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Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):522-523. doi: 10.1038/s41571-019-0236-y. No abstract available.


Magnetic Resonance Imaging Is More Sensitive Than PET for Detecting Treatment-Induced Cell Death-Dependent Changes in Glycolysis.

Hesketh RL, Wang J, Wright AJ, Lewis DY, Denton AE, Grenfell R, Miller JL, Bielik R, Gehrung M, Fala M, Ros S, Xie B, Hu DE, Brindle KM.

Cancer Res. 2019 Jul 15;79(14):3557-3569. doi: 10.1158/0008-5472.CAN-19-0182. Epub 2019 May 14.


Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi IY, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai EM, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkáč I, Vigneron DB, Howe FA.

Magn Reson Med. 2019 Aug;82(2):527-550. doi: 10.1002/mrm.27742. Epub 2019 Mar 28. Review.


Challenges to curing primary brain tumours.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.

Nat Rev Clin Oncol. 2019 Aug;16(8):509-520. doi: 10.1038/s41571-019-0177-5. Review.


Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, Woitek R, Daniels CJ, Kaggie JD, Matys T, Patterson I, Slough R, Gill AB, Chhabra A, Eichenberger R, Laurent MC, Comment A, Gillard JH, Coles AJ, Tyler DJ, Wilkinson I, Basu B, Lomas DJ, Graves MJ, Brindle KM, Gallagher FA.

Neuroimage. 2019 Apr 1;189:171-179. doi: 10.1016/j.neuroimage.2019.01.027. Epub 2019 Jan 11.


Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal.

Shishmarev D, Kuchel PW, Pagès G, Wright AJ, Hesketh RL, Kreis F, Brindle KM.

Commun Biol. 2018 Dec 21;1:232. doi: 10.1038/s42003-018-0241-1. eCollection 2018.


Enhanced detection of circulating tumor DNA by fragment size analysis.

Mouliere F, Chandrananda D, Piskorz AM, Moore EK, Morris J, Ahlborn LB, Mair R, Goranova T, Marass F, Heider K, Wan JCM, Supernat A, Hudecova I, Gounaris I, Ros S, Jimenez-Linan M, Garcia-Corbacho J, Patel K, Østrup O, Murphy S, Eldridge MD, Gale D, Stewart GD, Burge J, Cooper WN, van der Heijden MS, Massie CE, Watts C, Corrie P, Pacey S, Brindle KM, Baird RD, Mau-Sørensen M, Parkinson CA, Smith CG, Brenton JD, Rosenfeld N.

Sci Transl Med. 2018 Nov 7;10(466). pii: eaat4921. doi: 10.1126/scitranslmed.aat4921.


Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

Mouliere F, Mair R, Chandrananda D, Marass F, Smith CG, Su J, Morris J, Watts C, Brindle KM, Rosenfeld N.

EMBO Mol Med. 2018 Dec;10(12). pii: e9323. doi: 10.15252/emmm.201809323.


Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models.

Mair R, Mouliere F, Smith CG, Chandrananda D, Gale D, Marass F, Tsui DWY, Massie CE, Wright AJ, Watts C, Rosenfeld N, Brindle KM.

Cancer Res. 2019 Jan 1;79(1):220-230. doi: 10.1158/0008-5472.CAN-18-0074. Epub 2018 Nov 2.


Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates.

Marco-Rius I, Cheng T, Gaunt AP, Patel S, Kreis F, Capozzi A, Wright AJ, Brindle KM, Ouari O, Comment A.

J Am Chem Soc. 2018 Oct 31;140(43):14455-14463. doi: 10.1021/jacs.8b09326. Epub 2018 Oct 22.


Emerging Technologies to Image Tissue Metabolism.

Ntziachristos V, Pleitez MA, Aime S, Brindle KM.

Cell Metab. 2019 Mar 5;29(3):518-538. doi: 10.1016/j.cmet.2018.09.004. Epub 2018 Sep 27. Review.


Hyperpolarized 13 C spectroscopic imaging using single-shot 3D sequences with unpaired adiabatic refocusing pulses.

Wang J, Hesketh RL, Wright AJ, Brindle KM.

NMR Biomed. 2018 Nov;31(11):e4004. doi: 10.1002/nbm.4004. Epub 2018 Sep 10.


[18F]fluoroethyltyrosine-induced Cerenkov Luminescence Improves Image-Guided Surgical Resection of Glioma.

Lewis DY, Mair R, Wright A, Allinson K, Lyons SK, Booth T, Jones J, Bielik R, Soloviev D, Brindle KM.

Theranostics. 2018 Jul 1;8(14):3991-4002. doi: 10.7150/thno.23709. eCollection 2018.


Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.

Mair R, Wright AJ, Ros S, Hu DE, Booth T, Kreis F, Rao J, Watts C, Brindle KM.

Cancer Res. 2018 Sep 15;78(18):5408-5418. doi: 10.1158/0008-5472.CAN-18-0759. Epub 2018 Jul 27.


Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites.

Hesketh RL, Brindle KM.

Curr Opin Chem Biol. 2018 Aug;45:187-194. doi: 10.1016/j.cbpa.2018.03.004. Epub 2018 Jul 13. Review.


Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

Serrao EM, Kettunen MI, Rodrigues TB, Lewis DY, Gallagher FA, Hu DE, Brindle KM.

NMR Biomed. 2018 May;31(5):e3901. doi: 10.1002/nbm.3901. Epub 2018 Feb 19.


Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

Wright AJ, Husson ZMA, Hu DE, Callejo G, Brindle KM, Smith ESJ.

NMR Biomed. 2018 Apr;31(4):e3892. doi: 10.1002/nbm.3892. Epub 2018 Jan 30.


Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.

Neves AA, Di Pietro M, O'Donovan M, Waterhouse DJ, Bohndiek SE, Brindle KM, Fitzgerald RC.

Endoscopy. 2018 Jun;50(6):618-625. doi: 10.1055/s-0043-124080. Epub 2018 Jan 17.


Sub-minute kinetics of human red cell fumarase: 1 H spin-echo NMR spectroscopy and 13 C rapid-dissolution dynamic nuclear polarization.

Shishmarev D, Wright AJ, Rodrigues TB, Pileio G, Stevanato G, Brindle KM, Kuchel PW.

NMR Biomed. 2018 Mar;31(3). doi: 10.1002/nbm.3870. Epub 2018 Jan 8.


Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2017 Dec 15;7(1):99. doi: 10.1186/s13550-017-0349-1.


A referenceless Nyquist ghost correction workflow for echo planar imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate.

Wang J, Wright AJ, Hesketh RL, Hu DE, Brindle KM.

NMR Biomed. 2018 Feb;31(2). doi: 10.1002/nbm.3866. Epub 2017 Dec 7.


Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

Freedy AM, Matos MJ, Boutureira O, Corzana F, Guerreiro A, Akkapeddi P, Somovilla VJ, Rodrigues T, Nicholls K, Xie B, Jiménez-Osés G, Brindle KM, Neves AA, Bernardes GJL.

J Am Chem Soc. 2017 Dec 20;139(50):18365-18375. doi: 10.1021/jacs.7b10702. Epub 2017 Dec 5.


Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent.

Xie B, Tomaszewski MR, Neves AA, Ros S, Hu DE, McGuire S, Mullins SR, Tice D, Sainson RCA, Bohndiek SE, Wilkinson RW, Brindle KM.

Clin Cancer Res. 2017 Nov 15;23(22):6893-6903. doi: 10.1158/1078-0432.CCR-17-1029. Epub 2017 Aug 18.


Brain Tumor Imaging.

Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ.

J Clin Oncol. 2017 Jul 20;35(21):2432-2438. doi: 10.1200/JCO.2017.72.7636. Epub 2017 Jun 22. Review.


Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

Booth TC, Larkin TJ, Yuan Y, Kettunen MI, Dawson SN, Scoffings D, Canuto HC, Vowler SL, Kirschenlohr H, Hobson MP, Markowetz F, Jefferies S, Brindle KM.

PLoS One. 2017 May 17;12(5):e0176528. doi: 10.1371/journal.pone.0176528. eCollection 2017.


Dynamic 1 H imaging of hyperpolarized [1-13 C]lactate in vivo using a reverse INEPT experiment.

Wang J, Kreis F, Wright AJ, Hesketh RL, Levitt MH, Brindle KM.

Magn Reson Med. 2018 Feb;79(2):741-747. doi: 10.1002/mrm.26725. Epub 2017 May 5.


Site-Selective Modification of Proteins with Oxetanes.

Boutureira O, Martínez-Sáez N, Brindle KM, Neves AA, Corzana F, Bernardes GJL.

Chemistry. 2017 May 11;23(27):6483-6489. doi: 10.1002/chem.201700745. Epub 2017 Mar 29.


Rapid Imaging of Tumor Cell Death In Vivo Using the C2A Domain of Synaptotagmin-I.

Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu DE, Rodrigues TB, Lewis DY, Brindle KM.

J Nucl Med. 2017 Jun;58(6):881-887. doi: 10.2967/jnumed.116.183004. Epub 2017 Feb 16.


6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Ros S, Flöter J, Kaymak I, Da Costa C, Houddane A, Dubuis S, Griffiths B, Mitter R, Walz S, Blake S, Behrens A, Brindle KM, Zamboni N, Rider MH, Schulze A.

Oncogene. 2017 Jun 8;36(23):3287-3299. doi: 10.1038/onc.2016.477. Epub 2017 Jan 16.


Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.

Timm KN, Hu DE, Williams M, Wright AJ, Kettunen MI, Kennedy BW, Larkin TJ, Dzien P, Marco-Rius I, Bohndiek SE, Brindle KM.

J Biol Chem. 2017 Feb 3;292(5):1737-1748. doi: 10.1074/jbc.M116.761536. Epub 2016 Dec 19.


MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle KM.

Nat Biotechnol. 2017 Jan;35(1):75-80. doi: 10.1038/nbt.3714. Epub 2016 Dec 5.


Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.


Imaging Tumor Metabolism to Assess Disease Progression and Treatment Response.

Timm KN, Kennedy BW, Brindle KM.

Clin Cancer Res. 2016 Nov 1;22(21):5196-5203. Epub 2016 Sep 8. Review.


Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

Dzien P, Fages A, Jona G, Brindle KM, Schwaiger M, Frydman L.

J Am Chem Soc. 2016 Sep 21;138(37):12278-86. doi: 10.1021/jacs.6b07483. Epub 2016 Sep 6.


The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2016 Dec;6(1):63. doi: 10.1186/s13550-016-0218-3. Epub 2016 Aug 11. Erratum in: EJNMMI Res. 2017 Dec 15;7(1):99.


Design and validation of a near-infrared fluorescence endoscope for detection of early esophageal malignancy.

Waterhouse DJ, Joseph J, Neves AA, di Pietro M, Brindle KM, Fitzgerald RC, Bohndiek SE.

J Biomed Opt. 2016 Aug 1;21(8):84001. doi: 10.1117/1.JBO.21.8.084001.


A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

Daniels CJ, McLean MA, Schulte RF, Robb FJ, Gill AB, McGlashan N, Graves MJ, Schwaiger M, Lomas DJ, Brindle KM, Gallagher FA.

NMR Biomed. 2016 Apr;29(4):387-99. doi: 10.1002/nbm.3468. Epub 2016 Jan 18.


Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Neves AA, Wainman YA, Wright A, Kettunen MI, Rodrigues TB, McGuire S, Hu DE, Bulat F, Geninatti Crich S, Stöckmann H, Leeper FJ, Brindle KM.

Angew Chem Weinheim Bergstr Ger. 2016 Jan 22;128(4):1308-1312. Epub 2015 Dec 3.


Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

Serrao EM, Rodrigues TB, Gallagher FA, Kettunen MI, Kennedy BW, Vowler SL, Burling KA, Brindle KM.

NMR Biomed. 2016 Aug;29(8):1048-55. doi: 10.1002/nbm.3568. Epub 2016 Jun 16.


Detection of colorectal dysplasia using fluorescently labelled lectins.

Kuo JC, Ibrahim AE, Dawson S, Parashar D, Howat WJ, Guttula K, Miller R, Fearnhead NS, Winton DJ, Neves AA, Brindle KM.

Sci Rep. 2016 Apr 13;6:24231. doi: 10.1038/srep24231.


Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate.

Serrao EM, Brindle KM.

Front Oncol. 2016 Mar 11;6:59. doi: 10.3389/fonc.2016.00059. eCollection 2016. Review. No abstract available.


Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

Aigbirhio FI, Allwein S, Anwar A, Atzrodt J, Audisio D, Badman G, Bakale R, Berthon F, Bragg R, Brindle KM, Bushby N, Campos S, Cant AA, Chan MY, Colbon P, Cornelissen B, Czarny B, Derdau V, Dive V, Dunscombe M, Eggleston I, Ellis-Sawyer K, Elmore CS, Engstrom P, Ericsson C, Fairlamb IJ, Georgin D, Godfrey SP, He L, Hickey MJ, Huscroft IT, Kerr WJ, Lashford A, Lenz E, Lewinton S, L'Hermite MM, Lindelöf Å, Little G, Lockley WJ, Loreau O, Maddocks S, Marguerit M, Mirabello V, Mudd RJ, Nilsson GN, Owens PK, Pascu SI, Patriarche G, Pimlott SL, Pinault M, Plastow G, Racys DT, Reif J, Rossi J, Ruan J, Sarpaki S, Sephton SM, Simonsson R, Speed DJ, Sumal K, Sutherland A, Taran F, Thuleau A, Wang Y, Waring M, Watters WH, Wu J, Xiao J.

J Labelled Comp Radiopharm. 2016 Apr;59(4):175-86. doi: 10.1002/jlcr.3377. Epub 2016 Mar 18.


Single shot three-dimensional pulse sequence for hyperpolarized 13 C MRI.

Wang J, Wright AJ, Hu DE, Hesketh R, Brindle KM.

Magn Reson Med. 2017 Feb;77(2):740-752. doi: 10.1002/mrm.26168. Epub 2016 Feb 24.


31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

Sleigh A, Savage DB, Williams GB, Porter D, Carpenter TA, Brindle KM, Kemp GJ.

J Appl Physiol (1985). 2016 Mar 15;120(6):649-56. doi: 10.1152/japplphysiol.00871.2015. Epub 2016 Jan 7.


Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Neves AA, Wainman YA, Wright A, Kettunen MI, Rodrigues TB, McGuire S, Hu DE, Bulat F, Geninatti Crich S, Stöckmann H, Leeper FJ, Brindle KM.

Angew Chem Int Ed Engl. 2016 Jan 22;55(4):1286-90. doi: 10.1002/anie.201509858. Epub 2015 Dec 3.


(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo.

Dzien P, Tee SS, Kettunen MI, Lyons SK, Larkin TJ, Timm KN, Hu DE, Wright A, Rodrigues TB, Serrao EM, Marco-Rius I, Mannion E, D'Santos P, Kennedy BW, Brindle KM.

Magn Reson Med. 2016 Aug;76(2):391-401. doi: 10.1002/mrm.25879. Epub 2015 Sep 21.


MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

Serrao EM, Kettunen MI, Rodrigues TB, Dzien P, Wright AJ, Gopinathan A, Gallagher FA, Lewis DY, Frese KK, Almeida J, Howat WJ, Tuveson DA, Brindle KM.

Gut. 2016 Mar;65(3):465-75. doi: 10.1136/gutjnl-2015-310114. Epub 2015 Sep 7.


Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

Gallagher FA, Sladen H, Kettunen MI, Serrao EM, Rodrigues TB, Wright A, Gill AB, McGuire S, Booth TC, Boren J, McIntyre A, Miller JL, Lee SH, Honess D, Day SE, Hu DE, Howat WJ, Harris AL, Brindle KM.

Cancer Res. 2015 Oct 1;75(19):4109-18. doi: 10.1158/0008-5472.CAN-15-0857. Epub 2015 Aug 6.


Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

Irkle A, Vesey AT, Lewis DY, Skepper JN, Bird JL, Dweck MR, Joshi FR, Gallagher FA, Warburton EA, Bennett MR, Brindle KM, Newby DE, Rudd JH, Davenport AP.

Nat Commun. 2015 Jul 7;6:7495. doi: 10.1038/ncomms8495.


Development of Timd2 as a reporter gene for MRI.

Patrick PS, Rodrigues TB, Kettunen MI, Lyons SK, Neves AA, Brindle KM.

Magn Reson Med. 2016 Apr;75(4):1697-707. doi: 10.1002/mrm.25750. Epub 2015 May 15.

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