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Items: 1 to 50 of 89

1.

MALDI-TOF Mass Spectrometry-Based High-Throughput Screening for Inhibitors of the Cytosolic DNA Sensor cGAS.

Simon RP, Winter M, Kleiner C, Ries R, Schnapp G, Heimann A, Li J, Zuvela-Jelaska L, Bretschneider T, Luippold AH, Reindl W, Bischoff D, Büttner FH.

SLAS Discov. 2019 Oct 4:2472555219880185. doi: 10.1177/2472555219880185. [Epub ahead of print]

PMID:
31583948
2.

Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress.

Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA.

Psychoneuroendocrinology. 2019 Sep;107:148-159. doi: 10.1016/j.psyneuen.2019.04.006. Epub 2019 Apr 23.

PMID:
31129488
3.

Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis.

Schruf E, Schroeder V, Kuttruff CA, Weigle S, Krell M, Benz M, Bretschneider T, Holweg A, Schuler M, Frick M, Nicklin P, Garnett JP, Sobotta MC.

Respir Res. 2019 May 9;20(1):87. doi: 10.1186/s12931-019-1058-2.

4.

Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors.

Winter M, Bretschneider T, Thamm S, Kleiner C, Grabowski D, Chandler S, Ries R, Kley JT, Fowler D, Bartlett C, Binetti R, Broadwater J, Luippold AH, Bischoff D, Büttner FH.

SLAS Discov. 2019 Aug;24(7):766-777. doi: 10.1177/2472555219838216. Epub 2019 May 6.

PMID:
31059309
5.

RapidFire BLAZE-Mode Is Boosting ESI-MS Toward High-Throughput-Screening.

Bretschneider T, Ozbal C, Holstein M, Winter M, Buettner FH, Thamm S, Bischoff D, Luippold AH.

SLAS Technol. 2019 Aug;24(4):386-393. doi: 10.1177/2472630318822449. Epub 2019 Jan 30.

PMID:
30698995
6.

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti-inflammatory drug target.

Kästle M, Kistler B, Lamla T, Bretschneider T, Lamb D, Nicklin P, Wyatt D.

Eur J Immunol. 2018 Nov;48(11):1904-1914. doi: 10.1002/eji.201847699. Epub 2018 Sep 14.

7.

Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry-Based Screening for Drug Discovery.

Winter M, Ries R, Kleiner C, Bischoff D, Luippold AH, Bretschneider T, Büttner FH.

SLAS Technol. 2019 Apr;24(2):209-221. doi: 10.1177/2472630318791981. Epub 2018 Aug 3.

PMID:
30074850
8.

QuimP: analyzing transmembrane signalling in highly deformable cells.

Baniukiewicz P, Collier S, Bretschneider T.

Bioinformatics. 2018 Aug 1;34(15):2695-2697. doi: 10.1093/bioinformatics/bty169.

9.

Establishing MALDI-TOF as Versatile Drug Discovery Readout to Dissect the PTP1B Enzymatic Reaction.

Winter M, Bretschneider T, Kleiner C, Ries R, Hehn JP, Redemann N, Luippold AH, Bischoff D, Büttner FH.

SLAS Discov. 2018 Jul;23(6):561-573. doi: 10.1177/2472555218759267. Epub 2018 Feb 21.

PMID:
29466676
10.

Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.

Kuttruff CA, Ferrara M, Bretschneider T, Hoerer S, Handschuh S, Nosse B, Romig H, Nicklin P, Roth GJ.

ACS Med Chem Lett. 2017 Nov 8;8(12):1252-1257. doi: 10.1021/acsmedchemlett.7b00312. eCollection 2017 Dec 14.

11.

Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis.

Baader M, Bretschneider T, Broermann A, Rippmann JF, Stierstorfer B, Kuttruff CA, Mark M.

Br J Pharmacol. 2018 Feb;175(4):693-707. doi: 10.1111/bph.14118. Epub 2018 Jan 17.

12.

Image based modeling of bleb site selection.

Collier S, Paschke P, Kay RR, Bretschneider T.

Sci Rep. 2017 Jul 27;7(1):6692. doi: 10.1038/s41598-017-06875-9.

13.

Ultrafast and Predictive Mass Spectrometry-Based Autotaxin Assays for Label-Free Potency Screening.

Bretschneider T, Luippold AH, Romig H, Bischoff D, Klinder K, Nicklin P, Rist W.

SLAS Discov. 2017 Apr;22(4):425-432. doi: 10.1177/2472555217690484. Epub 2017 Feb 2.

PMID:
28328321
14.
15.

Image-guided high-dose-rate brachytherapy of malignancies in various inner organs - technique, indications, and perspectives.

Bretschneider T, Ricke J, Gebauer B, Streitparth F.

J Contemp Brachytherapy. 2016 Jun;8(3):251-61. doi: 10.5114/jcb.2016.61068. Epub 2016 Jul 1. Review.

16.

Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research.

Otto GP, Cocorocchio M, Munoz L, Tyson RA, Bretschneider T, Williams RS.

Methods Mol Biol. 2016;1407:123-30. doi: 10.1007/978-1-4939-3480-5_9.

PMID:
27271898
17.

Strategies for structuring interdisciplinary education in Systems Biology: an European perspective.

Cvijovic M, Höfer T, Aćimović J, Alberghina L, Almaas E, Besozzi D, Blomberg A, Bretschneider T, Cascante M, Collin O, de Atauri P, Depner C, Dickinson R, Dobrzynski M, Fleck C, Garcia-Ojalvo J, Gonze D, Hahn J, Hess HM, Hollmann S, Krantz M, Kummer U, Lundh T, Martial G, Dos Santos VM, Mauer-Oberthür A, Regierer B, Skene B, Stalidzans E, Stelling J, Teusink B, Workman CT, Hohmann S.

NPJ Syst Biol Appl. 2016 May 26;2:16011. doi: 10.1038/npjsba.2016.11. eCollection 2016.

18.

Localizing the lipid products of PI3Kγ in neutrophils.

Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.

Adv Biol Regul. 2016 Jan;60:36-45. doi: 10.1016/j.jbior.2015.10.005. Epub 2015 Nov 10.

19.

Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.

Xue M, Momiji H, Rabbani N, Bretschneider T, Rand DA, Thornalley PJ.

Biochem Soc Trans. 2015 Aug;43(4):669-73. doi: 10.1042/BST20150060. Epub 2015 Aug 3.

PMID:
26551710
20.

Conserved Cis-Regulatory Modules Control Robustness in Msx1 Expression at Single-Cell Resolution.

Vance KW, Woodcock DJ, Reid JE, Bretschneider T, Ott S, Koentges G.

Genome Biol Evol. 2015 Sep 4;7(9):2762-78. doi: 10.1093/gbe/evv179.

21.

Biomarker candidates for the detection of an infectious etiology of febrile neutropenia.

Richter ME, Neugebauer S, Engelmann F, Hagel S, Ludewig K, La Rosée P, Sayer HG, Hochhaus A, von Lilienfeld-Toal M, Bretschneider T, Pausch C, Engel C, Brunkhorst FM, Kiehntopf M.

Infection. 2016 Apr;44(2):175-86. doi: 10.1007/s15010-015-0830-6. Epub 2015 Aug 15.

PMID:
26275448
22.

Efficacy and safety of image-guided interstitial single fraction high-dose-rate brachytherapy in the management of metastatic malignant melanoma.

Bretschneider T, Mohnike K, Hass P, Seidensticker R, Göppner D, Dudeck O, Streitparth F, Ricke J.

J Contemp Brachytherapy. 2015 Apr;7(2):154-60. doi: 10.5114/jcb.2015.51095. Epub 2015 Apr 20.

23.

Twofold polyketide branching by a stereoselective enzymatic Michael addition.

Heine D, Sundaram S, Bretschneider T, Hertweck C.

Chem Commun (Camb). 2015 Jun 18;51(48):9872-5. doi: 10.1039/c5cc03085d.

PMID:
25994388
24.

Image based validation of dynamical models for cell reorientation.

Lockley R, Ladds G, Bretschneider T.

Cytometry A. 2015 Jun;87(6):471-80. doi: 10.1002/cyto.a.22600. Epub 2014 Dec 9.

25.

Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.

Heine D, Bretschneider T, Sundaram S, Hertweck C.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11645-9. doi: 10.1002/anie.201407282. Epub 2014 Sep 11.

PMID:
25214315
26.

Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.

Xue M, Momiji H, Rabbani N, Barker G, Bretschneider T, Shmygol A, Rand DA, Thornalley PJ.

Antioxid Redox Signal. 2015 Sep 1;23(7):613-29. doi: 10.1089/ars.2014.5962. Epub 2014 Oct 3.

27.

How blebs and pseudopods cooperate during chemotaxis.

Tyson RA, Zatulovskiy E, Kay RR, Bretschneider T.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11703-8. doi: 10.1073/pnas.1322291111. Epub 2014 Jul 29.

28.

Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver.

Schütte K, Schulz C, Poranzke J, Antweiler K, Bornschein J, Bretschneider T, Arend J, Ricke J, Malfertheiner P.

BMC Gastroenterol. 2014 Jul 3;14:117. doi: 10.1186/1471-230X-14-117.

29.

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

Feillet C, Krusche P, Tamanini F, Janssens RC, Downey MJ, Martin P, Teboul M, Saito S, Lévi FA, Bretschneider T, van der Horst GT, Delaunay F, Rand DA.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9828-33. doi: 10.1073/pnas.1320474111. Epub 2014 Jun 23.

30.

Bleb-driven chemotaxis of Dictyostelium cells.

Zatulovskiy E, Tyson R, Bretschneider T, Kay RR.

J Cell Biol. 2014 Mar 17;204(6):1027-44. doi: 10.1083/jcb.201306147. Epub 2014 Mar 10.

31.

MRI-guided and CT-guided cervical nerve root infiltration therapy: a cost comparison.

Maurer MH, Froeling V, Röttgen R, Bretschneider T, Hartwig T, Disch AC, de Bucourt M, Hamm B, Streitparth F.

Rofo. 2014 Jun;186(6):559-66. doi: 10.1055/s-0033-1356169. Epub 2013 Dec 17.

32.

Phenalenone-type phytoalexins mediate resistance of banana plants (Musa spp.) to the burrowing nematode Radopholus similis.

Hölscher D, Dhakshinamoorthy S, Alexandrov T, Becker M, Bretschneider T, Buerkert A, Crecelius AC, De Waele D, Elsen A, Heckel DG, Heklau H, Hertweck C, Kai M, Knop K, Krafft C, Maddula RK, Matthäus C, Popp J, Schneider B, Schubert US, Sikora RA, Svatoš A, Swennen RL.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):105-10. doi: 10.1073/pnas.1314168110. Epub 2013 Dec 9.

33.

Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease.

Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C.

Chembiochem. 2013 Dec 16;14(18):2439-43. doi: 10.1002/cbic.201300553. Epub 2013 Nov 12. No abstract available.

PMID:
24222604
34.

Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities.

Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C.

J Am Chem Soc. 2013 Nov 20;135(46):17408-16. doi: 10.1021/ja4080024. Epub 2013 Nov 6.

PMID:
24143864
35.

3D time series analysis of cell shape using Laplacian approaches.

Du CJ, Hawkins PT, Stephens LR, Bretschneider T.

BMC Bioinformatics. 2013 Oct 4;14:296. doi: 10.1186/1471-2105-14-296.

36.

Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C.

Nature. 2013 Oct 3;502(7469):124-8. doi: 10.1038/nature12588. Epub 2013 Sep 18.

PMID:
24048471
37.

A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.

Robery S, Tyson R, Dinh C, Kuspa A, Noegel AA, Bretschneider T, Andrews PL, Williams RS.

J Cell Sci. 2013 Dec 1;126(Pt 23):5465-76. doi: 10.1242/jcs.136440. Epub 2013 Sep 4.

38.

The distribution of Dishevelled in convergently extending mesoderm.

Panousopoulou E, Tyson RA, Bretschneider T, Green JB.

Dev Biol. 2013 Oct 15;382(2):496-503. doi: 10.1016/j.ydbio.2013.07.012. Epub 2013 Jul 19.

39.

MR guidance and thermometry of percutaneous laser disc decompression in open MRI: an initial clinical investigation.

Streitparth F, Hartwig T, Walter T, De Bucourt M, Putzier M, Strube P, Bretschneider T, Freyhardt P, Maurer M, Renz D, Gebauer B, Hamm B, Teichgräber UK.

Eur Radiol. 2013 Oct;23(10):2739-46. doi: 10.1007/s00330-013-2872-4. Epub 2013 May 9.

PMID:
23657288
40.

Rational design of an apoptosis-inducing photoreactive DNA intercalator.

Ueberschaar N, Dahse HM, Bretschneider T, Hertweck C.

Angew Chem Int Ed Engl. 2013 Jun 10;52(24):6185-9. doi: 10.1002/anie.201302439. Epub 2013 May 6. No abstract available.

PMID:
23649559
41.

Quantitative analysis of human ras localization and function in the fission yeast Schizosaccharomyces pombe.

Bond M, Croft W, Tyson R, Bretschneider T, Davey J, Ladds G.

Yeast. 2013 Apr;30(4):145-56. doi: 10.1002/yea.2949. Epub 2013 Mar 20.

42.

Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen.

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C.

Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13173-7. doi: 10.1002/anie.201206658. Epub 2012 Nov 19.

PMID:
23161559
43.

[Update on interstitial brachytherapy].

Bretschneider T, Peters N, Hass P, Ricke J.

Radiologe. 2012 Jan;52(1):70-3. doi: 10.1007/s00117-011-2213-z. German.

PMID:
22249704
44.

Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution.

Downey MJ, Jeziorska DM, Ott S, Tamai TK, Koentges G, Vance KW, Bretschneider T.

PLoS One. 2011;6(12):e27886. doi: 10.1371/journal.pone.0027886. Epub 2011 Dec 15.

45.

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.

Bretschneider T, Zocher G, Unger M, Scherlach K, Stehle T, Hertweck C.

Nat Chem Biol. 2011 Dec 18;8(2):154-61. doi: 10.1038/nchembio.746.

PMID:
22179067
46.

A ribonucleotide reductase-like electron transfer system in the nitroaryl-forming N-oxygenase AurF.

Fries A, Bretschneider T, Winkler R, Hertweck C.

Chembiochem. 2011 Aug 16;12(12):1832-5. doi: 10.1002/cbic.201100138. Epub 2011 Jun 15. No abstract available.

PMID:
21678538
47.

Interactive segmentation of clustered cells via geodesic commute distance and constrained density weighted Nyström method.

Du CJ, Marcello M, Spiller DG, White MR, Bretschneider T.

Cytometry A. 2010 Dec;77(12):1137-47. doi: 10.1002/cyto.a.20993.

48.

Validation of the body scanner as a measuring tool for a rapid quantification of body shape.

Bretschneider T, Koop U, Schreiner V, Wenck H, Jaspers S.

Skin Res Technol. 2009 Aug;15(3):364-9. doi: 10.1111/j.1600-0846.2009.00374.x.

PMID:
19624434
49.

Transformation from spots to waves in a model of actin pattern formation.

Whitelam S, Bretschneider T, Burroughs NJ.

Phys Rev Lett. 2009 May 15;102(19):198103. Epub 2009 May 13.

PMID:
19519000
50.

The three-dimensional dynamics of actin waves, a model of cytoskeletal self-organization.

Bretschneider T, Anderson K, Ecke M, Müller-Taubenberger A, Schroth-Diez B, Ishikawa-Ankerhold HC, Gerisch G.

Biophys J. 2009 Apr 8;96(7):2888-900. doi: 10.1016/j.bpj.2008.12.3942.

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