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Items: 47


Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

Deng M, Guo H, Tam JW, Johnson BM, Brickey WJ, New JS, Lenox A, Shi H, Golenbock DT, Koller BH, McKinnon KP, Beutler B, Ting JP.

J Exp Med. 2019 Sep 26. pii: jem.20190111. doi: 10.1084/jem.20190111. [Epub ahead of print]


NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.

Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP.

Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19.


The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.

Uchimura T, Oyama Y, Deng M, Guo H, Wilson JE, Rampanelli E, Cook KD, Misumi I, Tan X, Chen L, Johnson B, Tam J, Chou WC, Brickey WJ, Petrucelli A, Whitmire JK, Ting JPY.

Immunity. 2018 Dec 18;49(6):1049-1061.e6. doi: 10.1016/j.immuni.2018.10.008.


The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.

Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, Chou WC, Wilson JE, Brickey WJ, Petrucelli A, Liu R, Cooper DE, Koenigsknecht MJ, Young VB, Netea MG, Stienstra R, Sartor RB, Montgomery SA, Coleman RA, Ting JP.

Cell Host Microbe. 2018 Sep 12;24(3):364-378.e6. doi: 10.1016/j.chom.2018.08.009.


The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome.

Kurkjian CJ, Guo H, Montgomery ND, Cheng N, Yuan H, Merrill JR, Sempowski GD, Brickey WJ, Ting JP.

Sci Rep. 2017 Dec 11;7(1):17355. doi: 10.1038/s41598-017-17729-9.


Corrigendum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.

Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD, Brickey WJ, Packey CD, Maharshak N, Matsushima GK, Plevy SE, Young VB, Sartor RB, Ting JP.

Nat Immunol. 2017 Oct 18;18(11):1270. doi: 10.1038/ni1117-1270b.


Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer.

Taylor NA, Vick SC, Iglesia MD, Brickey WJ, Midkiff BR, McKinnon KP, Reisdorf S, Anders CK, Carey LA, Parker JS, Perou CM, Vincent BG, Serody JS.

J Clin Invest. 2017 Sep 1;127(9):3472-3483. doi: 10.1172/JCI90499. Epub 2017 Aug 21.


Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.

Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD, Brickey WJ, Packey CD, Maharshak N, Matsushima GK, Plevy SE, Young VB, Sartor RB, Ting JP.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951e. No abstract available.


NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.

Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP.

J Exp Med. 2017 May 1;214(5):1351-1370. doi: 10.1084/jem.20150237. Epub 2017 Apr 12.


NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth.

Chen L, Wilson JE, Koenigsknecht MJ, Chou WC, Montgomery SA, Truax AD, Brickey WJ, Packey CD, Maharshak N, Matsushima GK, Plevy SE, Young VB, Sartor RB, Ting JP.

Nat Immunol. 2017 May;18(5):541-551. doi: 10.1038/ni.3690. Epub 2017 Mar 13. Erratum in: Nat Immunol. 2017 Jul 19;18(8):951. Erratum in: Nat Immunol. 2017 Oct 18;18(11):1270.


Inflammasomes in Myeloid Cells: Warriors Within.

Jha S, Brickey WJ, Ting JP.

Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.MCHD-0049-2016. Review.


The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.

Koblansky AA, Truax AD, Liu R, Montgomery SA, Ding S, Wilson JE, Brickey WJ, Mühlbauer M, McFadden RM, Hu P, Li Z, Jobin C, Lund PK, Ting JP.

Cell Rep. 2016 Mar 22;14(11):2562-75. doi: 10.1016/j.celrep.2016.02.064. Epub 2016 Mar 10.


GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells.

Koehn BH, Apostolova P, Haverkamp JM, Miller JS, McCullar V, Tolar J, Munn DH, Murphy WJ, Brickey WJ, Serody JS, Gabrilovich DI, Bronte V, Murray PJ, Ting JP, Zeiser R, Blazar BR.

Blood. 2015 Sep 24;126(13):1621-8. doi: 10.1182/blood-2015-03-634691. Epub 2015 Aug 11.


Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Wilson JE, Petrucelli AS, Chen L, Koblansky AA, Truax AD, Oyama Y, Rogers AB, Brickey WJ, Wang Y, Schneider M, Mühlbauer M, Chou WC, Barker BR, Jobin C, Allbritton NL, Ramsden DA, Davis BK, Ting JP.

Nat Med. 2015 Aug;21(8):906-13. doi: 10.1038/nm.3908. Epub 2015 Jun 24.


Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia.

Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM.

Am J Respir Cell Mol Biol. 2015 Mar;52(3):349-64. doi: 10.1165/rcmb.2013-0316OC.


Expression profiling to identify candidate genes associated with allergic phenotypes.

Brickey WJ.

Methods Mol Biol. 2013;1032:287-95. doi: 10.1007/978-1-62703-496-8_22.


Toward a molecular pathogenic pathway for Yersinia pestis YopM.

Uittenbogaard AM, Chelvarajan RL, Myers-Morales T, Gorman AA, Brickey WJ, Ye Z, Kaplan AM, Cohen DA, Ting JP, Straley SC.

Front Cell Infect Microbiol. 2012 Dec 11;2:155. doi: 10.3389/fcimb.2012.00155. eCollection 2012.


Radiation combined with thermal injury induces immature myeloid cells.

Mendoza AE, Neely CJ, Charles AG, Kartchner LB, Brickey WJ, Khoury AL, Sempowski GD, Ting JP, Cairns BA, Maile R.

Shock. 2012 Nov;38(5):532-42. doi: 10.1097/SHK.0b013e31826c5b19.


Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers.

Hernandez ML, Herbst M, Lay JC, Alexis NE, Brickey WJ, Ting JP, Zhou H, Peden DB.

J Allergy Clin Immunol. 2012 Oct;130(4):869-76.e2. doi: 10.1016/j.jaci.2012.05.026. Epub 2012 Jul 4.


Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.

Robbins GR, Truax AD, Davis BK, Zhang L, Brickey WJ, Ting JP.

J Biol Chem. 2012 Jul 13;287(29):24294-303. doi: 10.1074/jbc.M112.364604. Epub 2012 May 29.


Analysis of NLRP3 in the development of allergic airway disease in mice.

Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP.

J Immunol. 2012 Mar 15;188(6):2884-93. doi: 10.4049/jimmunol.1102488. Epub 2012 Feb 8.


MyD88 provides a protective role in long-term radiation-induced lung injury.

Brickey WJ, Neuringer IP, Walton W, Hua X, Wang EY, Jha S, Sempowski GD, Yang X, Kirby SL, Tilley SL, Ting JP.

Int J Radiat Biol. 2012 Apr;88(4):335-47. doi: 10.3109/09553002.2012.652723. Epub 2012 Feb 6.


Airway cells from atopic asthmatic patients exposed to ozone display an enhanced innate immune gene profile.

Hernandez M, Brickey WJ, Alexis NE, Fry RC, Rager JE, Zhou B, Ting JP, Zhou H, Peden DB.

J Allergy Clin Immunol. 2012 Jan;129(1):259-61.e1-2. doi: 10.1016/j.jaci.2011.11.007. No abstract available.


Sputum inflammatory cells from patients with allergic rhinitis and asthma have decreased inflammasome gene expression.

Brickey WJ, Alexis NE, Hernandez ML, Reed W, Ting JP, Peden DB.

J Allergy Clin Immunol. 2011 Oct;128(4):900-3. doi: 10.1016/j.jaci.2011.08.012. Epub 2011 Aug 25. No abstract available.


Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP.

Nat Immunol. 2011 May;12(5):408-15. doi: 10.1038/ni.2022. Epub 2011 Apr 10.


Cutting edge: NLRC5-dependent activation of the inflammasome.

Davis BK, Roberts RA, Huang MT, Willingham SB, Conti BJ, Brickey WJ, Barker BR, Kwan M, Taxman DJ, Accavitti-Loper MA, Duncan JA, Ting JP.

J Immunol. 2011 Feb 1;186(3):1333-7. doi: 10.4049/jimmunol.1003111. Epub 2010 Dec 29.


The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells.

van Deventer HW, Burgents JE, Wu QP, Woodford RM, Brickey WJ, Allen IC, McElvania-Tekippe E, Serody JS, Ting JP.

Cancer Res. 2010 Dec 15;70(24):10161-9. doi: 10.1158/0008-5472.CAN-10-1921.


The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.

Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP.

J Neurosci. 2010 Nov 24;30(47):15811-20. doi: 10.1523/JNEUROSCI.4088-10.2010.


Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

Huang MT, Mortensen BL, Taxman DJ, Craven RR, Taft-Benz S, Kijek TM, Fuller JR, Davis BK, Allen IC, Brickey WJ, Gris D, Wen H, Kawula TH, Ting JP.

J Immunol. 2010 Nov 1;185(9):5476-85. doi: 10.4049/jimmunol.1002154. Epub 2010 Oct 4.


Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone.

Hernandez ML, Lay JC, Harris B, Esther CR Jr, Brickey WJ, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE, Peden DB.

J Allergy Clin Immunol. 2010 Sep;126(3):537-44.e1. doi: 10.1016/j.jaci.2010.06.043.


NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.

Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP.

J Immunol. 2009 Aug 1;183(3):2008-15. doi: 10.4049/jimmunol.0900138. Epub 2009 Jul 8.


Development of an inhaled endotoxin challenge protocol for characterizing evoked cell surface phenotype and genomic responses of airway cells in allergic individuals.

Alexis NE, Brickey WJ, Lay JC, Wang Y, Roubey RA, Ting JP, Peden DB.

Ann Allergy Asthma Immunol. 2008 Mar;100(3):206-15. doi: 10.1016/S1081-1206(10)60444-9.


Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription.

Bergstralh DT, Conti BJ, Moore CB, Brickey WJ, Taxman DJ, Ting JP.

Exp Cell Res. 2007 Jan 1;313(1):65-76. Epub 2006 Sep 26.


Combined donor specific transfusion and anti-CD154 therapy achieves airway allograft tolerance.

Chalermskulrat W, McKinnon KP, Brickey WJ, Neuringer IP, Park RC, Sterka DG, Long BR, McNeillie P, Noelle RJ, Ting JP, Aris RM.

Thorax. 2006 Jan;61(1):61-7. Epub 2005 Oct 27.


C-C chemokine receptor 5 on stromal cells promotes pulmonary metastasis.

van Deventer HW, O'Connor W Jr, Brickey WJ, Aris RM, Ting JP, Serody JS.

Cancer Res. 2005 Apr 15;65(8):3374-9.


PX3.102, a novel chinese herb extract, diminishes chronic airway allograft rejection.

Chalermskulrat W, Neuringer IP, Park RC, Brickey WJ, Braeckman RA, Randell SH, Aris RM.

Transplantation. 2004 Jul 15;78(1):158-61.


CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

Wong AW, Brickey WJ, Taxman DJ, van Deventer HW, Reed W, Gao JX, Zheng P, Liu Y, Li P, Blum JS, McKinnon KP, Ting JP.

Nat Immunol. 2003 Sep;4(9):891-8. Epub 2003 Aug 10.


Susceptibility of mice deficient in the MHC class II transactivator to infection with Mycobacterium tuberculosis.

Repique CJ, Li A, Brickey WJ, Ting JP, Collins FM, Morris SL.

Scand J Immunol. 2003 Jul;58(1):15-22.


The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.

Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS.

J Immunol. 2002 Dec 15;169(12):6720-32.


Hierarchical contributions of allorecognition pathways in chronic lung rejection.

Chalermskulrat W, Neuringer IP, Brickey WJ, Felix NJ, Randell SH, Ting JP, Aris RM.

Am J Respir Crit Care Med. 2003 Apr 1;167(7):999-1007. Epub 2002 Nov 21.


Transfection of macrophage inflammatory protein 1 alpha into B16 F10 melanoma cells inhibits growth of pulmonary metastases but not subcutaneous tumors.

van Deventer HW, Serody JS, McKinnon KP, Clements C, Brickey WJ, Ting JP.

J Immunol. 2002 Aug 1;169(3):1634-9.


H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.

Felix NJ, Brickey WJ, Griffiths R, Zhang J, Van Kaer L, Coffman T, Ting JP.

J Exp Med. 2000 Jul 3;192(1):31-40.


Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain.

Itoh-Lindstrom Y, Piskurich JF, Felix NJ, Wang Y, Brickey WJ, Platt JL, Koller BH, Ting JP.

J Immunol. 1999 Sep 1;163(5):2425-31.


The DMB promoter: delineation, in vivo footprint, trans-activation, and trans-dominant suppression.

Ting JP, Wright KL, Chin KC, Brickey WJ, Li G.

J Immunol. 1997 Dec 1;159(11):5457-62.


Assaying CTD kinases in vitro and phosphorylation-modulated properties of RNA polymerase II in vivo.

Morris DP, Lee JM, Sterner DE, Brickey WJ, Greenleaf AL.

Methods. 1997 Jul;12(3):264-75. Review.


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