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Items: 36

1.

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.

Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C.

Sci Transl Med. 2019 Aug 14;11(505). pii: eaau2291. doi: 10.1126/scitranslmed.aau2291.

PMID:
31413141
2.

The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.

Chanthamontri CK, Jordan DS, Wang W, Wu C, Lin Y, Brett TJ, Gross ML, Leung DW.

Biochemistry. 2019 Feb 12;58(6):657-664. doi: 10.1021/acs.biochem.8b01154. Epub 2019 Jan 10.

PMID:
30592210
3.

YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.

Ohlemacher SI, Xu Y, Kober DL, Malik M, Nix JC, Brett TJ, Henderson JP.

J Biol Chem. 2018 Dec 21;293(51):19572-19585. doi: 10.1074/jbc.RA118.005752. Epub 2018 Oct 24.

PMID:
30355735
4.

Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps.

Berry KN, Kober DL, Su A, Brett TJ.

Bioessays. 2018 Oct;40(10):e1800086. doi: 10.1002/bies.201800086. Epub 2018 Aug 16. Review.

5.

TREM2-Ligand Interactions in Health and Disease.

Kober DL, Brett TJ.

J Mol Biol. 2017 Jun 2;429(11):1607-1629. doi: 10.1016/j.jmb.2017.04.004. Epub 2017 Apr 19. Review.

6.

Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).

Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ.

J Biol Chem. 2017 Jun 2;292(22):9164-9174. doi: 10.1074/jbc.M117.788232. Epub 2017 Apr 18.

7.

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ.

Elife. 2016 Dec 20;5. pii: e20391. doi: 10.7554/eLife.20391.

8.

First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.

Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2335-2344. doi: 10.1016/j.bbagen.2016.06.023. Epub 2016 Jun 29.

9.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

10.

Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization.

Kober DL, Yurtsever Z, Brett TJ.

J Vis Exp. 2015 Dec 23;(106):e53445. doi: 10.3791/53445.

11.

Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.

Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H.

Br J Pharmacol. 2016 Apr;173(7):1208-18. doi: 10.1111/bph.13420. Epub 2016 Mar 1. Erratum in: Br J Pharmacol. 2016 Sep;173(18):2808.

12.

Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.

Sala-Rabanal M, Yurtsever Z, Berry KN, Brett TJ.

Mediators Inflamm. 2015;2015:497387. doi: 10.1155/2015/497387. Epub 2015 Nov 3. Review.

13.

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ.

Nat Immunol. 2015 Dec;16(12):1215-27. doi: 10.1038/ni.3279. Epub 2015 Oct 19.

14.

CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.

Brett TJ.

Expert Rev Respir Med. 2015 Oct;9(5):503-6. doi: 10.1586/17476348.2015.1081064. Epub 2015 Aug 20. Review.

15.

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.

Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ.

J Exp Med. 2015 May 4;212(5):681-97. doi: 10.1084/jem.20141732. Epub 2015 Apr 20.

16.

The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.

Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):790-9. doi: 10.1107/S1399004715001212. Epub 2015 Mar 26.

17.

Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.

Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ.

Elife. 2015 Mar 17;4. doi: 10.7554/eLife.05875.

18.

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK.

Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008.

19.

Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.

Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ.

Protein Expr Purif. 2014 Apr;96:32-8. doi: 10.1016/j.pep.2014.01.015. Epub 2014 Feb 7.

20.

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

Combs MD, Knutsen RH, Broekelmann TJ, Toennies HM, Brett TJ, Miller CA, Kober DL, Craft CS, Atkinson JJ, Shipley JM, Trask BC, Mecham RP.

J Biol Chem. 2013 Oct 4;288(40):28869-80. doi: 10.1074/jbc.M113.497727. Epub 2013 Aug 20.

21.

BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.

Swiecki M, Omattage NS, Brett TJ.

Mol Immunol. 2013 Jun;54(2):132-9. doi: 10.1016/j.molimm.2012.11.008. Epub 2012 Dec 27. Review.

PMID:
23274150
22.

IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.

Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ.

J Clin Invest. 2012 Dec;122(12):4555-68. doi: 10.1172/JCI64896. Epub 2012 Nov 26.

23.

Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ.

J Biol Chem. 2012 Dec 7;287(50):42138-49. doi: 10.1074/jbc.M112.410282. Epub 2012 Oct 30.

24.

Do GGA adaptors bind internal DXXLL motifs?

Doray B, Misra S, Qian Y, Brett TJ, Kornfeld S.

Traffic. 2012 Oct;13(10):1315-25. doi: 10.1111/j.1600-0854.2012.01396.x. Epub 2012 Jul 24.

25.

Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.

Akhtar K, Broekelmann TJ, Song H, Turk J, Brett TJ, Mecham RP, Adair-Kirk TL.

J Biol Chem. 2011 Apr 15;286(15):13574-82. doi: 10.1074/jbc.M110.192088. Epub 2011 Feb 14.

26.

Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release.

Swiecki M, Scheaffer SM, Allaire M, Fremont DH, Colonna M, Brett TJ.

J Biol Chem. 2011 Jan 28;286(4):2987-97. doi: 10.1074/jbc.M110.190538. Epub 2010 Nov 17.

27.

The role of CLCA proteins in inflammatory airway disease.

Patel AC, Brett TJ, Holtzman MJ.

Annu Rev Physiol. 2009;71:425-49. doi: 10.1146/annurev.physiol.010908.163253. Review.

28.

Molecular structures of coat and coat-associated proteins: function follows form.

Brett TJ, Traub LM.

Curr Opin Cell Biol. 2006 Aug;18(4):395-406. Epub 2006 Jun 27. Review.

PMID:
16806884
29.

Structural definition of the F-actin-binding THATCH domain from HIP1R.

Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH.

Nat Struct Mol Biol. 2006 Feb;13(2):121-30. Epub 2006 Jan 15.

PMID:
16415883
30.

Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage.

Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM.

J Biol Chem. 2004 Oct 29;279(44):46191-203. Epub 2004 Aug 2.

31.

N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.

Ota N, Brett TJ, Murphy TL, Fremont DH, Murphy KM.

Nat Immunol. 2004 Feb;5(2):208-15. Epub 2004 Jan 4.

PMID:
14704793
33.

Structural basis of chemokine sequestration by a herpesvirus decoy receptor.

Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH.

Cell. 2002 Nov 1;111(3):343-56.

34.

Accessory protein recruitment motifs in clathrin-mediated endocytosis.

Brett TJ, Traub LM, Fremont DH.

Structure. 2002 Jun;10(6):797-809.

35.

Chiral discrimination in cyclodextrin complexes of amino acid derivatives: beta-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexes.

Alexander JM, Clark JL, Brett TJ, Stezowski JJ.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5115-20. Epub 2002 Apr 9.

36.

Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.

Mishra SK, Agostinelli NR, Brett TJ, Mizukami I, Ross TS, Traub LM.

J Biol Chem. 2001 Dec 7;276(49):46230-6. Epub 2001 Sep 27.

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