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Items: 40


The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

Wong CK, Wade-Vallance AK, Luciani DS, Brindle PK, Lynn FC, Gibson WT.

Diabetes. 2018 Mar;67(3):412-422. doi: 10.2337/db17-0237. Epub 2017 Dec 7.


The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.

Zhang J, Vlasevska S, Wells VA, Nataraj S, Holmes AB, Duval R, Meyer SN, Mo T, Basso K, Brindle PK, Hussein S, Dalla-Favera R, Pasqualucci L.

Cancer Discov. 2017 Mar;7(3):322-337. doi: 10.1158/2159-8290.CD-16-1417. Epub 2017 Jan 9.


Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.

Zheng F, Kasper LH, Bedford DC, Lerach S, Teubner BJ, Brindle PK.

PLoS One. 2016 Jan 5;11(1):e0146366. doi: 10.1371/journal.pone.0146366. eCollection 2016.


Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.

Paz JC, Park S, Phillips N, Matsumura S, Tsai WW, Kasper L, Brindle PK, Zhang G, Zhou MM, Wright PE, Montminy M.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17116-21. doi: 10.1073/pnas.1420389111. Epub 2014 Nov 17.


Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression.

Kasper LH, Qu C, Obenauer JC, McGoldrick DJ, Brindle PK.

Nucleic Acids Res. 2014 Oct;42(18):11363-82. doi: 10.1093/nar/gku827. Epub 2014 Sep 23.


Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function.

Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW.

Mol Cell Biol. 2014 Nov;34(21):3993-4007. doi: 10.1128/MCB.00919-14. Epub 2014 Aug 25.


T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs.

Kasper LH, Fukuyama T, Brindle PK.

PLoS One. 2014 Jul 23;9(7):e102076. doi: 10.1371/journal.pone.0102076. eCollection 2014.


Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.

Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B.

Development. 2014 Feb;141(3):538-47. doi: 10.1242/dev.099481.


Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression.

Kasper LH, Fukuyama T, Lerach S, Chang Y, Xu W, Wu S, Boyd KL, Brindle PK.

PLoS One. 2013 Dec 10;8(12):e82684. doi: 10.1371/journal.pone.0082684. eCollection 2013.


Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A.

Nucleic Acids Res. 2013 Dec;41(22):10199-214. doi: 10.1093/nar/gkt824. Epub 2013 Sep 12.


Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW.

Nat Med. 2013 Sep;19(9):1173-7. doi: 10.1038/nm.3286. Epub 2013 Aug 18.


Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK.

Nat Genet. 2012 Oct;44(10):1104-10. doi: 10.1038/ng.2396. Epub 2012 Sep 2.


Is histone acetylation the most important physiological function for CBP and p300?

Bedford DC, Brindle PK.

Aging (Albany NY). 2012 Apr;4(4):247-55.


Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK.

Cell Metab. 2011 Aug 3;14(2):219-30. doi: 10.1016/j.cmet.2011.06.010.


CREBBP mutations in relapsed acute lymphoblastic leukaemia.

Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR.

Nature. 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727.


Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R.

Nature. 2011 Mar 10;471(7337):189-95. doi: 10.1038/nature09730.


Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.

Oliveira AM, Estévez MA, Hawk JD, Grimes S, Brindle PK, Abel T.

Learn Mem. 2011 Feb 23;18(3):161-9. doi: 10.1101/lm.1939811. Print 2011.


Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K.

EMBO J. 2011 Jan 19;30(2):249-62. doi: 10.1038/emboj.2010.318. Epub 2010 Dec 3.


CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.

Kasper LH, Lerach S, Wang J, Wu S, Jeevan T, Brindle PK.

EMBO J. 2010 Nov 3;29(21):3660-72. doi: 10.1038/emboj.2010.235. Epub 2010 Sep 21.


Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.

Bedford DC, Kasper LH, Fukuyama T, Brindle PK.

Epigenetics. 2010 Jan 1;5(1):9-15. Epub 2010 Jan 27. Review.


Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development.

Fukuyama T, Kasper LH, Boussouar F, Jeevan T, van Deursen J, Brindle PK.

Mol Cell Biol. 2009 Jul;29(14):3894-904. doi: 10.1128/MCB.01598-08. Epub 2009 May 11.


Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation.

Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA.

J Neurosci. 2007 Jun 6;27(23):6128-40.


Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.

Xu W, Kasper LH, Lerach S, Jeevan T, Brindle PK.

EMBO J. 2007 Jun 20;26(12):2890-903. Epub 2007 May 24.


A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes.

Wood MA, Attner MA, Oliveira AM, Brindle PK, Abel T.

Learn Mem. 2006 Sep-Oct;13(5):609-17. Epub 2006 Sep 15.


Differential role for CBP and p300 CREB-binding domain in motor skill learning.

Oliveira AM, Abel T, Brindle PK, Wood MA.

Behav Neurosci. 2006 Jun;120(3):724-9.


Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JM, Brindle PK.

Mol Cell Biol. 2006 Feb;26(3):789-809.


Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.

Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK.

Blood. 2006 Jun 1;107(11):4407-16. Epub 2006 Jan 19.


Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.

Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK.

EMBO J. 2005 Nov 16;24(22):3846-58. Epub 2005 Oct 20.


Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

Kang-Decker N, Tong C, Boussouar F, Baker DJ, Xu W, Leontovich AA, Taylor WR, Brindle PK, van Deursen JM.

Cancer Cell. 2004 Feb;5(2):177-89.


A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis.

Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK.

Nature. 2002 Oct 17;419(6908):738-43.


Role of secondary structure in discrimination between constitutive and inducible activators.

Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK.

Mol Cell Biol. 1999 Aug;19(8):5601-7.


CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.

Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM.

Mol Cell Biol. 1999 Jan;19(1):764-76.


A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions.

Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK.

Mol Cell Biol. 1998 Apr;18(4):2218-29.


Transcriptional regulation by an upstream repression sequence from the yeast enolase gene ENO1.

Carmen AA, Brindle PK, Park CS, Holland MJ.

Yeast. 1995 Sep 15;11(11):1031-43.


The CREB family of transcription activators.

Brindle PK, Montminy MR.

Curr Opin Genet Dev. 1992 Apr;2(2):199-204. Review.


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