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Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.

Brigham EF, Johnston TH, Brown C, Holt JDS, Fox SH, Hill MP, Howson PA, Brotchie JM, Nguyen JT.

J Pharmacol Exp Ther. 2018 Nov;367(2):373-381. doi: 10.1124/jpet.118.247650. Epub 2018 Aug 7.


The Role of Immunotherapy in the Treatment of Asthma [Internet].

Lin SY, Azar A, Suarez-Cuervo C, Diette GB, Brigham E, Rice J, Ramanathan M Jr., Gayleard J, Robinson KA.

Rockville, MD: Agency for Healthcare Research and Quality (US); 2018 Mar.


Role of sublingual immunotherapy in the treatment of asthma: An updated systematic review.

Lin SY, Azar A, Suarez-Cuervo C, Diette GB, Brigham E, Rice J, Ramanathan M Jr, Robinson KA.

Int Forum Allergy Rhinol. 2018 Sep;8(9):982-992. doi: 10.1002/alr.22152. Epub 2018 Jun 9.


In-Home Secondhand Smoke Exposure Among Urban Children With Asthma: Contrasting Households With and Without Residential Smokers.

Wu TD, Eakin MN, Rand CS, Brigham EP, Diette GB, Hansel NN, McCormack MC.

J Public Health Manag Pract. 2018 Apr 5. doi: 10.1097/PHH.0000000000000790. [Epub ahead of print]


Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children.

Wu TD, Brigham EP, Peng R, Koehler K, Rand C, Matsui EC, Diette GB, Hansel NN, McCormack MC.

J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2157-2159.e5. doi: 10.1016/j.jaip.2018.04.020. Epub 2018 May 3. No abstract available.


Allergen-Specific Immunotherapy in the Treatment of Pediatric Asthma: A Systematic Review.

Rice JL, Diette GB, Suarez-Cuervo C, Brigham EP, Lin SY, Ramanathan M Jr, Robinson KA, Azar A.

Pediatrics. 2018 May;141(5). pii: e20173833. doi: 10.1542/peds.2017-3833. Epub 2018 Mar 23. Review.


Diet Pattern and Respiratory Morbidity in the Atherosclerosis Risk in Communities Study.

Brigham EP, Steffen LM, London SJ, Boyce D, Diette GB, Hansel NN, Rice J, McCormack MC.

Ann Am Thorac Soc. 2018 Jun;15(6):675-682. doi: 10.1513/AnnalsATS.201707-571OC.


The effect of community socioeconomic status on sepsis-attributable mortality.

Galiatsatos P, Brigham EP, Pietri J, Littleton K, Hwang S, Grant MC, Hansel NN, Chen ES.

J Crit Care. 2018 Aug;46:129-133. doi: 10.1016/j.jcrc.2018.01.008. Epub 2018 Jan 12.


Editorial: JCP Communications-Updating a valued community resource.

Lester MI, Hamm P, Manolopoulos DE, Skinner JL, Brigham EC.

J Chem Phys. 2018 Jan 7;148(1):010401. doi: 10.1063/1.5019731. No abstract available.


Neighbourhood characteristics and health outcomes: evaluating the association between socioeconomic status, tobacco store density and health outcomes in Baltimore City.

Galiatsatos P, Kineza C, Hwang S, Pietri J, Brigham E, Putcha N, Rand CS, McCormack M, Hansel NN.

Tob Control. 2018 Jul;27(e1):e19-e24. doi: 10.1136/tobaccocontrol-2017-053945. Epub 2017 Nov 23.


The feasibility of an air purifier and secondhand smoke education intervention in homes of inner city pregnant women and infants living with a smoker.

Rice JL, Brigham E, Dineen R, Muqueeth S, O'Keefe G, Regenold S, Koehler K, Rule A, McCormack M, Hansel NN, Diette GB.

Environ Res. 2018 Jan;160:524-530. doi: 10.1016/j.envres.2017.10.020. Epub 2017 Oct 29.


Impact of Physical Activity on Reporting of Childhood Asthma Symptoms.

Nnodum BN, McCormack MC, Putcha N, Hwang S, Paulin LM, Brigham EP, Fawzy A, Romero K, Diette GB, Hansel NN.

Lung. 2017 Dec;195(6):693-698. doi: 10.1007/s00408-017-0049-7. Epub 2017 Sep 15.


Effect of home exposure to Staphylococcus aureus on asthma in adolescents.

Davis MF, Ludwig S, Brigham EP, McCormack MC, Matsui EC.

J Allergy Clin Immunol. 2018 Jan;141(1):402-405.e10. doi: 10.1016/j.jaci.2017.06.031. Epub 2017 Jul 21. No abstract available.


A pilot feeding study for adults with asthma: The healthy eating better breathing trial.

Brigham EP, Matsui EC, Appel LJ, Bull DA, Curtin-Brosnan J, Zhai S, White K, Charleston JB, Hansel NN, Diette GB, McCormack MC.

PLoS One. 2017 Jul 13;12(7):e0180068. doi: 10.1371/journal.pone.0180068. eCollection 2017.


Analysis of home dust for Staphylococcus aureus and staphylococcal enterotoxin genes using quantitative PCR.

Ludwig S, Jimenez-Bush I, Brigham E, Bose S, Diette G, McCormack MC, Matsui EC, Davis MF.

Sci Total Environ. 2017 Mar 1;581-582:750-755. doi: 10.1016/j.scitotenv.2017.01.003. Epub 2017 Jan 5.


Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis.

Brigham EM, Armstrong DG.

Spine Deform. 2017 Jan;5(1):46-51. doi: 10.1016/j.jspd.2016.09.004.


Editorial: The Future of Chemical Physics Conference 2016.

Michaelides A, Manolopoulos DE, Vega C, Hamm P, Chandler DW, Brigham EC, Lester MI.

J Chem Phys. 2016 Dec 14;145(22):220401. No abstract available.


Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD.

Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN; COPDGene Investigators.

Chest. 2017 Jan;151(1):68-77. doi: 10.1016/j.chest.2016.08.1432. Epub 2016 Aug 25.


Disentangling the Physical Processes Responsible for the Kinetic Complexity in Interfacial Electron Transfer of Excited Ru(II) Polypyridyl Dyes on TiO2.

Zigler DF, Morseth ZA, Wang L, Ashford DL, Brennaman MK, Grumstrup EM, Brigham EC, Gish MK, Dillon RJ, Alibabaei L, Meyer GJ, Meyer TJ, Papanikolas JM.

J Am Chem Soc. 2016 Apr 6;138(13):4426-38. doi: 10.1021/jacs.5b12996. Epub 2016 Mar 25.


Association of severity of illness and intensive care unit readmission: A systematic review.

Wong EG, Parker AM, Leung DG, Brigham EP, Arbaje AI.

Heart Lung. 2016 Jan-Feb;45(1):3-9.e2. doi: 10.1016/j.hrtlng.2015.10.040. Review.


Like Father, Like Son: Cleidocranial Dysplasia: A Case Report.

Brigham EM, Hennrikus WL.

JBJS Case Connect. 2015 Oct-Dec;5(4):e94. doi: 10.2106/JBJS.CC.O.00003.


Diagnosis of asthma: diagnostic testing.

Brigham EP, West NE.

Int Forum Allergy Rhinol. 2015 Sep;5 Suppl 1:S27-30. doi: 10.1002/alr.21597. Review.


Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

Giacomini A, Stagni F, Trazzi S, Guidi S, Emili M, Brigham E, Ciani E, Bartesaghi R.

Neurobiol Dis. 2015 Oct;82:385-396. doi: 10.1016/j.nbd.2015.08.001. Epub 2015 Aug 5.


Associations Between Parental Health Literacy, Use of Asthma Management Plans, and Child's Asthma Control.

Brigham EL, Goldenberg L, Stolfi A, Mueller GA, Forbis SG.

Clin Pediatr (Phila). 2016 Feb;55(2):111-7. doi: 10.1177/0009922815587089. Epub 2015 May 20.


Iron status is associated with asthma and lung function in US women.

Brigham EP, McCormack MC, Takemoto CM, Matsui EC.

PLoS One. 2015 Feb 17;10(2):e0117545. doi: 10.1371/journal.pone.0117545. eCollection 2015.


Obesity as a susceptibility factor to indoor particulate matter health effects in COPD.

McCormack MC, Belli AJ, Kaji DA, Matsui EC, Brigham EP, Peng RD, Sellers C, Williams DL, Diette GB, Breysse PN, Hansel NN.

Eur Respir J. 2015 May;45(5):1248-57. doi: 10.1183/09031936.00081414. Epub 2015 Jan 8.


Association between Western diet pattern and adult asthma: a focused review.

Brigham EP, Kolahdooz F, Hansel N, Breysse PN, Davis M, Sharma S, Matsui EC, Diette G, McCormack MC.

Ann Allergy Asthma Immunol. 2015 Apr;114(4):273-80. doi: 10.1016/j.anai.2014.11.003. Epub 2014 Dec 15. Review.


Excited state electron transfer after visible light absorption by the Co(I) state of vitamin B12.

Achey D, Brigham EC, DiMarco BN, Meyer GJ.

Chem Commun (Camb). 2014 Nov 11;50(87):13304-6. doi: 10.1039/c4cc02221a.


Comparison of cigarette smoking knowledge, attitudes, and practices among staff in perinatal and other substance abuse treatment settings.

Miller-Thomas T, Leoutsakos JM, Terplan M, Brigham EP, Chisolm MS.

J Addict Med. 2014 Sep-Oct;8(5):377-83. doi: 10.1097/ADM.0000000000000068.


Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection.

Brigham EP, Patil SP, Jacobson LP, Margolick JB, Godfrey R, Johnson J, Johnson-Hill LM, Reynolds S, Schwartz AR, Smith PL, Brown TT.

Antivir Ther. 2014;19(8):725-33. doi: 10.3851/IMP2745. Epub 2014 Feb 12.


Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.

Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M.

Mol Psychiatry. 2014 Aug;19(8):937-46. doi: 10.1038/mp.2013.122. Epub 2013 Sep 24.


Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.

Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ, Brennan RJ, Brigham EF, Olaharski AJ.

PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013.


Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.

Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS.

J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20.


Training perspective: the impact of starting an endobronchial ultrasound program at a major academic center on fellows training of transbronchial needle aspiration.

Feller-Kopman DJ, Brigham E, Lechtzin N, Gilbert C, Akulian J, Yarmus L.

Ann Am Thorac Soc. 2013 Apr;10(2):127-30. doi: 10.1513/AnnalsATS.201208-052OC.


Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.

Garofalo AW, Adler M, Aubele DL, Brigham EF, Chian D, Franzini M, Goldbach E, Kwong GT, Motter R, Probst GD, Quinn KP, Ruslim L, Sham HL, Tam D, Tanaka P, Truong AP, Ye XM, Ren Z.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):1974-7. doi: 10.1016/j.bmcl.2013.02.041. Epub 2013 Feb 15.


Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

Ye XM, Konradi AW, Sun M, Yuan S, Aubele DL, Dappen M, Dressen D, Garofalo AW, Jagodzinski JJ, Latimer L, Probst GD, Sham HL, Wone D, Xu YZ, Ness D, Brigham E, Kwong GT, Willtis C, Tonn G, Goldbach E, Quinn KP, Zhang HH, Sauer JM, Bova M, Basi GS.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):996-1000. doi: 10.1016/j.bmcl.2012.12.039. Epub 2012 Dec 21.


The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.

Lauritzen I, Pardossi-Piquard R, Bauer C, Brigham E, Abraham JD, Ranaldi S, Fraser P, St-George-Hyslop P, Le Thuc O, Espin V, Chami L, Dunys J, Checler F.

J Neurosci. 2012 Nov 14;32(46):16243-1655a. doi: 10.1523/JNEUROSCI.2775-12.2012.


Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies.

Gullapalli R, Wong A, Brigham E, Kwong G, Wadsworth A, Willits C, Quinn K, Goldbach E, Samant B.

Drug Deliv. 2012 Jun-Jul;19(5):239-46. doi: 10.3109/10717544.2012.691121. Epub 2012 Jun 1.


Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

Aubele DL, Truong AP, Dressen DB, Probst GD, Bowers S, Mattson MN, Semko CM, Sun M, Garofalo AW, Konradi AW, Sham HL, Zmolek W, Wong K, Goldbach E, Quinn KP, Sauer JM, Brigham EF, Wallace W, Nguyen L, Bova MP, Hemphill SS, Basi G.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5791-4. doi: 10.1016/j.bmcl.2011.08.008. Epub 2011 Aug 9.


Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

Neitzel ML, Aubele DL, Marugg JL, Jagodzinski JJ, Konradi AW, Pleiss MA, Szoke B, Zmolek W, Goldbach E, Quinn KP, Sauer JM, Brigham EF, Wallace W, Bova MP, Hemphill S, Basi G.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3715-20. doi: 10.1016/j.bmcl.2011.04.079. Epub 2011 May 1.


Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

Bowers S, Truong AP, Neitz RJ, Neitzel M, Probst GD, Hom RK, Peterson B, Galemmo RA Jr, Konradi AW, Sham HL, Tóth G, Pan H, Yao N, Artis DR, Brigham EF, Quinn KP, Sauer JM, Powell K, Ruslim L, Ren Z, Bard F, Yednock TA, Griswold-Prenner I.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1838-43. doi: 10.1016/j.bmcl.2011.01.046. Epub 2011 Jan 20.


Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.

Basi GS, Hemphill S, Brigham EF, Liao A, Aubele DL, Baker J, Barbour R, Bova M, Chen XH, Dappen MS, Eichenbaum T, Goldbach E, Hawkinson J, Lawler-Herbold R, Hu K, Hui T, Jagodzinski JJ, Keim PS, Kholodenko D, Latimer LH, Lee M, Marugg J, Mattson MN, McCauley S, Miller JL, Motter R, Mutter L, Neitzel ML, Ni H, Nguyen L, Quinn K, Ruslim L, Semko CM, Shapiro P, Smith J, Soriano F, Szoke B, Tanaka K, Tang P, Tucker JA, Ye XM, Yu M, Wu J, Xu YZ, Garofalo AW, Sauer JM, Konradi AW, Ness D, Shopp G, Pleiss MA, Freedman SB, Schenk D.

Alzheimers Res Ther. 2010 Dec 29;2(6):36. doi: 10.1186/alzrt60.


Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.

Truong AP, Tóth G, Probst GD, Sealy JM, Bowers S, Wone DW, Dressen D, Hom RK, Konradi AW, Sham HL, Wu J, Peterson BT, Ruslim L, Bova MP, Kholodenko D, Motter RN, Bard F, Santiago P, Ni H, Chian D, Soriano F, Cole T, Brigham EF, Wong K, Zmolek W, Goldbach E, Samant B, Chen L, Zhang H, Nakamura DF, Quinn KP, Yednock TA, Sauer JM.

Bioorg Med Chem Lett. 2010 Nov 1;20(21):6231-6. doi: 10.1016/j.bmcl.2010.08.102. Epub 2010 Aug 24.


Cigarette smoking knowledge, attitudes, and practices of patients and staff at a perinatal substance abuse treatment center.

Chisolm MS, Brigham EP, Lookatch SJ, Tuten M, Strain EC, Jones HE.

J Subst Abuse Treat. 2010 Oct;39(3):298-305. doi: 10.1016/j.jsat.2010.06.008. Epub 2010 Jul 29.


Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).

Ye XM, Konradi AW, Smith J, Aubele DL, Garofalo AW, Marugg J, Neitzel ML, Semko CM, Sham HL, Sun M, Truong AP, Wu J, Zhang H, Goldbach E, Sauer JM, Brigham EF, Bova M, Basi GS.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3502-6. doi: 10.1016/j.bmcl.2010.04.148. Epub 2010 May 6.


Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

Ye XM, Konradi AW, Smith J, Xu YZ, Dressen D, Garofalo AW, Marugg J, Sham HL, Truong AP, Jagodzinski J, Pleiss M, Zhang H, Goldbach E, Sauer JM, Brigham E, Bova M, Basi GS.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2195-9. doi: 10.1016/j.bmcl.2010.02.039. Epub 2010 Feb 13.


Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.

Mattson MN, Neitzel ML, Quincy DA, Semko CM, Garofalo AW, Keim PS, Konradi AW, Pleiss MA, Sham HL, Brigham EF, Goldbach EG, Zhang H, Sauer JM, Basi GS.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2148-50. doi: 10.1016/j.bmcl.2010.02.050. Epub 2010 Feb 14.


The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.

Chisolm MS, Brigham EP, Tuten M, Strain EC, Jones HE.

Am J Drug Alcohol Abuse. 2010 Jan;36(1):46-51. doi: 10.3109/00952990903544844.


Relationship between cigarette use and mood/anxiety disorders among pregnant methadone-maintained patients.

Chisolm MS, Tuten M, Brigham EC, Strain EC, Jones HE.

Am J Addict. 2009 Sep-Oct;18(5):422-9. doi: 10.3109/10550490903077721.


Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

Truong AP, Aubele DL, Probst GD, Neitzel ML, Semko CM, Bowers S, Dressen D, Hom RK, Konradi AW, Sham HL, Garofalo AW, Keim PS, Wu J, Dappen MS, Wong K, Goldbach E, Quinn KP, Sauer JM, Brigham EF, Wallace W, Nguyen L, Hemphill SS, Bova MP, Bard F, Yednock TA, Basi G.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):4920-3. doi: 10.1016/j.bmcl.2009.07.092. Epub 2009 Jul 23. Erratum in: Bioorg Med Chem Lett. 2010 Dec 15;20(24):7553. Bard, Frédérique [added]; Yednock, Ted A [added].


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