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Items: 25

1.

Structural basis for the docking of mTORC1 on the lysosomal surface.

Rogala KB, Gu X, Kedir JF, Abu-Remaileh M, Bianchi LF, Bottino AMS, Dueholm R, Niehaus A, Overwijn D, Fils AP, Zhou SX, Leary D, Laqtom NN, Brignole EJ, Sabatini DM.

Science. 2019 Oct 25;366(6464):468-475. doi: 10.1126/science.aay0166. Epub 2019 Oct 10.

PMID:
31601708
2.

Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.

Chen PY, Funk MA, Brignole EJ, Drennan CL.

J Biol Chem. 2018 Jun 29;293(26):10404-10412. doi: 10.1074/jbc.RA118.002569. Epub 2018 Apr 26.

3.

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM.

Nature. 2018 Apr 5;556(7699):64-69. doi: 10.1038/nature26158. Epub 2018 Mar 28.

4.

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F.

Elife. 2018 Feb 20;7. pii: e31502. doi: 10.7554/eLife.31502.

5.

Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5325-E5334. doi: 10.1073/pnas.1702849114. Epub 2017 Jun 20.

6.

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.

Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL.

Biochemistry. 2016 Jan 19;55(2):373-81. doi: 10.1021/acs.biochem.5b01207. Epub 2016 Jan 4.

7.

The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism.

Gibson MI, Brignole EJ, Pierce E, Can M, Ragsdale SW, Drennan CL.

Biochemistry. 2015 Jul 7;54(26):4112-20. doi: 10.1021/acs.biochem.5b00521. Epub 2015 Jun 24.

8.

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG.

Cancer Metab. 2015 Apr 29;3:5. doi: 10.1186/s40170-015-0131-7. eCollection 2015.

9.

Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase.

Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3835-40. doi: 10.1073/pnas.1220691110. Epub 2013 Feb 19.

10.

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers.

Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J.

Chem Biol. 2012 Jul 27;19(7):799-805. doi: 10.1016/j.chembiol.2012.05.015.

11.

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL.

Structure. 2012 Aug 8;20(8):1374-83. doi: 10.1016/j.str.2012.05.009. Epub 2012 Jun 21.

12.

The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years.

Brignole EJ, Ando N, Zimanyi CM, Drennan CL.

Biochem Soc Trans. 2012 Jun 1;40(3):523-30. doi: 10.1042/BST20120081. Review.

13.

Subunit architecture of general transcription factor TFIIH.

Gibbons BJ, Brignole EJ, Azubel M, Murakami K, Voss NR, Bushnell DA, Asturias FJ, Kornberg RD.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1949-54. doi: 10.1073/pnas.1105266109. Epub 2012 Jan 20.

14.

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.

Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51. doi: 10.1073/pnas.1112715108. Epub 2011 Dec 12.

15.

Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin).

Fernandes SM, Brignole EJ, Taori K, Gibson W.

J Virol. 2011 Apr;85(7):3526-34. doi: 10.1128/JVI.02663-10. Epub 2011 Jan 26. Erratum in: J Virol. 2011 Aug;85(15):7951. Taori, Kanchan [added].

16.

Single-particle electron microscopy of animal fatty acid synthase describing macromolecular rearrangements that enable catalysis.

Brignole EJ, Asturias F.

Methods Enzymol. 2010;483:179-202. doi: 10.1016/S0076-6879(10)83009-5.

PMID:
20888475
17.

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

Voss NR, Lyumkis D, Cheng A, Lau PW, Mulder A, Lander GC, Brignole EJ, Fellmann D, Irving C, Jacovetty EL, Leung A, Pulokas J, Quispe JD, Winkler H, Yoshioka C, Carragher B, Potter CS.

J Struct Biol. 2010 Mar;169(3):389-98. doi: 10.1016/j.jsb.2009.12.005. Epub 2009 Dec 16.

18.

Conformational flexibility of metazoan fatty acid synthase enables catalysis.

Brignole EJ, Smith S, Asturias FJ.

Nat Struct Mol Biol. 2009 Feb;16(2):190-7. doi: 10.1038/nsmb.1532. Epub 2009 Jan 18.

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Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.

McCartney SA, Brignole EJ, Kolegraff KN, Loveland AN, Ussin LM, Gibson W.

J Biol Chem. 2005 Sep 30;280(39):33206-12. Epub 2005 Jul 21.

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