Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 260

1.

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae.

Benesch MGK, Tang X, Brindley DN.

Cancers (Basel). 2020 Feb 6;12(2). pii: E374. doi: 10.3390/cancers12020374. Review.

2.

Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle.

Meng G, Wuest M, Tang X, Dufour J, Zhao Y, Curtis JM, McMullen TPW, Murray D, Wuest F, Brindley DN.

Cancers (Basel). 2019 Nov 19;11(11). pii: E1816. doi: 10.3390/cancers11111816.

3.

Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer.

Tang X, Wuest M, Benesch MGK, Dufour J, Zhao Y, Curtis JM, Monjardet A, Heckmann B, Murray D, Wuest F, Brindley DN.

Mol Cancer Ther. 2020 Jan;19(1):63-74. doi: 10.1158/1535-7163.MCT-19-0386. Epub 2019 Sep 23.

PMID:
31548293
4.
5.

Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.

Meshcheryakova A, Svoboda M, Jaritz M, Mungenast F, Salzmann M, Pils D, Cacsire Castillo-Tong D, Hager G, Wolf A, Braicu EI, Sehouli J, Lambrechts S, Vergote I, Mahner S, Birner P, Zimmermann P, Brindley DN, Heinze G, Zeillinger R, Mechtcheriakova D.

Comput Struct Biotechnol J. 2019 Apr 10;17:537-560. doi: 10.1016/j.csbj.2019.04.004. eCollection 2019.

6.

Latent Cytomegalovirus Infection in Female Mice Increases Breast Cancer Metastasis.

Yang Z, Tang X, Meng G, Benesch MGK, Mackova M, Belon AP, Serrano-Lomelin J, Goping IS, Brindley DN, Hemmings DG.

Cancers (Basel). 2019 Mar 29;11(4). pii: E447. doi: 10.3390/cancers11040447.

7.

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.

Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K.

J Clin Invest. 2019 Jan 2;129(1):281-295. doi: 10.1172/JCI122595. Epub 2018 Dec 3.

8.

Dexamethasone decreases the autotaxin-lysophosphatidate-inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer.

Meng G, Tang X, Yang Z, Zhao Y, Curtis JM, McMullen TPW, Brindley DN.

FASEB J. 2019 Feb;33(2):1899-1910. doi: 10.1096/fj.201801226R. Epub 2018 Sep 7.

PMID:
30192654
9.

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

Benesch MGK, MacIntyre ITK, McMullen TPW, Brindley DN.

Cancers (Basel). 2018 Mar 15;10(3). pii: E73. doi: 10.3390/cancers10030073. Review.

10.

Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis.

Benesch MGK, Yang Z, Tang X, Meng G, Brindley DN.

Trends Cancer. 2017 Nov;3(11):748-752. doi: 10.1016/j.trecan.2017.09.004. Epub 2017 Oct 2. Review.

PMID:
29120750
11.

Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations.

Pelosi M, Testet E, Le Lay S, Dugail I, Tang X, Mabilleau G, Hamel Y, Madrange M, Blanc T, Odent T, McMullen TPW, Alfò M, Brindley DN, de Lonlay P.

J Lipid Res. 2017 Dec;58(12):2348-2364. doi: 10.1194/jlr.P075440. Epub 2017 Oct 6.

12.

Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3.

Cao AT, Mackova M, Kerage D, Brindley DN, Hemmings DG.

Exp Gerontol. 2017 Dec 1;99:87-97. doi: 10.1016/j.exger.2017.09.013. Epub 2017 Sep 22.

PMID:
28943478
13.

Sensitivity of docetaxel-resistant MCF-7 breast cancer cells to microtubule-destabilizing agents including vinca alkaloids and colchicine-site binding agents.

Wang RC, Chen X, Parissenti AM, Joy AA, Tuszynski J, Brindley DN, Wang Z.

PLoS One. 2017 Aug 7;12(8):e0182400. doi: 10.1371/journal.pone.0182400. eCollection 2017.

14.

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.

Meng G, Tang X, Yang Z, Benesch MGK, Marshall A, Murray D, Hemmings DG, Wuest F, McMullen TPW, Brindley DN.

FASEB J. 2017 Sep;31(9):4064-4077. doi: 10.1096/fj.201700159R. Epub 2017 May 24.

PMID:
28539367
15.

Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation.

Tang X, Wang X, Zhao YY, Curtis JM, Brindley DN.

Mol Cancer. 2017 Feb 8;16(1):36. doi: 10.1186/s12943-017-0607-x.

16.

Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition.

Ekpe-Adewuyi E, Lopez-Campistrous A, Tang X, Brindley DN, McMullen TP.

Oncotarget. 2016 Dec 13;7(50):83684-83700. doi: 10.18632/oncotarget.13299.

17.

PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.

Lopez-Campistrous A, Adewuyi EE, Benesch MGK, Ko YM, Lai R, Thiesen A, Dewald J, Wang P, Chu K, Ghosh S, Williams DC, Vos LJ, Brindley DN, McMullen TPW.

EBioMedicine. 2016 Oct;12:86-97. doi: 10.1016/j.ebiom.2016.09.007. Epub 2016 Sep 10.

18.

Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo.

Benesch MG, Tang X, Venkatraman G, Bekele RT, Brindley DN.

J Biomed Res. 2016 Jul;30(4):272-84. doi: 10.7555/JBR.30.20150058. Epub 2015 Aug 28. Review.

19.

Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate.

Tang X, Zhao YY, Dewald J, Curtis JM, Brindley DN.

J Lipid Res. 2016 Apr;57(4):597-606. doi: 10.1194/jlr.M065086. Epub 2016 Feb 16.

20.

Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.

Bekele RT, Venkatraman G, Liu RZ, Tang X, Mi S, Benesch MG, Mackey JR, Godbout R, Curtis JM, McMullen TP, Brindley DN.

Sci Rep. 2016 Feb 17;6:21164. doi: 10.1038/srep21164.

21.

Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.

Benesch MG, Tang X, Dewald J, Dong WF, Mackey JR, Hemmings DG, McMullen TP, Brindley DN.

FASEB J. 2015 Sep;29(9):3990-4000. doi: 10.1096/fj.15-274480. Epub 2015 Jun 12.

PMID:
26071407
22.

Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer.

Benesch MG, Ko YM, Tang X, Dewald J, Lopez-Campistrous A, Zhao YY, Lai R, Curtis JM, Brindley DN, McMullen TP.

Endocr Relat Cancer. 2015 Aug;22(4):593-607. doi: 10.1530/ERC-15-0045. Epub 2015 Jun 2.

PMID:
26037280
23.

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.

Benesch MG, Zhao YY, Curtis JM, McMullen TP, Brindley DN.

J Lipid Res. 2015 Jun;56(6):1134-44. doi: 10.1194/jlr.M057661. Epub 2015 Apr 20.

24.

Lipid phosphate phosphatases and their roles in mammalian physiology and pathology.

Tang X, Benesch MG, Brindley DN.

J Lipid Res. 2015 Nov;56(11):2048-60. doi: 10.1194/jlr.R058362. Epub 2015 Mar 26. Review.

25.

PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis.

Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ.

FASEB J. 2015 Apr;29(4):1185-97. doi: 10.1096/fj.14-260570. Epub 2014 Dec 4.

26.

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity.

Pereira S, Breen DM, Naassan AE, Wang PY, Uchino H, Fantus IG, Carpentier AC, Gutierrez-Juarez R, Brindley DN, Lam TK, Giacca A.

Metabolism. 2015 Feb;64(2):315-22. doi: 10.1016/j.metabol.2014.10.019. Epub 2014 Oct 25.

PMID:
25467844
27.

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.

Venkatraman G, Benesch MG, Tang X, Dewald J, McMullen TP, Brindley DN.

FASEB J. 2015 Mar;29(3):772-85. doi: 10.1096/fj.14-262659. Epub 2014 Nov 14.

PMID:
25398768
28.

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.

Tang X, Benesch MG, Dewald J, Zhao YY, Patwardhan N, Santos WL, Curtis JM, McMullen TP, Brindley DN.

J Lipid Res. 2014 Nov;55(11):2389-400. doi: 10.1194/jlr.M053462. Epub 2014 Sep 10.

29.

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

Pereira S, Park E, Mori Y, Haber CA, Han P, Uchida T, Stavar L, Oprescu AI, Koulajian K, Ivovic A, Yu Z, Li D, Bowman TA, Dewald J, El-Benna J, Brindley DN, Gutierrez-Juarez R, Lam TK, Najjar SM, McKay RA, Bhanot S, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2014 Jul 1;307(1):E34-46. doi: 10.1152/ajpendo.00436.2013. Epub 2014 May 13.

30.

Lipin-1 and lipin-3 together determine adiposity in vivo.

Csaki LS, Dwyer JR, Li X, Nguyen MH, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong L, Young SG, Reue K.

Mol Metab. 2013 Nov 28;3(2):145-54. doi: 10.1016/j.molmet.2013.11.008. eCollection 2014 Apr.

31.

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice.

Benesch MG, Tang X, Maeda T, Ohhata A, Zhao YY, Kok BP, Dewald J, Hitt M, Curtis JM, McMullen TP, Brindley DN.

FASEB J. 2014 Jun;28(6):2655-66. doi: 10.1096/fj.13-248641. Epub 2014 Mar 5.

PMID:
24599971
32.

Autotaxin in the crosshairs: taking aim at cancer and other inflammatory conditions.

Benesch MG, Ko YM, McMullen TP, Brindley DN.

FEBS Lett. 2014 Aug 19;588(16):2712-27. doi: 10.1016/j.febslet.2014.02.009. Epub 2014 Feb 19. Review.

33.

Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity.

Kok BP, Skene-Arnold TD, Ling J, Benesch MG, Dewald J, Harris TE, Holmes CF, Brindley DN.

J Biol Chem. 2014 Apr 11;289(15):10876-86. doi: 10.1074/jbc.M114.552612. Epub 2014 Feb 20.

34.

Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells.

Wang H, Vo T, Hajar A, Li S, Chen X, Parissenti AM, Brindley DN, Wang Z.

BMC Cancer. 2014 Jan 22;14:37. doi: 10.1186/1471-2407-14-37.

35.

Review: novel insights into the regulation of vascular tone by sphingosine 1-phosphate.

Kerage D, Brindley DN, Hemmings DG.

Placenta. 2014 Feb;35 Suppl:S86-92. doi: 10.1016/j.placenta.2013.12.006. Epub 2013 Dec 21. Review.

PMID:
24411702
36.

Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver.

Kok BP, Dyck JR, Harris TE, Brindley DN.

J Lipid Res. 2013 Jun;54(6):1662-77. doi: 10.1194/jlr.M036624. Epub 2013 Mar 16.

37.

Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association.

Eaton JM, Mullins GR, Brindley DN, Harris TE.

J Biol Chem. 2013 Apr 5;288(14):9933-45. doi: 10.1074/jbc.M112.441493. Epub 2013 Feb 20.

38.

Myocardial fatty acid metabolism and lipotoxicity in the setting of insulin resistance.

Kok BP, Brindley DN.

Heart Fail Clin. 2012 Oct;8(4):643-61. doi: 10.1016/j.hfc.2012.06.008. Epub 2012 Aug 9. Review.

PMID:
22999246
39.

Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.

Brindley DN, Lin FT, Tigyi GJ.

Biochim Biophys Acta. 2013 Jan;1831(1):74-85. doi: 10.1016/j.bbalip.2012.08.015. Epub 2012 Aug 29. Review.

40.

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.

Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2486-95. doi: 10.1073/pnas.1205221109. Epub 2012 Aug 20.

41.

Unlike two peas in a pod: lipid phosphate phosphatases and phosphatidate phosphatases.

Kok BP, Venkatraman G, Capatos D, Brindley DN.

Chem Rev. 2012 Oct 10;112(10):5121-46. doi: 10.1021/cr200433m. Epub 2012 Jun 28. Review. No abstract available.

PMID:
22742522
42.

Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice.

Kok BP, Kienesberger PC, Dyck JR, Brindley DN.

J Lipid Res. 2012 Jan;53(1):105-18. doi: 10.1194/jlr.M019430. Epub 2011 Nov 5.

43.

Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest.

Samadi N, Bekele RT, Goping IS, Schang LM, Brindley DN.

PLoS One. 2011;6(5):e20608. doi: 10.1371/journal.pone.0020608. Epub 2011 May 27.

44.

Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in a pah1Δ mutant strain of Saccharomyces cerevisiae.

Mietkiewska E, Siloto RM, Dewald J, Shah S, Brindley DN, Weselake RJ.

FEBS J. 2011 Mar;278(5):764-75. doi: 10.1111/j.1742-4658.2010.07995.x. Epub 2011 Jan 12.

45.

Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.

Samadi N, Bekele R, Capatos D, Venkatraman G, Sariahmetoglu M, Brindley DN.

Biochimie. 2011 Jan;93(1):61-70. doi: 10.1016/j.biochi.2010.08.002. Epub 2010 Aug 13. Review.

PMID:
20709140
46.

Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization.

Brindley DN, Kok BP, Kienesberger PC, Lehner R, Dyck JR.

Am J Physiol Endocrinol Metab. 2010 May;298(5):E897-908. doi: 10.1152/ajpendo.00509.2009. Epub 2010 Jan 26. Review.

47.

Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy.

Yamamoto Y, Olson DM, van Bennekom M, Brindley DN, Hemmings DG.

Biol Reprod. 2010 Mar;82(3):628-35. doi: 10.1095/biolreprod.109.081497. Epub 2009 Dec 9.

PMID:
20007411
48.

Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation.

Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ.

J Clin Endocrinol Metab. 2009 Dec;94(12):5053-61. doi: 10.1210/jc.2008-2565. Epub 2009 Oct 16.

PMID:
19837942
49.

Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.

Douglas DS, Moran JL, Bermingham JR Jr, Chen XJ, Brindley DN, Soliven B, Beier DR, Popko B.

J Neurosci. 2009 Sep 30;29(39):12089-100. doi: 10.1523/JNEUROSCI.2029-09.2009.

50.

A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.

Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K.

J Biol Chem. 2009 Oct 23;284(43):29968-78. doi: 10.1074/jbc.M109.023663. Epub 2009 Aug 28.

Supplemental Content

Loading ...
Support Center