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Items: 1 to 50 of 312

1.

Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes.

Wiersma VR, Clarke A, Pouwels SD, Perry E, Abdullah TM, Kelly C, Soyza A, Hutchinson D, Eggleton P, Bremer E.

Int J Mol Sci. 2019 Aug 19;20(16). pii: E4046. doi: 10.3390/ijms20164046.

2.

CD47 Expression Defines Efficacy of Rituximab with CHOP in Non-Germinal Center B-cell (Non-GCB) Diffuse Large B-cell Lymphoma Patients (DLBCL), but Not in GCB DLBCL.

Bouwstra R, He Y, de Boer J, Kooistra H, Cendrowicz E, Fehrmann RSN, Ammatuna E, Zu Eulenburg C, Nijland M, Huls G, Bremer E, van Meerten T.

Cancer Immunol Res. 2019 Aug 13. doi: 10.1158/2326-6066.CIR-18-0781. [Epub ahead of print]

PMID:
31409608
3.

Reliable and Feasible Fitness Testing for Children on the Autism Spectrum.

Bremer E, Cairney J.

Res Q Exerc Sport. 2019 Jul 5:1-10. doi: 10.1080/02701367.2019.1623367. [Epub ahead of print]

PMID:
31274383
4.

A systematic review and meta-analysis on the effects of physically active classrooms on educational and enjoyment outcomes in school age children.

Bedard C, St John L, Bremer E, Graham JD, Cairney J.

PLoS One. 2019 Jun 25;14(6):e0218633. doi: 10.1371/journal.pone.0218633. eCollection 2019.

5.

Responses of Microorganisms to Osmotic Stress.

Bremer E, Krämer R.

Annu Rev Microbiol. 2019 Sep 8;73:313-334. doi: 10.1146/annurev-micro-020518-115504. Epub 2019 Jun 10.

PMID:
31180805
6.

Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Bouwstra R, van Meerten T, Bremer E.

Mol Cell Oncol. 2019 Apr 16;6(3):1600349. doi: 10.1080/23723556.2019.1600349. eCollection 2019.

PMID:
31131314
7.

Bispecific Antibody Approach for Improved Melanoma-Selective PD-L1 Immune Checkpoint Blockade.

Koopmans I, Hendriks MAJM, van Ginkel RJ, Samplonius DF, Bremer E, Helfrich W.

J Invest Dermatol. 2019 May 23. pii: S0022-202X(19)31565-9. doi: 10.1016/j.jid.2019.01.038. [Epub ahead of print]

PMID:
31128201
8.

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis.

He Y, Bouwstra R, Wiersma VR, de Jong M, Jan Lourens H, Fehrmann R, de Bruyn M, Ammatuna E, Huls G, van Meerten T, Bremer E.

Nat Commun. 2019 Feb 1;10(1):533. doi: 10.1038/s41467-018-08013-z.

9.

Illuminating the catalytic core of ectoine synthase through structural and biochemical analysis.

Czech L, Höppner A, Kobus S, Seubert A, Riclea R, Dickschat JS, Heider J, Smits SHJ, Bremer E.

Sci Rep. 2019 Jan 23;9(1):364. doi: 10.1038/s41598-018-36247-w.

10.

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.

Pandya UM, Egbuta C, Abdullah Norman TM, Chiang CE, Wiersma VR, Panchal RG, Bremer E, Eggleton P, Gold LI.

Int J Mol Sci. 2019 Jan 18;20(2). pii: E408. doi: 10.3390/ijms20020408.

11.

The Interrelationship Between Motor Coordination and Adaptive Behavior in Children With Autism Spectrum Disorder.

Bremer E, Cairney J.

Front Psychol. 2018 Nov 27;9:2350. doi: 10.3389/fpsyg.2018.02350. eCollection 2018.

12.

Development of Bispecific Antibody Derivatives for Cancer Immunotherapy.

He Y, Helfrich W, Bremer E.

Methods Mol Biol. 2019;1884:335-347. doi: 10.1007/978-1-4939-8885-3_23.

PMID:
30465214
13.

The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor.

Ronzheimer S, Warmbold B, Arnhold C, Bremer E.

Front Microbiol. 2018 Oct 24;9:2536. doi: 10.3389/fmicb.2018.02536. eCollection 2018.

14.

Multi-objective Parameter Auto-tuning for Tissue Image Segmentation Workflows.

Taveira LFR, Kurc T, Melo ACMA, Kong J, Bremer E, Saltz JH, Teodoro G.

J Digit Imaging. 2019 Jun;32(3):521-533. doi: 10.1007/s10278-018-0138-z.

PMID:
30402669
15.

The multifaceted role of autophagy in cancer and the microenvironment.

Folkerts H, Hilgendorf S, Vellenga E, Bremer E, Wiersma VR.

Med Res Rev. 2019 Mar;39(2):517-560. doi: 10.1002/med.21531. Epub 2018 Oct 9. Review.

16.

A novel bispecific antibody for EGFR-directed blockade of the PD-1/PD-L1 immune checkpoint.

Koopmans I, Hendriks D, Samplonius DF, van Ginkel RJ, Heskamp S, Wierstra PJ, Bremer E, Helfrich W.

Oncoimmunology. 2018 May 31;7(8):e1466016. doi: 10.1080/2162402X.2018.1466016. eCollection 2018.

17.

A program evaluation of an in-school daily physical activity initiative for children and youth.

Bremer E, Graham JD, Veldhuizen S, Cairney J.

BMC Public Health. 2018 Aug 16;18(1):1023. doi: 10.1186/s12889-018-5943-2.

18.

OpuF, a New Bacillus Compatible Solute ABC Transporter with a Substrate-Binding Protein Fused to the Transmembrane Domain.

Teichmann L, Kümmel H, Warmbold B, Bremer E.

Appl Environ Microbiol. 2018 Oct 1;84(20). pii: e01728-18. doi: 10.1128/AEM.01728-18. Print 2018 Oct 15.

19.

Are Canadian-born Major League Baseball players more likely to bat left-handed? A partial test of the hockey-influence on batting hypothesis.

Cairney J, Chirico D, Li YC, Bremer E, Graham JD.

PLoS One. 2018 May 2;13(5):e0195252. doi: 10.1371/journal.pone.0195252. eCollection 2018.

20.

Role of the Extremolytes Ectoine and Hydroxyectoine as Stress Protectants and Nutrients: Genetics, Phylogenomics, Biochemistry, and Structural Analysis.

Czech L, Hermann L, Stöveken N, Richter AA, Höppner A, Smits SHJ, Heider J, Bremer E.

Genes (Basel). 2018 Mar 22;9(4). pii: E177. doi: 10.3390/genes9040177. Review.

21.

Compatible Solute Synthesis and Import by the Moderate Halophile Spiribacter salinus: Physiology and Genomics.

León MJ, Hoffmann T, Sánchez-Porro C, Heider J, Ventosa A, Bremer E.

Front Microbiol. 2018 Feb 15;9:108. doi: 10.3389/fmicb.2018.00108. eCollection 2018.

22.

With a pinch of extra salt-Did predatory protists steal genes from their food?

Czech L, Bremer E.

PLoS Biol. 2018 Feb 2;16(2):e2005163. doi: 10.1371/journal.pbio.2005163. eCollection 2018 Feb.

23.

Evaluation of a Direct-Instruction Intervention to Improve Movement and Preliteracy Skills among Young Children: A Within-Subject Repeated-Measures Design.

Bedard C, Bremer E, Campbell W, Cairney J.

Front Pediatr. 2018 Jan 17;5:298. doi: 10.3389/fped.2017.00298. eCollection 2017.

24.

CD20-selective inhibition of CD47-SIRPα "don't eat me" signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab.

van Bommel PE, He Y, Schepel I, Hendriks MAJM, Wiersma VR, van Ginkel RJ, van Meerten T, Ammatuna E, Huls G, Samplonius DF, Helfrich W, Bremer E.

Oncoimmunology. 2017 Oct 31;7(2):e1386361. doi: 10.1080/2162402X.2017.1386361. eCollection 2018.

25.

Arsenobetaine: an ecophysiologically important organoarsenical confers cytoprotection against osmotic stress and growth temperature extremes.

Hoffmann T, Warmbold B, Smits SHJ, Tschapek B, Ronzheimer S, Bashir A, Chen C, Rolbetzki A, Pittelkow M, Jebbar M, Seubert A, Schmitt L, Bremer E.

Environ Microbiol. 2018 Jan;20(1):305-323. doi: 10.1111/1462-2920.13999. Epub 2017 Dec 7.

PMID:
29159878
26.

A Construct Validation Study of PLAYfun.

Cairney J, Veldhuizen S, Graham JD, Rodriguez C, Bedard C, Bremer E, Kriellaars D.

Med Sci Sports Exerc. 2018 Apr;50(4):855-862. doi: 10.1249/MSS.0000000000001494.

PMID:
29140898
27.

Tinkering with Osmotically Controlled Transcription Allows Enhanced Production and Excretion of Ectoine and Hydroxyectoine from a Microbial Cell Factory.

Czech L, Poehl S, Hub P, Stöveken N, Bremer E.

Appl Environ Microbiol. 2018 Jan 2;84(2). pii: e01772-17. doi: 10.1128/AEM.01772-17. Print 2018 Jan 15.

28.

A Containerized Software System for Generation, Management, and Exploration of Features from Whole Slide Tissue Images.

Saltz J, Sharma A, Iyer G, Bremer E, Wang F, Jasniewski A, DiPrima T, Almeida JS, Gao Y, Zhao T, Saltz M, Kurc T.

Cancer Res. 2017 Nov 1;77(21):e79-e82. doi: 10.1158/0008-5472.CAN-17-0316.

29.

A versatile pretargeting approach for tumour-selective delivery and activation of TNF superfamily members.

He Y, van Bommel PE, Samplonius DF, Bremer E, Helfrich W.

Sci Rep. 2017 Oct 16;7(1):13301. doi: 10.1038/s41598-017-13530-w.

30.

Circadian Phase and Phase Angle Disorders in Primary Insomnia.

Flynn-Evans EE, Shekleton JA, Miller B, Epstein LJ, Kirsch D, Brogna LA, Burke LM, Bremer E, Murray JM, Gehrman P, Rajaratnam SMW, Lockley SW.

Sleep. 2017 Dec 1;40(12). doi: 10.1093/sleep/zsx163.

PMID:
29029340
31.

Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.

van den Bremer ETJ, Labrijn AF, van den Boogaard R, Priem P, Scheffler K, Melis JPM, Schuurman J, Parren PWHI, de Jong RN.

Anal Chem. 2017 Oct 17;89(20):10873-10882. doi: 10.1021/acs.analchem.7b02543. Epub 2017 Oct 2.

PMID:
28922593
32.

Transcriptional regulation of ectoine catabolism in response to multiple metabolic and environmental cues.

Schulz A, Hermann L, Freibert SA, Bönig T, Hoffmann T, Riclea R, Dickschat JS, Heider J, Bremer E.

Environ Microbiol. 2017 Nov;19(11):4599-4619. doi: 10.1111/1462-2920.13924. Epub 2017 Oct 13.

PMID:
28892254
33.

Towards Generation, Management, and Exploration of Combined Radiomics and Pathomics Datasets for Cancer Research.

Saltz J, Almeida J, Gao Y, Sharma A, Bremer E, DiPrima T, Saltz M, Kalpathy-Cramer J, Kurc T.

AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:85-94. eCollection 2017.

34.

Synthesis of the compatible solute proline by Bacillus subtilis: point mutations rendering the osmotically controlled proHJ promoter hyperactive.

Hoffmann T, Bleisteiner M, Sappa PK, Steil L, Mäder U, Völker U, Bremer E.

Environ Microbiol. 2017 Sep;19(9):3700-3720. doi: 10.1111/1462-2920.13870. Epub 2017 Aug 24.

PMID:
28752945
35.

A Quasi-Experimental Study of a Movement and Preliteracy Program for 3- and 4-Year-Old Children.

Bedard C, Bremer E, Campbell W, Cairney J.

Front Pediatr. 2017 May 1;5:94. doi: 10.3389/fped.2017.00094. eCollection 2017.

36.

Clostridium difficile: A bad bug goes into defensive mode.

Bremer E.

Environ Microbiol. 2017 Jul;19(7):2523-2528. doi: 10.1111/1462-2920.13776. Epub 2017 May 11. No abstract available.

PMID:
28447375
37.

Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis.

Gundlach J, Herzberg C, Kaever V, Gunka K, Hoffmann T, Weiß M, Gibhardt J, Thürmer A, Hertel D, Daniel R, Bremer E, Commichau FM, Stülke J.

Sci Signal. 2017 Apr 18;10(475). pii: eaal3011. doi: 10.1126/scisignal.aal3011.

PMID:
28420751
38.

Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass Spectrometry.

Wang G, de Jong RN, van den Bremer ETJ, Parren PWHI, Heck AJR.

Anal Chem. 2017 May 2;89(9):4793-4797. doi: 10.1021/acs.analchem.6b05129. Epub 2017 Apr 13.

39.

Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches.

Hendriks D, Choi G, de Bruyn M, Wiersma VR, Bremer E.

Int Rev Cell Mol Biol. 2017;331:289-383. doi: 10.1016/bs.ircmb.2016.10.002. Epub 2017 Jan 27. Review.

PMID:
28325214
40.

Safe "cloudification" of large images through picker APIs.

Bremer E, Kurc T, Gao Y, Saltz J, Almeida JS.

AMIA Annu Symp Proc. 2017 Feb 10;2016:342-351. eCollection 2016.

41.

From substrate specificity to promiscuity: hybrid ABC transporters for osmoprotectants.

Teichmann L, Chen C, Hoffmann T, Smits SHJ, Schmitt L, Bremer E.

Mol Microbiol. 2017 Jun;104(5):761-780. doi: 10.1111/mmi.13660. Epub 2017 Mar 22.

42.

Guardians in a stressful world: the Opu family of compatible solute transporters from Bacillus subtilis.

Hoffmann T, Bremer E.

Biol Chem. 2017 Feb 1;398(2):193-214. doi: 10.1515/hsz-2016-0265. Review.

PMID:
27935846
43.

Identification of Differentially Expressed Genes during Bacillus subtilis Spore Outgrowth in High-Salinity Environments Using RNA Sequencing.

Nagler K, Krawczyk AO, De Jong A, Madela K, Hoffmann T, Laue M, Kuipers OP, Bremer E, Moeller R.

Front Microbiol. 2016 Oct 6;7:1564. eCollection 2016.

44.

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.

Komdeur FL, Wouters MC, Workel HH, Tijans AM, Terwindt AL, Brunekreeft KL, Plat A, Klip HG, Eggink FA, Leffers N, Helfrich W, Samplonius DF, Bremer E, Wisman GB, Daemen T, Duiker EW, Hollema H, Nijman HW, de Bruyn M.

Oncotarget. 2016 Nov 15;7(46):75130-75144. doi: 10.18632/oncotarget.12077.

45.

Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction.

Hendriks D, He Y, Koopmans I, Wiersma VR, van Ginkel RJ, Samplonius DF, Helfrich W, Bremer E.

Oncoimmunology. 2016 Jul 6;5(8):e1202390. doi: 10.1080/2162402X.2016.1202390. eCollection 2016 Aug.

46.

Autism spectrum disorder: family quality of life while waiting for intervention services.

Jones S, Bremer E, Lloyd M.

Qual Life Res. 2017 Feb;26(2):331-342. doi: 10.1007/s11136-016-1382-7. Epub 2016 Aug 2.

PMID:
27485916
47.

EctD-mediated biotransformation of the chemical chaperone ectoine into hydroxyectoine and its mechanosensitive channel-independent excretion.

Czech L, Stöveken N, Bremer E.

Microb Cell Fact. 2016 Jul 20;15(1):126. doi: 10.1186/s12934-016-0525-4.

48.

Influence of Organic Amendment and Compaction on Nutrient Dynamics in a Saturated Saline-Sodic Soil from the Riparian Zone.

Miller JJ, Bremer E, Curtis T.

J Environ Qual. 2016 Jul;45(4):1437-44. doi: 10.2134/jeq2016.01.0033.

PMID:
27380095
49.

Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.

Wang G, de Jong RN, van den Bremer ET, Beurskens FJ, Labrijn AF, Ugurlar D, Gros P, Schuurman J, Parren PW, Heck AJ.

Mol Cell. 2016 Jul 7;63(1):135-45. doi: 10.1016/j.molcel.2016.05.016. Epub 2016 Jun 16.

50.

Feeding on compatible solutes: A substrate-induced pathway for uptake and catabolism of ectoines and its genetic control by EnuR.

Schulz A, Stöveken N, Binzen IM, Hoffmann T, Heider J, Bremer E.

Environ Microbiol. 2017 Mar;19(3):926-946. doi: 10.1111/1462-2920.13414. Epub 2016 Aug 18.

PMID:
27318028

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