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Items: 37


Combining mGRASP and Optogenetics Enables High-Resolution Functional Mapping of Descending Cortical Projections.

Song JH, Lucaci D, Calangiu I, Brown MTC, Park JS, Kim J, Brickley SG, Chadderton P.

Cell Rep. 2018 Jul 24;24(4):1071-1080. doi: 10.1016/j.celrep.2018.06.076.


Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABAA Receptors with Different γ Subunits.

Ye Z, Yu X, Houston CM, Aboukhalil Z, Franks NP, Wisden W, Brickley SG.

Front Cell Neurosci. 2017 Apr 4;11:95. doi: 10.3389/fncel.2017.00095. eCollection 2017.


Exploring the significance of morphological diversity for cerebellar granule cell excitability.

Houston CM, Diamanti E, Diamantaki M, Kutsarova E, Cook A, Sultan F, Brickley SG.

Sci Rep. 2017 Apr 13;7:46147. doi: 10.1038/srep46147.


Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.

Jager P, Ye Z, Yu X, Zagoraiou L, Prekop HT, Partanen J, Jessell TM, Wisden W, Brickley SG, Delogu A.

Nat Commun. 2016 Dec 8;7:13579. doi: 10.1038/ncomms13579.


Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W.

J Neurosci. 2016 Nov 2;36(44):11171-11184.


Wakefulness Is Governed by GABA and Histamine Cotransmission.

Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W.

Neuron. 2015 Jul 1;87(1):164-78. doi: 10.1016/j.neuron.2015.06.003. Epub 2015 Jun 18.


Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists.

Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP.

Nat Neurosci. 2015 Apr;18(4):553-561. doi: 10.1038/nn.3957. Epub 2015 Feb 23.


Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels.

MacKenzie G, Franks NP, Brickley SG.

Pflugers Arch. 2015 May;467(5):989-99. doi: 10.1007/s00424-014-1660-6. Epub 2014 Dec 9. Review.


The role of K₂p channels in anaesthesia and sleep.

Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W.

Pflugers Arch. 2015 May;467(5):907-16. doi: 10.1007/s00424-014-1654-4. Epub 2014 Dec 9. Review.


Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.

Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W.

Curr Biol. 2014 Dec 1;24(23):2838-44. doi: 10.1016/j.cub.2014.10.019. Epub 2014 Nov 13.


Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.

Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP.

J Neurosci. 2014 Oct 1;34(40):13326-35. doi: 10.1523/JNEUROSCI.1519-14.2014.


The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex.

Ye Z, McGee TP, Houston CM, Brickley SG.

Front Neural Circuits. 2013 Dec 23;7:203. doi: 10.3389/fncir.2013.00203. eCollection 2013.


Copper block of extrasynaptic GABAA receptors in the mature cerebellum and striatum.

McGee TP, Houston CM, Brickley SG.

J Neurosci. 2013 Aug 14;33(33):13431-5. doi: 10.1523/JNEUROSCI.1908-13.2013.


GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.

Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W.

J Neurosci. 2012 Sep 19;32(38):13062-75.


Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?

Houston CM, McGee TP, Mackenzie G, Troyano-Cuturi K, Rodriguez PM, Kutsarova E, Diamanti E, Hosie AM, Franks NP, Brickley SG.

J Neurosci. 2012 Mar 14;32(11):3887-97. doi: 10.1523/JNEUROSCI.5406-11.2012.


Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease.

Brickley SG, Mody I.

Neuron. 2012 Jan 12;73(1):23-34. doi: 10.1016/j.neuron.2011.12.012.


Cerebellar Golgi cell inhibition gets slowly more complicated.

Houston CM, Brickley SG.

J Physiol. 2011 Sep 15;589(Pt 18):4403. doi: 10.1113/jphysiol.2011.216572. No abstract available.


Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover.

Bright DP, Renzi M, Bartram J, McGee TP, MacKenzie G, Hosie AM, Farrant M, Brickley SG.

J Neurosci. 2011 Jan 12;31(2):753-63. doi: 10.1523/JNEUROSCI.2996-10.2011.


An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.

Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17546-51. doi: 10.1073/pnas.0907228106. Epub 2009 Sep 24.


The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse.

Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP.

J Neurosci. 2009 Feb 18;29(7):2177-87. doi: 10.1523/JNEUROSCI.4997-08.2009.


Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus.

Bright DP, Brickley SG.

J Physiol. 2008 Nov 1;586(21):5091-9. doi: 10.1113/jphysiol.2008.158576. Epub 2008 Sep 4.


TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons.

Brickley SG, Aller MI, Sandu C, Veale EL, Alder FG, Sambi H, Mathie A, Wisden W.

J Neurosci. 2007 Aug 29;27(35):9329-40.


Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons.

Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SG.

J Neurosci. 2005 Dec 7;25(49):11455-67.


Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

Stell BM, Brickley SG, Tang CY, Farrant M, Mody I.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14439-44. Epub 2003 Nov 17.


NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites.

Brickley SG, Misra C, Mok MH, Mishina M, Cull-Candy SG.

J Neurosci. 2003 Jun 15;23(12):4958-66.


CNQX increases GABA-mediated synaptic transmission in the cerebellum by an AMPA/kainate receptor-independent mechanism.

Brickley SG, Farrant M, Swanson GT, Cull-Candy SG.

Neuropharmacology. 2001 Nov;41(6):730-6.


Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance.

Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M.

Nature. 2001 Jan 4;409(6816):88-92.


Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells.

Misra C, Brickley SG, Wyllie DJ, Cull-Candy SG.

J Physiol. 2000 Jun 1;525 Pt 2:299-305.


NMDA receptor diversity in the cerebellum: identification of subunits contributing to functional receptors.

Cull-Candy SG, Brickley SG, Misra C, Feldmeyer D, Momiyama A, Farrant M.

Neuropharmacology. 1998 Oct-Nov;37(10-11):1369-80.


Synchronizing retinal activity in both eyes disrupts binocular map development in the optic tectum.

Brickley SG, Dawes EA, Keating MJ, Grant S.

J Neurosci. 1998 Feb 15;18(4):1491-504.


The Maturation of the Superior Collicular Map of Auditory Space in the Guinea Pig is Disrupted by Developmental Auditory Deprivation.

Withington-Wray DJ, Binns KE, Dhanjal SS, Brickley SG, Keating MJ.

Eur J Neurosci. 1990;2(8):693-703.


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