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The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development.

Schumacher MA, den Hengst CD, Bush MJ, Le TBK, Tran NT, Chandra G, Zeng W, Travis B, Brennan RG, Buttner MJ.

Nat Commun. 2018 Mar 19;9(1):1139. doi: 10.1038/s41467-018-03576-3.


Dissection of the molecular circuitry controlling virulence in Francisella tularensis.

Cuthbert BJ, Ross W, Rohlfing AE, Dove SL, Gourse RL, Brennan RG, Schumacher MA.

Genes Dev. 2017 Aug 1;31(15):1549-1560. doi: 10.1101/gad.303701.117. Epub 2017 Sep 1.


Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.

Miao Y, Tenor JL, Toffaletti DL, Maskarinec SA, Liu J, Lee RE, Perfect JR, Brennan RG.

MBio. 2017 Jul 25;8(4). pii: e00643-17. doi: 10.1128/mBio.00643-17.


The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.

Schumacher MA, Zeng W, Findlay KC, Buttner MJ, Brennan RG, Tschowri N.

Nucleic Acids Res. 2017 Jun 20;45(11):6923-6933. doi: 10.1093/nar/gkx287.


Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Thammahong A, Puttikamonkul S, Perfect JR, Brennan RG, Cramer RA.

Microbiol Mol Biol Rev. 2017 Mar 15;81(2). pii: e00053-16. doi: 10.1128/MMBR.00053-16. Print 2017 Jun. Review.


Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.

Miao Y, Tenor JL, Toffaletti DL, Washington EJ, Liu J, Shadrick WR, Schumacher MA, Lee RE, Perfect JR, Brennan RG.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7148-53. doi: 10.1073/pnas.1601774113. Epub 2016 Jun 15.


Trehalose pathway as an antifungal target.

Perfect JR, Tenor JL, Miao Y, Brennan RG.

Virulence. 2017 Feb 17;8(2):143-149. doi: 10.1080/21505594.2016.1195529. Epub 2016 Jun 1. Review.


HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG.

Nature. 2015 Aug 6;524(7563):59-64. doi: 10.1038/nature14662. Epub 2015 Jul 29.


Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA).

Cuthbert BJ, Brennan RG, Schumacher MA.

PLoS One. 2015 Jun 29;10(6):e0128225. doi: 10.1371/journal.pone.0128225. eCollection 2015.


Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus.

Schindler BD, Seo SM, Birukou I, Brennan RG, Kaatz GW.

J Bacteriol. 2015 Mar;197(6):1104-14. doi: 10.1128/JB.02558-14. Epub 2015 Jan 12.


Glutathione activates virulence gene expression of an intracellular pathogen.

Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA.

Nature. 2015 Jan 8;517(7533):170-3. doi: 10.1038/nature14029.


Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.

Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG, Buttner MJ.

Cell. 2014 Aug 28;158(5):1136-1147. doi: 10.1016/j.cell.2014.07.022.


Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes.

Kovach AR, Hoff KE, Canty JT, Orans J, Brennan RG.

RNA. 2014 Oct;20(10):1548-59. doi: 10.1261/rna.044032.113. Epub 2014 Aug 22.


Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.

Birukou I, Seo SM, Schindler BD, Kaatz GW, Brennan RG.

Nucleic Acids Res. 2014 Feb;42(4):2774-88. doi: 10.1093/nar/gkt1215. Epub 2013 Nov 28.


Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching.

Robinson KE, Orans J, Kovach AR, Link TM, Brennan RG.

Nucleic Acids Res. 2014 Feb;42(4):2736-49. doi: 10.1093/nar/gkt1171. Epub 2013 Nov 27.


The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus.

Birukou I, Tonthat NK, Seo SM, Schindler BD, Kaatz GW, Brennan RG.

MBio. 2013 Aug 27;4(5):e00528-13. doi: 10.1128/mBio.00528-13.


Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.

Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW.

J Bacteriol. 2013 Aug;195(16):3651-62. doi: 10.1128/JB.00565-13. Epub 2013 Jun 7.


Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity.

Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ, Kiley PJ.

Nat Struct Mol Biol. 2013 Jun;20(6):740-7. doi: 10.1038/nsmb.2568. Epub 2013 May 5.


Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.

Xie TX, Zhou G, Zhao M, Sano D, Jasser SA, Brennan RG, Myers JN.

Laryngoscope. 2013 Jun;123(6):1416-23. doi: 10.1002/lary.23846. Epub 2013 Apr 26.


Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance.

Schumacher MA, Min J, Link TM, Guan Z, Xu W, Ahn YH, Soderblom EJ, Kurie JM, Evdokimov A, Moseley MA, Lewis K, Brennan RG.

Cell Rep. 2012 Sep 27;2(3):518-25. doi: 10.1016/j.celrep.2012.08.013. Epub 2012 Sep 20.


Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract.

Horstmann N, Orans J, Valentin-Hansen P, Shelburne SA 3rd, Brennan RG.

Nucleic Acids Res. 2012 Nov;40(21):11023-35. doi: 10.1093/nar/gks809. Epub 2012 Sep 10.


Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis.

Hansen S, Vulić M, Min J, Yen TJ, Schumacher MA, Brennan RG, Lewis K.

PLoS One. 2012;7(6):e39185. doi: 10.1371/journal.pone.0039185. Epub 2012 Jun 15. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/e608601c-eadd-4c11-adb2-7b605aba9c44.


GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.

Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA.

J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14.


Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.

Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA 3rd.

PLoS Pathog. 2011 Oct;7(10):e1002311. doi: 10.1371/journal.ppat.1002311. Epub 2011 Oct 20.


The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding.

Le TB, Schumacher MA, Lawson DM, Brennan RG, Buttner MJ.

Nucleic Acids Res. 2011 Nov;39(21):9433-47. doi: 10.1093/nar/gkr640. Epub 2011 Aug 10.


Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein.

Shelburne SA 3rd, Sahasrobhajane P, Suber B, Keith DB, Davenport MT, Horstmann N, Kumaraswami M, Olsen RJ, Brennan RG, Musser JM.

Mol Microbiol. 2011 Jul;81(2):500-14. doi: 10.1111/j.1365-2958.2011.07708.x. Epub 2011 Jun 5.


Achieving 0.2% relative expanded uncertainty in ion chromatography analysis using a high-performance methodology.

Brennan RG, Butler TA, Winchester MR.

Anal Chem. 2011 May 15;83(10):3801-7. doi: 10.1021/ac200290y. Epub 2011 Apr 25.


A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.

Peters KM, Brooks BE, Schumacher MA, Skurray RA, Brennan RG, Brown MH.

PLoS One. 2011 Jan 17;6(1):e15974. doi: 10.1371/journal.pone.0015974.


Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators.

Schumacher MA, Sprehe M, Bartholomae M, Hillen W, Brennan RG.

Nucleic Acids Res. 2011 Apr;39(7):2931-42. doi: 10.1093/nar/gkq1177. Epub 2010 Nov 23.


Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.

Cho K, Vaught TG, Ji H, Gu D, Papasakelariou-Yared C, Horstmann N, Jennings JM, Lee M, Sevilla LM, Kloc M, Reynolds AB, Watt FM, Brennan RG, Kowalczyk AP, McCrea PD.

J Cell Sci. 2010 Dec 1;123(Pt 23):4128-44. doi: 10.1242/jcs.072041. Epub 2010 Nov 9.


C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation.

Olsen AS, Møller-Jensen J, Brennan RG, Valentin-Hansen P.

J Mol Biol. 2010 Nov 26;404(2):173-82. doi: 10.1016/j.jmb.2010.09.038. Epub 2010 Oct 1.


A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection.

Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Sumby P, Brennan RG, Musser JM.

PLoS Pathog. 2010 Mar 19;6(3):e1000817. doi: 10.1371/journal.ppat.1000817.


Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.

Kumaraswami M, Newberry KJ, Brennan RG.

J Mol Biol. 2010 Apr 30;398(2):264-75. doi: 10.1016/j.jmb.2010.03.011. Epub 2010 Mar 15.


Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit.

Nakano MM, Lin A, Zuber CS, Newberry KJ, Brennan RG, Zuber P.

PLoS One. 2010 Jan 13;5(1):e8664. doi: 10.1371/journal.pone.0008664.


Structure of Escherichia coli Hfq bound to polyriboadenylate RNA.

Link TM, Valentin-Hansen P, Brennan RG.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19292-7. doi: 10.1073/pnas.0908744106. Epub 2009 Nov 4.


Characterization and structure of the manganese-responsive transcriptional regulator ScaR.

Stoll KE, Draper WE, Kliegman JI, Golynskiy MV, Brew-Appiah RA, Phillips RK, Brown HK, Breyer WA, Jakubovics NS, Jenkinson HF, Brennan RG, Cohen SM, Glasfeld A.

Biochemistry. 2009 Nov 3;48(43):10308-20. doi: 10.1021/bi900980g.


Heat-assisted argon electrospray interface for low-flow rate liquid sample introduction in plasma spectrometry.

Brennan RG, Rabb SA, Jorabchi K, Rutkowski WF, Turk GC.

Anal Chem. 2009 Oct 1;81(19):8126-33. doi: 10.1021/ac901332s.


Potential primary measurement tool for the quantification of DNA.

Brennan RG, Rabb SA, Holden MJ, Winchester MR, Turk GC.

Anal Chem. 2009 May 1;81(9):3414-20. doi: 10.1021/ac802688x.


Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.

Schumacher MA, Piro KM, Xu W, Hansen S, Lewis K, Brennan RG.

Science. 2009 Jan 16;323(5912):396-401. doi: 10.1126/science.1163806.


Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA.

Kumaraswami M, Schuman JT, Seo SM, Kaatz GW, Brennan RG.

Nucleic Acids Res. 2009 Mar;37(4):1211-24. doi: 10.1093/nar/gkn1046. Epub 2009 Jan 7.


Optimized production and analysis of the staphylococcal multidrug efflux protein QacA.

Hassan KA, Xu Z, Watkins RE, Brennan RG, Skurray RA, Brown MH.

Protein Expr Purif. 2009 Apr;64(2):118-24. doi: 10.1016/j.pep.2008.11.009. Epub 2008 Dec 6.


Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.

Newberry KJ, Huffman JL, Miller MC, Vazquez-Laslop N, Neyfakh AA, Brennan RG.

J Biol Chem. 2008 Sep 26;283(39):26795-804. doi: 10.1074/jbc.M804191200. Epub 2008 Jul 25.


QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

Peters KM, Schuman JT, Skurray RA, Brown MH, Brennan RG, Schumacher MA.

Biochemistry. 2008 Aug 5;47(31):8122-9. doi: 10.1021/bi8008246. Epub 2008 Jul 11.


Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis.

Shelburne SA 3rd, Keith DB, Davenport MT, Horstmann N, Brennan RG, Musser JM.

Mol Microbiol. 2008 Jul;69(2):436-52. doi: 10.1111/j.1365-2958.2008.06290.x.


A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.

Shelburne SA 3rd, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1698-703. doi: 10.1073/pnas.0711767105. Epub 2008 Jan 29. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8790.


Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.

Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin JF, Amendt BA.

Nucleic Acids Res. 2008 Feb;36(2):462-76. Epub 2007 Nov 27.


Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR.

Newberry KJ, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan RG.

Mol Cell. 2007 Nov 30;28(4):652-64.


Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions.

Brooks BE, Piro KM, Brennan RG.

J Am Chem Soc. 2007 Jul 4;129(26):8389-95. Epub 2007 Jun 13.


Hfq structure, function and ligand binding.

Brennan RG, Link TM.

Curr Opin Microbiol. 2007 Apr;10(2):125-33. Epub 2007 Mar 28. Review.


Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate.

Schumacher MA, Seidel G, Hillen W, Brennan RG.

J Mol Biol. 2007 May 11;368(4):1042-50. Epub 2007 Feb 27.


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