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Items: 1 to 50 of 83

1.

On Analyzing How the Th1/Th2 Phenotype of an Immune Response Is Determined: Classical Observations Must Not Be Ignored.

Bretscher P.

Front Immunol. 2019 Jun 5;10:1234. doi: 10.3389/fimmu.2019.01234. eCollection 2019.

2.

On how the immune system preferentially interacts with antigen-specific molecules bound to antigen over unbound molecules, with emphasis on B cell receptor signalling.

Bretscher PA, Al-Yassin GA.

Scand J Immunol. 2019 Sep;90(3):e12795. doi: 10.1111/sji.12795. Epub 2019 Jun 17. Review.

PMID:
31148206
3.

The history of the two-signal model of lymphocyte activation: A personal perspective.

Bretscher PA.

Scand J Immunol. 2019 Jun;89(6):e12762. doi: 10.1111/sji.12762. Epub 2019 Mar 18. Review.

PMID:
30825214
4.

Does T Cell Activation Require a Quorum of Lymphocytes?

Al-Yassin GA, Bretscher PA.

J Immunol. 2018 Nov 15;201(10):2855-2861. doi: 10.4049/jimmunol.1800805. Review.

PMID:
30397169
5.
6.

Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation.

Bretscher PA, Corthay A, Anderson CC, Dembic Z, Havele C, Nagy ZA, Øynebråten I.

Scand J Immunol. 2017 Apr;85(4):242-250. doi: 10.1111/sji.12525.

7.

Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation.

Anderson CC, Bretscher P, Corthay A, Dembic Z, Havele C, Nagy ZA, Øynebråten I.

Scand J Immunol. 2017 Feb;85(2):84-94. doi: 10.1111/sji.12500.

8.
9.

Total Synthesis of Prostaglandin 15d-PGJ(2) and Investigation of its Effect on the Secretion of IL-6 and IL-12.

Egger J, Fischer S, Bretscher P, Freigang S, Kopf M, Carreira EM.

Org Lett. 2015 Sep 4;17(17):4340-3. doi: 10.1021/acs.orglett.5b02181. Epub 2015 Aug 24.

PMID:
26301727
10.

A Conversation with Cohn on the Activation of CD4 T Cells.

Bretscher PA.

Scand J Immunol. 2015 Aug;82(2):147-59. doi: 10.1111/sji.12315.

11.

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.

Bretscher P, Egger J, Shamshiev A, Trötzmüller M, Köfeler H, Carreira EM, Kopf M, Freigang S.

EMBO Mol Med. 2015 May;7(5):593-607. doi: 10.15252/emmm.201404702.

12.

Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone.

Egger J, Bretscher P, Freigang S, Kopf M, Carreira EM.

J Am Chem Soc. 2014 Dec 17;136(50):17382-5. doi: 10.1021/ja509892u. Epub 2014 Dec 4.

PMID:
25474746
13.

The number of responding CD4 T cells and the dose of antigen conjointly determine the TH1/TH2 phenotype by modulating B7/CD28 interactions.

Rudulier CD, McKinstry KK, Al-Yassin GA, Kroeger DR, Bretscher PA.

J Immunol. 2014 Jun 1;192(11):5140-50. doi: 10.4049/jimmunol.1301691. Epub 2014 Apr 21.

15.

The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discrimination.

Bretscher PA.

Scand J Immunol. 2014 Jun;79(6):348-60. doi: 10.1111/sji.12173. Review.

16.

Antigen presenting B cells facilitate CD4 T cell cooperation resulting in enhanced generation of effector and memory CD4 T cells.

Kroeger DR, Rudulier CD, Bretscher PA.

PLoS One. 2013 Oct 14;8(10):e77346. doi: 10.1371/journal.pone.0077346. eCollection 2013.

17.

Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12.

Egger J, Bretscher P, Freigang S, Kopf M, Carreira EM.

Angew Chem Int Ed Engl. 2013 May 10;52(20):5382-5. doi: 10.1002/anie.201300739. Epub 2013 Apr 16. No abstract available.

PMID:
23592365
18.

Direct demonstration of CD4 T cell cooperation in the primary in vivo generation of CD4 effector T cells.

Kroeger DR, Rudulier CD, Peters NC, Bretscher PA.

Int Immunol. 2012 Aug;24(8):519-27. doi: 10.1093/intimm/dxs055. Epub 2012 Apr 22.

PMID:
22527289
19.

Distinct roles of dendritic and B cells in the activation of naive CD4+ T cells.

Rudulier CD, Kroeger DR, Bretscher PA.

Immunotherapy. 2012 Apr;4(4):355-7. doi: 10.2217/imt.12.17. No abstract available.

PMID:
22512626
20.
21.

Immunization of newborn and adult mice with low numbers of BCG leads to Th1 responses, Th1 imprints and enhanced protection upon BCG challenge.

Kiros TG, Power CA, Wei G, Bretscher PA.

Immunotherapy. 2010 Jan;2(1):25-35. doi: 10.2217/imt.09.80.

PMID:
20635889
22.

Development of Th1 imprints to rBCG expressing a foreign protein: implications for vaccination against HIV-1 and diverse influenza strains.

Power C, Marfleet TW, Qualtiere L, Xiao W, Bretscher P.

J Biomed Biotechnol. 2010;2010:591348. doi: 10.1155/2010/591348. Epub 2010 Jun 7.

23.

CD4 T cell cooperation is required for the in vivo activation of CD4 T cells.

Peters NC, Kroeger DR, Mickelwright S, Bretscher PA.

Int Immunol. 2009 Nov;21(11):1213-24. doi: 10.1093/intimm/dxp085. Epub 2009 Sep 7.

PMID:
19736293
24.

Macroimmunology and immunotherapy of cancer.

Hamilton D, Ismail N, Kroeger D, Rudulier C, Bretscher P.

Immunotherapy. 2009 May;1(3):367-83. doi: 10.2217/imt.09.6.

PMID:
20635957
25.

Different immune correlates associated with tumor progression and regression: implications for prevention and treatment of cancer.

Hamilton DH, Bretscher PA.

Cancer Immunol Immunother. 2008 Aug;57(8):1125-36. doi: 10.1007/s00262-007-0442-9. Epub 2008 Jan 10.

PMID:
18188562
26.

Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC.

Strutt TM, Uzonna J, McKinstry KK, Bretscher PA.

Int Immunol. 2006 May;18(5):719-28. Epub 2006 Mar 28.

PMID:
16569677
28.
30.

Living with the ups and downs of the two signal model.

Bretscher P.

Immunol Cell Biol. 2004 Apr;82(2):141-8. No abstract available.

PMID:
15061766
31.

What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?

Bretscher PA, Hamilton D, Ogunremi O.

Expert Rev Vaccines. 2002 Aug;1(2):179-92. Review.

PMID:
12901557
34.

Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease.

Uzonna JE, Wei G, Yurkowski D, Bretscher P.

J Immunol. 2001 Dec 15;167(12):6967-74.

35.

Distinct immunity in patients with visceral leishmaniasis from that in subclinically infected and drug-cured people: implications for the mechanism underlying drug cure.

Hailu A, Menon JN, Berhe N, Gedamu L, Hassard TH, Kager PA, Olobo J, Bretscher PA.

J Infect Dis. 2001 Jul 1;184(1):112-5. Epub 2001 May 31.

PMID:
11398119
37.

A case for a neonatal, low-dose BCG vaccination trial.

Bretscher P, Menon J, Power C, Uzonna J, Wei G.

Scand J Infect Dis. 2001;33(4):253-7. Review.

PMID:
11345215
38.

Contemporary models for peripheral tolerance and the classical 'historical postulate'.

Bretscher P.

Semin Immunol. 2000 Jun;12(3):221-9; discussion 257-344.

PMID:
10910743
39.
40.

A valid ELISPOT assay for enumeration of ex vivo, antigen-specific, IFNgamma-producing T cells.

Power CA, Grand CL, Ismail N, Peters NC, Yurkowski DP, Bretscher PA.

J Immunol Methods. 1999 Jul 30;227(1-2):99-107.

PMID:
10485258
41.

A two-step, two-signal model for the primary activation of precursor helper T cells.

Bretscher PA.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):185-90.

45.
47.

Prospects for low dose BCG vaccination against tuberculosis.

Bretscher PA.

Immunobiology. 1994 Oct;191(4-5):548-54.

PMID:
7713569
48.

Tuberculosis and HIV: light after darkness.

Grange JM, Stanford JL, Rook G, Onyebujoh P, Bretscher PA.

Thorax. 1994 Jun;49(6):537-9. No abstract available.

49.

Response.

Salk J, Bretscher PA, Salk PL, Clerici M, Shearer GM.

Science. 1993 Nov 12;262(5136):1075-6. No abstract available.

PMID:
17782052
50.

A strategy for prophylactic vaccination against HIV.

Salk J, Bretscher PA, Salk PL, Clerici M, Shearer GM.

Science. 1993 May 28;260(5112):1270-2. No abstract available.

PMID:
8098553

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