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Items: 1 to 50 of 129

1.

Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis.

Kuru E, Radkov A, Meng X, Egan A, Alvarez L, Dowson A, Booher G, Breukink E, Roper DI, Cava F, Vollmer W, Brun Y, VanNieuwenhze MS.

ACS Chem Biol. 2019 Dec 20;14(12):2745-2756. doi: 10.1021/acschembio.9b00664. Epub 2019 Dec 5.

2.

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions.

Mueller EA, Egan AJ, Breukink E, Vollmer W, Levin PA.

Elife. 2019 Apr 9;8. pii: e40754. doi: 10.7554/eLife.40754.

3.

Towards the Native Binding Modes of Antibiotics that Target Lipid II.

Medeiros-Silva J, Jekhmane S, Breukink E, Weingarth M.

Chembiochem. 2019 Jul 15;20(14):1731-1738. doi: 10.1002/cbic.201800796. Epub 2019 May 22. Review.

4.

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect.

Morè N, Martorana AM, Biboy J, Otten C, Winkle M, Serrano CKG, Montón Silva A, Atkinson L, Yau H, Breukink E, den Blaauwen T, Vollmer W, Polissi A.

mBio. 2019 Feb 5;10(1). pii: e02729-18. doi: 10.1128/mBio.02729-18.

5.

Publisher Correction: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division.

Pazos M, Peters K, Casanova M, Palacios P, VanNieuwenhze M, Breukink E, Vicente M, Vollmer W.

Nat Commun. 2019 Jan 30;10(1):591. doi: 10.1038/s41467-019-08410-y.

6.

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.

Boes A, Olatunji S, Breukink E, Terrak M.

mBio. 2019 Jan 8;10(1). pii: e01912-18. doi: 10.1128/mBio.01912-18.

7.

Correction: Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers.

Liu Y, Moura ECCM, Dörr JM, Scheidelaar S, Heger M, Egmond MR, Killian JA, Mohammadi T, Breukink E.

PLoS One. 2018 Dec 27;13(12):e0210135. doi: 10.1371/journal.pone.0210135. eCollection 2018.

8.

Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division.

Pazos M, Peters K, Casanova M, Palacios P, VanNieuwenhze M, Breukink E, Vicente M, Vollmer W.

Nat Commun. 2018 Nov 30;9(1):5090. doi: 10.1038/s41467-018-07559-2. Erratum in: Nat Commun. 2019 Jan 30;10(1):591.

9.

Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers.

Liu Y, Moura ECCM, Dörr JM, Scheidelaar S, Heger M, Egmond MR, Killian JA, Mohammadi T, Breukink E.

PLoS One. 2018 Nov 5;13(11):e0206692. doi: 10.1371/journal.pone.0206692. eCollection 2018. Erratum in: PLoS One. 2018 Dec 27;13(12):e0210135.

10.

High-resolution NMR studies of antibiotics in cellular membranes.

Medeiros-Silva J, Jekhmane S, Paioni AL, Gawarecka K, Baldus M, Swiezewska E, Breukink E, Weingarth M.

Nat Commun. 2018 Sep 27;9(1):3963. doi: 10.1038/s41467-018-06314-x.

11.

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli.

Montón Silva A, Otten C, Biboy J, Breukink E, VanNieuwenhze M, Vollmer W, den Blaauwen T.

Front Microbiol. 2018 Sep 4;9:2101. doi: 10.3389/fmicb.2018.02101. eCollection 2018.

12.

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae.

Morlot C, Straume D, Peters K, Hegnar OA, Simon N, Villard AM, Contreras-Martel C, Leisico F, Breukink E, Gravier-Pelletier C, Le Corre L, Vollmer W, Pietrancosta N, Håvarstein LS, Zapun A.

Nat Commun. 2018 Aug 9;9(1):3180. doi: 10.1038/s41467-018-05602-w.

13.

Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis.

Hernández-Rocamora VM, Otten CF, Radkov A, Simorre JP, Breukink E, VanNieuwenhze M, Vollmer W.

Cell Surf. 2018 Jun;2:1-13. doi: 10.1016/j.tcsw.2018.04.002.

14.

Induced conformational changes activate the peptidoglycan synthase PBP1B.

Egan AJF, Maya-Martinez R, Ayala I, Bougault CM, Banzhaf M, Breukink E, Vollmer W, Simorre JP.

Mol Microbiol. 2018 Nov;110(3):335-356. doi: 10.1111/mmi.14082. Epub 2018 Oct 25.

15.

Plantaricin NC8 from Lactobacillus plantarum causes cell membrane disruption to Micrococcus luteus without targeting lipid II.

Jiang H, Tang X, Zhou Q, Zou J, Li P, Breukink E, Gu Q.

Appl Microbiol Biotechnol. 2018 Sep;102(17):7465-7473. doi: 10.1007/s00253-018-9182-3. Epub 2018 Jul 7.

PMID:
29982926
16.

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.

Parmar A, Iyer A, Prior SH, Lloyd DG, Leng Goh ET, Vincent CS, Palmai-Pallag T, Bachrati CZ, Breukink E, Madder A, Lakshminarayanan R, Taylor EJ, Singh I.

Chem Sci. 2017 Dec 1;8(12):8183-8192. doi: 10.1039/c7sc03241b. Epub 2017 Oct 5.

17.

De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria.

't Hart P, Wood TM, Tehrani KHME, van Harten RM, Śleszyńska M, Rentero Rebollo I, Hendrickx APA, Willems RJL, Breukink E, Martin NI.

Chem Sci. 2017 Dec 1;8(12):7991-7997. doi: 10.1039/c7sc03413j. Epub 2017 Oct 2.

18.

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis.

Leclercq S, Derouaux A, Olatunji S, Fraipont C, Egan AJ, Vollmer W, Breukink E, Terrak M.

Sci Rep. 2017 Feb 24;7:43306. doi: 10.1038/srep43306.

19.

Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities.

Parmar A, Prior SH, Iyer A, Vincent CS, Van Lysebetten D, Breukink E, Madder A, Taylor EJ, Singh I.

Chem Commun (Camb). 2017 Feb 7;53(12):2016-2019. doi: 10.1039/c6cc09490b.

PMID:
28124045
20.

Substitutions in PBP2b from β-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity.

Calvez P, Breukink E, Roper DI, Dib M, Contreras-Martel C, Zapun A.

J Biol Chem. 2017 Feb 17;292(7):2854-2865. doi: 10.1074/jbc.M116.764696. Epub 2017 Jan 6.

21.

Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface.

Van't Veer IL, Leloup NO, Egan AJ, Janssen BJ, Martin NI, Vollmer W, Breukink E.

Chembiochem. 2016 Dec 2;17(23):2250-2256. doi: 10.1002/cbic.201600461. Epub 2016 Nov 7.

22.

The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets.

Liu Y, Breukink E.

Antibiotics (Basel). 2016 Aug 26;5(3). pii: E28. doi: 10.3390/antibiotics5030028. Review.

23.

Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis.

Cleverley RM, Rismondo J, Lockhart-Cairns MP, Van Bentum PT, Egan AJ, Vollmer W, Halbedel S, Baldock C, Breukink E, Lewis RJ.

Microb Drug Resist. 2016 Sep;22(6):446-60. doi: 10.1089/mdr.2016.0050. Epub 2016 Jun 3.

24.

New Insight into the Catalytic Mechanism of Bacterial MraY from Enzyme Kinetics and Docking Studies.

Liu Y, Rodrigues JP, Bonvin AM, Zaal EA, Berkers CR, Heger M, Gawarecka K, Swiezewska E, Breukink E, Egmond MR.

J Biol Chem. 2016 Jul 15;291(29):15057-68. doi: 10.1074/jbc.M116.717884. Epub 2016 May 18.

25.

Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action.

Kleijn LH, Oppedijk SF, 't Hart P, van Harten RM, Martin-Visscher LA, Kemmink J, Breukink E, Martin NI.

J Med Chem. 2016 Apr 14;59(7):3569-74. doi: 10.1021/acs.jmedchem.6b00219. Epub 2016 Mar 24.

PMID:
26967152
26.

Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy.

Broekgaarden M, van Vught R, Oliveira S, Roovers RC, van Bergen en Henegouwen PM, Pieters RJ, Van Gulik TM, Breukink E, Heger M.

Nanoscale. 2016 Mar 28;8(12):6490-4. doi: 10.1039/c6nr00014b.

PMID:
26954515
27.

New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.

't Hart P, Oppedijk SF, Breukink E, Martin NI.

Biochemistry. 2016 Jan 12;55(1):232-7. doi: 10.1021/acs.biochem.5b01173. Epub 2015 Dec 22.

PMID:
26653142
28.

Antibacterial photodynamic therapy: overview of a promising approach to fight antibiotic-resistant bacterial infections.

Liu Y, Qin R, Zaat SAJ, Breukink E, Heger M.

J Clin Transl Res. 2015 Dec 1;1(3):140-167. eCollection 2015 Dec 30. Review.

29.

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.

Sosič I, Anderluh M, Sova M, Gobec M, Mlinarič Raščan I, Derouaux A, Amoroso A, Terrak M, Breukink E, Gobec S.

J Med Chem. 2015 Dec 24;58(24):9712-21. doi: 10.1021/acs.jmedchem.5b01482. Epub 2015 Dec 3.

PMID:
26588190
30.

Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.

Oppedijk SF, Martin NI, Breukink E.

Biochim Biophys Acta. 2016 May;1858(5):947-57. doi: 10.1016/j.bbamem.2015.10.024. Epub 2015 Oct 31. Review.

31.

Activities and regulation of peptidoglycan synthases.

Egan AJ, Biboy J, van't Veer I, Breukink E, Vollmer W.

Philos Trans R Soc Lond B Biol Sci. 2015 Oct 5;370(1679). pii: 20150031. doi: 10.1098/rstb.2015.0031. Review.

32.

Development of a liquid chromatography/mass spectrometry assay for the bacterial transglycosylation reaction through measurement of Lipid II.

Blanchaert B, Wyseure T, Breukink E, Adams E, Declerck P, Van Schepdael A.

Electrophoresis. 2015 Nov;36(21-22):2841-2849. doi: 10.1002/elps.201500201. Epub 2015 Oct 7.

PMID:
26333884
33.

Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound.

Koopmans T, Wood TM, 't Hart P, Kleijn LH, Hendrickx AP, Willems RJ, Breukink E, Martin NI.

J Am Chem Soc. 2015 Jul 29;137(29):9382-9. doi: 10.1021/jacs.5b04501. Epub 2015 Jul 14.

PMID:
26122963
34.

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division.

Gray AN, Egan AJ, Van't Veer IL, Verheul J, Colavin A, Koumoutsi A, Biboy J, Altelaar AF, Damen MJ, Huang KC, Simorre JP, Breukink E, den Blaauwen T, Typas A, Gross CA, Vollmer W.

Elife. 2015 May 7;4. doi: 10.7554/eLife.07118.

35.

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity.

Slootweg JC, van Herwerden EF, van Doremalen MF, Breukink E, Liskamp RM, Rijkers DT.

Org Biomol Chem. 2015 Jun 7;13(21):5997-6009. doi: 10.1039/c5ob00336a.

PMID:
25940216
36.

Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers.

Scheidelaar S, Koorengevel MC, Pardo JD, Meeldijk JD, Breukink E, Killian JA.

Biophys J. 2015 Jan 20;108(2):279-90. doi: 10.1016/j.bpj.2014.11.3464.

37.

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.

Bury D, Dahmane I, Derouaux A, Dumbre S, Herdewijn P, Matagne A, Breukink E, Mueller-Seitz E, Petz M, Terrak M.

Biochem Pharmacol. 2015 Jan 15;93(2):141-50. doi: 10.1016/j.bcp.2014.11.003. Epub 2014 Nov 14.

38.

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.

Slootweg JC, Peters N, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT.

Bioorg Med Chem. 2014 Oct 1;22(19):5345-53. doi: 10.1016/j.bmc.2014.07.046. Epub 2014 Aug 2.

PMID:
25199583
39.

The chlamydial anomaly clarified?

Mohammadi T, Breukink E.

Chembiochem. 2014 Jul 7;15(10):1391-2. doi: 10.1002/cbic.201402143. Epub 2014 Jun 2.

PMID:
24891214
40.

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.

Egan AJ, Jean NL, Koumoutsi A, Bougault CM, Biboy J, Sassine J, Solovyova AS, Breukink E, Typas A, Vollmer W, Simorre JP.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8197-202. doi: 10.1073/pnas.1400376111. Epub 2014 May 12.

41.

Site-specific functionalization of proteins and their applications to therapeutic antibodies.

van Vught R, Pieters RJ, Breukink E.

Comput Struct Biotechnol J. 2014 Feb 14;9:e201402001. doi: 10.5936/csbj.201402001. eCollection 2014. Review.

42.

Specificity of the transport of lipid II by FtsW in Escherichia coli.

Mohammadi T, Sijbrandi R, Lutters M, Verheul J, Martin NI, den Blaauwen T, de Kruijff B, Breukink E.

J Biol Chem. 2014 May 23;289(21):14707-18. doi: 10.1074/jbc.M114.557371. Epub 2014 Apr 7.

43.

Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC.

Slootweg JC, van der Wal S, Quarles van Ufford HC, Breukink E, Liskamp RM, Rijkers DT.

Bioconjug Chem. 2013 Dec 18;24(12):2058-66. doi: 10.1021/bc400401k. Epub 2013 Dec 5.

PMID:
24266643
44.

Turning defense into offense: defensin mimetics as novel antibiotics targeting lipid II.

Varney KM, Bonvin AM, Pazgier M, Malin J, Yu W, Ateh E, Oashi T, Lu W, Huang J, Diepeveen-de Buin M, Bryant J, Breukink E, Mackerell AD Jr, de Leeuw EP.

PLoS Pathog. 2013;9(11):e1003732. doi: 10.1371/journal.ppat.1003732. Epub 2013 Nov 7. Erratum in: PLoS Pathog. 2014 Dec;10(12):e1004611.

45.

In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae.

Zapun A, Philippe J, Abrahams KA, Signor L, Roper DI, Breukink E, Vernet T.

ACS Chem Biol. 2013 Dec 20;8(12):2688-96. doi: 10.1021/cb400575t. Epub 2013 Sep 30.

PMID:
24044435
46.

Fluorescent labeling of nisin Z and assessment of anti-listerial action.

Imran M, Revol-Junelles AM, de Bruin M, Paris C, Breukink E, Desobry S.

J Microbiol Methods. 2013 Nov;95(2):107-13. doi: 10.1016/j.mimet.2013.07.009. Epub 2013 Jul 25.

PMID:
23892059
47.

Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.

Slootweg JC, van Schaik TB, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3749-52. doi: 10.1016/j.bmcl.2013.05.002. Epub 2013 May 9.

PMID:
23719232
48.

Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory.

Kindrachuk J, Jenssen H, Elliott M, Nijnik A, Magrangeas-Janot L, Pasupuleti M, Thorson L, Ma S, Easton DM, Bains M, Finlay B, Breukink EJ, Georg-Sahl H, Hancock RE.

Innate Immun. 2013 Jun;19(3):315-27. doi: 10.1177/1753425912461456. Epub 2012 Oct 29.

PMID:
23109507
49.

Synthesis and antifungal properties of papulacandin derivatives.

van der Kaaden M, Breukink E, Pieters RJ.

Beilstein J Org Chem. 2012;8:732-7. Epub 2012 May 14.

50.

Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity.

Paiva AD, de Oliveira MD, de Paula SO, Baracat-Pereira MC, Breukink E, Mantovani HC.

Microbiology. 2012 Nov;158(Pt 11):2851-2858. doi: 10.1099/mic.0.062190-0. Epub 2012 Sep 6.

PMID:
22956757

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