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Items: 1 to 50 of 61

1.

Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma.

Pangeni RP, Zhang Z, Alvarez AA, Wan X, Sastry N, Lu S, Shi T, Huang T, Lei CX, James CD, Kessler JA, Brennan CW, Nakano I, Lu X, Hu B, Zhang W, Cheng SY.

Epigenetics. 2018;13(4):432-448. doi: 10.1080/15592294.2018.1469892. Epub 2018 Aug 6.

PMID:
29927689
2.

Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients.

Miloushev VZ, Granlund KL, Boltyanskiy R, Lyashchenko SK, DeAngelis LM, Mellinghoff IK, Brennan CW, Tabar V, Yang TJ, Holodny AI, Sosa RE, Guo YW, Chen AP, Tropp J, Robb F, Keshari KR.

Cancer Res. 2018 Jul 15;78(14):3755-3760. doi: 10.1158/0008-5472.CAN-18-0221. Epub 2018 May 16.

PMID:
29769199
3.

Clinicians' perceptions of usefulness of the PubMed4Hh mobile device application for clinical decision making at the point of care: a pilot study.

Gartrell K, Brennan CW, Wallen GR, Liu F, Smith KG, Fontelo P.

BMC Med Inform Decis Mak. 2018 May 8;18(1):27. doi: 10.1186/s12911-018-0607-9.

4.

Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas.

Omuro A, Beal K, McNeill K, Young RJ, Thomas A, Lin X, Terziev R, Kaley TJ, DeAngelis LM, Daras M, Gavrilovic IT, Mellinghoff I, Diamond EL, McKeown A, Manne M, Caterfino A, Patel K, Bavisotto L, Gorman G, Lamson M, Gutin P, Tabar V, Chakravarty D, Chan TA, Brennan CW, Garrett-Mayer E, Karmali RA, Pentsova E.

J Clin Oncol. 2018 Jun 10;36(17):1702-1709. doi: 10.1200/JCO.2017.76.9992. Epub 2018 Apr 23.

PMID:
29683790
5.

Intracranial metastasis in fibrolamellar hepatocellular carcinoma.

Hammond WJ, Lalazar G, Saltsman JA, Farber BA, Danzer E, Sherpa TC, Banda CD, Andolina JR, Karimi S, Brennan CW, Torbenson MS, La Quaglia MP, Simon SM.

Pediatr Blood Cancer. 2018 Apr;65(4). doi: 10.1002/pbc.26919. Epub 2017 Dec 29.

6.

Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.

Perna F, Berman SH, Soni RK, Mansilla-Soto J, Eyquem J, Hamieh M, Hendrickson RC, Brennan CW, Sadelain M.

Cancer Cell. 2017 Oct 9;32(4):506-519.e5. doi: 10.1016/j.ccell.2017.09.004.

PMID:
29017060
7.

EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines.

Chakravarty D, Pedraza AM, Cotari J, Liu AH, Punko D, Kokroo A, Huse JT, Altan-Bonnet G, Brennan CW.

Sci Rep. 2017 Aug 22;7(1):9043. doi: 10.1038/s41598-017-08940-9.

8.

Feasibility of Automating Patient Acuity Measurement Using a Machine Learning Algorithm.

Brennan CW, Meng F, Meterko MM, D'Avolio LW.

J Nurs Meas. 2016 Dec 1;24(3):419-427. doi: 10.1891/1061-3749.24.3.419.

PMID:
28714447
9.

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.

Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK.

Cancer Discov. 2017 Sep;7(9):1018-1029. doi: 10.1158/2159-8290.CD-17-0613. Epub 2017 Jun 15.

10.

Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma.

Thomas AA, Abrey LE, Terziev R, Raizer J, Martinez NL, Forsyth P, Paleologos N, Matasar M, Sauter CS, Moskowitz C, Nimer SD, DeAngelis LM, Kaley T, Grimm S, Louis DN, Cairncross JG, Panageas KS, Briggs S, Faivre G, Mohile NA, Mehta J, Jonsson P, Chakravarty D, Gao J, Schultz N, Brennan CW, Huse JT, Omuro A.

Neuro Oncol. 2017 Oct 1;19(10):1380-1390. doi: 10.1093/neuonc/nox086.

11.

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA.

Cell Rep. 2016 Nov 22;17(9):2445-2459. doi: 10.1016/j.celrep.2016.10.052. Epub 2016 Nov 10.

12.

Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.

Rennert RC, Hoshide RR, Signorelli JW, Amaro D, Sack JA, Brennan CW, Chen CC.

J Neurosurg. 2017 May;126(5):1472-1478. doi: 10.3171/2016.4.JNS153052. Epub 2016 Jul 22.

PMID:
27447440
13.

Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases.

Kohutek ZA, Yamada Y, Chan TA, Brennan CW, Tabar V, Gutin PH, Yang TJ, Rosenblum MK, Ballangrud Å, Young RJ, Zhang Z, Beal K.

J Neurooncol. 2015 Oct;125(1):149-56. doi: 10.1007/s11060-015-1881-3. Epub 2015 Aug 26.

14.

Identifying Previously Undetected Harm: Piloting the Institute for Healthcare Improvement's Global Trigger Tool in the Veterans Health Administration.

Mull HJ, Brennan CW, Folkes T, Hermos J, Chan J, Rosen AK, Simon SR.

Qual Manag Health Care. 2015 Jul-Sep;24(3):140-6. doi: 10.1097/QMH.0000000000000060.

15.

Improving Palliative Care Team Meetings: Structure, Inclusion, and "Team Care".

Brennan CW, Kelly B, Skarf LM, Tellem R, Dunn KM, Poswolsky S.

Am J Hosp Palliat Care. 2016 Jul;33(6):585-93. doi: 10.1177/1049909115577049. Epub 2015 Mar 20.

PMID:
25794871
16.

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo.

Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB.

Sci Transl Med. 2015 Feb 11;7(274):274ra17. doi: 10.1126/scitranslmed.aaa1009.

17.

Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis.

Vyazunova I, Maklakova VI, Berman S, De I, Steffen MD, Hong W, Lincoln H, Morrissy AS, Taylor MD, Akagi K, Brennan CW, Rodriguez FJ, Collier LS.

PLoS One. 2014 Nov 25;9(11):e113489. doi: 10.1371/journal.pone.0113489. eCollection 2014.

18.

Emerging therapies for glioblastoma.

Thomas AA, Brennan CW, DeAngelis LM, Omuro AM.

JAMA Neurol. 2014 Nov;71(11):1437-44. doi: 10.1001/jamaneurol.2014.1701. Review.

PMID:
25244650
19.

Organization of nursing and quality of care for veterans at the end of life.

Kutney-Lee A, Brennan CW, Meterko M, Ersek M.

J Pain Symptom Manage. 2015 Mar;49(3):570-7. doi: 10.1016/j.jpainsymman.2014.07.002. Epub 2014 Aug 10.

20.

Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma.

Omuro A, Beal K, Gutin P, Karimi S, Correa DD, Kaley TJ, DeAngelis LM, Chan TA, Gavrilovic IT, Nolan C, Hormigo A, Lassman AB, Mellinghoff I, Grommes C, Reiner AS, Panageas KS, Baser RE, Tabar V, Pentsova E, Sanchez J, Barradas-Panchal R, Zhang J, Faivre G, Brennan CW, Abrey LE, Huse JT.

Clin Cancer Res. 2014 Oct 1;20(19):5023-31. doi: 10.1158/1078-0432.CCR-14-0822. Epub 2014 Aug 8.

21.

Methodological challenges of validating a clinical decision-making tool in the practice environment.

Brennan CW, Daly BJ.

West J Nurs Res. 2015 Apr;37(4):536-45. doi: 10.1177/0193945914539738. Epub 2014 Jun 18.

PMID:
24948588
22.

Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.

Ortiz B, Fabius AW, Wu WH, Pedraza A, Brennan CW, Schultz N, Pitter KL, Bromberg JF, Huse JT, Holland EC, Chan TA.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8149-54. doi: 10.1073/pnas.1401952111. Epub 2014 May 19.

23.

Transcriptional diversity of long-term glioblastoma survivors.

Gerber NK, Goenka A, Turcan S, Reyngold M, Makarov V, Kannan K, Beal K, Omuro A, Yamada Y, Gutin P, Brennan CW, Huse JT, Chan TA.

Neuro Oncol. 2014 Sep;16(9):1186-95. doi: 10.1093/neuonc/nou043. Epub 2014 Mar 23.

24.

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.

Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, Hawkins C, Majewski J, Jones C, Costello JF, Iavarone A, Aldape K, Brennan CW, Jabado N, Pfister SM.

Nat Rev Cancer. 2014 Feb;14(2):92-107. doi: 10.1038/nrc3655. Review.

25.

Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.

Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK.

Cancer Res. 2014 Mar 1;74(5):1429-39. doi: 10.1158/0008-5472.CAN-13-2117. Epub 2014 Jan 16.

26.

Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates.

Kastenhuber ER, Huse JT, Berman SH, Pedraza A, Zhang J, Suehara Y, Viale A, Cavatore M, Heguy A, Szerlip N, Ladanyi M, Brennan CW.

Acta Neuropathol. 2014 May;127(5):747-59. doi: 10.1007/s00401-013-1217-3. Epub 2013 Nov 29.

27.

The somatic genomic landscape of glioblastoma.

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L; TCGA Research Network.

Cell. 2013 Oct 10;155(2):462-77. doi: 10.1016/j.cell.2013.09.034. Erratum in: Cell. 2014 Apr 24;157(3):753.

28.

Learning by doing: observing an interprofessional process as an interprofessional team.

Brennan CW, Olds DM, Dolansky M, Estrada CA, Patrician PA.

J Interprof Care. 2014 May;28(3):249-51. doi: 10.3109/13561820.2013.838750. Epub 2013 Sep 27.

29.

CSF-1R inhibition alters macrophage polarization and blocks glioma progression.

Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA.

Nat Med. 2013 Oct;19(10):1264-72. doi: 10.1038/nm.3337. Epub 2013 Sep 22.

30.

Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons.

Sanborn JZ, Salama SR, Grifford M, Brennan CW, Mikkelsen T, Jhanwar S, Katzman S, Chin L, Haussler D.

Cancer Res. 2013 Oct 1;73(19):6036-45. doi: 10.1158/0008-5472.CAN-13-0186. Epub 2013 Aug 12.

31.

Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

Rutledge WC, Kong J, Gao J, Gutman DA, Cooper LA, Appin C, Park Y, Scarpace L, Mikkelsen T, Cohen ML, Aldape KD, McLendon RE, Lehman NL, Miller CR, Schniederjan MJ, Brennan CW, Saltz JH, Moreno CS, Brat DJ.

Clin Cancer Res. 2013 Sep 15;19(18):4951-60. doi: 10.1158/1078-0432.CCR-13-0551. Epub 2013 Jul 17.

32.

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.

Zheng S, Fu J, Vegesna R, Mao Y, Heathcock LE, Torres-Garcia W, Ezhilarasan R, Wang S, McKenna A, Chin L, Brennan CW, Yung WK, Weinstein JN, Aldape KD, Sulman EP, Chen K, Koul D, Verhaak RG.

Genes Dev. 2013 Jul 1;27(13):1462-72. doi: 10.1101/gad.213686.113. Epub 2013 Jun 24.

33.

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C, Tsoi J, Clark O, Oldrini B, Komisopoulou E, Kunii K, Pedraza A, Schalm S, Silverman L, Miller A, Wang F, Yang H, Chen Y, Kernytsky A, Rosenblum MK, Liu W, Biller SA, Su SM, Brennan CW, Chan TA, Graeber TG, Yen KE, Mellinghoff IK.

Science. 2013 May 3;340(6132):626-30. doi: 10.1126/science.1236062. Epub 2013 Apr 4.

34.

State of the science: the relationship between nurse staffing and patient outcomes.

Brennan CW, Daly BJ, Jones KR.

West J Nurs Res. 2013 Jul;35(6):760-94. doi: 10.1177/0193945913476577. Epub 2013 Feb 26.

PMID:
23444060
35.

The oncology acuity tool: a reliable, valid method for measuring patient acuity for nurse assignment decisions.

Brennan CW, Daly BJ, Dawson NV, Higgins PA, Jones KR, Madigan E, Van Der Meulen J.

J Nurs Meas. 2012;20(3):155-85.

PMID:
23362555
36.

Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.

Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M.

Science. 2013 Mar 1;339(6123):1077-80. doi: 10.1126/science.1233009. Epub 2013 Jan 24.

37.

MEF promotes stemness in the pathogenesis of gliomas.

Bazzoli E, Pulvirenti T, Oberstadt MC, Perna F, Wee B, Schultz N, Huse JT, Fomchenko EI, Voza F, Tabar V, Brennan CW, DeAngelis LM, Nimer SD, Holland EC, Squatrito M.

Cell Stem Cell. 2012 Dec 7;11(6):836-44. doi: 10.1016/j.stem.2012.09.012.

38.

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.

Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RL.

Nat Genet. 2012 Nov;44(11):1179-81. doi: 10.1038/ng.2413. Epub 2012 Sep 23.

39.

The role of radiotherapy following gross-total resection of atypical meningiomas.

Komotar RJ, Iorgulescu JB, Raper DM, Holland EC, Beal K, Bilsky MH, Brennan CW, Tabar V, Sherman JH, Yamada Y, Gutin PH.

J Neurosurg. 2012 Oct;117(4):679-86. doi: 10.3171/2012.7.JNS112113. Epub 2012 Aug 24.

PMID:
22920955
40.

Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.

Dougherty JD, Fomchenko EI, Akuffo AA, Schmidt E, Helmy KY, Bazzoli E, Brennan CW, Holland EC, Milosevic A.

Cancer Res. 2012 Sep 15;72(18):4856-68. doi: 10.1158/0008-5472.CAN-11-2632. Epub 2012 Aug 3.

41.

Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.

Vivanco I, Robins HI, Rohle D, Campos C, Grommes C, Nghiemphu PL, Kubek S, Oldrini B, Chheda MG, Yannuzzi N, Tao H, Zhu S, Iwanami A, Kuga D, Dang J, Pedraza A, Brennan CW, Heguy A, Liau LM, Lieberman F, Yung WK, Gilbert MR, Reardon DA, Drappatz J, Wen PY, Lamborn KR, Chang SM, Prados MD, Fine HA, Horvath S, Wu N, Lassman AB, DeAngelis LM, Yong WH, Kuhn JG, Mischel PS, Mehta MP, Cloughesy TF, Mellinghoff IK.

Cancer Discov. 2012 May;2(5):458-71. doi: 10.1158/2159-8290.CD-11-0284. Epub 2012 Mar 31.

42.

A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle.

Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan CW, Mellinghoff IK, Holland EC, Gambhir SS.

Nat Med. 2012 Apr 15;18(5):829-34. doi: 10.1038/nm.2721.

43.

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.

Szerlip NJ, Pedraza A, Chakravarty D, Azim M, McGuire J, Fang Y, Ozawa T, Holland EC, Huse JT, Jhanwar S, Leversha MA, Mikkelsen T, Brennan CW.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3041-6. doi: 10.1073/pnas.1114033109. Epub 2012 Feb 8.

44.

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.

Morris LG, Taylor BS, Bivona TG, Gong Y, Eng S, Brennan CW, Kaufman A, Kastenhuber ER, Banuchi VE, Singh B, Heguy A, Viale A, Mellinghoff IK, Huse J, Ganly I, Chan TA.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19024-9. doi: 10.1073/pnas.1111963108. Epub 2011 Nov 7.

45.

Providing a "good death" for oncology patients during the final hours of life in the intensive care unit.

Brennan CW, Prince-Paul M, Wiencek CA.

AACN Adv Crit Care. 2011 Oct-Dec;22(4):379-96. doi: 10.1097/NCI.0b013e31823100dc.

PMID:
22064586
46.

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.

Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L.

EMBO J. 2011 Sep 13;30(19):4084-97. doi: 10.1038/emboj.2011.259.

47.

Molecular subclassification of diffuse gliomas: seeing order in the chaos.

Huse JT, Phillips HS, Brennan CW.

Glia. 2011 Aug;59(8):1190-9. doi: 10.1002/glia.21165. Epub 2011 Mar 28. Review.

PMID:
21446051
48.

Neurosurgery for brain tumors: update on recent technical advances.

Sherman JH, Hoes K, Marcus J, Komotar RJ, Brennan CW, Gutin PH.

Curr Neurol Neurosci Rep. 2011 Jun;11(3):313-9. doi: 10.1007/s11910-011-0188-9. Review.

PMID:
21327735
49.

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.

Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC.

Cancer Cell. 2010 Dec 14;18(6):619-29. doi: 10.1016/j.ccr.2010.10.034.

50.

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.

Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC.

Genes Dev. 2010 Oct 1;24(19):2205-18. doi: 10.1101/gad.1972310.

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