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Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.

Cuevas IC, Sahoo SS, Kumar A, Zhang H, Westcott J, Aguilar M, Cortez JD, Sullivan SA, Xing C, Hayes DN, Brekken RA, Bae-Jump VL, Castrillon DH.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25880-25890. doi: 10.1073/pnas.1911310116. Epub 2019 Nov 26.


Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers.

Arner EN, Du W, Brekken RA.

Front Oncol. 2019 Oct 11;9:1049. doi: 10.3389/fonc.2019.01049. eCollection 2019. Review.


Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer.

Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, Hosein AN, Sathe AA, Xing C, Koay EJ, Driscoll KE, Brekken RA.

EMBO Mol Med. 2019 Nov 7;11(11):e10515. doi: 10.15252/emmm.201910515. Epub 2019 Oct 14.


APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice.

Liang Y, Besch-Williford C, Cook MT, Belenchia A, Brekken RA, Hyder SM.

Breast Cancer (Dove Med Press). 2019 Jul 31;11:249-259. doi: 10.2147/BCTT.S208706. eCollection 2019.


Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution.

Hosein AN, Huang H, Wang Z, Parmar K, Du W, Huang J, Maitra A, Olson E, Verma U, Brekken RA.

JCI Insight. 2019 Jul 23;5. pii: 129212. doi: 10.1172/jci.insight.129212.


2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy.

Zhu D, Huang H, Pinkas DM, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu ZC, Bullock AN, Brekken RA, Ding K, Lu X.

J Med Chem. 2019 Aug 22;62(16):7431-7444. doi: 10.1021/acs.jmedchem.9b00365. Epub 2019 Aug 2.


Getting a grip on adhesion: Cadherin switching and collagen signaling.

Huang H, Wright S, Zhang J, Brekken RA.

Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118472. doi: 10.1016/j.bbamcr.2019.04.002. Epub 2019 Apr 5. Review.


Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer.

Cruz VH, Arner EN, Du W, Bremauntz AE, Brekken RA.

JCI Insight. 2019 Apr 2;5. pii: 126117. doi: 10.1172/jci.insight.126117.


Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer.

Ham IH, Oh HJ, Jin H, Bae CA, Jeon SM, Choi KS, Son SY, Han SU, Brekken RA, Lee D, Hur H.

Mol Cancer. 2019 Mar 30;18(1):68. doi: 10.1186/s12943-019-0972-8.


The effect of flow on blood oxygen level dependent (R* 2 ) MRI of orthotopic lung tumors.

Zhou H, Belzile O, Zhang Z, Wagner J, Ahn C, Richardson JA, Saha D, Brekken RA, Mason RP.

Magn Reson Med. 2019 Jun;81(6):3787-3797. doi: 10.1002/mrm.27661. Epub 2019 Jan 30.


β1 Syntrophin Supports Autophagy Initiation and Protects against Cerulein-Induced Acute Pancreatitis.

Ye R, Onodera T, Blanchard PG, Kusminski CM, Esser V, Brekken RA, Scherer PE.

Am J Pathol. 2019 Apr;189(4):813-825. doi: 10.1016/j.ajpath.2019.01.002. Epub 2019 Jan 14.


The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer.

Huang H, Brekken RA.

Cancer Res. 2019 Jan 15;79(2):328-330. doi: 10.1158/0008-5472.CAN-18-3751.


Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues.

Sorrelle N, Ganguly D, Dominguez ATA, Zhang Y, Huang H, Dahal LN, Burton N, Ziemys A, Brekken RA.

J Immunol. 2019 Jan 1;202(1):292-299. doi: 10.4049/jimmunol.1800878. Epub 2018 Dec 3.


Sitravatinib potentiates immune checkpoint blockade in refractory cancer models.

Du W, Huang H, Sorrelle N, Brekken RA.

JCI Insight. 2018 Nov 2;3(21). pii: 124184. doi: 10.1172/jci.insight.124184.


Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer.

Zhang Y, Kirane A, Huang H, Sorrelle NB, Burrows FJ, Dellinger MT, Brekken RA.

Mol Cancer Res. 2019 Feb;17(2):348-355. doi: 10.1158/1541-7786.MCR-18-0427. Epub 2018 Oct 17.


Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma.

Li X, Lee Y, Kang Y, Dai B, Perez MR, Pratt M, Koay EJ, Kim M, Brekken RA, Fleming JB.

Cell Death Differ. 2019 Jan;26(2):382-393. doi: 10.1038/s41418-018-0207-3. Epub 2018 Oct 3.


Does Axl have potential as a therapeutic target in pancreatic cancer?

Du W, Brekken RA.

Expert Opin Ther Targets. 2018 Nov;22(11):955-966. doi: 10.1080/14728222.2018.1527315. Epub 2018 Oct 3. Review.


Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2.

Wang Z, Zhang Y, Pinkas DM, Fox AE, Luo J, Huang H, Cui S, Xiang Q, Xu T, Xun Q, Zhu D, Tu Z, Ren X, Brekken RA, Bullock AN, Liang G, Ding K, Lu X.

J Med Chem. 2018 Sep 13;61(17):7977-7990. doi: 10.1021/acs.jmedchem.8b01045. Epub 2018 Aug 20.


Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA.

Mol Metab. 2018 Oct;16:139-149. doi: 10.1016/j.molmet.2018.06.007. Epub 2018 Jun 11.


Inhibition of Discoidin Domain Receptor 1 Prevents Stroma-Induced Peritoneal Metastasis in Gastric Carcinoma.

Jin H, Ham IH, Oh HJ, Bae CA, Lee D, Kim YB, Son SY, Chwae YJ, Han SU, Brekken RA, Hur H.

Mol Cancer Res. 2018 Oct;16(10):1590-1600. doi: 10.1158/1541-7786.MCR-17-0710. Epub 2018 Jun 4.


Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.

Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA.

Nat Commun. 2018 May 21;9(1):2050. doi: 10.1038/s41467-018-04519-8.


Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay.

Fu G, Sanjay ST, Zhou W, Brekken RA, Kirken RA, Li X.

Anal Chem. 2018 May 1;90(9):5930-5937. doi: 10.1021/acs.analchem.8b00842. Epub 2018 Apr 17.


Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor.

Yingling JM, McMillen WT, Yan L, Huang H, Sawyer JS, Graff J, Clawson DK, Britt KS, Anderson BD, Beight DW, Desaiah D, Lahn MM, Benhadji KA, Lallena MJ, Holmgaard RB, Xu X, Zhang F, Manro JR, Iversen PW, Iyer CV, Brekken RA, Kalos MD, Driscoll KE.

Oncotarget. 2017 Dec 31;9(6):6659-6677. doi: 10.18632/oncotarget.23795. eCollection 2018 Jan 23.


Antibody targeting of phosphatidylserine for the detection and immunotherapy of cancer.

Belzile O, Huang X, Gong J, Carlson J, Schroit AJ, Brekken RA, Freimark BD.

Immunotargets Ther. 2018 Jan 23;7:1-14. doi: 10.2147/ITT.S134834. eCollection 2018. Review.


Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.

Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA.

Nat Commun. 2017 Dec 22;8(1):2270. doi: 10.1038/s41467-017-02332-3. Erratum in: Nat Commun. 2018 May 21;9(1):2050.


Assessment of TANK-binding kinase 1 as a therapeutic target in cancer.

Cruz VH, Brekken RA.

J Cell Commun Signal. 2018 Mar;12(1):83-90. doi: 10.1007/s12079-017-0438-y. Epub 2017 Dec 7. Review.


Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.

Ludwig KF, Du W, Sorrelle NB, Wnuk-Lipinska K, Topalovski M, Toombs JE, Cruz VH, Yabuuchi S, Rajeshkumar NV, Maitra A, Lorens JB, Brekken RA.

Cancer Res. 2018 Jan 1;78(1):246-255. doi: 10.1158/0008-5472.CAN-17-1973. Epub 2017 Nov 27.


Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma.

Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA.

Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1.


Extracellular Matrix Induction of Intracellular Reactive Oxygen Species.

Huang H, Du W, Brekken RA.

Antioxid Redox Signal. 2017 Oct 20;27(12):774-784. doi: 10.1089/ars.2017.7305. Review.


Detection of phosphatidylserine-positive exosomes for the diagnosis of early-stage malignancies.

Sharma R, Huang X, Brekken RA, Schroit AJ.

Br J Cancer. 2017 Aug 8;117(4):545-552. doi: 10.1038/bjc.2017.183. Epub 2017 Jun 22.


A positive crosstalk between CXCR4 and CXCR2 promotes gastric cancer metastasis.

Xiang Z, Zhou ZJ, Xia GK, Zhang XH, Wei ZW, Zhu JT, Yu J, Chen W, He Y, Schwarz RE, Brekken RA, Awasthi N, Zhang CH.

Oncogene. 2017 Sep 7;36(36):5122-5133. doi: 10.1038/onc.2017.108. Epub 2017 May 8.


From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.

Sorrelle N, Dominguez ATA, Brekken RA.

J Leukoc Biol. 2017 Aug;102(2):277-286. doi: 10.1189/jlb.3MR1116-475R. Epub 2017 Mar 29. Review.


Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

Wang Z, Zhang Y, Bartual SG, Luo J, Xu T, Du W, Xun Q, Tu Z, Brekken RA, Ren X, Bullock AN, Liang G, Lu X, Ding K.

ACS Med Chem Lett. 2017 Feb 9;8(3):327-332. doi: 10.1021/acsmedchemlett.6b00497. eCollection 2017 Mar 9.


Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and β2AR-Dependent Neo-Angiogenic Switch.

Mulcrone PL, Campbell JP, Clément-Demange L, Anbinder AL, Merkel AR, Brekken RA, Sterling JA, Elefteriou F.

J Bone Miner Res. 2017 Jul;32(7):1442-1454. doi: 10.1002/jbmr.3133. Epub 2017 Apr 28.


Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma.

Hur H, Ham IH, Lee D, Jin H, Aguilera KY, Oh HJ, Han SU, Kwon JE, Kim YB, Ding K, Brekken RA.

BMC Cancer. 2017 Jan 31;17(1):87. doi: 10.1186/s12885-017-3051-9.


Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma.

Dai B, Roife D, Kang Y, Gumin J, Rios Perez MV, Li X, Pratt M, Brekken RA, Fueyo-Margareto J, Lang FF, Fleming JB.

Mol Cancer Ther. 2017 Apr;16(4):662-670. doi: 10.1158/1535-7163.MCT-16-0526. Epub 2017 Jan 30.


SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers.

Tagal V, Wei S, Zhang W, Brekken RA, Posner BA, Peyton M, Girard L, Hwang T, Wheeler DA, Minna JD, White MA, Gazdar AF, Roth MG.

Nat Commun. 2017 Jan 19;8:14098. doi: 10.1038/ncomms14098.


The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity.

Wieczorek M, Tcherkezian J, Bernier C, Prota AE, Chaaban S, Rolland Y, Godbout C, Hancock MA, Arezzo JC, Ocal O, Rocha C, Olieric N, Hall A, Ding H, Bramoullé A, Annis MG, Zogopoulos G, Harran PG, Wilkie TM, Brekken RA, Siegel PM, Steinmetz MO, Shore GC, Brouhard GJ, Roulston A.

Sci Transl Med. 2016 Nov 16;8(365):365ra159. Erratum in: Sci Transl Med. 2017 Dec 20;9(421):.


Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco.

Wojtukiewicz MZ, Sierko E, Skalij P, Kamińska M, Zimnoch L, Brekken RA, Thorpe PE.

Adv Clin Exp Med. 2016 May-Jun;25(3):505-11. doi: 10.17219/acem/62398.


Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.

Topalovski M, Hagopian M, Wang M, Brekken RA.

J Biol Chem. 2016 Oct 14;291(42):22244-22252. Epub 2016 Aug 16.


Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

Mineo C, Lanier L, Jung E, Sengupta S, Ulrich V, Sacharidou A, Tarango C, Osunbunmi O, Shen YM, Salmon JE, Brekken RA, Huang X, Thorpe PE, Shaul PW.

PLoS One. 2016 Jul 27;11(7):e0158757. doi: 10.1371/journal.pone.0158757. eCollection 2016.


Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.

Díaz B, Ostapoff KT, Toombs JE, Lo J, Bonner MY, Curatolo A, Adsay V, Brekken RA, Arbiser JL.

Oncotarget. 2016 Aug 9;7(32):51569-51580. doi: 10.18632/oncotarget.10514.


Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer.

Hagopian MM, Brekken RA.

Mol Cell Oncol. 2014 Dec 1;2(3):e975606. doi: 10.4161/23723556.2014.975606. eCollection 2015 Jul-Sep.


Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy.

Zhang Z, Wodzak M, Belzile O, Zhou H, Sishc B, Yan H, Stojadinovic S, Mason RP, Brekken RA, Chopra R, Story MD, Timmerman R, Saha D.

Radiat Res. 2016 Jun;185(6):616-22. doi: 10.1667/RR14382.1. Epub 2016 May 25.


Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.

Wang Z, Bian H, Bartual SG, Du W, Luo J, Zhao H, Zhang S, Mo C, Zhou Y, Xu Y, Tu Z, Ren X, Lu X, Brekken RA, Yao L, Bullock AN, Su J, Ding K.

J Med Chem. 2016 Jun 23;59(12):5911-6. doi: 10.1021/acs.jmedchem.6b00140. Epub 2016 Jun 3.


Axl Receptor Axis: A New Therapeutic Target in Lung Cancer.

Levin PA, Brekken RA, Byers LA, Heymach JV, Gerber DE.

J Thorac Oncol. 2016 Aug;11(8):1357-1362. doi: 10.1016/j.jtho.2016.04.015. Epub 2016 Apr 26. No abstract available.


Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1.

Desai TJ, Toombs JE, Minna JD, Brekken RA, Udugamasooriya DG.

Oncotarget. 2016 May 24;7(21):30678-90. doi: 10.18632/oncotarget.8929.


Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma.

Freimark BD, Gong J, Ye D, Gray MJ, Nguyen V, Yin S, Hatch MM, Hughes CC, Schroit AJ, Hutchins JT, Brekken RA, Huang X.

Cancer Immunol Res. 2016 Jun;4(6):531-40. doi: 10.1158/2326-6066.CIR-15-0250. Epub 2016 Apr 4.


P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.

Goel HL, Pursell B, Shultz LD, Greiner DL, Brekken RA, Vander Kooi CW, Mercurio AM.

Cell Rep. 2016 Mar 8;14(9):2193-2208. doi: 10.1016/j.celrep.2016.02.016. Epub 2016 Feb 25.


Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer.

Birge RB, Boeltz S, Kumar S, Carlson J, Wanderley J, Calianese D, Barcinski M, Brekken RA, Huang X, Hutchins JT, Freimark B, Empig C, Mercer J, Schroit AJ, Schett G, Herrmann M.

Cell Death Differ. 2016 Jun;23(6):962-78. doi: 10.1038/cdd.2016.11. Epub 2016 Feb 26. Review.

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