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The potential for liquid biopsies in head and neck cancer.

Spector ME, Farlow JL, Haring CT, Brenner JC, Birkeland AC.

Discov Med. 2018 May;25(139):251-257.


Whole-Exome Sequencing of Sinonasal Small Cell Carcinoma Arising within a Papillary Schneiderian Carcinoma In Situ.

Smith J, Kulkarni A, Birkeland AC, McHugh JB, Brenner JC.

Otolaryngol Head Neck Surg. 2018 May 1:194599818774004. doi: 10.1177/0194599818774004. [Epub ahead of print]


Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma.

Hoesli R, Birkeland AC, Rosko AJ, Issa M, Chow KL, Michmerhuizen NL, Mann JE, Chinn SB, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME.

Oral Oncol. 2018 Feb;77:83-89. doi: 10.1016/j.oraloncology.2017.12.003. Epub 2017 Dec 23.


Specialty Group Medical Visits for Patients With Diabetes.

Ganetsky VS, Brenner JC, Kaufman ST.

Clin Diabetes. 2017 Dec;35(5):345-349. doi: 10.2337/cd15-0062. No abstract available.


Predictors of survival after total laryngectomy for recurrent/persistent laryngeal squamous cell carcinoma.

Birkeland AC, Beesley L, Bellile E, Rosko AJ, Hoesli R, Chinn SB, Shuman AG, Prince ME, Wolf GT, Bradford CR, Brenner JC, Spector ME.

Head Neck. 2017 Dec;39(12):2512-2518. doi: 10.1002/hed.24918. Epub 2017 Sep 30.


An Algorithm to Evaluate Suspected Lung Metastases in Patients with HPV-Associated Oropharyngeal Cancer.

VanKoevering KK, Marchiano E, Walline HM, Carey TE, McHugh JB, Brenner JC, Goudsmit CM, Belille E, Spector ME, Shuman AG; University of Michigan Head and Neck SPORE Team.

Otolaryngol Head Neck Surg. 2018 Jan;158(1):118-121. doi: 10.1177/0194599817733677. Epub 2017 Sep 26.


Pathogenetic Analysis of Sinonasal Teratocarcinosarcomas Reveal Actionable β-catenin Overexpression and a β-catenin Mutation.

Birkeland AC, Burgin SJ, Yanik M, Scott MV, Bradford CR, McHugh JB, McLean SA, Sullivan SE, Nor JE, McKean EL, Brenner JC.

J Neurol Surg B Skull Base. 2017 Aug;78(4):346-352. doi: 10.1055/s-0037-1601320. Epub 2017 Mar 27.


Preoperative Tracheostomy Is Associated with Poor Disease-Free Survival in Recurrent Laryngeal Cancer.

Birkeland AC, Rosko AJ, Beesley L, Bellile E, Chinn SB, Shuman AG, Prince ME, Wolf GT, Bradford CR, Brenner JC, Spector ME.

Otolaryngol Head Neck Surg. 2017 Sep;157(3):432-438. doi: 10.1177/0194599817709236. Epub 2017 Jun 6.


Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.

Birkeland AC, Foltin SK, Michmerhuizen NL, Hoesli RC, Rosko AJ, Byrd S, Yanik M, Nor JE, Bradford CR, Prince ME, Carey TE, McHugh JB, Spector ME, Brenner JC.

Oral Oncol. 2017 May;68:5-8. doi: 10.1016/j.oraloncology.2017.02.025. Epub 2017 Mar 10.


Immortal Life of the Common Rule: Ethics, Consent, and the Future of Cancer Research.

Smith JD, Birkeland AC, Goldman EB, Brenner JC, Carey TE, Spector-Bagdady K, Shuman AG, Goldman EB.

J Clin Oncol. 2017 Jun 10;35(17):1879-1883. doi: 10.1200/JCO.2016.68.4522. Epub 2017 Apr 20. No abstract available.


Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC.

Mann JE, Hoesli R, Michmerhuizen NL, Devenport SN, Ludwig ML, Vandenberg TR, Matovina C, Jawad N, Mierzwa M, Shuman AG, Spector ME, Brenner JC.

J Cancer. 2017 Feb 9;8(3):332-344. doi: 10.7150/jca.17547. eCollection 2017. Review.


Genomic sequencing and precision medicine in head and neck cancers.

Hoesli RC, Ludwig ML, Michmerhuizen NL, Rosko AJ, Spector ME, Brenner JC, Birkeland AC.

Eur J Surg Oncol. 2017 May;43(5):884-892. doi: 10.1016/j.ejso.2016.12.002. Epub 2016 Dec 15. Review.


Differential compensation mechanisms define resistance to PI3K inhibitors in PIK3CA amplified HNSCC.

Michmerhuizen NL, Leonard E, Kulkarni A, Brenner JC.

Otorhinolaryngol Head Neck Surg. 2016;1(2):44-50. Epub 2016 Jun 7.


Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine.

Michmerhuizen NL, Birkeland AC, Bradford CR, Brenner JC.

Genes Cancer. 2016 May;7(5-6):182-200. doi: 10.18632/genesandcancer.110.


Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma.

Walline HM, Komarck CM, McHugh JB, Bellile EL, Brenner JC, Prince ME, McKean EL, Chepeha DB, Wolf GT, Worden FP, Bradford CR, Carey TE.

Mol Cancer Res. 2016 Oct;14(10):941-952. Epub 2016 Jul 15.


Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma.

Ludwig ML, Birkeland AC, Hoesli R, Swiecicki P, Spector ME, Brenner JC.

Cancer Biol Med. 2016 Mar;13(1):87-100. doi: 10.28092/j.issn.2095-3941.2016.0010.


In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.

Rudy SF, Brenner JC, Harris JL, Liu J, Che J, Scott MV, Owen JH, Komarck CM, Graham MP, Bellile EL, Bradford CR, Prince ME, Carey TE.

J Otolaryngol Head Neck Surg. 2016 Apr 26;45:26. doi: 10.1186/s40463-016-0140-8.


Identification of Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma.

Birkeland AC, Yanik M, Tillman BN, Scott MV, Foltin SK, Mann JE, Michmerhuizen NL, Ludwig ML, Sandelski MM, Komarck CM, Carey TE, Prince ME, Bradford CR, McHugh JB, Spector ME, Brenner JC.

JAMA Otolaryngol Head Neck Surg. 2016 Jun 1;142(6):559-67. doi: 10.1001/jamaoto.2016.0335.


The potential for tumor suppressor gene therapy in head and neck cancer.

Birkeland AC, Ludwig ML, Spector ME, Brenner JC.

Discov Med. 2016 Jan;21(113):41-7. Review.


Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy.

Birkeland AC, Rosko AJ, Issa MR, Shuman AG, Prince ME, Wolf GT, Bradford CR, McHugh JB, Brenner JC, Spector ME.

Otolaryngol Head Neck Surg. 2016 Mar;154(3):473-9. doi: 10.1177/0194599815627811. Epub 2016 Feb 16.


Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.

Giefing M, Wierzbicka M, Szyfter K, Brenner JC, Braakhuis BJ, Brakenhoff RH, Bradford CR, Sorensen JA, Rinaldo A, Rodrigo JP, Takes RP, Ferlito A.

Eur J Cancer. 2016 Mar;55:147-57. doi: 10.1016/j.ejca.2015.10.070. Epub 2016 Feb 4. Review.


Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing.

Tillman BN, Yanik M, Birkeland AC, Liu CJ, Hovelson DH, Cani AK, Palanisamy N, Carskadon S, Carey TE, Bradford CR, Tomlins SA, McHugh JB, Spector ME, Brenner JCh.

Head Neck. 2016 Apr;38 Suppl 1:E1646-52. doi: 10.1002/hed.24292. Epub 2016 Feb 5.


A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma.

Birkeland AC, Swiecicki PL, Brenner JC, Shuman AG.

Expert Rev Precis Med Drug Dev. 2016;1(4):379-385. doi: 10.1080/23808993.2016.1208050. Epub 2016 Jul 15.


The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer.

Birkeland AC, Ludwig ML, Meraj TS, Brenner JC, Prince ME.

Cancers (Basel). 2015 Oct 21;7(4):2094-109. doi: 10.3390/cancers7040879. Review.


A lean neck mass clinic model: Adding value to care.

Tillman BN, Glazer TA, Ray A, Brenner JC, Spector ME.

Laryngoscope. 2015 Nov;125(11):2509-13. doi: 10.1002/lary.25535. Epub 2015 Aug 8.


Getting personal: Head and neck cancer management in the era of genomic medicine.

Birkeland AC, Uhlmann WR, Brenner JC, Shuman AG.

Head Neck. 2016 Apr;38 Suppl 1:E2250-8. doi: 10.1002/hed.24132. Epub 2015 Aug 13. Review.


Tumor evolution and progression in multifocal and paired non-invasive/invasive urothelial carcinoma.

Warrick JI, Hovelson DH, Amin A, Liu CJ, Cani AK, McDaniel AS, Yadati V, Quist MJ, Weizer AZ, Brenner JC, Feng FY, Mehra R, Grasso CS, Tomlins SA.

Virchows Arch. 2015 Mar;466(3):297-311. doi: 10.1007/s00428-014-1699-y. Epub 2014 Dec 11.


Molecular pathways: targeting ETS gene fusions in cancer.

Feng FY, Brenner JC, Hussain M, Chinnaiyan AM.

Clin Cancer Res. 2014 Sep 1;20(17):4442-8. doi: 10.1158/1078-0432.CCR-13-0275. Epub 2014 Jun 23. Review.


Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9. doi: 10.1073/pnas.1314239110. Epub 2013 Nov 25.


Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition.

Han S, Brenner JC, Sabolch A, Jackson W, Speers C, Wilder-Romans K, Knudsen KE, Lawrence TS, Chinnaiyan AM, Feng FY.

Neoplasia. 2013 Oct;15(10):1207-17.


Generating hypotheses about care needs of high utilizers: lessons from patient interviews.

Mautner DB, Pang H, Brenner JC, Shea JA, Gross KS, Frasso R, Cannuscio CC.

Popul Health Manag. 2013;16 Suppl 1:S26-33. doi: 10.1089/pop.2013.0033.


Building a citywide, all-payer, hospital claims database to improve health care delivery in a low-income, urban community.

Gross K, Brenner JC, Truchil A, Post EM, Riley AH.

Popul Health Manag. 2013;16 Suppl 1:S20-5. doi: 10.1089/pop.2013.0037.


Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors.

Tomlins SA, Palanisamy N, Brenner JC, Stall JN, Siddiqui J, Thomas DG, Lucas DR, Chinnaiyan AM, Kunju LP.

Am J Clin Pathol. 2013 Jun;139(6):771-9. doi: 10.1309/AJCPN4L1BMRQPEIT.


Jeffrey C Brenner: on driving down the cost of care.

Brenner JC.

Healthc Financ Manage. 2013 Jan;67(1):72-5. No abstract available.


Dual roles of PARP-1 promote cancer growth and progression.

Schiewer MJ, Goodwin JF, Han S, Brenner JC, Augello MA, Dean JL, Liu F, Planck JL, Ravindranathan P, Chinnaiyan AM, McCue P, Gomella LG, Raj GV, Dicker AP, Brody JR, Pascal JM, Centenera MM, Butler LM, Tilley WD, Feng FY, Knudsen KE.

Cancer Discov. 2012 Dec;2(12):1134-49. doi: 10.1158/2159-8290.CD-12-0120. Epub 2012 Sep 19.


The mutational landscape of lethal castration-resistant prostate cancer.

Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM, Tomlins SA.

Nature. 2012 Jul 12;487(7406):239-43. doi: 10.1038/nature11125.


Perspectives on humanism in medicine from the 2012 Edward J. III Excellence in Medicine honorees.

Abrams JS, Owen WF Jr, Brenner JC, Donlen J, Leone P, Carson JL, Slater EE.

MD Advis. 2012 Spring;5(2):4-9. No abstract available.


PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma.

Brenner JC, Feng FY, Han S, Patel S, Goyal SV, Bou-Maroun LM, Liu M, Lonigro R, Prensner JR, Tomlins SA, Chinnaiyan AM.

Cancer Res. 2012 Apr 1;72(7):1608-13. doi: 10.1158/0008-5472.CAN-11-3648. Epub 2012 Jan 27.


Coordinated regulation of polycomb group complexes through microRNAs in cancer.

Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR, Kim JH, Brenner JC, Jing X, Cao X, Wang R, Li Y, Dahiya A, Wang L, Pandhi M, Lonigro RJ, Wu YM, Tomlins SA, Palanisamy N, Qin Z, Yu J, Maher CA, Varambally S, Chinnaiyan AM.

Cancer Cell. 2011 Aug 16;20(2):187-99. doi: 10.1016/j.ccr.2011.06.016.


Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression.

Prensner JR, Iyer MK, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, Laxman B, Asangani IA, Grasso CS, Kominsky HD, Cao X, Jing X, Wang X, Siddiqui J, Wei JT, Robinson D, Iyer HK, Palanisamy N, Maher CA, Chinnaiyan AM.

Nat Biotechnol. 2011 Jul 31;29(8):742-9. doi: 10.1038/nbt.1914.


TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers.

Mani RS, Iyer MK, Cao Q, Brenner JC, Wang L, Ghosh A, Cao X, Lonigro RJ, Tomlins SA, Varambally S, Chinnaiyan AM.

Cancer Res. 2011 Aug 15;71(16):5387-92. doi: 10.1158/0008-5472.CAN-11-0876. Epub 2011 Jun 15.


Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog.

Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME, Carey TE.

Arch Otolaryngol Head Neck Surg. 2011 May;137(5):499-507. doi: 10.1001/archoto.2011.63.


Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.

Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Cao X, Mehra R, Sabolch A, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KS, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM.

Cancer Cell. 2011 May 17;19(5):664-78. doi: 10.1016/j.ccr.2011.04.010. Erratum in: Cancer Cell. 2013 Apr 15;23(4):557.


Disruptive events in the life of prostate cancer.

Brenner JC, Chinnaiyan AM.

Cancer Cell. 2011 Mar 8;19(3):301-3. doi: 10.1016/j.ccr.2011.02.020.


Antibody-based detection of ERG rearrangement-positive prostate cancer.

Park K, Tomlins SA, Mudaliar KM, Chiu YL, Esgueva R, Mehra R, Suleman K, Varambally S, Brenner JC, MacDonald T, Srivastava A, Tewari AK, Sathyanarayana U, Nagy D, Pestano G, Kunju LP, Demichelis F, Chinnaiyan AM, Rubin MA.

Neoplasia. 2010 Jul;12(7):590-8.


RhoC expression and head and neck cancer metastasis.

Islam M, Lin G, Brenner JC, Pan Q, Merajver SD, Hou Y, Kumar P, Teknos TN.

Mol Cancer Res. 2009 Nov;7(11):1771-80. doi: 10.1158/1541-7786.MCR-08-0512. Epub 2009 Oct 27.


Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.

Brenner JC, Graham MP, Kumar B, Saunders LM, Kupfer R, Lyons RH, Bradford CR, Carey TE.

Head Neck. 2010 Apr;32(4):417-26. doi: 10.1002/hed.21198.


Chimeric transcript discovery by paired-end transcriptome sequencing.

Maher CA, Palanisamy N, Brenner JC, Cao X, Kalyana-Sundaram S, Luo S, Khrebtukova I, Barrette TR, Grasso C, Yu J, Lonigro RJ, Schroth G, Kumar-Sinha C, Chinnaiyan AM.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12353-8. doi: 10.1073/pnas.0904720106. Epub 2009 Jul 10.


Translocations in epithelial cancers.

Brenner JC, Chinnaiyan AM.

Biochim Biophys Acta. 2009 Dec;1796(2):201-15. doi: 10.1016/j.bbcan.2009.04.005. Epub 2009 May 4. Review.

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