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Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation.

Zeng B, Lloyd-Jones LR, Montgomery GW, Metspalu A, Esko T, Franke L, Vosa U, Claringbould A, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G.

Genetics. 2019 Jul;212(3):905-918. doi: 10.1534/genetics.119.302091. Epub 2019 May 22.


Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression.

Zeng B, Lloyd-Jones LR, Holloway A, Marigorta UM, Metspalu A, Montgomery GW, Esko T, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G.

G3 (Bethesda). 2017 Aug 7;7(8):2533-2544. doi: 10.1534/g3.117.043752.


Health Care Expenditures for University and Academic Medical Center Employees Enrolled in a Pilot Workplace Health Partner Intervention.

Johnston KJ, Hockenberry JM, Rask KJ, Cunningham L, Brigham KL, Martin GS.

J Occup Environ Med. 2015 Aug;57(8):897-903. doi: 10.1097/JOM.0000000000000488.


A Longitudinal Study of Health Improvement in the Atlanta CHDWB Wellness Cohort.

Tabassum R, Cunningham L, Stephens EH, Sturdivant K, Martin GS, Brigham KL, Gibson G.

J Pers Med. 2014 Dec 22;4(4):489-507. doi: 10.3390/jpm4040489.


Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults.

Alvarez JA, Chowdhury R, Jones DP, Martin GS, Brigham KL, Binongo JN, Ziegler TR, Tangpricha V.

Clin Endocrinol (Oxf). 2014 Sep;81(3):458-66. doi: 10.1111/cen.12449. Epub 2014 Apr 15.


Whole genome sequencing in support of wellness and health maintenance.

Patel CJ, Sivadas A, Tabassum R, Preeprem T, Zhao J, Arafat D, Chen R, Morgan AA, Martin GS, Brigham KL, Butte AJ, Gibson G.

Genome Med. 2013 Jun 27;5(6):58. doi: 10.1186/gm462. eCollection 2013.


Fluid flux and clearance in acute lung injury.

Martin GS, Brigham KL.

Compr Physiol. 2012 Oct;2(4):2471-80. doi: 10.1002/cphy.c100050. Review.


Blood-informative transcripts define nine common axes of peripheral blood gene expression.

Preininger M, Arafat D, Kim J, Nath AP, Idaghdour Y, Brigham KL, Gibson G.

PLoS Genet. 2013;9(3):e1003362. doi: 10.1371/journal.pgen.1003362. Epub 2013 Mar 14.


Infusion of freshly isolated autologous bone marrow derived mononuclear cells prevents endotoxin-induced lung injury in an ex-vivo perfused swine model.

Rojas M, Parker RE, Thorn N, Corredor C, Iyer SS, Bueno M, Mroz L, Cardenes N, Mora AL, Stecenko AA, Brigham KL.

Stem Cell Res Ther. 2013 Mar 4;4(2):26. doi: 10.1186/scrt174.


Genetic risk prediction in a small cohort of healthy adults in Atlanta.

Zhao J, Arafat D, Brigham KL, Gibson G.

Genet Res (Camb). 2013 Feb;95(1):30-7. doi: 10.1017/S0016672313000025. Epub 2013 Feb 26.


Psychosocial factors associated with diet quality in a working adult population.

Ferranti EP, Dunbar SB, Higgins M, Dai J, Ziegler TR, Frediani JK, Reilly C, Brigham KL.

Res Nurs Health. 2013 Jun;36(3):242-56. doi: 10.1002/nur.21532. Epub 2013 Feb 13.


The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema.

Siore AM, Parker RE, Cuppels C, Thorn N, Hansen JM, Stecenko AA, Brigham KL.

Pulm Pharmacol Ther. 2012 Oct;25(5):407-12. doi: 10.1016/j.pupt.2012.08.002. Epub 2012 Aug 17.


High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring.

Park YH, Lee K, Soltow QA, Strobel FH, Brigham KL, Parker RE, Wilson ME, Sutliff RL, Mansfield KG, Wachtman LM, Ziegler TR, Jones DP.

Toxicology. 2012 May 16;295(1-3):47-55. doi: 10.1016/j.tox.2012.02.007. Epub 2012 Mar 1.


Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis.

Cribbs SK, Sutcliffe DJ, Taylor WR, Rojas M, Easley KA, Tang L, Brigham KL, Martin GS.

Intensive Care Med. 2012 Mar;38(3):429-36. doi: 10.1007/s00134-012-2480-9. Epub 2012 Feb 14.


Integrating comparative effectiveness research programs into predictive health: a unique role for academic health centers.

Rask KJ, Brigham KL, Johns MM.

Acad Med. 2011 Jun;86(6):718-23. doi: 10.1097/ACM.0b013e318217ea6c.


Effect of bone marrow-derived mesenchymal stem cells on endotoxin-induced oxidation of plasma cysteine and glutathione in mice.

Iyer SS, Torres-Gonzalez E, Neujahr DC, Kwon M, Brigham KL, Jones DP, Mora AL, Rojas M.

Stem Cells Int. 2010 Mar 8;2010:868076. doi: 10.4061/2010/868076.


Predictive health: the imminent revolution in health care.

Brigham KL.

J Am Geriatr Soc. 2010 Oct;58 Suppl 2:S298-302. doi: 10.1111/j.1532-5415.2010.03107.x. Review.


A senescence accelerated mouse model to study aging in the larynx.

Kolachala VL, Torres-Gonzalez E, Mwangi S, Kelly P, Brigham KL, Pavlath GK, Rojas M, Johns MM.

Otolaryngol Head Neck Surg. 2010 Jun;142(6):879-85. doi: 10.1016/j.otohns.2009.12.037.


Slow-release nanoparticle-encapsulated delivery system for laryngeal injection.

Kolachala VL, Henriquez OA, Shams S, Golub JS, Kim YT, Laroui H, Torres-Gonzalez E, Brigham KL, Rojas M, Bellamkonda RV, Johns MM.

Laryngoscope. 2010 May;120(5):988-94. doi: 10.1002/lary.20856.


Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice.

Xu J, Gonzalez ET, Iyer SS, Mac V, Mora AL, Sutliff RL, Reed A, Brigham KL, Kelly P, Rojas M.

J Gerontol A Biol Sci Med Sci. 2009 Jul;64(7):731-9. doi: 10.1093/gerona/glp040. Epub 2009 Apr 9.


Attenuation of obliterative bronchiolitis by a CXCR4 antagonist in the murine heterotopic tracheal transplant model.

Xu J, Torres E, Mora AL, Shim H, Ramirez A, Neujahr D, Brigham KL, Rojas M.

J Heart Lung Transplant. 2008 Dec;27(12):1302-10. doi: 10.1016/j.healun.2008.08.010.


Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis.

Iyer SS, Ramirez AM, Ritzenthaler JD, Torres-Gonzalez E, Roser-Page S, Mora AL, Brigham KL, Jones DP, Roman J, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L37-45. doi: 10.1152/ajplung.90401.2008. Epub 2008 Oct 17.


Transforming health care through prospective medicine: the first step.

Johns MM, Brigham KL.

Acad Med. 2008 Aug;83(8):706. doi: 10.1097/ACM.0b013e31817eb579. No abstract available.


Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury.

Iyer SS, Jones DP, Brigham KL, Rojas M.

Am J Respir Cell Mol Biol. 2009 Jan;40(1):90-8. doi: 10.1165/rcmb.2007-0447OC. Epub 2008 Jul 29.


Age-related changes in the murine larynx: initial validation of a mouse model.

Abdelkafy WM, Smith JQ, Henriquez OA, Golub JS, Xu J, Rojas M, Brigham KL, Johns MM.

Ann Otol Rhinol Laryngol. 2007 Aug;116(8):618-22.


Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

Xu J, Mora A, Shim H, Stecenko A, Brigham KL, Rojas M.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):291-9. Epub 2007 Apr 26.


Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.

Xu J, Woods CR, Mora AL, Joodi R, Brigham KL, Iyer S, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L131-41. Epub 2007 Apr 6.


Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet.

Xu J, Mora AL, LaVoy J, Brigham KL, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L658-67. Epub 2006 Apr 28.


Effects of aerosol vs IV UT-15 on prostaglandin H2 analog-induced pulmonary hypertension in sheep.

Sandifer BL, Brigham KL, Lawrence EC, Parker RE.

Chest. 2005 Dec;128(6 Suppl):616S. No abstract available.


Potent effects of aerosol compared with intravenous treprostinil on the pulmonary circulation.

Sandifer BL, Brigham KL, Lawrence EC, Mottola D, Cuppels C, Parker RE.

J Appl Physiol (1985). 2005 Dec;99(6):2363-8. Epub 2005 Sep 1.


Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.

Brigham KL.

Curr Infect Dis Rep. 2005 Sep;7(5):327-8. No abstract available.


Endotoxin-induced acute lung injury requires interaction with the liver.

Siore AM, Parker RE, Stecenko AA, Cuppels C, McKean M, Christman BW, Cruz-Gervis R, Brigham KL.

Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L769-76. Epub 2005 Jul 8.


Increased circulating endothelial progenitor cells are associated with survival in acute lung injury.

Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M.

Am J Respir Crit Care Med. 2005 Oct 1;172(7):854-60. Epub 2005 Jun 23.


Prevention of NF-kappaB activation in vivo by a cell-permeable NF-kappaB inhibitor peptide.

Mora AL, LaVoy J, McKean M, Stecenko A, Brigham KL, Parker R, Rojas M.

Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L536-44. Epub 2005 Jun 10.


Bone marrow-derived mesenchymal stem cells in repair of the injured lung.

Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL.

Am J Respir Cell Mol Biol. 2005 Aug;33(2):145-52. Epub 2005 May 12.


Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice.

Mora AL, Woods CR, Garcia A, Xu J, Rojas M, Speck SH, Roman J, Brigham KL, Stecenko AA.

Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L711-21. Epub 2005 Feb 25.


Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses.

Rojas M, Woods CR, Mora AL, Xu J, Brigham KL.

Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L333-41. Epub 2004 Oct 8.


Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis.

Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, Graham BS, Brigham KL, Oates JA Jr, Loyd JE, Stecenko AA.

J Clin Microbiol. 2003 Jun;41(6):2633-40.


Gene therapy progress and prospects: alpha-1 antitrypsin.

Stecenko AA, Brigham KL.

Gene Ther. 2003 Jan;10(2):95-9. Review.


Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis.

Cruz-Gervis R, Stecenko AA, Dworski R, Lane KB, Loyd JE, Pierson R, King G, Brigham KL.

Respir Res. 2002;3:17. Epub 2002 Feb 23.


Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells.

Stecenko AA, King G, Torii K, Breyer RM, Dworski R, Blackwell TS, Christman JW, Brigham KL.

Inflammation. 2001 Jun;25(3):145-55.


Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells.

Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, Christman JW, Blackwell TS.

Am J Respir Cell Mol Biol. 2000 Sep;23(3):396-403.


Hepatic cryoablation-induced acute lung injury: pulmonary hemodynamic and permeability effects in a sheep model.

Chapman WC, Debelak JP, Blackwell TS, Gainer KA, Christman JW, Pinson CW, Brigham KL, Parker RE.

Arch Surg. 2000 Jun;135(6):667-72; discussion 672-3.


Transfection of nasal mucosa with a normal alpha1-antitrypsin gene in alpha1-antitrypsin-deficient subjects: comparison with protein therapy.

Brigham KL, Lane KB, Meyrick B, Stecenko AA, Strack S, Cannon DR, Caudill M, Canonico AE.

Hum Gene Ther. 2000 May 1;11(7):1023-32.


Gene therapy for acute lung injury.

Brigham KL, Stecenko AA.

Intensive Care Med. 2000;26 Suppl 1:S119-23. Review.


Pulmonary edema and acute lung injury research.

Brigham KL, Staub NC.

Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 2):S109-13. No abstract available.


Targeted in vivo gene transfection modulated hyperacute rejection of pig lungs perfused with human blood.

Pierson RN 3rd, Conary JT, Langford G, White DG, Brigham KL, Parker RE.

Transplant Proc. 1996 Apr;28(2):763. No abstract available.


Plasmid-liposome transfer of the alpha 1 antitrypsin gene to cystic fibrosis bronchial epithelial cells prevents elastase-induced cell detachment and cytokine release.

Canonico AE, Brigham KL, Carmichael LC, Plitman JD, King GA, Blackwell TR, Christman JW.

Am J Respir Cell Mol Biol. 1996 Apr;14(4):348-55.


Secretory leukoprotease inhibitor attenuates lung injury induced by continuous air embolization into sheep.

Gossage JR, Perkett EA, Davidson JM, Starcher BC, Carmichael D, Brigham KL, Meyrick B.

J Appl Physiol (1985). 1995 Oct;79(4):1163-72.


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