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Ebola Viral Protein 35 N-terminus is a Parallel Tetramer.

Chanthamontri CK, Jordan D, Wang W, Wu C, Lin YL, Brett TJ, Gross ML, Leung DW.

Biochemistry. 2018 Dec 28. doi: 10.1021/acs.biochem.8b01154. [Epub ahead of print]


Experiences With the Levonorgestrel Intrauterine System Among Clients, Providers, and Key Opinion Leaders: A Mixed-Methods Study in Nigeria.

Eva G, Nanda G, Rademacher K, Mackay A, Negedu O, Taiwo A, Dal Santo L, Saleh M, Palmer L, Brett T.

Glob Health Sci Pract. 2018 Dec 27;6(4):680-692. doi: 10.9745/GHSP-D-18-00242. Print 2018 Dec 27.


Improving the detection of familial hypercholesterolaemia.

Lan NSR, Martin AC, Brett T, Watts GF, Bell DA.

Pathology. 2018 Dec 19. pii: S0031-3025(18)30425-2. doi: 10.1016/j.pathol.2018.10.015. [Epub ahead of print] Review.


YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.

Ohlemacher SI, Xu Y, Kober DL, Malik M, Nix JC, Brett TJ, Henderson JP.

J Biol Chem. 2018 Dec 21;293(51):19572-19585. doi: 10.1074/jbc.RA118.005752. Epub 2018 Oct 24.


Screening for familial hypercholesterolaemia in primary care: Time for general practice to play its part.

Brett T, Qureshi N, Gidding S, Watts GF.

Atherosclerosis. 2018 Oct;277:399-406. doi: 10.1016/j.atherosclerosis.2018.08.019. Review.


Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-2/Tetherin: Knowledge and Gaps.

Berry KN, Kober DL, Su A, Brett TJ.

Bioessays. 2018 Oct;40(10):e1800086. doi: 10.1002/bies.201800086. Epub 2018 Aug 16. Review.


Anticipating epidemic transitions with imperfect data.

Brett TS, O'Dea EB, Marty É, Miller PB, Park AW, Drake JM, Rohani P.

PLoS Comput Biol. 2018 Jun 8;14(6):e1006204. doi: 10.1371/journal.pcbi.1006204. eCollection 2018 Jun.


Increasing multimorbidity in an Australian street health service: A 10-year retrospective cohort study

Arnold-Reed D, Troeung L, Brett T, Chan She Ping-Delfos W, Strange C, Geelhoed E, Fisher C, Preen D.

Aust J Gen Pract. 2018 Apr;47(4):181-189.


A general practice street health service

Strange C, Fisher C, Ping-Delfos WCS, Arnold-Reed D, Brett T.

Aust J Gen Pract. 2018 Jan-Feb;47(1-2):44-49.


Detection and management of familial hypercholesterolaemia in primary care in Australia: protocol for a pragmatic cluster intervention study with pre-post intervention comparisons.

Arnold-Reed DE, Brett T, Troeung L, Vickery A, Garton-Smith J, Bell D, Pang J, Grace T, Bulsara C, Li I, Bulsara M, Watts GF.

BMJ Open. 2017 Oct 22;7(10):e017539. doi: 10.1136/bmjopen-2017-017539.


Anticipating the emergence of infectious diseases.

Brett TS, Drake JM, Rohani P.

J R Soc Interface. 2017 Jul;14(132). pii: 20170115. doi: 10.1098/rsif.2017.0115.


TREM2-Ligand Interactions in Health and Disease.

Kober DL, Brett TJ.

J Mol Biol. 2017 Jun 2;429(11):1607-1629. doi: 10.1016/j.jmb.2017.04.004. Epub 2017 Apr 19. Review.


Beyond cascade screening: detection of familial hypercholesterolaemia at childhood immunization and other strategies.

Martin AC, Bell DA, Brett T, Watts GF.

Curr Opin Lipidol. 2017 Aug;28(4):321-327. doi: 10.1097/MOL.0000000000000423. Review.


Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).

Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ.

J Biol Chem. 2017 Jun 2;292(22):9164-9174. doi: 10.1074/jbc.M117.788232. Epub 2017 Apr 18.


Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ.

Elife. 2016 Dec 20;5. pii: e20391. doi: 10.7554/eLife.20391.


Expanding Access to a New, More Affordable Levonorgestrel Intrauterine System in Kenya: Service Delivery Costs Compared With Other Contraceptive Methods and Perspectives of Key Opinion Leaders.

Rademacher KH, Solomon M, Brett T, Bratt JH, Pascual C, Njunguru J, Steiner MJ.

Glob Health Sci Pract. 2016 Aug 18;4 Suppl 2:S83-93. doi: 10.9745/GHSP-D-15-00327. Print 2016 Aug 11.


First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.

Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2335-2344. doi: 10.1016/j.bbagen.2016.06.023. Epub 2016 Jun 29.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


A new electronic screening tool for identifying risk of familial hypercholesterolaemia in general practice.

Troeung L, Arnold-Reed D, Chan She Ping-Delfos W, Watts GF, Pang J, Lugonja M, Bulsara M, Mortley D, James M, Brett T.

Heart. 2016 Jun 1;102(11):855-61. doi: 10.1136/heartjnl-2015-308824. Epub 2016 Feb 10.


Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization.

Kober DL, Yurtsever Z, Brett TJ.

J Vis Exp. 2015 Dec 23;(106):e53445. doi: 10.3791/53445.


Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.

Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H.

Br J Pharmacol. 2016 Apr;173(7):1208-18. doi: 10.1111/bph.13420. Epub 2016 Mar 1. Erratum in: Br J Pharmacol. 2016 Sep;173(18):2808.


Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.

Sala-Rabanal M, Yurtsever Z, Berry KN, Brett TJ.

Mediators Inflamm. 2015;2015:497387. doi: 10.1155/2015/497387. Epub 2015 Nov 3. Review.


Publisher's Note: Generating functionals and Gaussian approximations for interruptible delay reactions [Phys. Rev. E 92, 042105 (2015)].

Brett T, Galla T.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct;92(4):049902. doi: 10.1103/PhysRevE.92.049902. Epub 2015 Oct 19.


Generating functionals and Gaussian approximations for interruptible delay reactions.

Brett T, Galla T.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct;92(4):042105. doi: 10.1103/PhysRevE.92.042105. Epub 2015 Oct 5. Erratum in: Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct;92(4):049902.


PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ.

Nat Immunol. 2015 Dec;16(12):1215-27. doi: 10.1038/ni.3279. Epub 2015 Oct 19.


Challenges in the care of familial hypercholesterolemia: a community care perspective.

Brett T, Watts GF, Arnold-Reed DE, Bell DA, Garton-Smith J, Vickery AW, Ryan JD, Pang J.

Expert Rev Cardiovasc Ther. 2015 Oct;13(10):1091-100. doi: 10.1586/14779072.2015.1082907. Epub 2015 Aug 27. Review.


CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.

Brett TJ.

Expert Rev Respir Med. 2015 Oct;9(5):503-6. doi: 10.1586/17476348.2015.1081064. Epub 2015 Aug 20. Review.


TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.

Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ.

J Exp Med. 2015 May 4;212(5):681-97. doi: 10.1084/jem.20141732. Epub 2015 Apr 20.


The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.

Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):790-9. doi: 10.1107/S1399004715001212. Epub 2015 Mar 26.


Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.

Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ.

Elife. 2015 Mar 17;4. doi: 10.7554/eLife.05875.


Multimorbidity in patients enrolled in a community-based methadone maintenance treatment programme delivered through primary care.

Arnold-Reed DE, Brett T, Troeung L, O'Neill J, Backhouse R, Bulsara MK.

J Comorb. 2014 Oct 6;4:46-54. doi: 10.15256/joc.2014.4.42. eCollection 2014.


Multimorbidity in a marginalised, street-health Australian population: a retrospective cohort study.

Brett T, Arnold-Reed DE, Troeung L, Bulsara MK, Williams A, Moorhead RG.

BMJ Open. 2014 Aug 19;4(8):e005461. doi: 10.1136/bmjopen-2014-005461.


Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK.

Cell Host Microbe. 2014 Aug 13;16(2):187-200. doi: 10.1016/j.chom.2014.07.008.


Gaussian approximations for stochastic systems with delay: chemical Langevin equation and application to a Brusselator system.

Brett T, Galla T.

J Chem Phys. 2014 Mar 28;140(12):124112. doi: 10.1063/1.4867786.


Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.

Kober DL, Wanhainen KM, Johnson BM, Randolph DT, Holtzman MJ, Brett TJ.

Protein Expr Purif. 2014 Apr;96:32-8. doi: 10.1016/j.pep.2014.01.015. Epub 2014 Feb 7.


Multimorbidity in patients attending 2 Australian primary care practices.

Brett T, Arnold-Reed DE, Popescu A, Soliman B, Bulsara MK, Fine H, Bovell G, Moorhead RG.

Ann Fam Med. 2013 Nov-Dec;11(6):535-42. doi: 10.1370/afm.1570.


Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

Combs MD, Knutsen RH, Broekelmann TJ, Toennies HM, Brett TJ, Miller CA, Kober DL, Craft CS, Atkinson JJ, Shipley JM, Trask BC, Mecham RP.

J Biol Chem. 2013 Oct 4;288(40):28869-80. doi: 10.1074/jbc.M113.497727. Epub 2013 Aug 20.


Stochastic processes with distributed delays: chemical Langevin equation and linear-noise approximation.

Brett T, Galla T.

Phys Rev Lett. 2013 Jun 21;110(25):250601. Epub 2013 Jun 18.


BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.

Swiecki M, Omattage NS, Brett TJ.

Mol Immunol. 2013 Jun;54(2):132-9. doi: 10.1016/j.molimm.2012.11.008. Epub 2012 Dec 27. Review.


IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.

Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ.

J Clin Invest. 2012 Dec;122(12):4555-68. doi: 10.1172/JCI64896. Epub 2012 Nov 26.


Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.

Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ.

J Biol Chem. 2012 Dec 7;287(50):42138-49. doi: 10.1074/jbc.M112.410282. Epub 2012 Oct 30.


Perceptions of barriers to discussing and testing for sexually transmitted infections in a convenience sample of general practice patients.

Baker JR, Arnold-Reed DE, Brett T, Hince DA, O'Ferrall I, Bulsara MK.

Aust J Prim Health. 2013;19(2):98-101. doi: 10.1071/PY11110.


An approach to functional abdominal pain in children and adolescents.

Brett T, Rowland M, Drumm B.

Br J Gen Pract. 2012 Jul;62(600):386-7. doi: 10.3399/bjgp12X652562.


Do GGA adaptors bind internal DXXLL motifs?

Doray B, Misra S, Qian Y, Brett TJ, Kornfeld S.

Traffic. 2012 Oct;13(10):1315-25. doi: 10.1111/j.1600-0854.2012.01396.x. Epub 2012 Jul 24.


The Fremantle Primary Prevention Study: a multicentre randomised trial of absolute cardiovascular risk reduction.

Brett T, Arnold-Reed D, Phan C, Cadden F, Walker W, Manea-Walley W, Mora N, Young J, Bulsara M.

Br J Gen Pract. 2012 Jan;62(594):e22-8. doi: 10.3399/bjgp12X616337.


Missed opportunities--low levels of chlamydia retesting at Australian general practices, 2008-2009.

Bowring AL, Gouillou M, Guy R, Kong FY, Hocking J, Pirotta M, Heal C, Brett T, Donovan B, Hellard M; ACCESS Collaboration.

Sex Transm Infect. 2012 Aug;88(5):330-4. doi: 10.1136/sextrans-2011-050422. Epub 2012 Mar 10.


General practice teachers.

Moorhead R, Brett T, Arnold-Reed D, Saldanha M.

Med Teach. 2012;34(1):84-5. doi: 10.3109/0142159X.2012.640722. No abstract available.


Capacity census - a pilot study of general practices in Western Australia.

Brett T, Arnold-Reed D, Phan C, Jones F.

Aust Fam Physician. 2011 Oct;40(10):753-4.


Patient information - what is a PSA test?

Brett T.

Aust Fam Physician. 2011 Jul;40(7):501.

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