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Nucleoporin Nup155 is part of the p53 network in liver cancer.

Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S.

Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z.


YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells.

Wei T, Weiler SME, Tóth M, Sticht C, Lutz T, Thomann S, De La Torre C, Straub B, Merker S, Ruppert T, Marquardt J, Singer S, Gretz N, Schirmacher P, Breuhahn K.

Oncogene. 2019 Apr 1. doi: 10.1038/s41388-019-0801-y. [Epub ahead of print]


RSPO2 gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

Longerich T, Endris V, Neumann O, Rempel E, Kirchner M, Abadi Z, Uhrig S, Kriegsmann M, Weiss KH, Breuhahn K, Mehrabi A, Weber TF, Wilkens L, Straub BK, Rosenwald A, Schulze F, Brors B, Froehling S, Pellegrino R, Budczies J, Schirmacher P, Stenzinger A.

Gut. 2019 Feb 2. pii: gutjnl-2018-317632. doi: 10.1136/gutjnl-2018-317632. [Epub ahead of print]


Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma.

Waly AA, El-Ekiaby N, Assal RA, Abdelrahman MM, Hosny KA, El Tayebi HM, Esmat G, Breuhahn K, Abdelaziz AI.

Front Physiol. 2019 Jan 24;9:1918. doi: 10.3389/fphys.2018.01918. eCollection 2018.


Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.

Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC.

Gastroenterology. 2019 Mar;156(4):1190-1205.e14. doi: 10.1053/j.gastro.2018.11.018. Epub 2018 Nov 13.


Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.

González-Vallinas M, Rodríguez-Paredes M, Albrecht M, Sticht C, Stichel D, Gutekunst J, Pitea A, Sass S, Sánchez-Rivera FJ, Lorenzo-Bermejo J, Schmitt J, De La Torre C, Warth A, Theis FJ, Müller NS, Gretz N, Muley T, Meister M, Tschaharganeh DF, Schirmacher P, Matthäus F, Breuhahn K.

Mol Cancer Res. 2018 Mar;16(3):390-402. doi: 10.1158/1541-7786.MCR-17-0334. Epub 2018 Jan 12.


FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas.

Milewski D, Balli D, Ustiyan V, Le T, Dienemann H, Warth A, Breuhahn K, Whitsett JA, Kalinichenko VV, Kalin TV.

PLoS Genet. 2017 Dec 21;13(12):e1007097. doi: 10.1371/journal.pgen.1007097. eCollection 2017 Dec.


Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness.

Wan S, Meyer AS, Weiler SME, Rupp C, Tóth M, Sticht C, Singer S, Thomann S, Roessler S, Schorpp-Kistner M, Schmitt J, Gretz N, Angel P, Tschaharganeh DF, Marquardt J, Schirmacher P, Pinna F, Breuhahn K.

Hepatology. 2018 May;67(5):1842-1856. doi: 10.1002/hep.29669. Epub 2018 Apr 1.


[Nonautonomous effects of oncogenic YAP in hepatocarcinogenesis].

Marquard S, Thomann S, Weiler SME, Sticht C, Gretz N, Schirmacher P, Breuhahn K.

Pathologe. 2017 Nov;38(Suppl 2):175-179. doi: 10.1007/s00292-017-0361-2. Review. German.


A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes.

Pinna F, Bissinger M, Beuke K, Huber N, Longerich T, Kummer U, Schirmacher P, Sahle S, Breuhahn K.

Front Physiol. 2017 Aug 23;8:610. doi: 10.3389/fphys.2017.00610. eCollection 2017.


An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors.

Stichel D, Middleton AM, Müller BF, Depner S, Klingmüller U, Breuhahn K, Matthäus F.

NPJ Syst Biol Appl. 2017 Mar 3;3:5. doi: 10.1038/s41540-017-0006-3. eCollection 2017.


Tumor Cell Load and Heterogeneity Estimation From Diffusion-Weighted MRI Calibrated With Histological Data: an Example From Lung Cancer.

Yin Y, Sedlaczek O, Muller B, Warth A, Gonzalez-Vallinas M, Lahrmann B, Grabe N, Kauczor HU, Breuhahn K, Vignon-Clementel IE, Drasdo D.

IEEE Trans Med Imaging. 2018 Jan;37(1):35-46. doi: 10.1109/TMI.2017.2698525. Epub 2017 Apr 27.


Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.

Weiler SME, Pinna F, Wolf T, Lutz T, Geldiyev A, Sticht C, Knaub M, Thomann S, Bissinger M, Wan S, Rössler S, Becker D, Gretz N, Lang H, Bergmann F, Ustiyan V, Kalin TV, Singer S, Lee JS, Marquardt JU, Schirmacher P, Kalinichenko VV, Breuhahn K.

Gastroenterology. 2017 Jun;152(8):2037-2051.e22. doi: 10.1053/j.gastro.2017.02.018. Epub 2017 Feb 27.


Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction.

Beuke K, Schildberg FA, Pinna F, Albrecht U, Liebe R, Bissinger M, Schirmacher P, Dooley S, Bode JG, Knolle PA, Kummer U, Breuhahn K, Sahle S.

FEBS J. 2017 Mar;284(5):796-813. doi: 10.1111/febs.14022. Epub 2017 Feb 17.


TTCA: an R package for the identification of differentially expressed genes in time course microarray data.

Albrecht M, Stichel D, Müller B, Merkle R, Sticht C, Gretz N, Klingmüller U, Breuhahn K, Matthäus F.

BMC Bioinformatics. 2017 Jan 14;18(1):33. doi: 10.1186/s12859-016-1440-8.


Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.

Holzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, Eiteneuer EM, Herpel E, Breuhahn K, Zender L, Schirmacher P, Ori A, Singer S.

Am J Pathol. 2017 Feb;187(2):228-235. doi: 10.1016/j.ajpath.2016.09.022. Epub 2016 Dec 7.


Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V.

Cell Death Dis. 2016 Nov 10;7(11):e2461. doi: 10.1038/cddis.2016.342.


The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells.

Textor S, Bossler F, Henrich KO, Gartlgruber M, Pollmann J, Fiegler N, Arnold A, Westermann F, Waldburger N, Breuhahn K, Golfier S, Witzens-Harig M, Cerwenka A.

Oncoimmunology. 2016 Jul 28;5(7):e1116674. doi: 10.1080/2162402X.2015.1116674. eCollection 2016 Jul.


MicroRNAs are key regulators of hepatocellular carcinoma (HCC) cell dissemination-what we learned from microRNA-494.

González-Vallinas M, Breuhahn K.

Hepatobiliary Surg Nutr. 2016 Aug;5(4):372-6. doi: 10.21037/hbsn.2016.05.07. No abstract available.


Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma.

Wolf B, Krieg K, Falk C, Breuhahn K, Keppeler H, Biedermann T, Schmid E, Warmann S, Fuchs J, Vetter S, Thiele D, Nieser M, Avci-Adali M, Skokowa Y, Schöls L, Hauser S, Ringelhan M, Yevsa T, Heikenwalder M, Kossatz-Boehlert U.

Cancer Res. 2016 Sep 15;76(18):5550-61. doi: 10.1158/0008-5472.CAN-15-3453. Epub 2016 Aug 3.


Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.

Ploeger C, Waldburger N, Fraas A, Goeppert B, Pusch S, Breuhahn K, Wang XW, Schirmacher P, Roessler S.

Hepatology. 2016 Sep;64(3):828-42. doi: 10.1002/hep.28684. Epub 2016 Jul 15.


Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).

Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S.

Oncotarget. 2016 Apr 19;7(16):22883-92. doi: 10.18632/oncotarget.8256.


PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.

Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K.

Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357. Epub 2016 Jan 14.


Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation.

Holzer K, Drucker E, Oliver S, Winkler J, Eiteneuer E, Herpel E, Breuhahn K, Singer S.

Int J Oncol. 2016 Apr;48(4):1679-87. doi: 10.3892/ijo.2016.3388. Epub 2016 Feb 9.


Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images.

Lotz J, Olesch J, Muller B, Polzin T, Galuschka P, Lotz JM, Heldmann S, Laue H, Gonzalez-Vallinas M, Warth A, Lahrmann B, Grabe N, Sedlaczek O, Breuhahn K, Modersitzki J.

IEEE Trans Biomed Eng. 2016 Sep;63(9):1812-1819. doi: 10.1109/TBME.2015.2503122. Epub 2015 Nov 23.


Directed random walks and constraint programming reveal active pathways in hepatocyte growth factor signaling.

Kittas A, Delobelle A, Schmitt S, Breuhahn K, Guziolowski C, Grabe N.

FEBS J. 2016 Jan;283(2):350-60. doi: 10.1111/febs.13580. Epub 2015 Nov 26.


Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells.

Müller B, Bovet M, Yin Y, Stichel D, Malz M, González-Vallinas M, Middleton A, Ehemann V, Schmitt J, Muley T, Meister M, Herpel E, Singer S, Warth A, Schirmacher P, Drasdo D, Matthäus F, Breuhahn K.

J Pathol. 2015 Nov;237(3):390-401. doi: 10.1002/path.4588. Epub 2015 Sep 8.


Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer.

Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, Pinna F, Lee YH, Kitade M, Domínguez MP, Castven D, Breuhahn K, Conner EA, Galle PR, Andersen JB, Factor VM, Thorgeirsson SS.

J Hepatol. 2015 Sep;63(3):661-9. doi: 10.1016/j.jhep.2015.04.018. Epub 2015 May 1.


Implementation of systems theory in liver cancer research.

Pinna F, Breuhahn K.

Hepat Oncol. 2015 Jan;2(1):9-11. doi: 10.2217/hep.14.29. Epub 2015 Jan 12. No abstract available.


SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.

Delogu S, Wang C, Cigliano A, Utpatel K, Sini M, Longerich T, Waldburger N, Breuhahn K, Jiang L, Ribback S, Dombrowski F, Evert M, Chen X, Calvisi DF.

Oncotarget. 2015 Feb 10;6(4):2222-34.


Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma.

Welte S, Urbanik T, Elßner C, Kautz N, Koehler BC, Waldburger N, Bermejo JL, Pinna F, Weiss KH, Schemmer P, Jaeger D, Longerich T, Breuhahn K, Schulze-Bergkamen H.

PLoS One. 2014 Oct 16;9(10):e110591. doi: 10.1371/journal.pone.0110591. eCollection 2014.


Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma.

Malz M, Bovet M, Samarin J, Rabenhorst U, Sticht C, Bissinger M, Roessler S, Bermejo JL, Renner M, Calvisi DF, Singer S, Ganzinger M, Weber A, Gretz N, Zörnig M, Schirmacher P, Breuhahn K.

Hepatology. 2014 Oct;60(4):1241-50. doi: 10.1002/hep.27218. Epub 2014 Jul 31.


Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer.

Winkler J, Ori A, Holzer K, Sticht C, Dauch D, Eiteneuer EM, Pinna F, Geffers R, Ehemann V, Andres-Pons A, Breuhahn K, Longerich T, Bermejo JL, Gretz N, Zender L, Schirmacher P, Beck M, Singer S.

Hepatology. 2014 Sep;60(3):884-95. doi: 10.1002/hep.27207. Epub 2014 Jul 17.


Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E.

Cancer Discov. 2014 Jun;4(6):730-43. doi: 10.1158/2159-8290.CD-13-0782. Epub 2014 Mar 31.


Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma.

Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S.

Hepatology. 2014 May;59(5):1900-11. doi: 10.1002/hep.26997. Epub 2014 Apr 1.


Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models.

Safferling K, Sütterlin T, Westphal K, Ernst C, Breuhahn K, James M, Jäger D, Halama N, Grabe N.

J Cell Biol. 2013 Nov 25;203(4):691-709. doi: 10.1083/jcb.201212020.


Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.

Koschny R, Brost S, Hinz U, Sykora J, Batke EM, Singer S, Breuhahn K, Stremmel W, Walczak H, Schemmer P, Schirmacher P, Ganten TM.

BMC Cancer. 2013 Nov 9;13:532. doi: 10.1186/1471-2407-13-532.


Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration.

Schmitt S, Safferling K, Westphal K, Hrabowski M, Müller U, Angel P, Wiechert L, Ehemann V, Müller B, Holland-Cunz S, Stichel D, Harder N, Rohr K, Germann G, Matthäus F, Schirmacher P, Grabe N, Breuhahn K.

PLoS One. 2013 Sep 16;8(9):e75075. doi: 10.1371/journal.pone.0075075. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/1ece268f-578b-429a-b70b-c3ff002aec0b.


Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway.

Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, Gu L, Becker N, Zucknick M, Mehrabi A, Hafezi M, Klauschen F, Stenzinger A, Warth A, Breuhahn K, Renner M, Weichert W, Schirmacher P, Plass C, Weichenhan D.

Hepatology. 2014 Feb;59(2):544-54. doi: 10.1002/hep.26721. Epub 2013 Dec 24.


Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines.

Dzieran J, Fabian J, Feng T, Coulouarn C, Ilkavets I, Kyselova A, Breuhahn K, Dooley S, Meindl-Beinker NM.

PLoS One. 2013 Aug 22;8(8):e72252. doi: 10.1371/journal.pone.0072252. eCollection 2013. Erratum in: PLoS One. 2014;9(5):e95952.


Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival.

Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hämmerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG, Goerdt S.

Liver Int. 2013 Oct;33(9):1428-40. doi: 10.1111/liv.12262. Epub 2013 Jul 21.


High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice.

Kruse M, Seki Y, Vuguin PM, Du XQ, Fiallo A, Glenn AS, Singer S, Breuhahn K, Katz EB, Charron MJ.

Endocrinology. 2013 Oct;154(10):3565-76. doi: 10.1210/en.2012-1877. Epub 2013 Jul 16.


Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells.

Fiegler N, Textor S, Arnold A, Rölle A, Oehme I, Breuhahn K, Moldenhauer G, Witzens-Harig M, Cerwenka A.

Blood. 2013 Aug 1;122(5):684-93. doi: 10.1182/blood-2013-02-482513. Epub 2013 Jun 25.


Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).

Hämmerle M, Gutschner T, Uckelmann H, Ozgur S, Fiskin E, Gross M, Skawran B, Geffers R, Longerich T, Breuhahn K, Schirmacher P, Stoecklin G, Diederichs S.

Hepatology. 2013 Nov;58(5):1703-12. doi: 10.1002/hep.26537. Epub 2013 Aug 7.


Endothelial plasticity governs the site-specific leukocyte recruitment in hepatocellular cancer.

Salnikova O, Breuhahn K, Hartmann N, Schmidt J, Ryschich E.

Int J Cancer. 2013 Nov 15;133(10):2372-82. doi: 10.1002/ijc.28268. Epub 2013 Jun 10.


Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma.

Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K.

Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16.


A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes.

Pinna F, Sahle S, Beuke K, Bissinger M, Tuncay S, D'Alessandro LA, Gauges R, Raue A, Timmer J, Klingmüller U, Schirmacher P, Kummer U, Breuhahn K.

Front Physiol. 2012 Dec 31;3:466. doi: 10.3389/fphys.2012.00466. eCollection 2012.


On the ontology based representation of cell lines.

Ganzinger M, He S, Breuhahn K, Knaup P.

PLoS One. 2012;7(11):e48584. doi: 10.1371/journal.pone.0048584. Epub 2012 Nov 7.


Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.

Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C.

Mol Cell. 2012 Dec 14;48(5):799-810. doi: 10.1016/j.molcel.2012.09.020. Epub 2012 Oct 24.


miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma.

El Tayebi HM, Hosny KA, Esmat G, Breuhahn K, Abdelaziz AI.

FEBS Lett. 2012 Sep 21;586(19):3309-16. doi: 10.1016/j.febslet.2012.06.054. Epub 2012 Jul 20.

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