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Items: 1 to 50 of 88

1.
2.

O6-methylguanine-DNA methyltransferase gene: epigenetic silencing and prognostic value in head and neck squamous cell carcinoma.

Zuo C, Ai L, Ratliff P, Suen JY, Hanna E, Brent TP, Fan CY.

Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):967-75.

3.

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition.

Penketh PG, Shyam K, Baumann RP, Remack JS, Brent TP, Sartorelli AC.

Cancer Chemother Pharmacol. 2004 Apr;53(4):279-87. Epub 2003 Dec 24.

PMID:
14704831
4.

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity.

Baumann RP, Shyam K, Penketh PG, Remack JS, Brent TP, Sartorelli AC.

Cancer Chemother Pharmacol. 2004 Apr;53(4):288-95. Epub 2003 Dec 17.

PMID:
14685775
5.

Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma.

Petak I, Danam RP, Tillman DM, Vernes R, Howell SR, Berczi L, Kopper L, Brent TP, Houghton JA.

Cell Death Differ. 2003 Feb;10(2):211-7.

6.

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.

Persons DA, Allay ER, Sawai N, Hargrove PW, Brent TP, Hanawa H, Nienhuis AW, Sorrentino BP.

Blood. 2003 Jul 15;102(2):506-13. Epub 2003 Mar 27.

PMID:
12663444
7.

Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines.

Danam RP, Howell SR, Remack JS, Brent TP.

Int J Oncol. 2001 Jun;18(6):1187-93.

PMID:
11351250
8.
9.

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.

Houghton PJ, Stewart CF, Cheshire PJ, Richmond LB, Kirstein MN, Poquette CA, Tan M, Friedman HS, Brent TP.

Clin Cancer Res. 2000 Oct;6(10):4110-8.

10.

Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.

Middlemas DS, Stewart CF, Kirstein MN, Poquette C, Friedman HS, Houghton PJ, Brent TP.

Clin Cancer Res. 2000 Mar;6(3):998-1007.

11.
12.

A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers.

Herfarth KK, Brent TP, Danam RP, Remack JS, Kodner IJ, Wells SA Jr, Goodfellow PJ.

Mol Carcinog. 1999 Feb;24(2):90-8.

PMID:
10078936
13.
14.

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.

Friedman HS, Pegg AE, Johnson SP, Loktionova NA, Dolan ME, Modrich P, Moschel RC, Struck R, Brent TP, Ludeman S, Bullock N, Kilborn C, Keir S, Dong Q, Bigner DD, Colvin OM.

Cancer Chemother Pharmacol. 1999;43(1):80-5.

PMID:
9923545
15.

O6-Methylguanine-DNA methyltransferase protein levels in pediatric brain tumors.

Hongeng S, Brent TP, Sanford RA, Li H, Kun LE, Heideman RL.

Clin Cancer Res. 1997 Dec;3(12 Pt 1):2459-63.

16.

Evidence for nucleotide excision repair as a modifying factor of O6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines.

Chen ZP, Malapetsa A, McQuillan A, Marcantonio D, Bello V, Mohr G, Remack J, Brent TP, Panasci LC.

Mol Pharmacol. 1997 Nov;52(5):815-20.

PMID:
9351972
18.
20.

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.

Kokkinakis DM, von Wronski MA, Vuong TH, Brent TP, Schold SC Jr.

Br J Cancer. 1997;75(6):779-88.

21.

Glial cell-specific differences in repair of O6-methylguanine.

LeDoux SP, Williams BA, Hollensworth BS, Shen C, Thomale J, Rajewsky MF, Brent TP, Wilson GL.

Cancer Res. 1996 Dec 15;56(24):5615-9.

22.
23.

Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.

Harris LC, Remack JS, Houghton PJ, Brent TP.

Cancer Res. 1996 May 1;56(9):2029-32.

24.

Changes in O6-methylguanine-DNA methyltransferase expression during immortalization of cloned human fibroblasts.

Harris LC, von Wronski MA, Venable CC, Remack JS, Howell SR, Brent TP.

Carcinogenesis. 1996 Feb;17(2):219-24.

PMID:
8625442
25.

Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity.

Harris LC, Marathi UK, Edwards CC, Houghton PJ, Srivastava DK, Vanin EF, Sorrentino BP, Brent TP.

Clin Cancer Res. 1995 Nov;1(11):1359-68.

26.
27.

A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.

Roy R, Shiota S, Kennel SJ, Raha R, von Wronski M, Brent TP, Mitra S.

Carcinogenesis. 1995 Feb;16(2):405-11.

PMID:
7532116
28.
29.
30.

In vitro methylation of the human O6-methylguanine-DNA methyltransferase promoter reduces transcription.

Harris LC, Remack JS, Brent TP.

Biochim Biophys Acta. 1994 Mar 1;1217(2):141-6.

PMID:
8110828
31.

Ribozyme-mediated modulation of human O6-methylguanine-DNA methyltransferase expression.

Potter PM, Harris LC, Remack JS, Edwards CC, Brent TP.

Cancer Res. 1993 Apr 15;53(8):1731-4.

32.

Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase.

Brent TP, von Wronski MA, Edwards CC, Bromley M, Margison GP, Rafferty JA, Pegram CN, Bigner DD.

Oncol Res. 1993;5(2):83-6.

PMID:
8364257
33.

A comparison of human O6-methylguanine-DNA methyltransferase promoter activity in Mer+ and Mer- cells.

Harris LC, Potter PM, Remack JS, Brent TP.

Cancer Res. 1992 Nov 15;52(22):6404-6.

34.

Identification of the cross-link between human O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea-treated DNA.

Gonzaga PE, Potter PM, Niu TQ, Yu D, Ludlum DB, Rafferty JA, Margison GP, Brent TP.

Cancer Res. 1992 Nov 1;52(21):6052-8.

35.

Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines.

He XM, Ostrowski LE, von Wronski MA, Friedman HS, Wikstrand CJ, Bigner SH, Rasheed A, Batra SK, Mitra S, Brent TP, et al.

Cancer Res. 1992 Mar 1;52(5):1144-8.

36.
37.

Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization.

Natarajan AT, Vermeulen S, Darroudi F, Valentine MB, Brent TP, Mitra S, Tano K.

Mutagenesis. 1992 Jan;7(1):83-5.

PMID:
1635460
38.

Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.

von Wronski MA, Harris LC, Tano K, Mitra S, Bigner DD, Brent TP.

Oncol Res. 1992;4(4-5):167-74.

PMID:
1504376
39.

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene.

Harris LC, Potter PM, Tano K, Shiota S, Mitra S, Brent TP.

Nucleic Acids Res. 1991 Nov 25;19(22):6163-7.

40.

Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.

Ostrowski LE, von Wronski MA, Bigner SH, Rasheed A, Schold SC Jr, Brent TP, Mitra S, Bigner DD.

Carcinogenesis. 1991 Sep;12(9):1739-44.

PMID:
1893534
41.

The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.

Tano K, Shiota S, Remack JS, Brent TP, Bigner DD, Mitra S.

Mutat Res. 1991 Sep;255(2):175-82.

PMID:
1922149
42.

Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase.

Ostrowski LE, Pegram CN, Von Wronski MA, Humphrey PA, He XM, Shiota S, Mitra S, Brent TP, Bigner DD.

Cancer Res. 1991 Jul 1;51(13):3339-44.

43.

Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.

von Wronski MA, Shiota S, Tano K, Mitra S, Bigner DD, Brent TP.

J Biol Chem. 1991 Jan 15;266(2):1064-70.

44.
45.

Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.

Brent TP, von Wronski M, Pegram CN, Bigner DD.

Cancer Res. 1990 Jan 1;50(1):58-61.

PMID:
2403418
47.

O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts.

Schold SC Jr, Brent TP, von Hofe E, Friedman HS, Mitra S, Bigner DD, Swenberg JA, Kleihues P.

J Neurosurg. 1989 Apr;70(4):573-7.

PMID:
2926498
48.

Wavelength dependence of DNA incision by a human ultraviolet endonuclease.

Gallagher PE, Weiss RB, Brent TP, Duker NJ.

Photochem Photobiol. 1989 Mar;49(3):363-7.

PMID:
2734370
49.

Cytosine photoproduct-DNA glycosylase in Escherichia coli and cultured human cells.

Weiss RB, Gallagher PE, Brent TP, Duker NJ.

Biochemistry. 1989 Feb 21;28(4):1488-92.

PMID:
2655693

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