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Items: 1 to 50 of 136

1.

Palladium-Mediated Cleavage of Proteins with Thiazolidine-Modified Backbone in Live Cells.

Mann G, Satish G, Meledin R, Vamisetti GB, Brik A.

Angew Chem Int Ed Engl. 2019 Aug 11. doi: 10.1002/anie.201906545. [Epub ahead of print] Review.

PMID:
31402546
2.

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains.

Nawatha M, Rogers JM, Bonn SM, Livneh I, Lemma B, Mali SM, Vamisetti GB, Sun H, Bercovich B, Huang Y, Ciechanover A, Fushman D, Suga H, Brik A.

Nat Chem. 2019 Jul;11(7):644-652. doi: 10.1038/s41557-019-0278-x. Epub 2019 Jun 10.

PMID:
31182821
3.

Mirroring Life's Building Blocks.

Meledin R, Brik A.

Cell Chem Biol. 2019 May 16;26(5):616-619. doi: 10.1016/j.chembiol.2019.04.013.

PMID:
31100259
4.

Multi-walled carbon nanotubes induce stronger migration of inflammatory cells in vitro than asbestos or granular particles but a similar pattern of inflammatory mediators.

Westphal GA, Rosenkranz N, Brik A, Weber D, Föhring I, Monsé C, Kaiser N, Hellack B, Mattenklott M, Brüning T, Johnen G, Bünger J.

Toxicol In Vitro. 2019 Aug;58:215-223. doi: 10.1016/j.tiv.2019.03.036. Epub 2019 Mar 27.

5.

Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles.

Sun H, Mali SM, Singh SK, Meledin R, Brik A, Kwon YT, Kravtsova-Ivantsiv Y, Bercovich B, Ciechanover A.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7805-7812. doi: 10.1073/pnas.1822148116. Epub 2019 Mar 13.

PMID:
30867293
6.

Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.

Morgan M, Jbara M, Brik A, Wolberger C.

Methods Enzymol. 2019;618:1-27. doi: 10.1016/bs.mie.2019.01.003. Epub 2019 Feb 26.

PMID:
30850047
7.

Palladium-Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-cysteine under Aqueous Conditions.

Laps S, Sun H, Kamnesky G, Brik A.

Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5729-5733. doi: 10.1002/anie.201900988. Epub 2019 Mar 20.

PMID:
30828918
8.

Are circulating microRNAs suitable for the early detection of malignant mesothelioma? Results from a nested case-control study.

Weber DG, Brik A, Casjens S, Burek K, Lehnert M, Pesch B, Taeger D, Brüning T, Johnen G; MoMar study group.

BMC Res Notes. 2019 Feb 11;12(1):77. doi: 10.1186/s13104-019-4113-7.

9.

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics.

Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C.

Elife. 2019 Jan 25;8. pii: e40988. doi: 10.7554/eLife.40988.

10.

Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7.

Vamisetti GB, Meledin R, Gopinath P, Brik A.

Chembiochem. 2019 Jan 18;20(2):282-286. doi: 10.1002/cbic.201800612. Epub 2018 Dec 14.

PMID:
30474907
11.

Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins.

Jbara M, Laps S, Morgan M, Kamnesky G, Mann G, Wolberger C, Brik A.

Nat Commun. 2018 Aug 8;9(1):3154. doi: 10.1038/s41467-018-05628-0.

12.

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites.

Jbara M, Eid E, Brik A.

Org Biomol Chem. 2018 Jun 6;16(22):4061-4064. doi: 10.1039/c8ob00890f.

PMID:
29766191
13.

Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases.

Sun H, Meledin R, Mali SM, Brik A.

Chem Sci. 2018 Jan 11;9(6):1661-1665. doi: 10.1039/c7sc04518b. eCollection 2018 Feb 14.

14.

Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α-Globin-Modulating Deubiquitinase.

Meledin R, Mali SM, Kleifeld O, Brik A.

Angew Chem Int Ed Engl. 2018 May 14;57(20):5645-5649. doi: 10.1002/anie.201800032. Epub 2018 Apr 14.

PMID:
29527788
15.

Chemical chromatin ubiquitylation.

Jbara M, Sun H, Kamnesky G, Brik A.

Curr Opin Chem Biol. 2018 Aug;45:18-26. doi: 10.1016/j.cbpa.2018.02.001. Epub 2018 Feb 20. Review.

PMID:
29459258
16.

Total chemical synthesis of histones and their analogs, assisted by native chemical ligation and palladium complexes.

Maity SK, Jbara M, Mann G, Kamnesky G, Brik A.

Nat Protoc. 2017 Nov;12(11):2293-2322. doi: 10.1038/nprot.2017.049. Epub 2017 Oct 5.

PMID:
28981125
17.

Switching Futile para-Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin-Specific Protease-2 Inhibition, Electrocatalysis, and Quantification.

Gopinath P, Mahammed A, Eilon-Shaffer T, Nawatha M, Ohayon S, Shabat D, Gross Z, Brik A.

Chembiochem. 2017 Sep 5;18(17):1683-1687. doi: 10.1002/cbic.201700330. Epub 2017 Jul 19.

PMID:
28639727
18.

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A.

Chem Sci. 2017 May 1;8(5):4027-4034. doi: 10.1039/c7sc00488e. Epub 2017 Apr 5.

19.

Antiepileptic Drug Treatment in Community-Dwelling Older Patients with Epilepsy: A Retrospective Observational Study of Old- Versus New-Generation Antiepileptic Drugs.

Theitler J, Brik A, Shaniv D, Berkovitch M, Gandelman-Marton R.

Drugs Aging. 2017 Jun;34(6):479-487. doi: 10.1007/s40266-017-0465-7.

PMID:
28478592
20.

Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2.

Gopinath P, Mahammed A, Ohayon S, Gross Z, Brik A.

Chem Sci. 2016 Dec 1;7(12):7079-7086. doi: 10.1039/c6sc02758j. Epub 2016 Aug 5.

21.

Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3.

Jbara M, Guttmann-Raviv N, Maity SK, Ayoub N, Brik A.

Bioorg Med Chem. 2017 Sep 15;25(18):4966-4970. doi: 10.1016/j.bmc.2017.04.015. Epub 2017 Apr 12.

PMID:
28434780
22.

Palladium in the Chemical Synthesis and Modification of Proteins.

Jbara M, Maity SK, Brik A.

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10644-10655. doi: 10.1002/anie.201702370. Epub 2017 Aug 7. Review.

PMID:
28383786
23.

Ubiquitin Signaling: Chemistry Comes to the Rescue.

Mali SM, Singh SK, Eid E, Brik A.

J Am Chem Soc. 2017 Apr 12;139(14):4971-4986. doi: 10.1021/jacs.7b00089. Epub 2017 Mar 28.

PMID:
28328208
24.

Circulating miR-132-3p as a Candidate Diagnostic Biomarker for Malignant Mesothelioma.

Weber DG, Gawrych K, Casjens S, Brik A, Lehnert M, Taeger D, Pesch B, Kollmeier J, Bauer TT, Johnen G, Brüning T.

Dis Markers. 2017;2017:9280170. doi: 10.1155/2017/9280170. Epub 2017 Feb 21.

25.

Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin.

Singh SK, Sahu I, Mali SM, Hemantha HP, Kleifeld O, Glickman MH, Brik A.

J Am Chem Soc. 2016 Dec 14;138(49):16004-16015. Epub 2016 Dec 6.

PMID:
27960333
26.

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway.

Gogiashvili M, Edlund K, Gianmoena K, Marchan R, Brik A, Andersson JT, Lambert J, Madjar K, Hellwig B, Rahnenführer J, Hengstler JG, Hergenröder R, Cadenas C.

Anal Bioanal Chem. 2017 Feb;409(6):1591-1606. doi: 10.1007/s00216-016-0100-1. Epub 2016 Nov 28.

PMID:
27896396
27.

Kinetics of chemotaxis, cytokine, and chemokine release of NR8383 macrophages after exposure to inflammatory and inert granular insoluble particles.

Schremmer I, Brik A, Weber DG, Rosenkranz N, Rostek A, Loza K, Brüning T, Johnen G, Epple M, Bünger J, Westphal GA.

Toxicol Lett. 2016 Nov 30;263:68-75. doi: 10.1016/j.toxlet.2016.08.014. Epub 2016 Aug 24.

PMID:
27565850
28.

Palladium-Assisted Cleavage of Peptides and Proteins Containing a Backbone with Thiazolidine Linkage.

Jbara M, Laps S, Maity SK, Brik A.

Chemistry. 2016 Oct 10;22(42):14851-14855. doi: 10.1002/chem.201603676. Epub 2016 Sep 9.

PMID:
27550063
29.

Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis.

Maity SK, Mann G, Jbara M, Laps S, Kamnesky G, Brik A.

Org Lett. 2016 Jun 17;18(12):3026-9. doi: 10.1021/acs.orglett.6b01442. Epub 2016 Jun 8.

PMID:
27268382
30.

Protein ubiquitination via dehydroalanine: development and insights into the diastereoselective 1,4-addition step.

Meledin R, Mali SM, Singh SK, Brik A.

Org Biomol Chem. 2016 Jun 7;14(21):4817-23. doi: 10.1039/c6ob00882h. Epub 2016 May 4.

PMID:
27143624
31.

Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis.

Maity SK, Jbara M, Laps S, Brik A.

Angew Chem Int Ed Engl. 2016 Jul 4;55(28):8108-12. doi: 10.1002/anie.201603169. Epub 2016 Apr 29.

PMID:
27126503
32.

Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins.

Bondalapati S, Jbara M, Brik A.

Nat Chem. 2016 Apr 22;8(5):407-18. doi: 10.1038/nchem.2476. Review.

PMID:
27102674
33.

Chemical and semisynthetic approaches to study and target deubiquitinases.

Gopinath P, Ohayon S, Nawatha M, Brik A.

Chem Soc Rev. 2016 Jul 25;45(15):4171-98. doi: 10.1039/c6cs00083e. Review.

PMID:
27049734
34.

Palladium Mediated Rapid Deprotection of N-Terminal Cysteine under Native Chemical Ligation Conditions for the Efficient Preparation of Synthetically Challenging Proteins.

Jbara M, Maity SK, Seenaiah M, Brik A.

J Am Chem Soc. 2016 Apr 20;138(15):5069-75. doi: 10.1021/jacs.5b13580. Epub 2016 Apr 6.

PMID:
27023072
35.

Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

Jbara M, Maity SK, Morgan M, Wolberger C, Brik A.

Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4972-6. doi: 10.1002/anie.201600638. Epub 2016 Mar 9.

36.

Structural basis for histone H2B deubiquitination by the SAGA DUB module.

Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, Wolberger C.

Science. 2016 Feb 12;351(6274):725-8. doi: 10.1126/science.aac5681.

37.

Chemical and semisynthesis of modified histones.

Maity SK, Jbara M, Brik A.

J Pept Sci. 2016 May;22(5):252-9. doi: 10.1002/psc.2848. Epub 2016 Jan 18. Review.

PMID:
26778211
38.

Chemical Synthesis of Ubiquitin Chains.

Hemantha HP, Bondalapati S, Singh SK, Brik A.

Curr Protoc Chem Biol. 2015 Dec 2;7(4):229-248. doi: 10.1002/9780470559277.ch150099.

PMID:
26629614
39.

Pushing the Boundaries of Chemical Protein Synthesis: The Case of Ubiquitin Chains and Polyubiquitinated Peptides and Proteins.

Meledin R, Mali SM, Brik A.

Chem Rec. 2016 Feb;16(1):509-19. doi: 10.1002/tcr.201500209. Epub 2015 Oct 19. Review.

PMID:
26477936
40.

Rapid optimization of labeled ubiquitinated peptides for monitoring deubiquitinases activities.

Ohayon S, Refua M, Brik A.

Org Biomol Chem. 2015 Aug 14;13(30):8182-6. doi: 10.1039/c5ob01142f.

PMID:
26160015
41.

Synthesis of N-Hydroxy Isopeptide Containing Proteins.

Maity SK, Ohayon S, Brik A.

Org Lett. 2015 Jul 17;17(14):3438-41. doi: 10.1021/acs.orglett.5b01443. Epub 2015 Jun 25.

PMID:
26111051
42.

Convergent versus sequential protein synthesis: the case of ubiquitinated and glycosylated H2B.

Seenaiah M, Jbara M, Mali SM, Brik A.

Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12374-8. doi: 10.1002/anie.201503309. Epub 2015 Jun 16.

PMID:
26079184
43.

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.

Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A.

Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.

44.

Chemical synthesis of phosphorylated ubiquitin and diubiquitin exposes positional sensitivities of e1-e2 enzymes and deubiquitinases.

Bondalapati S, Mansour W, Nakasone MA, Maity SK, Glickman MH, Brik A.

Chemistry. 2015 May 11;21(20):7360-4. doi: 10.1002/chem.201500540. Epub 2015 Apr 1.

PMID:
25829361
45.

Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules.

Ohayon S, Refua M, Hendler A, Aharoni A, Brik A.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):599-603. doi: 10.1002/anie.201408411. Epub 2014 Oct 19.

PMID:
25327786
46.

Rapid End-Group Modification of Polysaccharides for Biomaterial Applications in Regenerative Medicine.

Bondalapati S, Ruvinov E, Kryukov O, Cohen S, Brik A.

Macromol Rapid Commun. 2014 Sep 15. doi: 10.1002/marc.201400354. [Epub ahead of print]

PMID:
25220432
47.

Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein.

Jbara M, Seenaiah M, Brik A.

Chem Commun (Camb). 2014 Oct 25;50(83):12534-7. doi: 10.1039/c4cc06499b.

PMID:
25196573
48.

Extended ubiquitin species are protein-based DUB inhibitors.

Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH.

Nat Chem Biol. 2014 Aug;10(8):664-70. doi: 10.1038/nchembio.1574. Epub 2014 Jul 6.

49.

The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.

Long L, Thelen JP, Furgason M, Haj-Yahya M, Brik A, Cheng D, Peng J, Yao T.

J Biol Chem. 2014 Mar 28;289(13):8916-30. doi: 10.1074/jbc.M114.551754. Epub 2014 Feb 13.

50.

Chemical protein synthesis.

Becker CF, Brik A, Dawson P, Hackenberger CP.

J Pept Sci. 2014 Feb;20(2):63. doi: 10.1002/psc.2607. No abstract available.

PMID:
25975419

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