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Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer.

Baker KT, Nachmanson D, Kumar S, Emond MJ, Ussakli C, Brentnall TA, Kennedy SR, Risques RA.

Mol Cancer Res. 2019 Feb;17(2):488-498. doi: 10.1158/1541-7786.MCR-18-0520. Epub 2018 Nov 16.


Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS.

Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R.

Cell Rep. 2018 May 29;23(9):2819-2831.e5. doi: 10.1016/j.celrep.2018.04.114.


Precancer in ulcerative colitis: the role of the field effect and its clinical implications.

Baker KT, Salk JJ, Brentnall TA, Risques RA.

Carcinogenesis. 2018 Jan 12;39(1):11-20. doi: 10.1093/carcin/bgx117. Review.


Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer.

Chen R, Lai LA, Sullivan Y, Wong M, Wang L, Riddell J, Jung L, Pillarisetty VG, Brentnall TA, Pan S.

Sci Rep. 2017 Aug 11;7(1):7950. doi: 10.1038/s41598-017-08436-6.


Spectral library-based glycopeptide analysis-detection of circulating galectin-3 binding protein in pancreatic cancer.

Nigjeh EN, Chen R, Allen-Tamura Y, Brand RE, Brentnall TA, Pan S.

Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201700064. Epub 2017 Jul 10.


BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS.

Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.


Quantitative Proteomics Based on Optimized Data-Independent Acquisition in Plasma Analysis.

Nigjeh EN, Chen R, Brand RE, Petersen GM, Chari ST, von Haller PD, Eng JK, Feng Z, Yan Q, Brentnall TA, Pan S.

J Proteome Res. 2017 Feb 3;16(2):665-676. doi: 10.1021/acs.jproteome.6b00727. Epub 2017 Jan 3.


Glycoproteins and glycoproteomics in pancreatic cancer.

Pan S, Brentnall TA, Chen R.

World J Gastroenterol. 2016 Nov 14;22(42):9288-9299. Review.


Biomarkers for colitis-associated colorectal cancer.

Chen R, Lai LA, Brentnall TA, Pan S.

World J Gastroenterol. 2016 Sep 21;22(35):7882-91. doi: 10.3748/wjg.v22.i35.7882. Review.


Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report.

Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA.

Pancreas. 2016 Sep;45(8):1080-91. doi: 10.1097/MPA.0000000000000705.


Progress in the Earlier Detection of Pancreatic Cancer.

Brentnall TA.

J Clin Oncol. 2016 Jun 10;34(17):1973-4. doi: 10.1200/JCO.2016.66.5265. Epub 2016 Apr 25. No abstract available.


Combining in Vitro Diagnostics with in Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions.

Laeseke PF, Chen R, Jeffrey RB, Brentnall TA, Willmann JK.

Radiology. 2015 Dec;277(3):644-61. doi: 10.1148/radiol.2015141020.


Early detection of sporadic pancreatic cancer: summative review.

Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D.

Pancreas. 2015 Jul;44(5):693-712. doi: 10.1097/MPA.0000000000000368. Review.


Proteomics analysis of bodily fluids in pancreatic cancer.

Pan S, Brentnall TA, Chen R.

Proteomics. 2015 Aug;15(15):2705-15. doi: 10.1002/pmic.201400476. Epub 2015 Apr 27. Review.


Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.

Chen R, Pan S, Lai K, Lai LA, Crispin DA, Bronner MP, Brentnall TA.

World J Gastroenterol. 2014 Dec 7;20(45):17037-48. doi: 10.3748/wjg.v20.i45.17037.


Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma.

Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA.

Lab Invest. 2015 Jan;95(1):43-55. doi: 10.1038/labinvest.2014.128. Epub 2014 Oct 27.


Vascular endothelial growth factor receptor type 2-targeted contrast-enhanced US of pancreatic cancer neovasculature in a genetically engineered mouse model: potential for earlier detection.

Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK.

Radiology. 2015 Mar;274(3):790-9. doi: 10.1148/radiol.14140568. Epub 2014 Oct 14.


Quantitative glycoproteomics analysis reveals changes in N-glycosylation level associated with pancreatic ductal adenocarcinoma.

Pan S, Chen R, Tamura Y, Crispin DA, Lai LA, May DH, McIntosh MW, Goodlett DR, Brentnall TA.

J Proteome Res. 2014 Mar 7;13(3):1293-306. doi: 10.1021/pr4010184. Epub 2014 Jan 28.



Risques RA, Ussakli C, Salk JJ, Rabinovitch PS, Brentnall TA.

J Natl Cancer Inst. 2014 Feb;106(2):djt437. doi: 10.1093/jnci/djt437. Epub 2014 Jan 8. No abstract available.


Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.

Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19414-9. doi: 10.1073/pnas.1309720110. Epub 2013 Nov 11.


Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.

Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA.

Inflamm Bowel Dis. 2013 Nov;19(12):2593-602. doi: 10.1097/MIB.0b013e3182a87640.


Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study.

Austin MA, Kuo E, Van Den Eeden SK, Mandelson MT, Brentnall TA, Kamineni A, Potter JD.

Cancer Epidemiol Biomarkers Prev. 2013 Oct;22(10):1913-7. doi: 10.1158/1055-9965.EPI-13-0518. Epub 2013 Aug 21.


Mitochondria and tumor progression in ulcerative colitis.

Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS, Risques RA.

J Natl Cancer Inst. 2013 Aug 21;105(16):1239-48. doi: 10.1093/jnci/djt167. Epub 2013 Jul 12.


Detection of pancreatic ductal adenocarcinoma in mice by ultrasound imaging of thymocyte differentiation antigen 1.

Foygel K, Wang H, Machtaler S, Lutz AM, Chen R, Pysz M, Lowe AW, Tian L, Carrigan T, Brentnall TA, Willmann JK.

Gastroenterology. 2013 Oct;145(4):885-894.e3. doi: 10.1053/j.gastro.2013.06.011. Epub 2013 Jun 18.


Screening and surgical outcomes of familial pancreatic cancer.

Templeton AW, Brentnall TA.

Surg Clin North Am. 2013 Jun;93(3):629-45. doi: 10.1016/j.suc.2013.02.002. Epub 2013 Apr 13. Review.


Clinical importance of Familial Pancreatic Cancer Registry in Japan: a report from kick-off meeting at International Symposium on Pancreas Cancer 2012.

Wada K, Takaori K, Traverso LW, Hruban RH, Furukawa T, Brentnall TA, Hatori T, Sano K, Takada T, Majima Y, Shimosegawa T.

J Hepatobiliary Pancreat Sci. 2013 Aug;20(6):557-66. doi: 10.1007/s00534-013-0611-5. Review.


Molecular analysis of precursor lesions in familial pancreatic cancer.

Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M, Lemoine NR, Brentnall TA.

PLoS One. 2013;8(1):e54830. doi: 10.1371/journal.pone.0054830. Epub 2013 Jan 23.


Metastatic biomarker discovery through proteomics.

Brinton LT, Brentnall TA, Smith JA, Kelly KA.

Cancer Genomics Proteomics. 2012 Nov;9(6):345-55. Review.


Tissue proteomics in pancreatic cancer study: discovery, emerging technologies, and challenges.

Pan S, Brentnall TA, Kelly K, Chen R.

Proteomics. 2013 Feb;13(3-4):710-21. doi: 10.1002/pmic.201200319. Epub 2013 Jan 7. Review.


Arousal of cancer-associated stromal fibroblasts: palladin-activated fibroblasts promote tumor invasion.

Brentnall TA.

Cell Adh Migr. 2012 Nov-Dec;6(6):488-94. doi: 10.4161/cam.21453. Epub 2012 Oct 17.


Large-scale quantitative glycoproteomics analysis of site-specific glycosylation occupancy.

Pan S, Tamura Y, Chen R, May D, McIntosh MW, Brentnall TA.

Mol Biosyst. 2012 Nov;8(11):2850-6. doi: 10.1039/c2mb25268f. Epub 2012 Aug 14.


Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma.

Chen R, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, Lane Z, Post J, Bronner MP, Willmann JK, Maitra A, Brentnall TA.

Cancer Biol Ther. 2012 Aug;13(10):899-907. doi: 10.4161/cbt.20842. Epub 2012 Aug 1.


Prospective study of the progression of low-grade dysplasia in ulcerative colitis using current cancer surveillance guidelines.

Zisman TL, Bronner MP, Rulyak S, Kowdley KV, Saunders M, Lee SD, Ko C, Kimmey MB, Stevens A, Maurer J, Brentnall TA.

Inflamm Bowel Dis. 2012 Dec;18(12):2240-6. doi: 10.1002/ibd.22912. Epub 2012 Apr 16.


Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.

Lai LA, Risques RA, Bronner MP, Rabinovitch PS, Crispin D, Chen R, Brentnall TA.

Cancer Lett. 2012 Jul 28;320(2):180-8. doi: 10.1016/j.canlet.2012.02.031. Epub 2012 Mar 2.


Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study.

Pan S, Chen R, Brand RE, Hawley S, Tamura Y, Gafken PR, Milless BP, Goodlett DR, Rush J, Brentnall TA.

J Proteome Res. 2012 Mar 2;11(3):1937-48. doi: 10.1021/pr201117w. Epub 2012 Feb 8.


Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion.

Brentnall TA, Lai LA, Coleman J, Bronner MP, Pan S, Chen R.

PLoS One. 2012;7(1):e30219. doi: 10.1371/journal.pone.0030219. Epub 2012 Jan 23.


Proteomics portrait of archival lesions of chronic pancreatitis.

Pan S, Chen R, Stevens T, Bronner MP, May D, Tamura Y, McIntosh MW, Brentnall TA.

PLoS One. 2011;6(11):e27574. doi: 10.1371/journal.pone.0027574. Epub 2011 Nov 23.


AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.

Dumartin L, Whiteman HJ, Weeks ME, Hariharan D, Dmitrovic B, Iacobuzio-Donahue CA, Brentnall TA, Bronner MP, Feakins RM, Timms JF, Brennan C, Lemoine NR, Crnogorac-Jurcevic T.

Cancer Res. 2011 Nov 15;71(22):7091-102. doi: 10.1158/0008-5472.CAN-11-1367. Epub 2011 Sep 26.


Pancreatic cancer surveillance: learning as we go.

Brentnall TA.

Am J Gastroenterol. 2011 May;106(5):955-6. doi: 10.1038/ajg.2011.68.


Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.

Pan S, Chen R, Crispin DA, May D, Stevens T, McIntosh MW, Bronner MP, Ziogas A, Anton-Culver H, Brentnall TA.

J Proteome Res. 2011 May 6;10(5):2359-76. doi: 10.1021/pr101148r. Epub 2011 Mar 28.


Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

Risques RA, Lai LA, Himmetoglu C, Ebaee A, Li L, Feng Z, Bronner MP, Al-Lahham B, Kowdley KV, Lindor KD, Rabinovitch PS, Brentnall TA.

Cancer Res. 2011 Mar 1;71(5):1669-79. doi: 10.1158/0008-5472.CAN-10-1966.


Using optical markers of nondysplastic rectal epithelial cells to identify patients with ulcerative colitis-associated neoplasia.

Bista RK, Brentnall TA, Bronner MP, Langmead CJ, Brand RE, Liu Y.

Inflamm Bowel Dis. 2011 Dec;17(12):2427-35. doi: 10.1002/ibd.21639. Epub 2011 Feb 23.


Nanoscale nuclear architecture for cancer diagnosis beyond pathology via spatial-domain low-coherence quantitative phase microscopy.

Wang P, Bista RK, Khalbuss WE, Qiu W, Uttam S, Staton K, Zhang L, Brentnall TA, Brand RE, Liu Y.

J Biomed Opt. 2010 Nov-Dec;15(6):066028. doi: 10.1117/1.3523618.


Characterization of alternative spliceoforms and the RNA splicing machinery in pancreatic cancer.

Carrigan PE, Bingham JL, Srinvasan S, Brentnall TA, Miller LJ.

Pancreas. 2011 Mar;40(2):281-8. doi: 10.1097/MPA.0b013e31820128d2.


Investigating neoplastic progression of ulcerative colitis with label-free comparative proteomics.

May D, Pan S, Crispin DA, Lai K, Bronner MP, Hogan J, Hockenbery DM, McIntosh M, Brentnall TA, Chen R.

J Proteome Res. 2011 Jan 7;10(1):200-9. doi: 10.1021/pr100574p. Epub 2010 Oct 20.


Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non-dysplastic biopsies distinguish progressors from non-progressors.

Bronner MP, Skacel M, Crispin DA, Hoff PD, Emond MJ, Lai LA, Tubbs RR, O'Sullivan JN, Rabinovitch PS, Brentnall TA.

Mod Pathol. 2010 Dec;23(12):1624-33. doi: 10.1038/modpathol.2010.161. Epub 2010 Aug 27.


Mass spectrometry based glycoproteomics--from a proteomics perspective.

Pan S, Chen R, Aebersold R, Brentnall TA.

Mol Cell Proteomics. 2011 Jan;10(1):R110.003251. doi: 10.1074/mcp.R110.003251. Epub 2010 Aug 24. Review.


Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia.

Chen R, Pan S, Duan X, Nelson BH, Sahota RA, de Rham S, Kozarek RA, McIntosh M, Brentnall TA.

Mol Cancer. 2010 Jun 15;9:149. doi: 10.1186/1476-4598-9-149.


Pilot study of blood biomarker candidates for detection of pancreatic cancer.

Chen R, Crispin DA, Pan S, Hawley S, McIntosh MW, May D, Anton-Culver H, Ziogas A, Bronner MP, Brentnall TA.

Pancreas. 2010 Oct;39(7):981-8. doi: 10.1097/MPA.0b013e3181dac920.


Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers.

Fong PY, Fesinmeyer MD, White E, Farin FM, Srinouanprachanh S, Afsharinejad Z, Mandelson MT, Brentnall TA, Barnett MJ, Goodman GE, Austin MA.

J Gastrointest Cancer. 2010 Sep;41(3):203-8. doi: 10.1007/s12029-010-9130-7.

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