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Items: 1 to 50 of 70

1.

Spectral Characterization of Stem Cell-Derived Myelination within the Injured Adult PNS Using the Solvatochromic Dye Nile Red.

Grochmal J, Teo W, Gambhir H, Kumar R, Stratton JA, Dhaliwal R, Brideau C, Biernaskie J, Stys P, Midha R.

Cells. 2020 Jan 11;9(1). pii: E189. doi: 10.3390/cells9010189.

2.

Excitation parameters optimized for coherent anti-Stokes Raman scattering imaging of myelinated tissue.

Brideau C, Poon KWC, Colarusso P, Stys PK.

J Biomed Opt. 2019 Apr;24(4):1-8. doi: 10.1117/1.JBO.24.4.046502.

3.

Lipid biochemical changes detected in normal appearing white matter of chronic multiple sclerosis by spectral coherent Raman imaging.

Poon KWC, Brideau C, Klaver R, Schenk GJ, Geurts JJ, Stys PK.

Chem Sci. 2018 Jan 2;9(6):1586-1595. doi: 10.1039/c7sc03992a. eCollection 2018 Feb 14.

4.

A novel approach to 32-channel peripheral nervous system myelin imaging in vivo, with single axon resolution.

Grochmal J, Teo W, Gambhir H, Kumar R, Stratton JA, Dhaliwal R, Brideau C, Biernaskie J, Stys PK, Midha R.

J Neurosurg. 2018 Jan 19;130(1):163-171. doi: 10.3171/2017.6.JNS17239.

PMID:
29350602
5.

Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord.

Chu TH, Cummins K, Sparling JS, Tsutsui S, Brideau C, Nilsson KPR, Joseph JT, Stys PK.

PLoS One. 2017 Nov 27;12(11):e0188218. doi: 10.1371/journal.pone.0188218. eCollection 2017.

6.

Effects of laser polarization on responses of the fluorescent Ca2+ indicator X-Rhod-1 in neurons and myelin.

Micu I, Brideau C, Lu L, Stys PK.

Neurophotonics. 2017 Apr;4(2):025002. doi: 10.1117/1.NPh.4.2.025002. Epub 2017 Jun 5.

7.

Dose and Radioadaptive Response Analysis of Micronucleus Induction in Mouse Bone Marrow.

Bannister LA, Mantha RR, Devantier Y, Petoukhov ES, Brideau CL, Serran ML, Klokov DY.

Int J Mol Sci. 2016 Sep 13;17(9). pii: E1548. doi: 10.3390/ijms17091548.

8.

Functional ionotropic glutamate receptors on peripheral axons and myelin.

Christensen PC, Welch NC, Brideau C, Stys PK.

Muscle Nerve. 2016 Sep;54(3):451-9. doi: 10.1002/mus.25078. Epub 2016 Jul 4.

PMID:
26872412
9.

Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury.

Shakhbazau A, Mishra M, Chu TH, Brideau C, Cummins K, Tsutsui S, Shcharbin D, Majoral JP, Mignani S, Blanchard-Desce M, Bryszewska M, Yong VW, Stys PK, van Minnen J.

Macromol Biosci. 2015 Nov;15(11):1523-34. doi: 10.1002/mabi.201500150. Epub 2015 Jul 14.

PMID:
26175127
10.

High-resolution fluorescence microscopy of myelin without exogenous probes.

Christensen PC, Brideau C, Poon KW, Döring A, Yong VW, Stys PK.

Neuroimage. 2014 Feb 15;87:42-54. doi: 10.1016/j.neuroimage.2013.10.050. Epub 2013 Nov 2.

PMID:
24188810
11.

Portable, miniaturized, fibre delivered, multimodal CARS exoscope.

Smith B, Naji M, Murugkar S, Alarcon E, Brideau C, Stys P, Anis H.

Opt Express. 2013 Jul 15;21(14):17161-75. doi: 10.1364/OE.21.017161.

PMID:
23938563
12.

Data mining as a discovery tool for imprinted genes.

Brideau C, Soloway P.

Methods Mol Biol. 2012;925:89-134. doi: 10.1007/978-1-62703-011-3_7.

PMID:
22907493
13.

Discovery of novel P2Y14 agonist and antagonist using conventional and nonconventional methods.

Hamel M, Henault M, Hyjazie H, Morin N, Bayly C, Skorey K, Therien AG, Mancini J, Brideau C, Kargman S.

J Biomol Screen. 2011 Oct;16(9):1098-105. doi: 10.1177/1087057111415525. Epub 2011 Aug 5.

PMID:
21821827
14.

Trisubstituted ureas as potent and selective mPGES-1 inhibitors.

Chiasson JF, Boulet L, Brideau C, Chau A, Claveau D, Côté B, Ethier D, Giroux A, Guay J, Guiral S, Mancini J, Massé F, Méthot N, Riendeau D, Roy P, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1488-92. doi: 10.1016/j.bmcl.2011.01.006. Epub 2011 Jan 13.

PMID:
21295979
15.

Miniaturized multimodal CARS microscope based on MEMS scanning and a single laser source.

Murugkar S, Smith B, Srivastava P, Moica A, Naji M, Brideau C, Stys PK, Anis H.

Opt Express. 2010 Nov 8;18(23):23796-804. doi: 10.1364/OE.18.023796.

PMID:
21164724
16.

A non-coding RNA within the Rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans.

Brideau CM, Kauppinen KP, Holmes R, Soloway PD.

PLoS One. 2010 Nov 2;5(11):e13784. doi: 10.1371/journal.pone.0013784.

17.

Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.

Wu TY, Juteau H, Ducharme Y, Friesen RW, Guiral S, Dufresne L, Poirier H, Salem M, Riendeau D, Mancini J, Brideau C.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6978-82. doi: 10.1016/j.bmcl.2010.09.129. Epub 2010 Oct 19.

PMID:
20965723
18.

The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.

Ducharme Y, Blouin M, Brideau C, Châteauneuf A, Gareau Y, Grimm EL, Juteau H, Laliberté S, MacKay B, Massé F, Ouellet M, Salem M, Styhler A, Friesen RW.

ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. doi: 10.1021/ml100029k. eCollection 2010 Jul 8.

19.

Successful computational prediction of novel imprinted genes from epigenomic features.

Brideau CM, Eilertson KE, Hagarman JA, Bustamante CD, Soloway PD.

Mol Cell Biol. 2010 Jul;30(13):3357-70. doi: 10.1128/MCB.01355-09. Epub 2010 Apr 26.

20.

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.

Giroux A, Boulet L, Brideau C, Chau A, Claveau D, Côté B, Ethier D, Frenette R, Gagnon M, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. doi: 10.1016/j.bmcl.2009.08.085. Epub 2009 Aug 28.

PMID:
19748780
21.

Fast diagnosis with sensors of uncertain quality.

Erdinc O, Brideau C, Willett P, Kirubarajan T.

IEEE Trans Syst Man Cybern B Cybern. 2008 Aug;38(4):1157-65. doi: 10.1109/TSMCB.2008.924585.

PMID:
18632405
22.

Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.

Macdonald D, Brideau C, Chan CC, Falgueyret JP, Frenette R, Guay J, Hutchinson JH, Perrier H, Prasit P, Riendeau D, Tagari P, Thérien M, Young RN, Girard Y.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2023-7. doi: 10.1016/j.bmcl.2008.01.105. Epub 2008 Feb 2.

PMID:
18276139
23.

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

Côté B, Boulet L, Brideau C, Claveau D, Ethier D, Frenette R, Gagnon M, Giroux A, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. Epub 2007 Oct 17.

PMID:
18029174
24.

Coherent anti-Stokes Raman scattering microscopy using photonic crystal fiber with two closely lying zero dispersion wavelengths.

Murugkar S, Brideau C, Ridsdale A, Naji M, Stys PK, Anis H.

Opt Express. 2007 Oct 17;15(21):14028-37.

PMID:
19550675
25.

Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species.

Rowland SE, Clark P, Gordon R, Mullen AK, Guay J, Dufresne L, Brideau C, Cote B, Ducharme Y, Mancini J, Chan CC, Audoly L, Xu D.

Eur J Pharmacol. 2007 Apr 10;560(2-3):216-24. Epub 2007 Jan 20.

PMID:
17316604
26.

Identification of an indole series of prostaglandin D2 receptor antagonists.

Sturino CF, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Brideau C, Cauchon E, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, O'Neill G, Wang Z, Zamboni R, Metters KM, Young RN.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):3043-8. Epub 2006 Mar 10.

PMID:
16529930
27.

Substituted coumarins as potent 5-lipoxygenase inhibitors.

Grimm EL, Brideau C, Chauret N, Chan CC, Delorme D, Ducharme Y, Ethier D, Falgueyret JP, Friesen RW, Guay J, Hamel P, Riendeau D, Soucy-Breau C, Tagari P, Girard Y.

Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. Epub 2006 Feb 7.

PMID:
16464579
28.

In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia.

McCann ME, Rickes EL, Hora DF, Cunningham PK, Zhang D, Brideau C, Black WC, Hickey GJ.

Am J Vet Res. 2005 Jul;66(7):1278-84.

PMID:
16111170
29.

An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1.

Massé F, Guiral S, Fortin LJ, Cauchon E, Ethier D, Guay J, Brideau C.

J Biomol Screen. 2005 Sep;10(6):599-605. Epub 2005 Aug 15.

PMID:
16103419
30.

In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis.

McCann ME, Andersen DR, Zhang D, Brideau C, Black WC, Hanson PD, Hickey GJ.

Am J Vet Res. 2004 Apr;65(4):503-12.

PMID:
15077695
31.

Improved statistical methods for hit selection in high-throughput screening.

Brideau C, Gunter B, Pikounis B, Liaw A.

J Biomol Screen. 2003 Dec;8(6):634-47.

PMID:
14711389
32.

Statistical and graphical methods for quality control determination of high-throughput screening data.

Gunter B, Brideau C, Pikounis B, Liaw A.

J Biomol Screen. 2003 Dec;8(6):624-33.

PMID:
14711388
33.

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.

Black WC, Brideau C, Chan CC, Charleson S, Cromlish W, Gordon R, Grimm EL, Hughes G, Leger S, Li CS, Riendeau D, Thérien M, Wang Z, Xu LJ, Prasit P.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1195-8.

PMID:
12643942
34.

Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.

Côté B, Frenette R, Prescott S, Blouin M, Brideau C, Ducharme Y, Friesen RW, Laliberté F, Masson P, Styhler A, Girard Y.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):741-4.

PMID:
12639571
35.

Pyridazinones as selective cyclooxygenase-2 inhibitors.

Li CS, Brideau C, Chan CC, Savoie C, Claveau D, Charleson S, Gordon R, Greig G, Gauthier JY, Lau CK, Riendeau D, Thérien M, Wong E, Prasit P.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):597-600.

PMID:
12639538
36.

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.

Leblanc Y, Roy P, Wang Z, Li CS, Chauret N, Nicoll-Griffith DA, Silva JM, Aubin Y, Yergey JA, Chan CC, Riendeau D, Brideau C, Gordon R, Xu L, Webb J, Visco DM, Prasit P.

Bioorg Med Chem Lett. 2002 Nov 18;12(22):3317-20.

PMID:
12392741
37.

Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.

Frenette R, Blouin M, Brideau C, Chauret N, Ducharme Y, Friesen RW, Hamel P, Jones TR, Laliberté F, Li C, Masson P, McAuliffe M, Girard Y.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13.

PMID:
12270195
38.

Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.

Guay D, Hamel P, Blouin M, Brideau C, Chan CC, Chauret N, Ducharme Y, Huang Z, Girard M, Jones TR, Laliberté F, Masson P, McAuliffe M, Piechuta H, Silva J, Young RN, Girard Y.

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61.

PMID:
12031319
39.

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats.

Brideau C, Van Staden C, Chan CC.

Am J Vet Res. 2001 Nov;62(11):1755-60.

PMID:
11703020
40.

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

Chauret N, Yergey JA, Brideau C, Friesen RW, Mancini J, Riendeau D, Silva J, Styhler A, Trimble LA, Nicoll-Griffith DA.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62.

PMID:
11327589
41.

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

Riendeau D, Percival MD, Brideau C, Charleson S, Dubé D, Ethier D, Falgueyret JP, Friesen RW, Gordon R, Greig G, Guay J, Mancini J, Ouellet M, Wong E, Xu L, Boyce S, Visco D, Girard Y, Prasit P, Zamboni R, Rodger IW, Gresser M, Ford-Hutchinson AW, Young RN, Chan CC.

J Pharmacol Exp Ther. 2001 Feb;296(2):558-66.

PMID:
11160644
42.

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

Nicoll-Griffith DA, Yergey JA, Trimble LA, Silva JM, Li C, Chauret N, Gauthier JY, Grimm E, Léger S, Roy P, Thérien M, Wang Z, Prasit P, Zamboni R, Young RN, Brideau C, Chan CC, Mancini J, Riendeau D.

Bioorg Med Chem Lett. 2000 Dec 4;10(23):2683-6.

PMID:
11128651
43.

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.

Lau CK, Brideau C, Chan CC, Charleson S, Cromlish WA, Ethier D, Gauthier JY, Gordon R, Guay J, Kargman S, Li CS, Prasit P, Riendeau D, Thérien M, Visco DM, Xu L.

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3187-92.

PMID:
10576685
44.

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.

Li CS, Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Thérien M, Visco DM, Wong E, Xu L, Prasit P.

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3181-6.

PMID:
10576684
45.

Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.

Frenette R, Hutchinson JH, Léger S, Thérien M, Brideau C, Chan CC, Charleson S, Ethier D, Guay J, Jones TR, McAuliffe M, Piechuta H, Riendeau D, Tagari P, Girard Y.

Bioorg Med Chem Lett. 1999 Aug 16;9(16):2391-6.

PMID:
10476875
46.

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.

Leblanc Y, Roy P, Boyce S, Brideau C, Chan CC, Charleson S, Gordon R, Grimm E, Guay J, Léger S, Li CS, Riendeau D, Visco D, Wang Z, Webb J, Xu LJ, Prasit P.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2207-12.

PMID:
10465547
47.

Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, Gordon R, Gresser M, Guay J, Kargman S, Kennedy B, Leblanc Y, Leger S, Mancini J, O'Neill GP, Ouellet M, Patrick D, Percival MD, Perrier H, Prasit P, Rodger I, et al.

J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.

PMID:
10411562
48.

The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.

Prasit P, Wang Z, Brideau C, Chan CC, Charleson S, Cromlish W, Ethier D, Evans JF, Ford-Hutchinson AW, Gauthier JY, Gordon R, Guay J, Gresser M, Kargman S, Kennedy B, Leblanc Y, Léger S, Mancini J, O'Neill GP, Ouellet M, Percival MD, Perrier H, Riendeau D, Rodger I, Zamboni R, et al.

Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8.

PMID:
10406640
49.

2-heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors.

Dubé D, Brideau C, Deschênes D, Fortin R, Friesen RW, Gordon R, Girard Y, Riendeau D, Savoie C, Chan CC.

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1715-20.

PMID:
10397507
50.

2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.

Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, Hughes G, Jolicoeur P, Leblanc Y, Nicoll-Griffith D, Ouimet N, Riendeau D, Visco D, Wang Z, Xu L, Prasit P.

J Med Chem. 1999 Apr 8;42(7):1274-81.

PMID:
10197970

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