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Items: 1 to 50 of 88

1.

Respiratory health among professionals exposed to extreme SO2 levels from a volcanic eruption.

Carlsen HK, Aspelund T, Briem H, Gislason T, Jóhannsson T, Valdimarsdóttir U, Gudnason T.

Scand J Work Environ Health. 2019 May 1;45(3):312-315. doi: 10.5271/sjweh.3783. Epub 2019 Mar 5.

PMID:
30835315
2.

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM, Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K, Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von Nussbaum F, Bader B.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25.

3.

An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?

Follmann M, Briem H, Steinmeyer A, Hillisch A, Schmitt MH, Haning H, Meier H.

Drug Discov Today. 2019 Mar;24(3):668-672. doi: 10.1016/j.drudis.2018.12.003. Epub 2018 Dec 15. Review.

4.

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo.

Siemeister G, Mengel A, Fernández-Montalván AE, Bone W, Schröder J, Zitzmann-Kolbe S, Briem H, Prechtl S, Holton SJ, Mönning U, von Ahsen O, Johanssen S, Cleve A, Pütter V, Hitchcock M, von Nussbaum F, Brands M, Ziegelbauer K, Mumberg D.

Clin Cancer Res. 2019 Feb 15;25(4):1404-1414. doi: 10.1158/1078-0432.CCR-18-0628. Epub 2018 Nov 14.

PMID:
30429199
5.

Binding Kinetics Survey of the Drugged Kinome.

Georgi V, Schiele F, Berger BT, Steffen A, Marin Zapata PA, Briem H, Menz S, Preusse C, Vasta JD, Robers MB, Brands M, Knapp S, Fernández-Montalván A.

J Am Chem Soc. 2018 Nov 21;140(46):15774-15782. doi: 10.1021/jacs.8b08048. Epub 2018 Nov 6.

PMID:
30362749
6.

[European outbreak of Hepatitis A in Iceland in 2017. Common radiological changes of the gallbladder].

Ormarsdottir S, Moller PH, Oskarsdottir AR, Hannesson P, Love A, Briem H.

Laeknabladid. 2018 Juni;104(6):283-287. doi: 10.17992/lbl.2018.06.188. Icelandic.

7.

Computational Macrocyclization: From de novo Macrocycle Generation to Binding Affinity Estimation.

Wagner V, Jantz L, Briem H, Sommer K, Rarey M, Christ CD.

ChemMedChem. 2017 Nov 22;12(22):1866-1872. doi: 10.1002/cmdc.201700478. Epub 2017 Oct 25.

8.

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.

Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M.

ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16.

9.

Malignant mesothelioma incidence by nation-wide cancer registry: a population-based study.

Tomasson K, Gudmundsson G, Briem H, Rafnsson V.

J Occup Med Toxicol. 2016 Jul 26;11:37. doi: 10.1186/s12995-016-0127-4. eCollection 2016.

10.
11.

Public opinion on childhood immunisations in Iceland.

Óskarsson Ý, Guðnason Þ, Jónsdóttir GA, Kristinsson KG, Briem H, Haraldsson Á.

Vaccine. 2015 Dec 16;33(51):7211-7216. doi: 10.1016/j.vaccine.2015.10.125. Epub 2015 Nov 10.

PMID:
26555350
12.

Age-specific measles mortality during the late 19th-early 20th centuries.

Shanks GD, Waller M, Briem H, Gottfredsson M.

Epidemiol Infect. 2015 Dec;143(16):3434-41. doi: 10.1017/S0950268815000631. Epub 2015 Apr 13.

PMID:
25865777
13.

Facing the challenges of structure-based target prediction by inverse virtual screening.

Schomburg KT, Bietz S, Briem H, Henzler AM, Urbaczek S, Rarey M.

J Chem Inf Model. 2014 Jun 23;54(6):1676-86. doi: 10.1021/ci500130e. Epub 2014 May 22.

PMID:
24851945
14.

[Extent and impact of the measles epidemics of 1846 and 1882 in Iceland].

Gunnarsdottir S, Briem H, Gottfredsson M.

Laeknabladid. 2014 Apr;100(4):211-6. Icelandic.

PMID:
24713538
15.

The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer.

Lücking U, Jautelat R, Krüger M, Brumby T, Lienau P, Schäfer M, Briem H, Schulze J, Hillisch A, Reichel A, Wengner AM, Siemeister G.

ChemMedChem. 2013 Jul;8(7):1067-85. doi: 10.1002/cmdc.201300096. Epub 2013 May 13.

PMID:
23671017
16.

Health effects following the Eyjafjallajokull volcanic eruption: a cohort study.

Carlsen HK, Hauksdottir A, Valdimarsdottir UA, Gíslason T, Einarsdottir G, Runolfsson H, Briem H, Finnbjornsdottir RG, Gudmundsson S, Kolbeinsson TB, Thorsteinsson T, Pétursdóttir G.

BMJ Open. 2012 Nov 8;2(6). pii: e001851. doi: 10.1136/bmjopen-2012-001851. Print 2012.

17.

Influenza epidemics in Iceland over 9 decades: changes in timing and synchrony with the United States and Europe.

Weinberger DM, Krause TG, Mølbak K, Cliff A, Briem H, Viboud C, Gottfredsson M.

Am J Epidemiol. 2012 Oct 1;176(7):649-55. Epub 2012 Sep 7.

18.

A survey of early health effects of the Eyjafjallajokull 2010 eruption in Iceland: a population-based study.

Carlsen HK, Gislason T, Benediktsdottir B, Kolbeinsson TB, Hauksdottir A, Thorsteinsson T, Briem H.

BMJ Open. 2012 Mar 8;2(2):e000343. doi: 10.1136/bmjopen-2011-000343. Print 2012.

19.

Substantial improvements in large-scale redocking and screening using the novel HYDE scoring function.

Schneider N, Hindle S, Lange G, Klein R, Albrecht J, Briem H, Beyer K, Claußen H, Gastreich M, Lemmen C, Rarey M.

J Comput Aided Mol Des. 2012 Jun;26(6):701-23. doi: 10.1007/s10822-011-9531-0. Epub 2011 Dec 27.

PMID:
22203423
20.

Enteropathogens in acute diarrhea: a general practice-based study in a Nordic country.

Hilmarsdóttir I, Baldvinsdóttir GE, Harðardóttir H, Briem H, Sigurðsson SI.

Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1501-9. doi: 10.1007/s10096-011-1470-0. Epub 2011 Nov 5.

PMID:
22057365
21.

A national epidemic of campylobacteriosis in Iceland, lessons learned.

Tustin J, Laberge K, Michel P, Reiersen J, Dađadóttir S, Briem H, Harđardóttir H, Kristinsson K, Gunnarsson E, Friđriksdóttir V, Georgsson F.

Zoonoses Public Health. 2011 Sep;58(6):440-7. doi: 10.1111/j.1863-2378.2010.01387.x. Epub 2011 Jan 17.

PMID:
21824341
22.

A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors.

Schulz MN, Fanghänel J, Schäfer M, Badock V, Briem H, Boemer U, Nguyen D, Husemann M, Hillig RC.

Acta Crystallogr D Biol Crystallogr. 2011 Mar;67(Pt 3):156-66. doi: 10.1107/S0907444910054144. Epub 2011 Feb 15.

PMID:
21358046
23.

Surveillance of influenza in Iceland during the 2009 pandemic.

Sigmundsdottir G, Gudnason T, Ólafsson Ö, Baldvinsdottir GE, Atladottir A, Löve A, Danon L, Briem H.

Euro Surveill. 2010 Dec 9;15(49). pii: 19742.

24.

An international outbreak of Shiga toxin-producing Escherichia coli O157 infection due to lettuce, September-October 2007.

Friesema I, Sigmundsdottir G, van der Zwaluw K, Heuvelink A, Schimmer B, de Jager C, Rump B, Briem H, Hardardottir H, Atladottir A, Gudmundsdottir E, van Pelt W.

Euro Surveill. 2008 Dec 11;13(50). pii: 19065.

25.

The efficacy of HPV 16/18 vaccines on sexually active 18-23 year old women and the impact of HPV vaccination on organized cervical cancer screening.

Sigurdsson K, Sigvaldason H, Gudmundsdottir T, Sigurdsson R, Briem H.

Acta Obstet Gynecol Scand. 2009;88(1):27-35. doi: 10.1080/00016340802566770.

PMID:
19031282
26.

[The Spanish flu in Iceland in 1918. Lessons learned].

Briem H.

Laeknabladid. 2008 Nov;94(11):721. Icelandic. No abstract available.

PMID:
18974432
27.

Broiler Campylobacter contamination and human campylobacteriosis in Iceland.

Callicott KA, Harğardóttir H, Georgsson F, Reiersen J, Friğriksdóttir V, Gunnarsson E, Michel P, Bisaillon JR, Kristinsson KG, Briem H, Hiett KL, Needleman DS, Stern NJ.

Appl Environ Microbiol. 2008 Nov;74(21):6483-94. doi: 10.1128/AEM.01129-08. Epub 2008 Sep 12.

28.

An interactive central database of vaccinations in Iceland.

Gudnason T, Briem H.

Euro Surveill. 2008 Jan 10;13(2). pii: 8010. No abstract available. Erratum in: Euro Surveill. 2008 Oct 23;13(43):pii/19012.

29.

[The use of anti-viral agents in pandemic influenza, Icelandic guidelines].

Gudnason T, Sigmundsdottir G, Briem H.

Laeknabladid. 2008 Jan;94(1):19-25. Review. Icelandic.

PMID:
18204108
30.

STEC O157 outbreak in Iceland, September-October 2007.

Sigmundsdottir G, Atladottir A, Hardardottir H, Gudmundsdottir E, Geirsdottir M, Briem H.

Euro Surveill. 2007 Nov 1;12(11):E071101.2. No abstract available.

31.

Ultrafast de novo docking combining pharmacophores and combinatorics.

Gastreich M, Lilienthal M, Briem H, Claussen H.

J Comput Aided Mol Des. 2006 Dec;20(12):717-34. Epub 2007 Jan 30.

PMID:
17265098
32.

Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities.

Lücking U, Siemeister G, Schäfer M, Briem H, Krüger M, Lienau P, Jautelat R.

ChemMedChem. 2007 Jan;2(1):63-77.

PMID:
17131463
33.

[Viral hepatitis B and C among immigrants in Iceland].

Jónsdóttir G, Briem H, Blöndal T, Pálsson G, Olafsson S, Gudnason T.

Laeknabladid. 2006 Oct;92(10):669-73. Icelandic.

PMID:
17062900
34.

[Food-borne Infections in a new Millennium [Editorial].].

Briem H.

Laeknabladid. 2000 Nov;86(11):735-7. Icelandic. No abstract available.

PMID:
17018959
35.

[Quality control of antimicrobial usage in Reykjavik Hospital in 1994 - 1998: economic impact.].

Thornráinsdóttir IS, Bjœrgvinsson S, Linnet K, Thornórisdóttir A, Jóhannesson B, Briem H.

Laeknabladid. 2001 Jan;87(1):33-8. Icelandic.

PMID:
16940682
36.

[Meningitis in Children due to Bacteria [Editorial].].

Briem H.

Laeknabladid. 2002 May;88(5):387-8. Icelandic. No abstract available.

PMID:
16940637
37.

[Henoch-Schönlein purpura, patients admitted to Landspítali-University Hospital 1984-2000.].

Thors VS, Kristinsson JR, Laxdal T, Jónmundsson G, Eðvarðsson VO, Sigfússon A, Briem H, Haraldsson A.

Laeknabladid. 2002 Nov;88(11):807-11. Icelandic.

PMID:
16940615
38.

[Why preparedness for smallpox? [Editorial].].

Briem H.

Laeknabladid. 2003 Sep;89(9):655. Icelandic. No abstract available.

PMID:
16940590
39.

[Design of a hospital [editorial].].

Briem H.

Laeknabladid. 2003 Oct;89(10):743. Icelandic. No abstract available.

PMID:
16940587
40.

[Design of a hospital [editorial].].

Briem H.

Laeknabladid. 2003 Sep;89(9):743. Icelandic. No abstract available.

PMID:
16940586
41.

[Change of Legislation and Bylaws - and what then? [Editorial].].

Briem H.

Laeknabladid. 2004 Dec;90(12):827-8. Icelandic. No abstract available.

PMID:
16819064
42.

[Cost-effectiveness analysis on meningococca serogroup C vaccination.].

Bergþórsson GI, Matthíasson T, Guðnason T, Briem H.

Laeknabladid. 2004 May;90(5):379-83. Icelandic.

PMID:
16819032
43.

[Deadly birdflu and its affect on people [Editorial].].

Briem H.

Laeknabladid. 2004 Apr;90(4):291-2. Icelandic. No abstract available.

PMID:
16819025
44.

[The risk of influenza pandemic and the preparedness against it].

Briem H.

Laeknabladid. 2006 Feb;92(2):93. Icelandic. No abstract available.

PMID:
16464996
45.

[The next influenza pandemic].

Briem H.

Laeknabladid. 2005 Jul-Aug;91(7-8):576-7. Icelandic. No abstract available.

PMID:
16155340
46.

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors.

Jautelat R, Brumby T, Schäfer M, Briem H, Eisenbrand G, Schwahn S, Krüger M, Lücking U, Prien O, Siemeister G.

Chembiochem. 2005 Mar;6(3):531-40. No abstract available.

PMID:
15742375
47.

Classifying "kinase inhibitor-likeness" by using machine-learning methods.

Briem H, Günther J.

Chembiochem. 2005 Mar;6(3):558-66.

PMID:
15696507
48.

Mining high-throughput screening data of combinatorial libraries: development of a filter to distinguish hits from nonhits.

Teckentrup A, Briem H, Gasteiger J.

J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):626-34.

PMID:
15032544
49.

A European outbreak of Salmonella enterica serotype Typhimurium definitive phage type 204b in 2000.

Crook PD, Aguilera JF, Threlfall EJ, O'Brien SJ, Sigmundsdóttir G, Wilson D, Fisher IS, Ammon A, Briem H, Cowden JM, Locking ME, Tschäpe H, van Pelt W, Ward LR, Widdowson MA.

Clin Microbiol Infect. 2003 Aug;9(8):839-45.

50.

Flexsim-R: a virtual affinity fingerprint descriptor to calculate similarities of functional groups.

Weber A, Teckentrup A, Briem H.

J Comput Aided Mol Des. 2002 Dec;16(12):903-16.

PMID:
12825622

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