminopeptidases of the blood fluke, Schistosoma mansoni.

Maggioli G, Rinaldi G, Giaudrone I, Berasain P, Tort JF, Brindley PJ, Carmona C.

Mol Biochem Parasitol. 2018 Jan;219:17-23. doi: 10.1016/j.molbiopara.2017.11.006. Epub 2017 Nov 21.


Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes.

Chaiyadet S, Krueajampa W, Hipkaeo W, Plosan Y, Piratae S, Sotillo J, Smout M, Sripa B, Brindley PJ, Loukas A, Laha T.

Sci Rep. 2017 Oct 30;7(1):14342. doi: 10.1038/s41598-017-13527-5.


Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model.

Gouveia MJ, Pakharukova MY, Laha T, Sripa B, Maksimova GA, Rinaldi G, Brindley PJ, Mordvinov VA, Amaro T, Santos LL, Costa JMCD, Vale N.

Carcinogenesis. 2017 Sep 1;38(9):929-937. doi: 10.1093/carcin/bgx042.


Parasite Microbiome Project: Systematic Investigation of Microbiome Dynamics within and across Parasite-Host Interactions.

Dheilly NM, Bolnick D, Bordenstein S, Brindley PJ, Figuères C, Holmes EC, Martínez Martínez J, Phillips AJ, Poulin R, Rosario K.

mSystems. 2017 Jul 18;2(4). pii: e00050-17. doi: 10.1128/mSystems.00050-17. eCollection 2017 Jul-Aug.


Helminth infection-induced malignancy.

Brindley PJ, Loukas A.

PLoS Pathog. 2017 Jul 27;13(7):e1006393. doi: 10.1371/journal.ppat.1006393. eCollection 2017 Jul. Review. No abstract available.


Subsets of Inflammatory Cytokine Gene Polymorphisms are Associated with Risk of Carcinogenic Liver Fluke Opisthorchis viverrini-Associated Advanced Periductal Fibrosis and Cholangiocarcinoma.

Surapaitoon A, Suttiprapa S, Mairiang E, Khuntikeo N, Pairojkul C, Bethony J, Brindley PJ, Sripa B.

Korean J Parasitol. 2017 Jun;55(3):295-304. doi: 10.3347/kjp.2017.55.3.295. Epub 2017 Jun 30.


Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural Fold.

Bansal PS, Smout MJ, Wilson D, Cobos Caceres C, Dastpeyman M, Sotillo J, Seifert J, Brindley PJ, Loukas A, Daly NL.

J Med Chem. 2017 May 25;60(10):4258-4266. doi: 10.1021/acs.jmedchem.7b00047. Epub 2017 May 3.


The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer.

Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Brindley PJ, da Costa JM.

Tumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247. Review.


Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum.

Wang J, Yu Y, Shen H, Qing T, Zheng Y, Li Q, Mo X, Wang S, Li N, Chai R, Xu B, Liu M, Brindley PJ, McManus DP, Feng Z, Shi L, Hu W.

Nat Commun. 2017 Mar 13;8:14693. doi: 10.1038/ncomms14693.


Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance.

Vale N, Gouveia MJ, Rinaldi G, Brindley PJ, Gärtner F, Correia da Costa JM.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02582-16. doi: 10.1128/AAC.02582-16. Print 2017 May. Review.


Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease.

Deenonpoe R, Mairiang E, Mairiang P, Pairojkul C, Chamgramol Y, Rinaldi G, Loukas A, Brindley PJ, Sripa B.

Sci Rep. 2017 Feb 15;7:42744. doi: 10.1038/srep42744.


Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers.

McNulty SN, Tort JF, Rinaldi G, Fischer K, Rosa BA, Smircich P, Fontenla S, Choi YJ, Tyagi R, Hallsworth-Pepin K, Mann VH, Kammili L, Latham PS, Dell'Oca N, Dominguez F, Carmona C, Fischer PU, Brindley PJ, Mitreva M.

PLoS Genet. 2017 Jan 6;13(1):e1006537. doi: 10.1371/journal.pgen.1006537. eCollection 2017 Jan.


Parasite Infection, Carcinogenesis and Human Malignancy.

van Tong H, Brindley PJ, Meyer CG, Velavan TP.

EBioMedicine. 2017 Feb;15:12-23. doi: 10.1016/j.ebiom.2016.11.034. Epub 2016 Dec 2. Review.

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