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FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target.

Kästle M, Kistler B, Lamla T, Bretschneider T, Lamb D, Nicklin P, Wyatt D.

Eur J Immunol. 2018 Nov;48(11):1904-1914. doi: 10.1002/eji.201847699. Epub 2018 Sep 14.


Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry-Based Screening for Drug Discovery.

Winter M, Ries R, Kleiner C, Bischoff D, Luippold AH, Bretschneider T, Büttner FH.

SLAS Technol. 2018 Aug 3:2472630318791981. doi: 10.1177/2472630318791981. [Epub ahead of print]


QuimP: analyzing transmembrane signalling in highly deformable cells.

Baniukiewicz P, Collier S, Bretschneider T.

Bioinformatics. 2018 Aug 1;34(15):2695-2697. doi: 10.1093/bioinformatics/bty169.


Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction.

Winter M, Bretschneider T, Kleiner C, Ries R, Hehn JP, Redemann N, Luippold AH, Bischoff D, Büttner FH.

SLAS Discov. 2018 Jul;23(6):561-573. doi: 10.1177/2472555218759267. Epub 2018 Feb 21.


Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.

Kuttruff CA, Ferrara M, Bretschneider T, Hoerer S, Handschuh S, Nosse B, Romig H, Nicklin P, Roth GJ.

ACS Med Chem Lett. 2017 Nov 8;8(12):1252-1257. doi: 10.1021/acsmedchemlett.7b00312. eCollection 2017 Dec 14.


Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis.

Baader M, Bretschneider T, Broermann A, Rippmann JF, Stierstorfer B, Kuttruff CA, Mark M.

Br J Pharmacol. 2018 Feb;175(4):693-707. doi: 10.1111/bph.14118. Epub 2018 Jan 17.


Image based modeling of bleb site selection.

Collier S, Paschke P, Kay RR, Bretschneider T.

Sci Rep. 2017 Jul 27;7(1):6692. doi: 10.1038/s41598-017-06875-9.


Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.

Bretschneider T, Luippold AH, Romig H, Bischoff D, Klinder K, Nicklin P, Rist W.

SLAS Discov. 2017 Apr;22(4):425-432. doi: 10.1177/2472555217690484. Epub 2017 Feb 2.


Image-guided high-dose-rate brachytherapy of malignancies in various inner organs - technique, indications, and perspectives.

Bretschneider T, Ricke J, Gebauer B, Streitparth F.

J Contemp Brachytherapy. 2016 Jun;8(3):251-61. doi: 10.5114/jcb.2016.61068. Epub 2016 Jul 1. Review.


Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research.

Otto GP, Cocorocchio M, Munoz L, Tyson RA, Bretschneider T, Williams RS.

Methods Mol Biol. 2016;1407:123-30. doi: 10.1007/978-1-4939-3480-5_9.


Strategies for structuring interdisciplinary education in Systems Biology: an European perspective.

Cvijovic M, Höfer T, Aćimović J, Alberghina L, Almaas E, Besozzi D, Blomberg A, Bretschneider T, Cascante M, Collin O, de Atauri P, Depner C, Dickinson R, Dobrzynski M, Fleck C, Garcia-Ojalvo J, Gonze D, Hahn J, Hess HM, Hollmann S, Krantz M, Kummer U, Lundh T, Martial G, Dos Santos VM, Mauer-Oberthür A, Regierer B, Skene B, Stalidzans E, Stelling J, Teusink B, Workman CT, Hohmann S.

NPJ Syst Biol Appl. 2016 May 26;2:16011. doi: 10.1038/npjsba.2016.11. eCollection 2016.


Localizing the lipid products of PI3Kγ in neutrophils.

Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.

Adv Biol Regul. 2016 Jan;60:36-45. doi: 10.1016/j.jbior.2015.10.005. Epub 2015 Nov 10.


Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.

Xue M, Momiji H, Rabbani N, Bretschneider T, Rand DA, Thornalley PJ.

Biochem Soc Trans. 2015 Aug;43(4):669-73. doi: 10.1042/BST20150060. Epub 2015 Aug 3.


Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution.

Vance KW, Woodcock DJ, Reid JE, Bretschneider T, Ott S, Koentges G.

Genome Biol Evol. 2015 Sep 4;7(9):2762-78. doi: 10.1093/gbe/evv179.


Biomarker candidates for the detection of an infectious etiology of febrile neutropenia.

Richter ME, Neugebauer S, Engelmann F, Hagel S, Ludewig K, La Rosée P, Sayer HG, Hochhaus A, von Lilienfeld-Toal M, Bretschneider T, Pausch C, Engel C, Brunkhorst FM, Kiehntopf M.

Infection. 2016 Apr;44(2):175-86. doi: 10.1007/s15010-015-0830-6. Epub 2015 Aug 15.


Efficacy and safety of image-guided interstitial single fraction high-dose-rate brachytherapy in the management of metastatic malignant melanoma.

Bretschneider T, Mohnike K, Hass P, Seidensticker R, Göppner D, Dudeck O, Streitparth F, Ricke J.

J Contemp Brachytherapy. 2015 Apr;7(2):154-60. doi: 10.5114/jcb.2015.51095. Epub 2015 Apr 20.


Twofold polyketide branching by a stereoselective enzymatic Michael addition.

Heine D, Sundaram S, Bretschneider T, Hertweck C.

Chem Commun (Camb). 2015 Jun 18;51(48):9872-5. doi: 10.1039/c5cc03085d.


Image based validation of dynamical models for cell reorientation.

Lockley R, Ladds G, Bretschneider T.

Cytometry A. 2015 Jun;87(6):471-80. doi: 10.1002/cyto.a.22600. Epub 2014 Dec 9.


Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.

Heine D, Bretschneider T, Sundaram S, Hertweck C.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11645-9. doi: 10.1002/anie.201407282. Epub 2014 Sep 11.


Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.

Xue M, Momiji H, Rabbani N, Barker G, Bretschneider T, Shmygol A, Rand DA, Thornalley PJ.

Antioxid Redox Signal. 2015 Sep 1;23(7):613-29. doi: 10.1089/ars.2014.5962. Epub 2014 Oct 3.


How blebs and pseudopods cooperate during chemotaxis.

Tyson RA, Zatulovskiy E, Kay RR, Bretschneider T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11703-8. doi: 10.1073/pnas.1322291111. Epub 2014 Jul 29.


Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

Schütte K, Schulz C, Poranzke J, Antweiler K, Bornschein J, Bretschneider T, Arend J, Ricke J, Malfertheiner P.

BMC Gastroenterol. 2014 Jul 3;14:117. doi: 10.1186/1471-230X-14-117.


Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

Feillet C, Krusche P, Tamanini F, Janssens RC, Downey MJ, Martin P, Teboul M, Saito S, Lévi FA, Bretschneider T, van der Horst GT, Delaunay F, Rand DA.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9828-33. doi: 10.1073/pnas.1320474111. Epub 2014 Jun 23.


Bleb-driven chemotaxis of Dictyostelium cells.

Zatulovskiy E, Tyson R, Bretschneider T, Kay RR.

J Cell Biol. 2014 Mar 17;204(6):1027-44. doi: 10.1083/jcb.201306147. Epub 2014 Mar 10.


MRI-guided and CT-guided cervical nerve root infiltration therapy: a cost comparison.

Maurer MH, Froeling V, Röttgen R, Bretschneider T, Hartwig T, Disch AC, de Bucourt M, Hamm B, Streitparth F.

Rofo. 2014 Jun;186(6):559-66. doi: 10.1055/s-0033-1356169. Epub 2013 Dec 17.


Phenalenone-type phytoalexins mediate resistance of banana plants (Musa spp.) to the burrowing nematode Radopholus similis.

Hölscher D, Dhakshinamoorthy S, Alexandrov T, Becker M, Bretschneider T, Buerkert A, Crecelius AC, De Waele D, Elsen A, Heckel DG, Heklau H, Hertweck C, Kai M, Knop K, Krafft C, Maddula RK, Matthäus C, Popp J, Schneider B, Schubert US, Sikora RA, Svatoš A, Swennen RL.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):105-10. doi: 10.1073/pnas.1314168110. Epub 2013 Dec 9.


Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease.

Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C.

Chembiochem. 2013 Dec 16;14(18):2439-43. doi: 10.1002/cbic.201300553. Epub 2013 Nov 12. No abstract available.


Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities.

Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C.

J Am Chem Soc. 2013 Nov 20;135(46):17408-16. doi: 10.1021/ja4080024. Epub 2013 Nov 6.


3D time series analysis of cell shape using Laplacian approaches.

Du CJ, Hawkins PT, Stephens LR, Bretschneider T.

BMC Bioinformatics. 2013 Oct 4;14:296. doi: 10.1186/1471-2105-14-296.


Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C.

Nature. 2013 Oct 3;502(7469):124-8. doi: 10.1038/nature12588. Epub 2013 Sep 18.


A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.

Robery S, Tyson R, Dinh C, Kuspa A, Noegel AA, Bretschneider T, Andrews PL, Williams RS.

J Cell Sci. 2013 Dec 1;126(Pt 23):5465-76. doi: 10.1242/jcs.136440. Epub 2013 Sep 4.


The distribution of Dishevelled in convergently extending mesoderm.

Panousopoulou E, Tyson RA, Bretschneider T, Green JB.

Dev Biol. 2013 Oct 15;382(2):496-503. doi: 10.1016/j.ydbio.2013.07.012. Epub 2013 Jul 19.


MR guidance and thermometry of percutaneous laser disc decompression in open MRI: an initial clinical investigation.

Streitparth F, Hartwig T, Walter T, De Bucourt M, Putzier M, Strube P, Bretschneider T, Freyhardt P, Maurer M, Renz D, Gebauer B, Hamm B, Teichgräber UK.

Eur Radiol. 2013 Oct;23(10):2739-46. doi: 10.1007/s00330-013-2872-4. Epub 2013 May 9.


Rational design of an apoptosis-inducing photoreactive DNA intercalator.

Ueberschaar N, Dahse HM, Bretschneider T, Hertweck C.

Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6185-9. doi: 10.1002/anie.201302439. Epub 2013 May 6. No abstract available.


Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

Bond M, Croft W, Tyson R, Bretschneider T, Davey J, Ladds G.

Yeast. 2013 Apr;30(4):145-56. doi: 10.1002/yea.2949. Epub 2013 Mar 20.


Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen.

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C.

Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13173-7. doi: 10.1002/anie.201206658. Epub 2012 Nov 19.


[Update on interstitial brachytherapy].

Bretschneider T, Peters N, Hass P, Ricke J.

Radiologe. 2012 Jan;52(1):70-3. doi: 10.1007/s00117-011-2213-z. German.


Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution.

Downey MJ, Jeziorska DM, Ott S, Tamai TK, Koentges G, Vance KW, Bretschneider T.

PLoS One. 2011;6(12):e27886. doi: 10.1371/journal.pone.0027886. Epub 2011 Dec 15.


A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.

Bretschneider T, Zocher G, Unger M, Scherlach K, Stehle T, Hertweck C.

Nat Chem Biol. 2011 Dec 18;8(2):154-61. doi: 10.1038/nchembio.746.


A ribonucleotide reductase-like electron transfer system in the nitroaryl-forming N-oxygenase AurF.

Fries A, Bretschneider T, Winkler R, Hertweck C.

Chembiochem. 2011 Aug 16;12(12):1832-5. doi: 10.1002/cbic.201100138. Epub 2011 Jun 15. No abstract available.


Interactive segmentation of clustered cells via geodesic commute distance and constrained density weighted Nyström method.

Du CJ, Marcello M, Spiller DG, White MR, Bretschneider T.

Cytometry A. 2010 Dec;77(12):1137-47. doi: 10.1002/cyto.a.20993.


Validation of the body scanner as a measuring tool for a rapid quantification of body shape.

Bretschneider T, Koop U, Schreiner V, Wenck H, Jaspers S.

Skin Res Technol. 2009 Aug;15(3):364-9. doi: 10.1111/j.1600-0846.2009.00374.x.


Transformation from spots to waves in a model of actin pattern formation.

Whitelam S, Bretschneider T, Burroughs NJ.

Phys Rev Lett. 2009 May 15;102(19):198103. Epub 2009 May 13.


The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization.

Bretschneider T, Anderson K, Ecke M, Müller-Taubenberger A, Schroth-Diez B, Ishikawa-Ankerhold HC, Gerisch G.

Biophys J. 2009 Apr 8;96(7):2888-900. doi: 10.1016/j.bpj.2008.12.3942.


Analysis of cell movement by simultaneous quantification of local membrane displacement and fluorescent intensities using Quimp2.

Bosgraaf L, van Haastert PJ, Bretschneider T.

Cell Motil Cytoskeleton. 2009 Mar;66(3):156-65. doi: 10.1002/cm.20338.


A novel semi-automatic image processing approach to determine Plasmodium falciparum parasitemia in Giemsa-stained thin blood smears.

Le MT, Bretschneider TR, Kuss C, Preiser PR.

BMC Cell Biol. 2008 Mar 28;9:15. doi: 10.1186/1471-2121-9-15.


Comparative phyloinformatics of virus genes at micro and macro levels in a distributed computing environment.

Singh DT, Trehan R, Schmidt B, Bretschneider T.

BMC Bioinformatics. 2008;9 Suppl 1:S23. doi: 10.1186/1471-2105-9-S1-S23.


Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation.

Dalous J, Burghardt E, Müller-Taubenberger A, Bruckert F, Gerisch G, Bretschneider T.

Biophys J. 2008 Feb 1;94(3):1063-74. Epub 2007 Sep 28.


Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells.

Etzrodt M, Ishikawa HC, Dalous J, Müller-Taubenberger A, Bretschneider T, Gerisch G.

FEBS Lett. 2006 Dec 11;580(28-29):6707-13. Epub 2006 Nov 20.

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