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Items: 21


Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3686-3691. doi: 10.1073/pnas.1706096114. Epub 2018 Mar 19.


Identification of individuals by trait prediction using whole-genome sequencing data.

Lippert C, Sabatini R, Maher MC, Kang EY, Lee S, Arikan O, Harley A, Bernal A, Garst P, Lavrenko V, Yocum K, Wong T, Zhu M, Yang WY, Chang C, Lu T, Lee CWH, Hicks B, Ramakrishnan S, Tang H, Xie C, Piper J, Brewerton S, Turpaz Y, Telenti A, Roby RK, Och FJ, Venter JC.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10166-10171. doi: 10.1073/pnas.1711125114. Epub 2017 Sep 5. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 2;:.


Fast and accurate HLA typing from short-read next-generation sequence data with xHLA.

Xie C, Yeo ZX, Wong M, Piper J, Long T, Kirkness EF, Biggs WH, Bloom K, Spellman S, Vierra-Green C, Brady C, Scheuermann RH, Telenti A, Howard S, Brewerton S, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8059-8064. doi: 10.1073/pnas.1707945114. Epub 2017 Jul 3.


Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat.

Drakakis G, Wafford KA, Brewerton SC, Bodkin MJ, Evans DA, Bender A.

ACS Chem Biol. 2017 Jun 16;12(6):1593-1602. doi: 10.1021/acschembio.7b00209. Epub 2017 May 1.


Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.

Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A.

Nat Genet. 2017 Apr;49(4):568-578. doi: 10.1038/ng.3809. Epub 2017 Mar 6.


Deep sequencing of 10,000 human genomes.

Telenti A, Pierce LC, Biggs WH, di Iulio J, Wong EH, Fabani MM, Kirkness EF, Moustafa A, Shah N, Xie C, Brewerton SC, Bulsara N, Garner C, Metzker G, Sandoval E, Perkins BA, Och FJ, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11901-11906. Epub 2016 Oct 4.


Comparing global and local likelihood score thresholds in multiclass laplacian-modified Naive Bayes protein target prediction.

Drakakis G, Koutsoukas A, Brewerton SC, Bodkin MJ, Evans DA, Bender A.

Comb Chem High Throughput Screen. 2015;18(3):323-30.


Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.

Liggi S, Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martínez-Alonso P, Malliavin TE, Velazquez-Campoy A, Brewerton SC, Bodkin MJ, Evans DA, Glen RC, Carrodeguas JA, Bender A.

Future Med Chem. 2014;6(18):2029-56. doi: 10.4155/fmc.14.137.


Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.

Ravindranath AC, Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton SC, Mason D, Bodkin MJ, Evans DA, Bhagwat A, Talloen W, Göhlmann HW, Shkedy Z, Bender A; QSTAR Consortium.

Mol Biosyst. 2015 Jan;11(1):86-96. doi: 10.1039/c4mb00328d. Epub 2014 Sep 25.


Extensions to In Silico Bioactivity Predictions Using Pathway Annotations and Differential Pharmacology Analysis: Application to Xenopus laevis Phenotypic Readouts.

Liggi S, Drakakis G, Hendry AE, Hanson KM, Brewerton SC, Wheeler GN, Bodkin MJ, Evans DA, Bender A.

Mol Inform. 2013 Dec;32(11-12):1009-24. doi: 10.1002/minf.201300102. Epub 2013 Oct 18.


An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.

Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, Moore R, Calley J, Ramachandran D, Poidinger M, Karran E, Davies P, Hutton M, Szekeres P, Bose S.

J Biol Chem. 2013 Aug 9;288(32):23331-47. doi: 10.1074/jbc.M113.463984. Epub 2013 Jun 24.


ChEMBLSpace--a graphical explorer of the chemogenomic space covered by the ChEMBL database.

Fechner N, Papadatos G, Evans D, Morphy JR, Brewerton SC, Thorner D, Bodkin M.

Bioinformatics. 2013 Feb 15;29(4):523-4. doi: 10.1093/bioinformatics/bts711. Epub 2012 Dec 20.


Structure-based drug design - an Informa conference.

Brewerton S.

IDrugs. 2008 Nov;11(11):803-6. No abstract available.


Using buriedness to improve discrimination between actives and inactives in docking.

O'Boyle NM, Brewerton SC, Taylor R.

J Chem Inf Model. 2008 Jun;48(6):1269-78. doi: 10.1021/ci8000452. Epub 2008 Jun 6.


The use of protein-ligand interaction fingerprints in docking.

Brewerton SC.

Curr Opin Drug Discov Devel. 2008 May;11(3):356-64. Review.


Autonomous folding of interdomain regions of a modular polyketide synthase.

Richter CD, Stanmore DA, Miguel RN, Moncrieffe MC, Tran L, Brewerton S, Meersman F, Broadhurst RW, Weissman KJ.

FEBS J. 2007 May;274(9):2196-209. Epub 2007 Apr 5.


Diverse, high-quality test set for the validation of protein-ligand docking performance.

Hartshorn MJ, Verdonk ML, Chessari G, Brewerton SC, Mooij WT, Mortenson PN, Murray CW.

J Med Chem. 2007 Feb 22;50(4):726-41.


Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D.

Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):413-23. Review.


The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity.

Bolanos-Garcia VM, Beaufils S, Renault A, Grossmann JG, Brewerton S, Lee M, Venkitaraman A, Blundell TL.

Biophys J. 2005 Oct;89(4):2640-9. Epub 2005 Jul 22.


Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture.

Brewerton SC, Doré AS, Drake AC, Leuther KK, Blundell TL.

J Struct Biol. 2004 Mar;145(3):295-306.


Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining.

Doré AS, Drake AC, Brewerton SC, Blundell TL.

DNA Repair (Amst). 2004 Jan 5;3(1):33-41.


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