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Items: 49

1.

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor.

Bosma R, Stoddart LA, Georgi V, Bouzo-Lorenzo M, Bushby N, Inkoom L, Waring MJ, Briddon SJ, Vischer HF, Sheppard RJ, Fernández-Montalván A, Hill SJ, Leurs R.

Sci Rep. 2019 May 27;9(1):7906. doi: 10.1038/s41598-019-44025-5.

2.

GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.

Gondin AB, Halls ML, Canals M, Briddon SJ.

Front Mol Neurosci. 2019 May 1;12:104. doi: 10.3389/fnmol.2019.00104. eCollection 2019.

3.

Context-dependent signalling of CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3).

Heuninck J, Perpina Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C.

Mol Pharmacol. 2019 May 15. pii: mol.118.115477. doi: 10.1124/mol.118.115477. [Epub ahead of print]

4.

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A3 receptor.

Bouzo-Lorenzo M, Stoddart LA, Xia L, IJzerman AP, Heitman LH, Briddon SJ, Hill SJ.

Purinergic Signal. 2019 Mar 27. doi: 10.1007/s11302-019-09650-9. [Epub ahead of print]

PMID:
30919204
5.

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.

Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano CP, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, de Graaf C, de Esch IJP, Leurs R.

Eur J Med Chem. 2019 Jan 15;162:631-649. doi: 10.1016/j.ejmech.2018.10.060. Epub 2018 Oct 30.

PMID:
30476826
6.

Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes.

Gherbi K, Briddon SJ, Charlton SJ.

Sci Rep. 2018 Feb 22;8(1):3479. doi: 10.1038/s41598-018-21100-x.

7.

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells.

Stoddart LA, Vernall AJ, Bouzo-Lorenzo M, Bosma R, Kooistra AJ, de Graaf C, Vischer HF, Leurs R, Briddon SJ, Kellam B, Hill SJ.

Sci Rep. 2018 Jan 25;8(1):1572. doi: 10.1038/s41598-018-19714-2.

8.

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.

Arruda MA, Stoddart LA, Gherbi K, Briddon SJ, Kellam B, Hill SJ.

Front Pharmacol. 2017 Dec 13;8:908. doi: 10.3389/fphar.2017.00908. eCollection 2017.

9.

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.

Lam R, Gondin AB, Canals M, Kellam B, Briddon SJ, Graham B, Scammells PJ.

J Med Chem. 2018 Feb 8;61(3):1316-1329. doi: 10.1021/acs.jmedchem.7b01811. Epub 2018 Jan 10.

PMID:
29291353
10.

Studying GPCR Pharmacology in Membrane Microdomains: Fluorescence Correlation Spectroscopy Comes of Age.

Briddon SJ, Kilpatrick LE, Hill SJ.

Trends Pharmacol Sci. 2018 Feb;39(2):158-174. doi: 10.1016/j.tips.2017.11.004. Epub 2017 Dec 22. Review.

PMID:
29277246
11.

Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.

Kilpatrick LE, Friedman-Ohana R, Alcobia DC, Riching K, Peach CJ, Wheal AJ, Briddon SJ, Robers MB, Zimmerman K, Machleidt T, Wood KV, Woolard J, Hill SJ.

Biochem Pharmacol. 2017 Jul 15;136:62-75. doi: 10.1016/j.bcp.2017.04.006. Epub 2017 Apr 7.

12.

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

Schembri LS, Stoddart LA, Briddon SJ, Kellam B, Canals M, Graham B, Scammells PJ.

J Med Chem. 2015 Dec 24;58(24):9754-67. doi: 10.1021/acs.jmedchem.5b01664. Epub 2015 Dec 16.

PMID:
26632862
13.

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.

Wong K, Briddon SJ, Holliday ND, Kerr ID.

Biochim Biophys Acta. 2016 Jan;1863(1):19-29. doi: 10.1016/j.bbamcr.2015.10.002. Epub 2015 Oct 8.

14.

Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

Stoddart LA, Kilpatrick LE, Briddon SJ, Hill SJ.

Neuropharmacology. 2015 Nov;98:48-57. doi: 10.1016/j.neuropharm.2015.04.033. Epub 2015 May 13. Review.

15.

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ.

Neuropharmacology. 2015 Nov;98:68-77. doi: 10.1016/j.neuropharm.2015.04.013. Epub 2015 Apr 30.

16.

Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation.

Gherbi K, May LT, Baker JG, Briddon SJ, Hill SJ.

FASEB J. 2015 Jul;29(7):2859-71. doi: 10.1096/fj.14-265199. Epub 2015 Apr 2.

17.
18.

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.

Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ.

FASEB J. 2014 Oct;28(10):4211-22. doi: 10.1096/fj.13-247270. Epub 2014 Jun 26.

19.
20.

Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery.

Stoddart LA, Briddon SJ, Hill SJ.

Future Med Chem. 2013 Aug;5(12):1367-9. doi: 10.4155/fmc.13.110. No abstract available.

PMID:
23919546
21.

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.

Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B.

Org Biomol Chem. 2013 Sep 14;11(34):5673-82. doi: 10.1039/c3ob41221k.

PMID:
23881285
22.

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.

Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ.

EMBO Rep. 2013 Aug;14(8):726-32. doi: 10.1038/embor.2013.89. Epub 2013 Jul 2.

23.

Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.

Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ.

Chem Biol. 2012 Sep 21;19(9):1105-15. doi: 10.1016/j.chembiol.2012.07.014.

24.
25.

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

Ayling LJ, Briddon SJ, Halls ML, Hammond GR, Vaca L, Pacheco J, Hill SJ, Cooper DM.

J Cell Sci. 2012 Feb 15;125(Pt 4):869-86. doi: 10.1242/jcs.091090. Epub 2012 Mar 7.

26.

Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.

Vernall AJ, Stoddart LA, Briddon SJ, Hill SJ, Kellam B.

J Med Chem. 2012 Feb 23;55(4):1771-82. doi: 10.1021/jm201722y. Epub 2012 Feb 13.

PMID:
22277057
27.
28.

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.

May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ.

FASEB J. 2011 Oct;25(10):3465-76. doi: 10.1096/fj.11-186296. Epub 2011 Jun 29.

29.

Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells.

Briddon SJ, Kellam B, Hill SJ.

Methods Mol Biol. 2011;746:211-36. doi: 10.1007/978-1-61779-126-0_11.

PMID:
21607859
30.

The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.

May LT, Self TJ, Briddon SJ, Hill SJ.

Mol Pharmacol. 2010 Sep;78(3):511-23. doi: 10.1124/mol.110.064493. Epub 2010 Jun 22.

31.

Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation.

Kilpatrick LE, Briddon SJ, Hill SJ, Holliday ND.

Br J Pharmacol. 2010 Jun;160(4):892-906. doi: 10.1111/j.1476-5381.2010.00676.x. Epub 2010 Apr 28.

32.

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ.

Br J Pharmacol. 2010 Feb;159(4):772-86. doi: 10.1111/j.1476-5381.2009.00488.x. Epub 2010 Jan 26.

33.

Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions.

May LT, Briddon SJ, Hill SJ.

Mol Pharmacol. 2010 Apr;77(4):678-86. doi: 10.1124/mol.109.063065. Epub 2010 Jan 19.

34.

Using fluorescent pH-sensitive nanosensors to report their intracellular location after Tat-mediated delivery.

Coupland PG, Briddon SJ, Aylott JW.

Integr Biol (Camb). 2009 Apr;1(4):318-23. doi: 10.1039/b822569a. Epub 2009 Mar 3.

PMID:
20023732
35.

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks.

Rose RH, Briddon SJ, Holliday ND.

Br J Pharmacol. 2010 Feb;159(4):738-50. doi: 10.1111/j.1476-5381.2009.00480.x. Epub 2009 Dec 10. Review.

36.

Plasma membrane diffusion of G protein-coupled receptor oligomers.

Briddon SJ, Gandía J, Amaral OB, Ferré S, Lluís C, Franco R, Hill SJ, Ciruela F.

Biochim Biophys Acta. 2008 Dec;1783(12):2262-8. doi: 10.1016/j.bbamcr.2008.07.006. Epub 2008 Jul 21.

37.
38.

Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.

Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ.

FASEB J. 2008 Mar;22(3):850-60. Epub 2007 Oct 24.

PMID:
17959910
39.

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B.

J Med Chem. 2007 Feb 22;50(4):782-93. Epub 2007 Jan 24.

PMID:
17249651
40.

The LSM 510 META - ConfoCor 2 system: an integrated imaging and spectroscopic platform for single-molecule detection.

Weisshart K, Jüngel V, Briddon SJ.

Curr Pharm Biotechnol. 2004 Apr;5(2):135-54.

PMID:
15078148
41.

Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.

Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4673-8. Epub 2004 Mar 16.

42.

Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level.

Briddon SJ, Middleton RJ, Yates AS, George MW, Kellam B, Hill SJ.

Faraday Discuss. 2004;126:197-207; discussion 245-54.

PMID:
14992407
43.
45.

Collagen mediates changes in intracellular calcium in primary mouse megakaryocytes through syk-dependent and -independent pathways.

Briddon SJ, Melford SK, Turner M, Tybulewicz V, Watson SP.

Blood. 1999 Jun 1;93(11):3847-55.

46.
47.
48.

Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide.

Melford SK, Turner M, Briddon SJ, Tybulewicz VL, Watson SP.

J Biol Chem. 1997 Oct 31;272(44):27539-42.

49.

Characterization of the 5-hydroxytryptamine2A receptor-activated cascade in rat C6 glioma cells.

Elliott JM, Newberry NR, Cholewinski AJ, Bartrup JT, Briddon SJ, Carey JE, Flanigan TP, Newton RA, Phipps SL, Reavley AC, et al.

Neuroscience. 1995 Dec;69(4):1119-31.

PMID:
8848101

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