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Items: 1 to 20 of 58


Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.

Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P.

J Cell Biol. 2020 Feb 3;219(2). pii: e201904161. doi: 10.1083/jcb.201904161.


Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.

Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE.

J Biol Chem. 2018 Nov 23;293(47):18353-18364. doi: 10.1074/jbc.RA118.005651. Epub 2018 Oct 10.


The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering.

Rossi G, Watson K, Kennedy W, Brennwald P.

Mol Biol Cell. 2018 Jun 15;29(12):1476-1486. doi: 10.1091/mbc.E18-02-0138. Epub 2018 Apr 18.


An evidence-based evaluation of transferrable skills and job satisfaction for science PhDs.

Sinche M, Layton RL, Brandt PD, O'Connell AB, Hall JD, Freeman AM, Harrell JR, Cook JG, Brennwald PJ.

PLoS One. 2017 Sep 20;12(9):e0185023. doi: 10.1371/journal.pone.0185023. eCollection 2017.


Structural basis for recognition of the Sec4 Rab GTPase by its effector, the Lgl/tomosyn homologue, Sro7.

Watson K, Rossi G, Temple B, Brennwald P.

Mol Biol Cell. 2015 Sep 15;26(18):3289-300. doi: 10.1091/mbc.E15-04-0228. Epub 2015 Jul 22.


In vitro reconstitution of Rab GTPase-dependent vesicle clustering by the yeast lethal giant larvae/tomosyn homolog, Sro7.

Rossi G, Watson K, Demonch M, Temple B, Brennwald P.

J Biol Chem. 2015 Jan 2;290(1):612-24. doi: 10.1074/jbc.M114.595892. Epub 2014 Nov 17.


Quantitative analysis of membrane trafficking in regulation of Cdc42 polarity.

Watson LJ, Rossi G, Brennwald P.

Traffic. 2014 Dec;15(12):1330-43. doi: 10.1111/tra.12211. Epub 2014 Oct 8.


Membrane traffic: the exocyst meets the cell cycle.

Brennwald P.

Curr Biol. 2013 Sep 23;23(18):R838-40. doi: 10.1016/j.cub.2013.08.007.


Quantitative proteomics of yeast post-Golgi vesicles reveals a discriminating role for Sro7p in protein secretion.

Forsmark A, Rossi G, Wadskog I, Brennwald P, Warringer J, Adler L.

Traffic. 2011 Jun;12(6):740-53. doi: 10.1111/j.1600-0854.2011.01186.x. Epub 2011 Apr 8.


Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.

Rossi G, Brennwald P.

Mol Biol Cell. 2011 Mar 15;22(6):842-57. doi: 10.1091/mbc.E10-07-0570. Epub 2011 Jan 19.


The function of two Rho family GTPases is determined by distinct patterns of cell surface localization.

Wu H, Brennwald P.

Mol Cell Biol. 2010 Nov;30(21):5207-17. doi: 10.1128/MCB.00366-10. Epub 2010 Sep 7.


Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

Boulter E, Garcia-Mata R, Guilluy C, Dubash A, Rossi G, Brennwald PJ, Burridge K.

Nat Cell Biol. 2010 May;12(5):477-83. doi: 10.1038/ncb2049. Epub 2010 Apr 18.


Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium.

Ivanov AI, Young C, Den Beste K, Capaldo CT, Humbert PO, Brennwald P, Parkos CA, Nusrat A.

Am J Pathol. 2010 Jan;176(1):134-45. doi: 10.2353/ajpath.2010.090220. Epub 2009 Dec 3.


The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis.

Wu H, Turner C, Gardner J, Temple B, Brennwald P.

Mol Biol Cell. 2010 Feb 1;21(3):430-42. doi: 10.1091/mbc.E09-06-0501. Epub 2009 Dec 2.


The ghost in the machine: small GTPases as spatial regulators of exocytosis.

Wu H, Rossi G, Brennwald P.

Trends Cell Biol. 2008 Sep;18(9):397-404. doi: 10.1016/j.tcb.2008.06.007. Epub 2008 Aug 14. Review.


Spatial regulation of exocytosis and cell polarity: yeast as a model for animal cells.

Brennwald P, Rossi G.

FEBS Lett. 2007 May 22;581(11):2119-24. Epub 2007 Mar 30. Review.


Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism.

Hattendorf DA, Andreeva A, Gangar A, Brennwald PJ, Weis WI.

Nature. 2007 Mar 29;446(7135):567-71.


The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface.

Wadskog I, Forsmark A, Rossi G, Konopka C, Oyen M, Goksör M, Ronne H, Brennwald P, Adler L.

Mol Biol Cell. 2006 Dec;17(12):4988-5003. Epub 2006 Sep 27.


Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains.

Kallay LM, McNickle A, Brennwald PJ, Hubbard AL, Braiterman LT.

J Cell Biochem. 2006 Oct 1;99(2):647-64.


The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p.

Grosshans BL, Andreeva A, Gangar A, Niessen S, Yates JR 3rd, Brennwald P, Novick P.

J Cell Biol. 2006 Jan 2;172(1):55-66.

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