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Items: 1 to 50 of 286

1.

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions.

Gutierrez-Arcelus M, Teslovich N, Mola AR, Polidoro RB, Nathan A, Kim H, Hannes S, Slowikowski K, Watts GFM, Korsunsky I, Brenner MB, Raychaudhuri S, Brennan PJ.

Nat Commun. 2019 Feb 8;10(1):687. doi: 10.1038/s41467-019-08604-4.

2.

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L.

Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0330-4.

PMID:
30728493
3.

Plateletpheresis-associated lymphopenia in frequent platelet donors.

Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM.

Blood. 2019 Feb 7;133(6):605-614. doi: 10.1182/blood-2018-09-873125. Epub 2018 Nov 14.

PMID:
30429159
4.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses.

Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L.

Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7. Epub 2018 Nov 12.

PMID:
30420624
5.

Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis.

Fonseka CY, Rao DA, Teslovich NC, Korsunsky I, Hannes SK, Slowikowski K, Gurish MF, Donlin LT, Lederer JA, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Todd DJ, Bykerk VP, Karlson EW, Ermann J, Lee YC, Brenner MB, Raychaudhuri S.

Sci Transl Med. 2018 Oct 17;10(463). pii: eaaq0305. doi: 10.1126/scitranslmed.aaq0305.

PMID:
30333237
6.

Innate T Cells Govern Adipose Tissue Biology.

LaMarche NM, Kohlgruber AC, Brenner MB.

J Immunol. 2018 Oct 1;201(7):1827-1834. doi: 10.4049/jimmunol.1800556. Review.

PMID:
30224362
7.

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.

Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.

Nat Genet. 2018 Aug;50(8):1180-1188. doi: 10.1038/s41588-018-0159-z. Epub 2018 Jul 16.

8.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.

9.

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L.

Nat Immunol. 2018 May;19(5):464-474. doi: 10.1038/s41590-018-0094-2. Epub 2018 Apr 18. Erratum in: Nat Immunol. 2019 Feb 7;:.

PMID:
29670241
10.

Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection.

Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold HG, Brenner MB.

J Immunol. 2018 May 1;200(9):3160-3169. doi: 10.4049/jimmunol.1700829. Epub 2018 Mar 28.

11.

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB.

Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y.

12.

Functional genomics of stromal cells in chronic inflammatory diseases.

Slowikowski K, Wei K, Brenner MB, Raychaudhuri S.

Curr Opin Rheumatol. 2018 Jan;30(1):65-71. doi: 10.1097/BOR.0000000000000455. Review.

13.

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.

Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB.

J Clin Invest. 2017 Sep 1;127(9):3300-3312. doi: 10.1172/JCI86881. Epub 2017 Jul 31.

14.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

15.

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity.

Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L.

Immunity. 2017 Feb 21;46(2):273-286. doi: 10.1016/j.immuni.2017.01.008.

16.

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.

Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB.

Immunity. 2017 Feb 21;46(2):220-232. doi: 10.1016/j.immuni.2017.01.004.

17.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.

Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810.

18.

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.

Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2.

19.

Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration.

Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, Pandol SJ.

Am J Pathol. 2017 Jan;187(1):146-155. doi: 10.1016/j.ajpath.2016.09.012. Epub 2016 Nov 14.

20.

Activation strategies for invariant natural killer T cells.

Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ.

Immunogenetics. 2016 Aug;68(8):649-63. doi: 10.1007/s00251-016-0944-8. Epub 2016 Jul 25. Review.

21.

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair.

Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV.

J Cell Biol. 2016 Jun 20;213(6):631-40. doi: 10.1083/jcb.201511093.

22.

Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.

J Immunol. 2016 May 1;196(9):3514-6. Epub 2016 Apr 18. No abstract available.

23.

Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149.

Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS.

J Immunol. 2016 May 1;196(9):3509-13. Epub 2016 Apr 18. No abstract available.

24.

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.

Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA.

Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001.

25.

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues.

Schlein C, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK, Brenner MB, Heeren J, Scheja L.

Cell Metab. 2016 Mar 8;23(3):441-53. doi: 10.1016/j.cmet.2016.01.006. Epub 2016 Feb 4.

26.

Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

27.

Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells.

Orent W, Mchenry AR, Rao DA, White C, Klein HU, Bassil R, Srivastava G, Replogle JM, Raj T, Frangieh M, Cimpean M, Cuerdon N, Chibnik L, Khoury SJ, Karlson EW, Brenner MB, De Jager P, Bradshaw EM, Elyaman W.

Hum Mol Genet. 2016 Jan 15;25(2):404-17. doi: 10.1093/hmg/ddv474. Epub 2015 Nov 24.

28.

Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.

Noss EH, Nguyen HN, Chang SK, Watts GF, Brenner MB.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14948-53. doi: 10.1073/pnas.1520861112. Epub 2015 Nov 17.

29.

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.

Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.

J Immunol. 2015 Sep 15;195(6):2540-51. doi: 10.4049/jimmunol.1501019. Epub 2015 Aug 7.

30.

Immune cell profiling to guide therapeutic decisions in rheumatic diseases.

Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S.

Nat Rev Rheumatol. 2015 Sep;11(9):541-51. doi: 10.1038/nrrheum.2015.71. Epub 2015 Jun 2. Review.

31.

Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.

Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.

Arthritis Res Ther. 2015 May 15;17:126. doi: 10.1186/s13075-015-0647-9.

32.

The transcriptional programs of iNKT cells.

Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB.

Semin Immunol. 2015 Feb;27(1):26-32. doi: 10.1016/j.smim.2015.02.005. Epub 2015 Apr 2. Review.

33.

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice.

Weng Y, Chabot JR, Bernardo B, Yan Q, Zhu Y, Brenner MB, Vage C, Logan A, Calle R, Talukdar S.

PLoS One. 2015 Mar 19;10(3):e0119104. doi: 10.1371/journal.pone.0119104. eCollection 2015.

34.

RNAi screens of lysosomal trafficking.

Garg S, Brenner MB.

Methods Cell Biol. 2015;126:119-38. doi: 10.1016/bs.mcb.2014.10.030. Epub 2015 Jan 14.

PMID:
25665444
35.

Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization.

Tatituri RV, Wolf BJ, Brenner MB, Turk J, Hsu FF.

Anal Bioanal Chem. 2015 Mar;407(9):2519-28. doi: 10.1007/s00216-015-8480-1. Epub 2015 Feb 6.

36.

MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.

Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB.

J Immunol. 2015 Mar 1;194(5):2079-88. doi: 10.4049/jimmunol.1401072. Epub 2015 Jan 30.

37.

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.

Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB.

Nat Immunol. 2015 Jan;16(1):85-95. doi: 10.1038/ni.3047. Epub 2014 Dec 1.

38.

Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes.

Lee DV, Li D, Yan Q, Zhu Y, Goodwin B, Calle R, Brenner MB, Talukdar S.

PLoS One. 2014 Nov 3;9(11):e111767. doi: 10.1371/journal.pone.0111767. eCollection 2014.

39.

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.

Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13433-8. doi: 10.1073/pnas.1415357111. Epub 2014 Sep 2.

41.

Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S.

PLoS Genet. 2014 Jun 26;10(6):e1004404. doi: 10.1371/journal.pgen.1004404. eCollection 2014 Jun.

42.

Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis.

Wu M, Pedroza M, Lafyatis R, George AT, Mayes MD, Assassi S, Tan FK, Brenner MB, Agarwal SK.

Arthritis Rheumatol. 2014 Apr;66(4):1010-21. doi: 10.1002/art.38275.

43.

iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo .

Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE.

Cancer Immunol Res. 2014 Jan;2(1):59-69.

44.

Soft matrix is a natural stimulator for cellular invasiveness.

Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.

Mol Biol Cell. 2014 Feb;25(4):457-69. doi: 10.1091/mbc.E13-05-0260. Epub 2013 Dec 11.

45.

Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.

Hu X, Kim H, Brennan PJ, Han B, Baecher-Allan CM, De Jager PL, Brenner MB, Raychaudhuri S.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19030-5. doi: 10.1073/pnas.1318322110. Epub 2013 Nov 4.

46.

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.

Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB.

Mol Biol Cell. 2013 Dec;24(23):3721-35. doi: 10.1091/mbc.E13-05-0259. Epub 2013 Oct 2.

47.

Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion.

Syed SK, Kauffman AL, Beavers LS, Alston JT, Farb TB, Ficorilli J, Marcelo MC, Brenner MB, Bokvist K, Barrett DG, Efanov AM.

Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1319-26. doi: 10.1152/ajpendo.00328.2013. Epub 2013 Oct 1.

48.

Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.

Gutteridge A, Rukstalis JM, Ziemek D, Tié M, Ji L, Ramos-Zayas R, Nardone NA, Norquay LD, Brenner MB, Tang K, McNeish JD, Rowntree RK.

PLoS One. 2013;8(2):e56024. doi: 10.1371/journal.pone.0056024. Epub 2013 Feb 13.

49.

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.

Brennan PJ, Brigl M, Brenner MB.

Nat Rev Immunol. 2013 Feb;13(2):101-17. doi: 10.1038/nri3369. Epub 2013 Jan 21. Review.

PMID:
23334244
50.

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32. doi: 10.1073/pnas.1220601110. Epub 2013 Jan 10.

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