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Items: 1 to 50 of 69

1.

PI3Kβ is selectively required for growth factor-stimulated macropinocytosis.

Salloum G, Jakubik CT, Erami Z, Heitz SD, Bresnick AR, Backer JM.

J Cell Sci. 2019 Aug 16;132(16). pii: jcs231639. doi: 10.1242/jcs.231639.

PMID:
31409694
2.

PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation.

Erami Z, Heitz S, Bresnick AR, Backer JM.

Mol Biol Cell. 2019 Aug 15;30(18):2367-2376. doi: 10.1091/mbc.E19-03-0182. Epub 2019 Jul 18.

PMID:
31318314
3.

CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.

Ajasin DO, Rao VR, Wu X, Ramasamy S, Pujato M, Ruiz AP, Fiser A, Bresnick AR, Kalpana GV, Prasad VR.

Elife. 2019 Jun 7;8. pii: e35546. doi: 10.7554/eLife.35546.

4.

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.

Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM.

J Biol Chem. 2019 Mar 22;294(12):4621-4633. doi: 10.1074/jbc.RA118.006032. Epub 2019 Jan 18.

PMID:
30659094
5.

PI3Kβ-A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling.

Bresnick AR, Backer JM.

Endocrinology. 2019 Mar 1;160(3):536-555. doi: 10.1210/en.2018-00843.

PMID:
30601996
6.

S100 proteins as therapeutic targets.

Bresnick AR.

Biophys Rev. 2018 Dec;10(6):1617-1629. doi: 10.1007/s12551-018-0471-y. Epub 2018 Oct 31. Review.

7.

Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Oct;562(7725):E3. doi: 10.1038/s41586-018-0355-0.

PMID:
29980769
8.

Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor metastasis.

Norwood Toro LE, Wang Y, Condeelis JS, Jones JG, Backer JM, Bresnick AR.

Exp Cell Res. 2018 Sep 15;370(2):273-282. doi: 10.1016/j.yexcr.2018.06.028. Epub 2018 Jun 25.

9.

A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Jun;558(7711):610-614. doi: 10.1038/s41586-018-0238-4. Epub 2018 Jun 20. Erratum in: Nature. 2018 Oct;562(7725):E3.

10.

S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms.

Dulyaninova NG, Ruiz PD, Gamble MJ, Backer JM, Bresnick AR.

Mol Biol Cell. 2018 Mar 1;29(5):632-642. doi: 10.1091/mbc.E17-07-0460. Epub 2017 Dec 27.

11.

Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ.

Erami Z, Khalil BD, Salloum G, Yao Y, LoPiccolo J, Shymanets A, Nürnberg B, Bresnick AR, Backer JM.

Biochem J. 2017 Nov 16;474(23):3903-3914. doi: 10.1042/BCJ20170279.

12.

Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin.

Sun JB, Holmgren J, Larena M, Terrinoni M, Fang Y, Bresnick AR, Xiang Z.

Front Immunol. 2017 Sep 11;8:1119. doi: 10.3389/fimmu.2017.01119. eCollection 2017.

13.

GPCR Signaling Mediates Tumor Metastasis via PI3Kβ.

Khalil BD, Hsueh C, Cao Y, Abi Saab WF, Wang Y, Condeelis JS, Bresnick AR, Backer JM.

Cancer Res. 2016 May 15;76(10):2944-53. doi: 10.1158/0008-5472.CAN-15-1675. Epub 2016 Mar 24.

14.

Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.

LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM.

J Biol Chem. 2015 Dec 18;290(51):30390-405. doi: 10.1074/jbc.M115.689604. Epub 2015 Oct 16.

15.

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis.

Qian BZ, Zhang H, Li J, He T, Yeo EJ, Soong DY, Carragher NO, Munro A, Chang A, Bresnick AR, Lang RA, Pollard JW.

J Exp Med. 2015 Aug 24;212(9):1433-48. doi: 10.1084/jem.20141555. Epub 2015 Aug 10.

16.

Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5.

Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM.

Methods Mol Biol. 2015;1298:271-81. doi: 10.1007/978-1-4939-2569-8_23.

17.

S100 proteins in cancer.

Bresnick AR, Weber DJ, Zimmer DB.

Nat Rev Cancer. 2015 Feb;15(2):96-109. doi: 10.1038/nrc3893. Review.

18.

Structure of the S100A4/myosin-IIA complex.

Ramagopal UA, Dulyaninova NG, Varney KM, Wilder PT, Nallamsetty S, Brenowitz M, Weber DJ, Almo SC, Bresnick AR.

BMC Struct Biol. 2013 Nov 20;13:31. doi: 10.1186/1472-6807-13-31.

19.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.

20.

The heavy chain has its day: regulation of myosin-II assembly.

Dulyaninova NG, Bresnick AR.

Bioarchitecture. 2013 Jul-Aug;3(4):77-85. Review.

21.

Wiskott-Aldrich syndrome protein regulates leukocyte-dependent breast cancer metastasis.

Ishihara D, Dovas A, Hernandez L, Pozzuto M, Wyckoff J, Segall JE, Condeelis JS, Bresnick AR, Cox D.

Cell Rep. 2013 Aug 15;4(3):429-36. doi: 10.1016/j.celrep.2013.07.007. Epub 2013 Aug 1.

22.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

23.

Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells.

Chen M, Bresnick AR, O'Connor KL.

Oncogene. 2013 Aug 8;32(32):3754-64. doi: 10.1038/onc.2012.383. Epub 2012 Sep 10.

24.

Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens.

Ivkovic S, Beadle C, Noticewala S, Massey SC, Swanson KR, Toro LN, Bresnick AR, Canoll P, Rosenfeld SS.

Mol Biol Cell. 2012 Feb;23(4):533-42. doi: 10.1091/mbc.E11-01-0039. Epub 2012 Jan 4.

25.

Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition.

Beach JR, Hussey GS, Miller TE, Chaudhury A, Patel P, Monslow J, Zheng Q, Keri RA, Reizes O, Bresnick AR, Howe PH, Egelhoff TT.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17991-6. doi: 10.1073/pnas.1106499108. Epub 2011 Oct 24.

26.

Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA.

Dulyaninova NG, Hite KM, Zencheck WD, Scudiero DA, Almo SC, Shoemaker RH, Bresnick AR.

Biochemistry. 2011 Aug 23;50(33):7218-27. doi: 10.1021/bi200853y. Epub 2011 Jul 21.

27.

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.

Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE.

Oncogene. 2012 Feb 9;31(6):706-15. doi: 10.1038/onc.2011.275. Epub 2011 Jul 4.

28.

Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion.

House RP, Pozzuto M, Patel P, Dulyaninova NG, Li ZH, Zencheck WD, Vitolo MI, Weber DJ, Bresnick AR.

Biochemistry. 2011 Aug 16;50(32):6920-32. doi: 10.1021/bi200498q. Epub 2011 Jul 13.

29.

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.

Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS.

J Cell Sci. 2011 Jul 1;124(Pt 13):2120-31. doi: 10.1242/jcs.086231.

30.

The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier?

Bogatcheva NV, Zemskova MA, Poirier C, Mirzapoiazova T, Kolosova I, Bresnick AR, Verin AD.

J Cell Physiol. 2011 Dec;226(12):3132-46. doi: 10.1002/jcp.22669.

31.

S100A4 regulates macrophage chemotaxis.

Li ZH, Dulyaninova NG, House RP, Almo SC, Bresnick AR.

Mol Biol Cell. 2010 Aug 1;21(15):2598-610. doi: 10.1091/mbc.E09-07-0609. Epub 2010 Jun 2.

32.

Phenothiazines inhibit S100A4 function by inducing protein oligomerization.

Malashkevich VN, Dulyaninova NG, Ramagopal UA, Liriano MA, Varney KM, Knight D, Brenowitz M, Weber DJ, Almo SC, Bresnick AR.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10. doi: 10.1073/pnas.0913660107. Epub 2010 Apr 26.

33.

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.

Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET, Wu H, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM.

Cancer Res. 2009 Dec 1;69(23):8868-76. doi: 10.1158/0008-5472.CAN-09-1968. Epub 2009 Nov 10.

34.

Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin.

Chen M, Sinha M, Luxon BA, Bresnick AR, O'Connor KL.

J Biol Chem. 2009 Jan 16;284(3):1484-94. doi: 10.1074/jbc.M803997200. Epub 2008 Nov 14.

35.

Rap1 activation in collagen phagocytosis is dependent on nonmuscle myosin II-A.

Arora PD, Conti MA, Ravid S, Sacks DB, Kapus A, Adelstein RS, Bresnick AR, McCulloch CA.

Mol Biol Cell. 2008 Dec;19(12):5032-46. doi: 10.1091/mbc.E08-04-0430. Epub 2008 Sep 17.

36.

Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA.

Malashkevich VN, Varney KM, Garrett SC, Wilder PT, Knight D, Charpentier TH, Ramagopal UA, Almo SC, Weber DJ, Bresnick AR.

Biochemistry. 2008 May 6;47(18):5111-26. doi: 10.1021/bi702537s. Epub 2008 Apr 15.

37.

TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.

Clark K, Middelbeek J, Lasonder E, Dulyaninova NG, Morrice NA, Ryazanov AG, Bresnick AR, Figdor CG, van Leeuwen FN.

J Mol Biol. 2008 May 9;378(4):790-803. doi: 10.1016/j.jmb.2008.02.057. Epub 2008 Mar 4.

38.

A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics.

Garrett SC, Hodgson L, Rybin A, Toutchkine A, Hahn KM, Lawrence DS, Bresnick AR.

Biochemistry. 2008 Jan 22;47(3):986-96. Epub 2007 Dec 23.

39.

Visual snapshots of intracellular kinase activity at the onset of mitosis.

Dai Z, Dulyaninova NG, Kumar S, Bresnick AR, Lawrence DS.

Chem Biol. 2007 Nov;14(11):1254-60.

40.

Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cells.

Dulyaninova NG, House RP, Betapudi V, Bresnick AR.

Mol Biol Cell. 2007 Aug;18(8):3144-55. Epub 2007 Jun 13.

42.
43.
44.

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.

Wang W, Mouneimne G, Sidani M, Wyckoff J, Chen X, Makris A, Goswami S, Bresnick AR, Condeelis JS.

J Cell Biol. 2006 May 8;173(3):395-404. Epub 2006 May 1.

45.

S100A4, a mediator of metastasis.

Garrett SC, Varney KM, Weber DJ, Bresnick AR.

J Biol Chem. 2006 Jan 13;281(2):677-80. Epub 2005 Oct 21. Review. No abstract available.

46.

Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation.

Dulyaninova NG, Malashkevich VN, Almo SC, Bresnick AR.

Biochemistry. 2005 May 10;44(18):6867-76.

PMID:
15865432
47.

The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis.

Dulyaninova NG, Bresnick AR.

Exp Cell Res. 2004 Oct 1;299(2):303-14.

PMID:
15350530
48.

Cell type-specific regulation of RhoA activity during cytokinesis.

Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M.

J Biol Chem. 2004 Oct 22;279(43):44756-62. Epub 2004 Aug 12.

49.

The N-terminus of the long MLCK induces a disruption in normal spindle morphology and metaphase arrest.

Dulyaninova NG, Patskovsky YV, Bresnick AR.

J Cell Sci. 2004 Mar 15;117(Pt 8):1481-93.

50.

Periodic lamellipodial contractions correlate with rearward actin waves.

Giannone G, Dubin-Thaler BJ, Döbereiner HG, Kieffer N, Bresnick AR, Sheetz MP.

Cell. 2004 Feb 6;116(3):431-43.

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