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Items: 1 to 50 of 239

1.

Chronic prenatal ethanol exposure alters expression of central and peripheral insulin signaling molecules in adult guinea pig offspring.

Dobson CC, Thevasundaram K, Mongillo DL, Winterborn A, Holloway AC, Brien JF, Reynolds JN.

Alcohol. 2014 Nov;48(7):687-93. doi: 10.1016/j.alcohol.2014.09.001. Epub 2014 Sep 6.

PMID:
25278255
2.

Chronic ethanol exposure increases the non-dominant glucocorticoid, corticosterone, in the near-term pregnant guinea pig.

Hewitt AJ, Dobson CC, Brien JF, Wynne-Edwards KE, Reynolds JN.

Alcohol. 2014 Aug;48(5):477-81. doi: 10.1016/j.alcohol.2014.06.005. Epub 2014 Jun 7.

PMID:
24961542
3.

Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheep.

Parkington HC, Kenna KR, Sozo F, Coleman HA, Bocking A, Brien JF, Harding R, Walker DW, Morley R, Tare M.

J Physiol. 2014 Jun 15;592(12):2591-603. doi: 10.1113/jphysiol.2013.262873. Epub 2014 Apr 22.

4.

In vitro Activation of heme oxygenase-2 by menadione and its analogs.

Vukomanovic D, Rahman MN, Bilokin Y, Golub AG, Brien JF, Szarek WA, Jia Z, Nakatsu K.

Med Gas Res. 2014 Feb 18;4(1):4. doi: 10.1186/2045-9912-4-4.

5.

Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells.

Roth FC, Mulder JE, Brien JF, Takahashi T, Massey TE.

Chem Biol Interact. 2013 Aug 25;204(3):135-9. doi: 10.1016/j.cbi.2013.05.006. Epub 2013 May 23.

PMID:
23707191
6.

Alcohol exposure during late ovine gestation alters fetal liver iron homeostasis without apparent dysmorphology.

Sozo F, Dick AM, Bensley JG, Kenna K, Brien JF, Harding R, De Matteo R.

Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15;304(12):R1121-9. doi: 10.1152/ajpregu.00479.2012. Epub 2013 Apr 17.

7.

Meconium fatty acid ethyl esters as biomarkers of late gestational ethanol exposure and indicator of ethanol-induced multi-organ injury in fetal sheep.

Zelner I, Kenna K, Brien JF, Bocking A, Harding R, Walker D, Koren G.

PLoS One. 2013;8(3):e59168. doi: 10.1371/journal.pone.0059168. Epub 2013 Mar 22.

8.

Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring.

Dobson CC, Mongillo DL, Brien DC, Stepita R, Poklewska-Koziell M, Winterborn A, Holloway AC, Brien JF, Reynolds JN.

Nutr Diabetes. 2012 Dec 17;2:e57. doi: 10.1038/nutd.2012.31.

9.

Alcohol exposure during late gestation: multiple developmental outcomes in sheep.

Kenna K, Sozo F, De Matteo R, Hanita T, Gray SP, Tare M, Moritz K, Bertram JF, Black MJ, Brien JF, Parkington HC, Walker DW, Harding R.

J Dev Orig Health Dis. 2012 Aug;3(4):224-36. doi: 10.1017/S2040174412000244.

PMID:
25102144
10.

Sensitivity of modified Biel-maze task, compared with Y-maze task, to measure spatial learning and memory deficits of ethanol teratogenicity in the guinea pig.

Dobson CC, Mongillo DL, Poklewska-Koziell M, Winterborn A, Brien JF, Reynolds JN.

Behav Brain Res. 2012 Jul 15;233(1):162-8. doi: 10.1016/j.bbr.2012.04.042. Epub 2012 Apr 27.

PMID:
22562040
11.

Maternal ethanol consumption by pregnant guinea pigs causes neurobehavioral deficits and increases ethanol preference in offspring.

Shea KM, Hewitt AJ, Olmstead MC, Brien JF, Reynolds JN.

Behav Pharmacol. 2012 Feb;23(1):105-12. doi: 10.1097/FBP.0b013e32834ed866.

PMID:
22157142
12.

Selective activation of heme oxygenase-2 by menadione.

Vukomanovic D, McLaughlin BE, Rahman MN, Szarek WA, Brien JF, Jia Z, Nakatsu K.

Can J Physiol Pharmacol. 2011 Nov;89(11):861-4. doi: 10.1139/y11-091. Epub 2011 Nov 1.

PMID:
22039914
13.

Chronic ethanol exposure and folic acid supplementation: fetal growth and folate status in the maternal and fetal guinea pig.

Hewitt AJ, Knuff AL, Jefkins MJ, Collier CP, Reynolds JN, Brien JF.

Reprod Toxicol. 2011 May;31(4):500-6. doi: 10.1016/j.reprotox.2011.01.008. Epub 2011 Feb 16.

PMID:
21315145
14.

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells.

Mulder JE, Brien JF, Racz WJ, Takahashi T, Massey TE.

J Pharmacol Exp Ther. 2011 Feb;336(2):551-9. doi: 10.1124/jpet.110.173120. Epub 2010 Nov 15.

PMID:
21078785
15.

Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.

Vukomanovic D, McLaughlin B, Rahman MN, Vlahakis JZ, Roman G, Dercho RA, Kinobe RT, Hum M, Brien JF, Jia Z, Szarek WA, Nakatsu K.

Can J Physiol Pharmacol. 2010 Apr;88(4):480-6. doi: 10.1139/y10-004.

PMID:
20555417
16.

Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic-pituitary-adrenal axis in the maternal-fetal unit of the guinea pig.

Hewitt AJ, Walker KR, Kobus SM, Poklewska-Koziell M, Reynolds JN, Brien JF.

Neurotoxicol Teratol. 2010 Mar-Apr;32(2):164-70. doi: 10.1016/j.ntt.2009.12.002. Epub 2009 Dec 16.

PMID:
20006703
17.

Chronic prenatal ethanol exposure increases disinhibition and perseverative responding in the adult guinea pig.

Olmstead MC, Martin A, Brien JF, Reynolds JN.

Behav Pharmacol. 2009 Sep;20(5-6):554-7. doi: 10.1097/FBP.0b013e3283305e27.

PMID:
19633537
18.

Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep.

Gray SP, Kenna K, Bertram JF, Hoy WE, Yan EB, Bocking AD, Brien JF, Walker DW, Harding R, Moritz KM.

Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R568-74. doi: 10.1152/ajpregu.90316.2008. Epub 2008 Jun 18.

19.

Altered water-maze search behavior in adult guinea pigs following chronic prenatal ethanol exposure: lack of mitigation by postnatal fluoxetine treatment.

McAdam TD, Brien JF, Reynolds JN, Dringenberg HC.

Behav Brain Res. 2008 Aug 22;191(2):202-9. doi: 10.1016/j.bbr.2008.03.029. Epub 2008 Mar 27.

PMID:
18455245
20.

Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells.

Nicolescu AC, Ji Y, Comeau JL, Hill BC, Takahashi T, Brien JF, Racz WJ, Massey TE.

Toxicol Appl Pharmacol. 2008 Mar 15;227(3):370-9. doi: 10.1016/j.taap.2007.12.009. Epub 2007 Dec 15.

PMID:
18191165
21.

Effects of maternal administration of vitamins C and E on ethanol neurobehavioral teratogenicity in the guinea pig.

Nash CM, Ibram F, Dringenberg HC, Reynolds JN, Brien JF.

Alcohol. 2007 Dec;41(8):577-86. Epub 2007 Nov 5.

PMID:
17980996
22.

Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells.

Kinobe RT, Ji Y, Vlahakis JZ, Motterlini R, Brien JF, Szarek WA, Nakatsu K.

J Pharmacol Exp Ther. 2007 Dec;323(3):763-70. Epub 2007 Aug 30.

PMID:
17761847
23.

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.

Roman G, Riley JG, Vlahakis JZ, Kinobe RT, Brien JF, Nakatsu K, Szarek WA.

Bioorg Med Chem. 2007 May 1;15(9):3225-34. Epub 2007 Feb 22.

PMID:
17339115
24.

Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones.

Nicolescu AC, Comeau JL, Hill BC, Bedard LL, Takahashi T, Brien JF, Racz WJ, Massey TE.

Toxicol Appl Pharmacol. 2007 Apr 1;220(1):60-71. Epub 2007 Jan 9.

PMID:
17316728
25.

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia.

Kinobe RT, Vlahakis JZ, Soong JM, Szarek WA, Brien JF, Longo LD, Nakatsu K.

Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):893-901.

PMID:
17111034
26.

Chronic prenatal ethanol exposure increases glucocorticoid-induced glutamate release in the hippocampus of the near-term foetal guinea pig.

Iqbal U, Brien JF, Kapoor A, Matthews SG, Reynolds JN.

J Neuroendocrinol. 2006 Nov;18(11):826-34.

PMID:
17026532
27.
28.

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.

Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA.

J Med Chem. 2006 Jul 13;49(14):4437-41.

PMID:
16821802
29.

Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.

Kinobe RT, Dercho RA, Vlahakis JZ, Brien JF, Szarek WA, Nakatsu K.

J Pharmacol Exp Ther. 2006 Oct;319(1):277-84. Epub 2006 Jun 28.

PMID:
16807364
30.

Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal Guinea pig.

Brien JF, Chan D, Green CR, Iqbal U, Gareri J, Kobus SM, McLaughlin BE, Klein J, Rao C, Reynolds JN, Bocking AD, Koren G.

Ther Drug Monit. 2006 Jun;28(3):345-50.

PMID:
16778718
31.

Spatial learning deficits induced by chronic prenatal ethanol exposure can be overcome by non-spatial pre-training.

Iqbal U, Rikhy S, Dringenberg HC, Brien JF, Reynolds JN.

Neurotoxicol Teratol. 2006 May-Jun;28(3):333-41. Epub 2006 Mar 10.

PMID:
16530381
32.

Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms.

Kinobe RT, Vlahakis JZ, Vreman HJ, Stevenson DK, Brien JF, Szarek WA, Nakatsu K.

Br J Pharmacol. 2006 Feb;147(3):307-15.

33.

The source of endogenous carbon monoxide formation in human placental chorionic villi.

Ahmed H, McLaughlin BE, Soong J, Marks GS, Brien JF, Nakatsu K.

Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):447-51.

PMID:
16309566
34.

A Guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair.

Caprara DL, Brien JF, Iqbal U, Reynolds JN, Klein J, Koren G.

Pediatr Res. 2005 Dec;58(6):1158-63.

PMID:
16306186
35.

Chronic prenatal ethanol exposure increases apoptosis in the hippocampus of the term fetal guinea pig.

Green CR, Kobus SM, Ji Y, Bennett BM, Reynolds JN, Brien JF.

Neurotoxicol Teratol. 2005 Nov-Dec;27(6):871-81. Epub 2005 Aug 19. Erratum in: Neurotoxicol Teratol. 2006 Mar-Apr;28(2):296-7.

PMID:
16112842
36.

Chronic prenatal ethanol exposure alters glucocorticoid signalling in the hippocampus of the postnatal Guinea pig.

Iqbal U, Brien JF, Banjanin S, Andrews MH, Matthews SG, Reynolds JN.

J Neuroendocrinol. 2005 Sep;17(9):600-8.

PMID:
16101899
37.

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1457-61.

PMID:
15713406
38.

Spatial acquisition in the Morris water maze and hippocampal long-term potentiation in the adult guinea pig following brain growth spurt--prenatal ethanol exposure.

Byrnes ML, Richardson DP, Brien JF, Reynolds JN, Dringenberg HC.

Neurotoxicol Teratol. 2004 Jul-Aug;26(4):543-51.

PMID:
15203176
39.

The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.

Jaronczyk K, Bui L, Soong JM, McLaughlin BE, Marks GS, Brien JF, Nakatsu K.

Can J Physiol Pharmacol. 2004 Apr;82(4):218-24.

PMID:
15181459
40.

The source of heme for vascular heme oxygenase I: heme uptake in rat aorta.

Bui L, Rish K, Jaronczyk K, Bourque S, McLaughlin BE, Brien JF, Marks GS, Smith A, Nakatsu K.

Can J Physiol Pharmacol. 2004 Apr;82(4):209-17.

PMID:
15181458
41.

Elimination kinetics of ethanol in pregnant women.

Nava-Ocampo AA, Velázquez-Armenta Y, Brien JF, Koren G.

Reprod Toxicol. 2004 Jun;18(4):613-7.

PMID:
15135856
42.

Chronic prenatal ethanol exposure alters hippocampal GABA(A) receptors and impairs spatial learning in the guinea pig.

Iqbal U, Dringenberg HC, Brien JF, Reynolds JN.

Behav Brain Res. 2004 Apr 2;150(1-2):117-25.

PMID:
15033285
43.
44.

Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells.

Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH.

Am J Physiol Regul Integr Comp Physiol. 2003 Dec;285(6):R1453-60.

45.

Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig.

Hayward ML, Martin AE, Brien JF, Dringenberg HC, Olmstead MC, Reynolds JN.

J Pharmacol Exp Ther. 2004 Feb;308(2):644-50. Epub 2003 Nov 4.

PMID:
14600252
47.

What role does the heme-- heme oxygenase--carbon monoxide system play in vasoregulation?

Marks GS, Brien JF, Nakatsu K.

Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R522-3. Review. No abstract available.

48.

Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.

Card JW, Racz WJ, Brien JF, Margolin SB, Massey TE.

Toxicol Sci. 2003 Sep;75(1):169-80. Epub 2003 Jun 27.

PMID:
12832656
49.
50.

Brain growth spurt-prenatal ethanol exposure and the guinea pig hippocampal glutamate signaling system.

Byrnes ML, Reynolds JN, Brien JF.

Neurotoxicol Teratol. 2003 May-Jun;25(3):303-10.

PMID:
12757827

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