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Metal Organic Polyhedra: A Click-and-Clack Approach Toward Targeted Delivery.

Samanta SK, Moncelet D, Vinciguerra B, Briken V, Isaacs L.

Helv Chim Acta. 2018 Jun;101(6). pii: e1800057. doi: 10.1002/hlca.201800057. Epub 2018 May 6.


Apoptosis inhibition by intracellular bacteria and its consequence on host immunity.

Behar SM, Briken V.

Curr Opin Immunol. 2019 Oct;60:103-110. doi: 10.1016/j.coi.2019.05.007. Epub 2019 Jun 19. Review.


Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival.

Banks DA, Ahlbrand SE, Hughitt VK, Shah S, Mayer-Barber KD, Vogel SN, El-Sayed NM, Briken V.

J Immunol. 2019 Apr 15;202(8):2348-2359. doi: 10.4049/jimmunol.1801303. Epub 2019 Mar 4.


Cucurbit[7]uril Enables Multi-Stimuli-Responsive Release from the Self-Assembled Hydrophobic Phase of a Metal Organic Polyhedron.

Samanta SK, Quigley J, Vinciguerra B, Briken V, Isaacs L.

J Am Chem Soc. 2017 Jul 5;139(26):9066-9074. doi: 10.1021/jacs.7b05154. Epub 2017 Jun 23.


The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis.

Quigley J, Hughitt VK, Velikovsky CA, Mariuzza RA, El-Sayed NM, Briken V.

mBio. 2017 Mar 7;8(2). pii: e00148-17. doi: 10.1128/mBio.00148-17.


Metal-Organic Polyhedron Capped with Cucurbit[8]uril Delivers Doxorubicin to Cancer Cells.

Samanta SK, Moncelet D, Briken V, Isaacs L.

J Am Chem Soc. 2016 Nov 2;138(43):14488-14496. Epub 2016 Oct 20.


Glycoluril-Derived Molecular Clips are Potent and Selective Receptors for Cationic Dyes in Water.

She N, Moncelet D, Gilberg L, Lu X, Sindelar V, Briken V, Isaacs L.

Chemistry. 2016 Oct 17;22(43):15270-15279. doi: 10.1002/chem.201601796. Epub 2016 Aug 5.


A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2.

Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M.

Anesthesiology. 2016 Aug;125(2):333-45. doi: 10.1097/ALN.0000000000001199.


Modular Organization of the ESX-5 Secretion System in Mycobacterium tuberculosis.

Shah S, Briken V.

Front Cell Infect Microbiol. 2016 May 2;6:49. doi: 10.3389/fcimb.2016.00049. eCollection 2016. Review.


Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis.

Srinivasan L, Gurses SA, Hurley BE, Miller JL, Karakousis PC, Briken V.

PLoS Pathog. 2016 May 18;12(5):e1005652. doi: 10.1371/journal.ppat.1005652. eCollection 2016 May.


Acyclic Cucurbit[n]uril-Type Molecular Containers: Influence of Linker Length on Their Function as Solubilizing Agents.

Sigwalt D, Moncelet D, Falcinelli S, Mandadapu V, Zavalij PY, Day A, Briken V, Isaacs L.

ChemMedChem. 2016 May 6;11(9):980-9. doi: 10.1002/cmdc.201600090. Epub 2016 Mar 15.


Acyclic Cucurbit[n]uril-Type Molecular Container Enables Systemic Delivery of Effective Doses of Albendazole for Treatment of SK-OV-3 Xenograft Tumors.

Hettiarachchi G, Samanta SK, Falcinelli S, Zhang B, Moncelet D, Isaacs L, Briken V.

Mol Pharm. 2016 Mar 7;13(3):809-18. doi: 10.1021/acs.molpharmaceut.5b00723. Epub 2016 Jan 22.


Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.

Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH.

J Immunol. 2016 Jan 15;196(2):846-56. doi: 10.4049/jimmunol.1501595. Epub 2015 Dec 14.


Acyclic Cucurbit[n]uril Dendrimers.

Sigwalt D, Ahlbrand S, Zhang M, Vinciguerra B, Briken V, Isaacs L.

Org Lett. 2015 Dec 4;17(23):5914-7. doi: 10.1021/acs.orglett.5b03145. Epub 2015 Nov 23.


A Duplicated ESAT-6 Region of ESX-5 Is Involved in Protein Export and Virulence of Mycobacteria.

Shah S, Cannon JR, Fenselau C, Briken V.

Infect Immun. 2015 Nov;83(11):4349-61. doi: 10.1128/IAI.00827-15. Epub 2015 Aug 24.


Interaction of Mycobacterium tuberculosis with host cell death pathways.

Srinivasan L, Ahlbrand S, Briken V.

Cold Spring Harb Perspect Med. 2014 Jun 26;4(8). pii: a022459. doi: 10.1101/cshperspect.a022459. Review.


Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship.

Briken V, Ahlbrand SE, Shah S.

Front Cell Infect Microbiol. 2013 Oct 9;3:62. doi: 10.3389/fcimb.2013.00062. eCollection 2013. Review.


Cucurbit[7]uril containers for targeted delivery of oxaliplatin to cancer cells.

Cao L, Hettiarachchi G, Briken V, Isaacs L.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12033-7. doi: 10.1002/anie.201305061. Epub 2013 Sep 13. No abstract available.


Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.

Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V.

J Immunol. 2013 Oct 1;191(7):3514-8. doi: 10.4049/jimmunol.1301331. Epub 2013 Aug 30.


Mycobacterium tuberculosis genes involved in regulation of host cell death.

Briken V.

Adv Exp Med Biol. 2013;783:93-102. doi: 10.1007/978-1-4614-6111-1_5. Review.


"With a little help from my friends": efferocytosis as an antimicrobial mechanism.

Briken V.

Cell Host Microbe. 2012 Sep 13;12(3):261-3. doi: 10.1016/j.chom.2012.08.008.


Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.

Abdalla H, Srinivasan L, Shah S, Mayer-Barber KD, Sher A, Sutterwala FS, Briken V.

PLoS One. 2012;7(7):e40722. doi: 10.1371/journal.pone.0040722. Epub 2012 Jul 24.


Acyclic cucurbit[n]uril molecular containers enhance the solubility and bioactivity of poorly soluble pharmaceuticals.

Ma D, Hettiarachchi G, Nguyen D, Zhang B, Wittenberg JB, Zavalij PY, Briken V, Isaacs L.

Nat Chem. 2012 Apr 15;4(6):503-10. doi: 10.1038/nchem.1326.


Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.

Blomgran R, Desvignes L, Briken V, Ernst JD.

Cell Host Microbe. 2012 Jan 19;11(1):81-90. doi: 10.1016/j.chom.2011.11.012.


Editorial: switching on arginase in M2 macrophages.

Briken V, Mosser DM.

J Leukoc Biol. 2011 Nov;90(5):839-41. doi: 10.1189/jlb.0411203. No abstract available.


A model for using a concept inventory as a tool for students' assessment and faculty professional development.

Marbach-Ad G, McAdams KC, Benson S, Briken V, Cathcart L, Chase M, El-Sayed NM, Frauwirth K, Fredericksen B, Joseph SW, Lee V, McIver KS, Mosser D, Quimby BB, Shields P, Song W, Stein DC, Stewart R, Thompson KV, Smith AC.

CBE Life Sci Educ. 2010 Winter;9(4):408-16. doi: 10.1187/cbe.10-05-0069.


The non-pathogenic mycobacteria M. smegmatis and M. fortuitum induce rapid host cell apoptosis via a caspase-3 and TNF dependent pathway.

Bohsali A, Abdalla H, Velmurugan K, Briken V.

BMC Microbiol. 2010 Sep 10;10:237. doi: 10.1186/1471-2180-10-237.


Toxicology and drug delivery by cucurbit[n]uril type molecular containers.

Hettiarachchi G, Nguyen D, Wu J, Lucas D, Ma D, Isaacs L, Briken V.

PLoS One. 2010 May 6;5(5):e10514. doi: 10.1371/journal.pone.0010514.


The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis.

Miller JL, Velmurugan K, Cowan MJ, Briken V.

PLoS Pathog. 2010 Apr 22;6(4):e1000864. doi: 10.1371/journal.ppat.1000864.


CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.

Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.

J Exp Med. 2009 Jun 8;206(6):1409-22. doi: 10.1084/jem.20082480. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug 3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C].


Assessing student understanding of host pathogen interactions using a concept inventory.

Marbach-Ad G, Briken V, El-Sayed NM, Frauwirth K, Fredericksen B, Hutcheson S, Gao LY, Joseph S, Lee VT, McIver KS, Mosser D, Quimby BB, Shields P, Song W, Stein DC, Yuan RT, Smith AC.

J Microbiol Biol Educ. 2009 Dec 17;10(1):43-50. Print 2009.


Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis.

Briken V, Miller JL.

Future Microbiol. 2008 Aug;3(4):415-22. doi: 10.2217/17460913.3.4.415. Review.


Immune response induced by three Mycobacterium bovis BCG substrains with diverse regions of deletion in a C57BL/6 mouse model.

Irwin SM, Goodyear A, Keyser A, Christensen R, Troudt JM, Taylor JL, Bohsali A, Briken V, Izzo AA.

Clin Vaccine Immunol. 2008 May;15(5):750-6. doi: 10.1128/CVI.00018-08. Epub 2008 Mar 19.


Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.

Velmurugan K, Chen B, Miller JL, Azogue S, Gurses S, Hsu T, Glickman M, Jacobs WR Jr, Porcelli SA, Briken V.

PLoS Pathog. 2007 Jul;3(7):e110.


A faculty team works to create content linkages among various courses to increase meaningful learning of targeted concepts of microbiology.

Marbach-Ad G, Briken V, Frauwirth K, Gao LY, Hutcheson SW, Joseph SW, Mosser D, Parent B, Shields P, Song W, Stein DC, Swanson K, Thompson KV, Yuan R, Smith AC.

CBE Life Sci Educ. 2007 Summer;6(2):155-62.


Role of lipid trimming and CD1 groove size in cellular antigen presentation.

Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, Briken V, Zajonc DM, Wilson IA, Porcelli S, Moody DB.

EMBO J. 2006 Jul 12;25(13):2989-99. Epub 2006 Jun 22.


Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.

Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR Jr, Moody DB.

J Exp Med. 2004 Dec 20;200(12):1559-69.


Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.

Briken V, Porcelli SA, Besra GS, Kremer L.

Mol Microbiol. 2004 Jul;53(2):391-403. Review.


Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.

Dao DN, Kremer L, Guérardel Y, Molano A, Jacobs WR Jr, Porcelli SA, Briken V.

Infect Immun. 2004 Apr;72(4):2067-74.


Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties.

Guérardel Y, Maes E, Briken V, Chirat F, Leroy Y, Locht C, Strecker G, Kremer L.

J Biol Chem. 2003 Sep 19;278(38):36637-51. Epub 2003 Jun 26.


Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.

Moody DB, Briken V, Cheng TY, Roura-Mir C, Guy MR, Geho DH, Tykocinski ML, Besra GS, Porcelli SA.

Nat Immunol. 2002 May;3(5):435-42. Epub 2002 Apr 8.


Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.

Lankar D, Vincent-Schneider H, Briken V, Yokozeki T, Raposo G, Bonnerot C.

J Exp Med. 2002 Feb 18;195(4):461-72.


Intracellular trafficking pathway of newly synthesized CD1b molecules.

Briken V, Jackman RM, Dasgupta S, Hoening S, Porcelli SA.

EMBO J. 2002 Feb 15;21(4):825-34. Erratum in: EMBO J 2002 Mar15;21(6):1504.


Diversification of CD1 proteins: sampling the lipid content of different cellular compartments.

Briken V, Moody DB, Porcelli SA.

Semin Immunol. 2000 Dec;12(6):517-25. Review.


Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.

Briken V, Jackman RM, Watts GF, Rogers RA, Porcelli SA.

J Exp Med. 2000 Jul 17;192(2):281-8.


syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes.

Bonnerot C, Briken V, Brachet V, Lankar D, Cassard S, Jabri B, Amigorena S.

EMBO J. 1998 Aug 17;17(16):4606-16.


Type II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens.

Amigorena S, Lankar D, Briken V, Gapin L, Viguier M, Bonnerot C.

J Exp Med. 1998 Feb 16;187(4):505-15.


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