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Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system.

Maxwell R, Luksik AS, Garzon-Muvdi T, Hung AL, Kim ES, Wu A, Xia Y, Belcaid Z, Gorelick N, Choi J, Theodros D, Jackson CM, Mathios D, Ye X, Tran PT, Redmond KJ, Brem H, Pardoll DM, Kleinberg LR, Lim M.

Oncoimmunology. 2018 Sep 6;7(12):e1500108. doi: 10.1080/2162402X.2018.1500108. eCollection 2018.


Dural Reconstruction With Autologous Rectus Fascia: A New Technique for Addressing Large-Sized Defects During Cranioplasty.

Santiago G, Wolff A, Huang J, Weingart J, Brem H, Gordon CR.

J Craniofac Surg. 2018 Nov 13. doi: 10.1097/SCS.0000000000004895. [Epub ahead of print]


Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty.

Wolff AY, Santiago GF, Belzberg M, Manson PN, Huang J, Brem H, Gordon CR.

J Craniofac Surg. 2018 Nov 2. doi: 10.1097/SCS.0000000000004872. [Epub ahead of print]


Costs and Their Predictors in Transsphenoidal Pituitary Surgery.

Asemota AO, Ishii M, Brem H, Gallia GL.

Neurosurgery. 2018 Oct 18. doi: 10.1093/neuros/nyy441. [Epub ahead of print]


A Framework to Assist Providers in the Management of Patients with Chronic, Nonhealing Wounds.

Howell RS, Gorenstein S, Gillette BM, DiGregorio J, Criscitelli T, Davitz MS, Woods JS, Acerra M, Brem H.

Adv Skin Wound Care. 2018 Nov;31(11):491-501. doi: 10.1097/01.ASW.0000546117.86938.75.


Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma.

Harris-Bookman S, Mathios D, Martin AM, Xia Y, Kim E, Xu H, Belcaid Z, Polanczyk M, Barberi T, Theodros D, Kim J, Taube JM, Burger PC, Selby M, Taitt C, Korman A, Ye X, Drake CG, Brem H, Pardoll DM, Lim M.

Int J Cancer. 2018 Dec 15;143(12):3201-3208. doi: 10.1002/ijc.31661. Epub 2018 Sep 24.


TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.

Hung AL, Maxwell R, Theodros D, Belcaid Z, Mathios D, Luksik AS, Kim E, Wu A, Xia Y, Garzon-Muvdi T, Jackson C, Ye X, Tyler B, Selby M, Korman A, Barnhart B, Park SM, Youn JI, Chowdhury T, Park CK, Brem H, Pardoll DM, Lim M.

Oncoimmunology. 2018 May 24;7(8):e1466769. doi: 10.1080/2162402X.2018.1466769. eCollection 2018.


Ethical Issues and Recommendations in Grateful Patient Fundraising and Philanthropy.

Collins ME, Rum S, Wheeler J, Antman K, Brem H, Carrese J, Glennon M, Kahn J, Ohman EM, Jagsi R, Konrath S, Tovino S, Wright S, Sugarman J; Participants in the Summit on the Ethics of Grateful Patient Fundraising.

Acad Med. 2018 Nov;93(11):1631-1637. doi: 10.1097/ACM.0000000000002365.


Targeted Local Therapy for Management of Intracranial High-Grade Gliomas.

Paldor I, Chaichana KL, Brem H, Tyler BM.

Prog Neurol Surg. 2018;32:159-171. doi: 10.1159/000469688. Epub 2018 Jul 10. Review.


Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications.

Santiago GF, Terner J, Wolff A, Teixeira J, Brem H, Huang J, Gordon CR.

J Craniofac Surg. 2018 Oct;29(7):1723-1729. doi: 10.1097/SCS.0000000000004639. Review.


Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.

Garzon-Muvdi T, Theodros D, Luksik AS, Maxwell R, Kim E, Jackson CM, Belcaid Z, Ganguly S, Tyler B, Brem H, Pardoll DM, Lim M.

Oncotarget. 2018 Apr 17;9(29):20681-20697. doi: 10.18632/oncotarget.25061. eCollection 2018 Apr 17.


Practical Application of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Patients with Wounds.

Brem H, Howell R, Criscitelli T, Senderowicz A, Siegart N, Gorenstein S, Gillette B.

Surg Technol Int. 2018 Jun 1;32:61-66. Review.


A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes.

Howell RS, Criscitelli T, Woods JS, Gillette BM, Brem H, Gorenstein S.

AORN J. 2018 Apr;107(4):431-440. doi: 10.1002/aorn.12099.


Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials.

Wolff A, Santiago GF, Belzberg M, Huggins C, Lim M, Weingart J, Anderson W, Coon A, Huang J, Brem H, Gordon C.

J Craniofac Surg. 2018 Jun;29(4):887-894. doi: 10.1097/SCS.0000000000004385.


Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors.

Casaos J, Huq S, Lott T, Felder R, Choi J, Gorelick N, Peters M, Xia Y, Maxwell R, Zhao T, Ji C, Simon T, Sesen J, Scotland SJ, Kast RE, Rubens J, Raabe E, Eberhart CG, Jackson EM, Brem H, Tyler B, Skuli N.

Oncotarget. 2018 Jan 3;9(8):8054-8067. doi: 10.18632/oncotarget.23883. eCollection 2018 Jan 30.


Wound Care Center of Excellence: Guide to Operative Technique for Chronic Wounds.

Howell RS, Gorenstein S, Castellano M, Slone E, Woods JS, Gillette BM, Donovan V, Criscitelli T, Brem H, Brathwaite C.

J Am Coll Surg. 2018 Feb;226(2):e7-e17. doi: 10.1016/j.jamcollsurg.2017.11.002. Epub 2017 Dec 6. No abstract available.


NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017.

Nabors LB, Portnow J, Ammirati M, Baehring J, Brem H, Butowski N, Fenstermaker RA, Forsyth P, Hattangadi-Gluth J, Holdhoff M, Howard S, Junck L, Kaley T, Kumthekar P, Loeffler JS, Moots PL, Mrugala MM, Nagpal S, Pandey M, Parney I, Peters K, Puduvalli VK, Ragsdale J 3rd, Rockhill J, Rogers L, Rusthoven C, Shonka N, Shrieve DC, Sills AK Jr, Swinnen LJ, Tsien C, Weiss S, Wen PY, Willmarth N, Bergman MA, Engh A.

J Natl Compr Canc Netw. 2017 Nov;15(11):1331-1345. doi: 10.6004/jnccn.2017.0166.


HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

Mangraviti A, Raghavan T, Volpin F, Skuli N, Gullotti D, Zhou J, Asnaghi L, Sankey E, Liu A, Wang Y, Lee DH, Gorelick N, Serra R, Peters M, Schriefer D, Delaspre F, Rodriguez FJ, Eberhart CG, Brem H, Olivi A, Tyler B.

Sci Rep. 2017 Nov 2;7(1):14978. doi: 10.1038/s41598-017-14990-w.


Neuroplastic Surgery.

Gordon CR, Huang J, Brem H.

J Craniofac Surg. 2018 Jan;29(1):4-5. doi: 10.1097/SCS.0000000000004063. No abstract available.


The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas.

Ehresman JS, Garzon-Muvdi T, Rogers D, Lim M, Gallia GL, Weingart J, Brem H, Bettegowda C, Chaichana KL.

World Neurosurg. 2018 Jan;109:e588-e593. doi: 10.1016/j.wneu.2017.10.028. Epub 2017 Oct 16.


First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant.

Gordon CR, Santiago GF, Huang J, Bergey GK, Liu S, Armand M, Brem H, Anderson WS.

Oper Neurosurg (Hagerstown). 2018 Jul 1;15(1):39-45. doi: 10.1093/ons/opx210.


Starting a Medical Technology Venture as a Young Academic Innovator or Student Entrepreneur.

Manbachi A, Kreamer-Tonin K, Walch P, Gamo NJ, Khoshakhlagh P, Zhang YS, Montague C, Acharya S, Logsdon EA, Allen RH, Durr NJ, Luciano MG, Theodore N, Brem H, Yazdi Y.

Ann Biomed Eng. 2018 Jan;46(1):1-13. doi: 10.1007/s10439-017-1938-x. Epub 2017 Oct 10. Review.


Comparison of Complications, Trends, and Costs in Endoscopic vs Microscopic Pituitary Surgery: Analysis From a US Health Claims Database.

Asemota AO, Ishii M, Brem H, Gallia GL.

Neurosurgery. 2017 Sep 1;81(3):458-472. doi: 10.1093/neuros/nyx350.


Developing Therapies for Brain Tumors: The Impact of the Johns Hopkins Hunterian Neurosurgical Research Laboratory.

Brem H, Sankey EW, Liu A, Mangraviti A, Tyler BM.

Trans Am Clin Climatol Assoc. 2017;128:55-74. Review.


The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.

Paldor I, Abbadi S, Bonne N, Ye X, Rodriguez FJ, Rowshanshad D, Itzoe M, Vigilar V, Giovannini M, Brem H, Blakeley JO, Tyler BM.

J Neurooncol. 2017 Oct;135(1):47-56. doi: 10.1007/s11060-017-2567-9. Epub 2017 Jul 22.


Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors.

Wu A, Weingart JD, Gallia GL, Lim M, Brem H, Bettegowda C, Chaichana KL.

World Neurosurg. 2017 Aug;104:120-128. doi: 10.1016/j.wneu.2017.05.028. Epub 2017 May 13.


Atypical and anaplastic meningioma: outcomes in a population based study.

Garzon-Muvdi T, Yang W, Lim M, Brem H, Huang J.

J Neurooncol. 2017 Jun;133(2):321-330. doi: 10.1007/s11060-017-2436-6. Epub 2017 Apr 20.


Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

Zhang C, Nance EA, Mastorakos P, Chisholm J, Berry S, Eberhart C, Tyler B, Brem H, Suk JS, Hanes J.

J Control Release. 2017 Oct 10;263:112-119. doi: 10.1016/j.jconrel.2017.03.007. Epub 2017 Mar 7.


Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature.

Kessler RA, Garzon-Muvdi T, Yang W, Weingart J, Olivi A, Huang J, Brem H, Lim M.

World Neurosurg. 2017 May;101:47-56. doi: 10.1016/j.wneu.2017.01.070. Epub 2017 Jan 29. Review.


Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.

Mathios D, Kim JE, Mangraviti A, Phallen J, Park CK, Jackson CM, Garzon-Muvdi T, Kim E, Theodros D, Polanczyk M, Martin AM, Suk I, Ye X, Tyler B, Bettegowda C, Brem H, Pardoll DM, Lim M.

Sci Transl Med. 2016 Dec 21;8(370):370ra180. doi: 10.1126/scitranslmed.aag2942.


Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic.

Volpin F, Casaos J, Sesen J, Mangraviti A, Choi J, Gorelick N, Frikeche J, Lott T, Felder R, Scotland SJ, Eisinger-Mathason TSK, Brem H, Tyler B, Skuli N.

Oncogene. 2017 May 25;36(21):3037-3047. doi: 10.1038/onc.2016.457. Epub 2016 Dec 12.


Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Patel MA, Kim JE, Theodros D, Tam A, Velarde E, Kochel CM, Francica B, Nirschl TR, Ghasemzadeh A, Mathios D, Harris-Bookman S, Jackson CC, Jackson C, Ye X, Tran PT, Tyler B, Coric V, Selby M, Brem H, Drake CG, Pardoll DM, Lim M.

J Immunother Cancer. 2016 Nov 4;4:74. doi: 10.1186/s40425-016-0181-6. eCollection 2016.


Protocol for Psychopharmacologic Management of Behavioral Health Comorbidity in Adult Patients with Diabetes and Soft Tissue Infections in a Tertiary Care Hospital Setting.

Pinkhasov A, Singh D, Kashan B, DiGregorio J, Criscitelli TM, Gorenstein S, Brem H.

Adv Skin Wound Care. 2016 Nov;29(11):518-526.


Modalities to Treat Venous Ulcers: Compression, Surgery, and Bioengineered Tissue.

Gould LJ, Dosi G, Couch K, Gibbons GW, Howell RS, Brem H, Tomic-Canic M.

Plast Reconstr Surg. 2016 Sep;138(3 Suppl):199S-208S. doi: 10.1097/PRS.0000000000002677. Review.


Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction.

Gordon CR, Murphy RJ, Armand M, Liacouras P, Weingart J, Huang J, Brem H, Lim M.

J Craniofac Surg. 2016 Sep;27(6):1568-70. doi: 10.1097/SCS.0000000000002999. No abstract available.


Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

Sonabend AM, Zacharia BE, Cloney MB, Sonabend A, Showers C, Ebiana V, Nazarian M, Swanson KR, Baldock A, Brem H, Bruce JN, Butler W, Cahill DP, Carter B, Orringer DA, Roberts DW, Sagher O, Sanai N, Schwartz TH, Silbergeld DL, Sisti MB, Thompson RC, Waziri AE, Ghogawala Z, McKhann G 2nd.

Neurosurgery. 2017 Apr 1;80(4):590-601. doi: 10.1227/NEU.0000000000001374.


Syndrome of the Trephined: A Systematic Review.

Ashayeri K, M Jackson E, Huang J, Brem H, Gordon CR.

Neurosurgery. 2016 Oct;79(4):525-34. doi: 10.1227/NEU.0000000000001366. Review.


Major Histopathologic Diagnoses of Chronic Wounds.

Turi GK, Donovan V, DiGregorio J, Criscitelli TM, Kashan B, Barrientos S, Balingcongan JR, Gorenstein S, Brem H.

Adv Skin Wound Care. 2016 Aug;29(8):376-82. doi: 10.1097/01.ASW.0000484665.45022.b3. Review.


Polylactic acid (PLA) controlled delivery carriers for biomedical applications.

Tyler B, Gullotti D, Mangraviti A, Utsuki T, Brem H.

Adv Drug Deliv Rev. 2016 Dec 15;107:163-175. doi: 10.1016/j.addr.2016.06.018. Epub 2016 Jul 15. Review.


Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas.

Kim JE, Patel MA, Mangraviti A, Kim ES, Theodros D, Velarde E, Liu A, Sankey EW, Tam A, Xu H, Mathios D, Jackson CM, Harris-Bookman S, Garzon-Muvdi T, Sheu M, Martin AM, Tyler BM, Tran PT, Ye X, Olivi A, Taube JM, Burger PC, Drake CG, Brem H, Pardoll DM, Lim M.

Clin Cancer Res. 2017 Jan 1;23(1):124-136. doi: 10.1158/1078-0432.CCR-15-1535. Epub 2016 Jun 29.


Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.

Chintakunta R, Buaron N, Kahn N, Moriah A, Lifshiz R, Goldbart R, Traitel T, Tyler B, Brem H, Kost J.

Carbohydr Polym. 2016 Oct 5;150:308-18. doi: 10.1016/j.carbpol.2016.05.015. Epub 2016 May 10.


Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Mangraviti A, Tzeng SY, Gullotti D, Kozielski KL, Kim JE, Seng M, Abbadi S, Schiapparelli P, Sarabia-Estrada R, Vescovi A, Brem H, Olivi A, Tyler B, Green JJ, Quinones-Hinojosa A.

Biomaterials. 2016 Sep;100:53-66. doi: 10.1016/j.biomaterials.2016.05.025. Epub 2016 May 21.


Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Patel MA, Kim JE, Theodros D, Tam A, Velarde E, Kochel CM, Francica B, Nirschl TR, Ghasemzadeh A, Mathios D, Harris-Bookman S, Jackson CC, Jackson C, Ye X, Tran PT, Tyler B, Coric V, Selby M, Brem H, Drake CG, Pardoll DM, Lim M.

J Immunother Cancer. 2016 May 17;4:28. doi: 10.1186/s40425-016-0132-2. eCollection 2016. Erratum in: J Immunother Cancer. 2016 Nov 4;4:74.


Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours.

Nailor A, Walker DA, Jacques TS, Warren KE, Brem H, Kearns PR, Greenwood J, Penny JI, Pilkington GJ, Carcaboso AM, Fleischhack G, Macarthur D, Slavc I, Meijer L, Gill S, Lowis S, van Vuurden DG, Pearl MS, Clifford SC, Morrissy S, Ivanov DP, Beccaria K, Gilbertson RJ, Straathof K, Green JJ, Smith S, Rahman R, Kilday JP.

Ecancermedicalscience. 2016 Mar 31;10:630. doi: 10.3332/ecancer.2016.630. eCollection 2016.


Discussion of Effect of Reflection of Temporalis Muscle During Cranioplasty With Titanium Mesh After Standard Trauma Craniectomy.

Gordon CR, Tamargo RJ, Brem H, Huang J.

J Craniofac Surg. 2016 May;27(3):654-5. doi: 10.1097/SCS.0000000000002533. No abstract available.


Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines.

Binder ZA, Wilson KM, Salmasi V, Orr BA, Eberhart CG, Siu IM, Lim M, Weingart JD, Quinones-Hinojosa A, Bettegowda C, Kassam AB, Olivi A, Brem H, Riggins GJ, Gallia GL.

PLoS One. 2016 Mar 30;11(3):e0150271. doi: 10.1371/journal.pone.0150271. eCollection 2016.


Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies.

Mangraviti A, Gullotti D, Tyler B, Brem H.

J Control Release. 2016 Oct 28;240:443-453. doi: 10.1016/j.jconrel.2016.03.031. Epub 2016 Mar 23. Review.


The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.

Tyler BM, Liu A, Sankey EW, Mangraviti A, Barone MA, Brem H.

Acad Med. 2016 Jun;91(6):778-84. doi: 10.1097/ACM.0000000000001136.


Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis.

Lopez J, Zhong SS, Sankey EW, Swanson EW, Susarla H, Jusue-Torres I, Huang J, Brem H, Auwaerter PG, Gordon CR.

Plast Reconstr Surg. 2016 Feb;137(2):394e-404e. doi: 10.1097/01.prs.0000475770.14396.1e.


Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction.

Sankey EW, Lopez J, Zhong SS, Susarla H, Jusué-Torres I, Liauw J, Huang J, Streiff M, Brem H, Gordon CR.

Plast Reconstr Surg. 2016 Feb;137(2):595-607. doi: 10.1097/


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