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TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection.

Natesampillai S, Paim AC, Cummins NW, Chandrasekar AP, Bren GD, Lewin SR, Kiem HP, Badley AD.

J Immunol. 2019 Aug 1;203(3):718-724. doi: 10.4049/jimmunol.1900271. Epub 2019 Jun 12.


HIV elite control is associated with reduced TRAILshort expression.

Paim AC, Cummins NW, Natesampillai S, Garcia-Rivera E, Kogan N, Neogi U, Sönnerborg A, Sperk M, Bren GD, Deeks S, Polley E, Badley AD.

AIDS. 2019 Sep 1;33(11):1757-1763. doi: 10.1097/QAD.0000000000002279.


Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.

Nie Z, Aboulnasr F, Natesampillai S, Burke SP, Krogman A, Bren GD, Chung TDY, Anderson JR, Smart MK, Katzmann DJ, Rajagopalan G, Cummins NW, Badley AD.

J Immunol. 2018 Sep 1;201(5):1599. doi: 10.4049/jimmunol.1800867. Epub 2018 Jul 13. No abstract available.


HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome.

Natesampillai S, Cummins NW, Nie Z, Sampath R, Baker JV, Henry K, Pinzone M, O'Doherty U, Polley EC, Bren GD, Katzmann DJ, Badley AD.

J Virol. 2018 Jun 13;92(13). pii: e00037-18. doi: 10.1128/JVI.00037-18. Print 2018 Jul 1.


Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.

Nie Z, Aboulnasr F, Natesampillai S, Burke SP, Krogman A, Bren GD, Chung TDY, Anderson JR, Smart MK, Katzmann DJ, Rajagopalan G, Cummins NW, Badley AD.

J Immunol. 2018 Feb 1;200(3):1110-1123. doi: 10.4049/jimmunol.1701113. Epub 2017 Dec 20. Erratum in: J Immunol. 2018 Sep 1;201(5):1599.


Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells.

Sampath R, Cummins NW, Natesampillai S, Bren GD, Chung TD, Baker J, Henry K, Pagliuzza A, Badley AD.

PLoS One. 2017 Jun 19;12(6):e0179327. doi: 10.1371/journal.pone.0179327. eCollection 2017.


Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size.

Cummins NW, Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, de Araujo Correia MCM, Sampath R, Rizza SA, O'Brien D, Yao JD, Kaufmann SH, Badley AD.

J Virol. 2016 Mar 28;90(8):4032-4048. doi: 10.1128/JVI.03179-15. Print 2016 Apr.


Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

Sainski AM, Dai H, Natesampillai S, Pang YP, Bren GD, Cummins NW, Correia C, Meng XW, Tarara JE, Ramirez-Alvarado M, Katzmann DJ, Ochsenbauer C, Kappes JC, Kaufmann SH, Badley AD.

J Cell Biol. 2014 Sep 29;206(7):867-76. doi: 10.1083/jcb.201405051. Epub 2014 Sep 22. Erratum in: J Cell Biol. 2014 Oct 13;207(1):159.


Choice of antiretroviral therapy differentially impacts survival of HIV-infected CD4 T cells.

Cummins NW, Sainski AM, Natesampillai S, Bren GD, Badley AD.

Mol Cell Ther. 2014 Jan 3;2:1. doi: 10.1186/2052-8426-2-1. eCollection 2014.


SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory.

Trushin SA, Carena AA, Bren GD, Rizza SA, Dong X, Abraham RS, Badley AD.

J Immunol. 2012 Aug 15;189(4):1835-42. doi: 10.4049/jimmunol.1100275. Epub 2012 Jul 16.


TRAIL dependent fratricidal killing of gp120 primed hepatocytes by HCV core expressing hepatocytes.

Rizza SA, Challagundla KB, Natesampillai S, Bren GD, Sykora J, Walczak H, Badley AD.

PLoS One. 2011;6(11):e27171. doi: 10.1371/journal.pone.0027171. Epub 2011 Nov 14.


Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations.

Cummins NW, Klicpera A, Sainski AM, Bren GD, Khosla S, Westendorf JJ, Badley AD.

PLoS One. 2011;6(9):e24876. doi: 10.1371/journal.pone.0024876. Epub 2011 Sep 12.


Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

Schnepple DJ, Shepard B, Bren GD, Cummins NW, Natesampillai S, Trushin S, Algeciras-Schimnich A, Meng XW, Sainski AM, Rizza SA, Kaufmann SH, Badley AD.

J Biol Chem. 2011 Oct 14;286(41):35742-54. doi: 10.1074/jbc.M111.274639. Epub 2011 Aug 22.


The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak.

Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD.

J Virol. 2011 Aug;85(16):7965-75. doi: 10.1128/JVI.02515-10. Epub 2011 Jun 8.


Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.

Natesampillai S, Nie Z, Cummins NW, Jochmans D, Bren GD, Angel JB, Badley AD.

PLoS Pathog. 2010 Nov 24;6(11):e1001213. doi: 10.1371/journal.ppat.1001213.


CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1α-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation.

Trushin SA, Bren GD, Badley AD.

Open Virol J. 2010 Jun 23;4:157-62. doi: 10.2174/1874357901004010157.


Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.

J Infect Dis. 2010 Aug 15;202(3):386-91. doi: 10.1086/653705.


Casp8p41 expression in primary T cells induces a proinflammatory response.

Taylor JA, Cummins NW, Bren GD, Rizza SA, Kolbert CP, Behrens MD, Knutson KL, Kahl JC, Asmann YW, Badley AD.

AIDS. 2010 Jun 1;24(9):1251-8. doi: 10.1097/QAD.0b013e3283389e90.


CD4 T Cells Treated with gp120 Acquire a CD45R0+/CD45RA+ Phenotype.

Trushin SA, Bren GD, Badley AD.

Open Virol J. 2009 Apr 1;3:21-5. doi: 10.2174/1874357900903010021.


HIV gp120 induces, NF-kappaB dependent, HIV replication that requires procaspase 8.

Bren GD, Trushin SA, Whitman J, Shepard B, Badley AD.

PLoS One. 2009;4(3):e4875. doi: 10.1371/journal.pone.0004875. Epub 2009 Mar 16.


Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis.

Singh VP, Bren GD, Algeciras-Schimnich A, Schnepple D, Navina S, Rizza SA, Dawra RK, Saluja AK, Chari ST, Vege SS, Badley AD.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1040-6. doi: 10.1152/ajpgi.90642.2008. Epub 2009 Mar 12.


HIV induces TRAIL sensitivity in hepatocytes.

Babu CK, Suwansrinon K, Bren GD, Badley AD, Rizza SA.

PLoS One. 2009;4(2):e4623. doi: 10.1371/journal.pone.0004623. Epub 2009 Feb 27.


HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-Infected Cells.

Nie Z, Bren GD, Rizza SA, Badley AD.

Open Virol J. 2008;2:1-7. doi: 10.2174/1874357900802010001.


Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria.

Algeciras-Schimnich A, Belzacq-Casagrande AS, Bren GD, Nie Z, Taylor JA, Rizza SA, Brenner C, Badley AD.

Open Virol J. 2007 Dec 27;1:39-46. doi: 10.2174/1874357900701010039.


Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication.

Bren GD, Whitman J, Cummins N, Shepard B, Rizza SA, Trushin SA, Badley AD.

PLoS One. 2008 May 7;3(5):e2112. doi: 10.1371/journal.pone.0002112.


Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo.

Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.

J Virol. 2007 Jul;81(13):6947-56. Epub 2007 Apr 18.


Glycoprotein 120 binding to CXCR4 causes p38-dependent primary T cell death that is facilitated by, but does not require cell-associated CD4.

Trushin SA, Algeciras-Schimnich A, Vlahakis SR, Bren GD, Warren S, Schnepple DJ, Badley AD.

J Immunol. 2007 Apr 15;178(8):4846-53.


Flying in the face of resistance: antiviral-independent benefit of HIV protease inhibitors on T-cell survival.

Vlahakis SR, Bren GD, Algeciras-Schimnich A, Trushin SA, Schnepple DJ, Badley AD.

Clin Pharmacol Ther. 2007 Sep;82(3):294-9. Epub 2007 Mar 14.


Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease.

Murali NS, Ackerman AW, Croatt AJ, Cheng J, Grande JP, Sutor SL, Bram RJ, Bren GD, Badley AD, Alam J, Nath KA.

Am J Physiol Renal Physiol. 2007 Feb;292(2):F837-44. Epub 2006 Sep 12.


Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta.

Trushin SA, Bren GD, Asin S, Pennington KN, Paya CV, Badley AD.

J Virol. 2005 Aug;79(15):9821-30.


MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates.

Pittock ST, Norby SM, Grande JP, Croatt AJ, Bren GD, Badley AD, Caplice NM, Griffin MD, Nath KA.

Kidney Int. 2005 Aug;68(2):611-22.


Elimination of senescent neutrophils by TNF-related apoptosis-inducing [corrected] ligand.

Lum JJ, Bren G, McClure R, Badley AD.

J Immunol. 2005 Jul 15;175(2):1232-8. Erratum in: J Immunol. 2005 Sep 1;175(5):3446.


Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor.

Weaver JG, Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C, Bren GD, Morin MY, Phenix BN, Dong L, Jiang SX, Sim VL, Zurakowski B, Lallier J, Hardin H, Wettstein P, van Heeswijk RP, Douen A, Kroemer RT, Hou ST, Bennett SA, Lynch DH, Kroemer G, Badley AD.

J Clin Invest. 2005 Jul;115(7):1828-38.


Human immunodeficiency virus-induced apoptosis of human hepatocytes via CXCR4.

Vlahakis SR, Villasis-Keever A, Gomez TS, Bren GD, Paya CV.

J Infect Dis. 2003 Nov 15;188(10):1455-60. Epub 2003 Nov 18.


Transcription of the RelB gene is regulated by NF-kappaB.

Bren GD, Solan NJ, Miyoshi H, Pennington KN, Pobst LJ, Paya CV.

Oncogene. 2001 Nov 22;20(53):7722-33.


RelB cellular regulation and transcriptional activity are regulated by p100.

Solan NJ, Miyoshi H, Carmona EM, Bren GD, Paya CV.

J Biol Chem. 2002 Jan 11;277(2):1405-18. Epub 2001 Oct 30.


PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha.

Bren GD, Pennington KN, Paya CV.

J Mol Biol. 2000 Apr 14;297(5):1245-58.


Signal transduction pathways triggered by the FcepsilonRIIb receptor (CD23) in human monocytes lead to nuclear factor-kappaB activation.

Ten RM, McKinstry MJ, Bren GD, Paya CV.

J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):376-87.


Serine 32 and serine 36 of IkappaBalpha are directly phosphorylated by protein kinase CKII in vitro.

Taylor JA, Bren GD, Pennington KN, Trushin SA, Asin S, Paya CV.

J Mol Biol. 1999 Jul 23;290(4):839-50.


Ikappakappa mediates NF-kappaB activation in human immunodeficiency virus-infected cells.

Asin S, Taylor JA, Trushin S, Bren G, Paya CV.

J Virol. 1999 May;73(5):3893-903.


Activation of IkappaB kinase beta by protein kinase C isoforms.

Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J.

Mol Cell Biol. 1999 Mar;19(3):2180-8.


Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation.

McElhinny JA, Trushin SA, Bren GD, Chester N, Paya CV.

Mol Cell Biol. 1996 Mar;16(3):899-906.


Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes.

Folgueira L, McElhinny JA, Bren GD, MacMorran WS, Diaz-Meco MT, Moscat J, Paya CV.

J Virol. 1996 Jan;70(1):223-31.


Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways.

Steffan NM, Bren GD, Frantz B, Tocci MJ, O'Neill EA, Paya CV.

J Immunol. 1995 Nov 15;155(10):4685-91.


Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.

McElhinny JA, MacMorran WS, Bren GD, Ten RM, Israel A, Paya CV.

J Virol. 1995 Mar;69(3):1500-9.


Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

Frantz B, Nordby EC, Bren G, Steffan N, Paya CV, Kincaid RL, Tocci MJ, O'Keefe SJ, O'Neill EA.

EMBO J. 1994 Feb 15;13(4):861-70.


Microsatellite instability in cancer of the proximal colon.

Thibodeau SN, Bren G, Schaid D.

Science. 1993 May 7;260(5109):816-9.


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