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Items: 1 to 50 of 59

1.

Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.

Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J.

Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7.

2.

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants.

Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1990-1994. doi: 10.1002/anie.201809424. Epub 2019 Jan 21.

3.

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ.

Elife. 2018 Dec 3;7. pii: e39865. doi: 10.7554/eLife.39865.

4.

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases.

Salimraj R, Hinchliffe P, Kosmopoulou M, Tyrrell JM, Brem J, van Berkel SS, Verma A, Owens RJ, McDonough MA, Walsh TR, Schofield CJ, Spencer J.

FEBS J. 2019 Jan;286(1):169-183. doi: 10.1111/febs.14695. Epub 2018 Nov 23.

5.

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2928-2936. doi: 10.1016/j.bmc.2018.02.043. Epub 2018 Feb 23.

6.

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Cain R, Brem J, Zollman D, McDonough MA, Johnson RM, Spencer J, Makena A, Abboud MI, Cahill S, Lee SY, McHugh PJ, Schofield CJ, Fishwick CWG.

J Med Chem. 2018 Feb 8;61(3):1255-1260. doi: 10.1021/acs.jmedchem.7b01728. Epub 2018 Jan 10.

7.

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.

Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI.

Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17.

8.

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.

Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1282-1285. doi: 10.1002/anie.201711308. Epub 2018 Jan 5.

9.

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

Lohans CT, Brem J, Schofield CJ.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01224-17. doi: 10.1128/AAC.01224-17. Print 2017 Dec. No abstract available.

10.

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.

Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB.

Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21.

11.

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.

Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ.

Org Biomol Chem. 2017 Jul 19;15(28):6024-6032. doi: 10.1039/c7ob01514c.

PMID:
28678295
12.

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ.

Chem Commun (Camb). 2017 May 30;53(43):5806-5809. doi: 10.1039/c7cc02394d.

13.

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors.

Li GB, Abboud MI, Brem J, Someya H, Lohans CT, Yang SY, Spencer J, Wareham DW, McDonough MA, Schofield CJ.

Chem Sci. 2017 Feb 1;8(2):928-937. doi: 10.1039/c6sc04524c. Epub 2016 Dec 14.

14.

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

Abboud MI, Hinchliffe P, Brem J, Macsics R, Pfeffer I, Makena A, Umland KD, Rydzik AM, Li GB, Spencer J, Claridge TD, Schofield CJ.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3862-3866. doi: 10.1002/anie.201612185. Epub 2017 Mar 2.

15.

Cyclic Boronates Inhibit All Classes of β-Lactamases.

Cahill ST, Cain R, Wang DY, Lohans CT, Wareham DW, Oswin HP, Mohammed J, Spencer J, Fishwick CW, McDonough MA, Schofield CJ, Brem J.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02260-16. doi: 10.1128/AAC.02260-16. Print 2017 Apr.

16.

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.

Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J.

Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392.

17.

Use of ferrous iron by metallo-β-lactamases.

Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J.

J Inorg Biochem. 2016 Oct;163:185-193. doi: 10.1016/j.jinorgbio.2016.07.013. Epub 2016 Jul 26.

18.

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.

González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ.

ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20.

19.

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ.

Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406.

20.

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

Salimraj R, Zhang L, Hinchliffe P, Wellington EM, Brem J, Schofield CJ, Gaze WH, Spencer J.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5828-40. doi: 10.1128/AAC.00750-16. Print 2016 Oct.

21.

Interaction of Avibactam with Class B Metallo-β-Lactamases.

Abboud MI, Damblon C, Brem J, Smargiasso N, Mercuri P, Gilbert B, Rydzik AM, Claridge TD, Schofield CJ, Frère JM.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5655-62. doi: 10.1128/AAC.00897-16. Print 2016 Oct.

22.

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam.

Wang DY, Abboud MI, Markoulides MS, Brem J, Schofield CJ.

Future Med Chem. 2016 Jun;8(10):1063-84. doi: 10.4155/fmc-2016-0078. Epub 2016 Jun 21. Review.

23.

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.

Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4170-5. doi: 10.1128/AAC.00371-16. Print 2016 Jul.

24.

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

Lee SY, Brem J, Pettinati I, Claridge TD, Gileadi O, Schofield CJ, McHugh PJ.

Chem Commun (Camb). 2016 May 10;52(40):6727-30. doi: 10.1039/c6cc00529b.

25.

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.

Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ.

Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Review.

26.

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.

Makena A, Düzgün AÖ, Brem J, McDonough MA, Rydzik AM, Abboud MI, Saral A, Çiçek AÇ, Sandalli C, Schofield CJ.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1377-84. doi: 10.1128/AAC.01768-15.

27.

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis.

Kamps JJ, Khan A, Choi H, Lesniak RK, Brem J, Rydzik AM, McDonough MA, Schofield CJ, Claridge TD, Mecinović J.

Chemistry. 2016 Jan 22;22(4):1270-6. doi: 10.1002/chem.201503761. Epub 2015 Dec 14.

28.

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.

Brem J, van Berkel SS, Zollman D, Lee SY, Gileadi O, McHugh PJ, Walsh TR, McDonough MA, Schofield CJ.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):142-50. doi: 10.1128/AAC.01335-15. Print 2016 Jan.

29.

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.

Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI.

Anal Biochem. 2015 Oct 1;486:75-7. doi: 10.1016/j.ab.2015.06.032. Epub 2015 Jul 2.

PMID:
26142222
31.

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

Pettinati I, Brem J, McDonough MA, Schofield CJ.

Hum Mol Genet. 2015 May 1;24(9):2458-69. doi: 10.1093/hmg/ddv007. Epub 2015 Jan 16.

32.

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ.

Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17.

PMID:
25411887
33.

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

Makena A, Brem J, Pfeffer I, Geffen RE, Wilkins SE, Tarhonskaya H, Flashman E, Phee LM, Wareham DW, Schofield CJ.

J Antimicrob Chemother. 2015 Feb;70(2):463-9. doi: 10.1093/jac/dku403. Epub 2014 Oct 16.

34.

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Rydzik AM, Brem J, Struwe WB, Kochan GT, Benesch JL, Schofield CJ.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):4954-7. doi: 10.1016/j.bmcl.2014.09.035. Epub 2014 Sep 19.

PMID:
25266780
35.

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy.

Rydzik AM, Brem J, van Berkel SS, Pfeffer I, Makena A, Claridge TD, Schofield CJ.

Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3129-33. doi: 10.1002/anie.201310866. Epub 2014 Feb 24.

36.

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

Makena A, van Berkel SS, Lejeune C, Owens RJ, Verma A, Salimraj R, Spencer J, Brem J, Schofield CJ.

ChemMedChem. 2013 Dec;8(12):1923-9. doi: 10.1002/cmdc.201300350. Epub 2013 Oct 25.

PMID:
24166830
37.

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase.

Hamed RB, Henry L, Gomez-Castellanos JR, Asghar A, Brem J, Claridge TD, Schofield CJ.

Org Biomol Chem. 2013 Dec 21;11(47):8191-6. doi: 10.1039/c3ob41525b. Epub 2013 Oct 9.

PMID:
24108359
38.

Binding of (5S)-penicilloic acid to penicillin binding protein 3.

van Berkel SS, Nettleship JE, Leung IK, Brem J, Choi H, Stuart DI, Claridge TD, McDonough MA, Owens RJ, Ren J, Schofield CJ.

ACS Chem Biol. 2013 Oct 18;8(10):2112-6. doi: 10.1021/cb400200h. Epub 2013 Aug 15.

PMID:
23899657
39.

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ.

J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16.

40.

Bacteremia and sepsis due to Prevotella oris from dentoalveolar abscesses.

Bein T, Brem J, Schüsselbauer T.

Intensive Care Med. 2003 May;29(5):856. Epub 2003 Mar 28. No abstract available.

PMID:
12664220
41.

Canine dioctophymosis in the North East of Argentine.

Coppo JA, Brem JJ.

Rev Inst Med Trop Sao Paulo. 1983 Sep-Oct;25(5):259-62. No abstract available.

PMID:
6231710
42.

Vertebral ankylosis in a patient with hereditary chondrocalcinosis: a chance association?

Brem JB.

Arthritis Rheum. 1982 Oct;25(10):1257-63. No abstract available.

PMID:
7138595
43.

Effective topical method of therapy for onychomycosis.

Brem J.

Cutis. 1981;27(1):69-76. No abstract available.

PMID:
6451356
44.

Salicylates in spinal fluid.

Brem J, Miller TB.

N Engl J Med. 1978 Mar 30;298(13):744. No abstract available.

PMID:
628403
45.

Treating onychomycosis.

Brem J.

Lancet. 1977 Oct 29;2(8044):937. No abstract available.

PMID:
72283
46.

A family study of pigeon breeders' disease.

Purtilo DT, Brem J, Ceccaci L, Cassel C, Fitzpatrick AJ.

J Pediatr. 1975 Apr;86(4):569-71. No abstract available.

PMID:
1092820
47.

Salicylism, hyperventilation, and the central nervous system.

Brem J, Pereli EM, Gopalan SK, Miller TB.

J Pediatr. 1973 Aug;83(2):264-6. No abstract available.

PMID:
4717583
48.

Koplik spots for the record. An illustrated historical note.

Brem J.

Clin Pediatr (Phila). 1972 Mar;11(3):161-3. No abstract available.

PMID:
4553321
49.

Measly lesions.

Brem J.

N Engl J Med. 1971 Feb 18;284(7):391-2. No abstract available.

PMID:
5539927
50.

Hidden meatal stenosis in male infants and children.

Brem J, Jaffee SR.

Am Fam Physician GP. 1970 Aug;2(2):72-3. No abstract available.

PMID:
5271265

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