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Items: 1 to 50 of 57

1.

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV.

Cell Rep. 2018 Jan 23;22(4):1054-1066. doi: 10.1016/j.celrep.2017.12.089. Epub 2018 Jan 28.

2.

Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2σ) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling.

Gorvin CM, Metpally R, Stokes VJ, Hannan FM, Krishnamurthy SB, Overton JD, Reid JG, Breitwieser GE, Thakker RV.

Hum Mol Genet. 2018 Mar 1;27(5):901-911. doi: 10.1093/hmg/ddy010.

3.

14-3-3 Proteins Buffer Intracellular Calcium Sensing Receptors to Constrain Signaling.

Grant MP, Cavanaugh A, Breitwieser GE.

PLoS One. 2015 Aug 28;10(8):e0136702. doi: 10.1371/journal.pone.0136702. eCollection 2015.

4.

Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.

Moore BS, Mirshahi UL, Yost EA, Stepanchick AN, Bedrin MD, Styer AM, Jackson KK, Still CD, Breitwieser GE, Gerhard GS, Carey DJ, Mirshahi T.

PLoS One. 2014 Apr 4;9(4):e93629. doi: 10.1371/journal.pone.0093629. eCollection 2014.

5.

Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators.

Breitwieser GE.

Pharmacol Res. 2014 May;83:30-7. doi: 10.1016/j.phrs.2013.11.006. Epub 2013 Nov 27. Review.

PMID:
24291533
6.

Cellular calcium dynamics in lactation and breast cancer: from physiology to pathology.

Cross BM, Breitwieser GE, Reinhardt TA, Rao R.

Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C515-26. doi: 10.1152/ajpcell.00330.2013. Epub 2013 Nov 13. Review.

7.

The calcium sensing receptor life cycle: trafficking, cell surface expression, and degradation.

Breitwieser GE.

Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):303-13. doi: 10.1016/j.beem.2013.03.003. Epub 2013 Apr 19. Review.

PMID:
23856261
8.

Calcium signaling regulates trafficking of familial hypocalciuric hypercalcemia (FHH) mutants of the calcium sensing receptor.

Grant MP, Stepanchick A, Breitwieser GE.

Mol Endocrinol. 2012 Dec;26(12):2081-91. doi: 10.1210/me.2012-1232. Epub 2012 Oct 17.

9.

Minireview: the intimate link between calcium sensing receptor trafficking and signaling: implications for disorders of calcium homeostasis.

Breitwieser GE.

Mol Endocrinol. 2012 Sep;26(9):1482-95. doi: 10.1210/me.2011-1370. Epub 2012 Jun 28. Review.

10.

Agonist-driven maturation and plasma membrane insertion of calcium-sensing receptors dynamically control signal amplitude.

Grant MP, Stepanchick A, Cavanaugh A, Breitwieser GE.

Sci Signal. 2011 Nov 22;4(200):ra78. doi: 10.1126/scisignal.2002208.

11.

Regulation of stability and trafficking of calcium-sensing receptors by pharmacologic chaperones.

Huang Y, Cavanaugh A, Breitwieser GE.

Adv Pharmacol. 2011;62:143-73. doi: 10.1016/B978-0-12-385952-5.00007-5. Review.

PMID:
21907909
12.

Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors.

Cavanaugh A, Huang Y, Breitwieser GE.

Br J Pharmacol. 2012 Mar;165(6):1670-1677. doi: 10.1111/j.1476-5381.2011.01403.x. Review.

13.

Calcium sensing receptor mutations implicated in pancreatitis and idiopathic epilepsy syndrome disrupt an arginine-rich retention motif.

Stepanchick A, McKenna J, McGovern O, Huang Y, Breitwieser GE.

Cell Physiol Biochem. 2010;26(3):363-74. doi: 10.1159/000320560. Epub 2010 Aug 24.

14.

Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention.

Cavanaugh A, McKenna J, Stepanchick A, Breitwieser GE.

J Biol Chem. 2010 Jun 25;285(26):19854-64. doi: 10.1074/jbc.M110.124792. Epub 2010 Apr 26.

15.

The cargo receptor p24A facilitates calcium sensing receptor maturation and stabilization in the early secretory pathway.

Stepanchick A, Breitwieser GE.

Biochem Biophys Res Commun. 2010 Apr 23;395(1):136-40. doi: 10.1016/j.bbrc.2010.03.156. Epub 2010 Mar 31.

16.

Pharmacochaperone-mediated rescue of calcium-sensing receptor loss-of-function mutants.

White E, McKenna J, Cavanaugh A, Breitwieser GE.

Mol Endocrinol. 2009 Jul;23(7):1115-23. doi: 10.1210/me.2009-0041. Epub 2009 Apr 23.

17.

Extracellular calcium as an integrator of tissue function.

Breitwieser GE.

Int J Biochem Cell Biol. 2008;40(8):1467-80. doi: 10.1016/j.biocel.2008.01.019. Epub 2008 Feb 2. Review.

18.
19.
20.

Calcium sensing receptors and calcium oscillations: calcium as a first messenger.

Breitwieser GE.

Curr Top Dev Biol. 2006;73:85-114. Review.

PMID:
16782456
21.

Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.

Huang Y, Niwa J, Sobue G, Breitwieser GE.

J Biol Chem. 2006 Apr 28;281(17):11610-7. Epub 2006 Mar 2.

22.

Postnatal development of carotid body glomus cell response to hypoxia.

Wasicko MJ, Breitwieser GE, Kim I, Carroll JL.

Respir Physiol Neurobiol. 2006 Dec;154(3):356-71. Epub 2006 Feb 8.

PMID:
16466972
24.

High affinity interaction with filamin A protects against calcium-sensing receptor degradation.

Zhang M, Breitwieser GE.

J Biol Chem. 2005 Mar 25;280(12):11140-6. Epub 2005 Jan 18.

25.

Calcium sensing receptors as integrators of multiple metabolic signals.

Breitwieser GE, Miedlich SU, Zhang M.

Cell Calcium. 2004 Mar;35(3):209-16. Review.

PMID:
15200144
26.
27.

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.

Miedlich SU, Gama L, Seuwen K, Wolf RM, Breitwieser GE.

J Biol Chem. 2004 Feb 20;279(8):7254-63. Epub 2003 Dec 2.

28.

Human calcium-sensing receptor can be suppressed by antisense sequences.

Maldonado-Pérez D, Breitwieser GE, Gama L, Elliott AC, Ward DT, Riccardi D.

Biochem Biophys Res Commun. 2003 Nov 21;311(3):610-7.

PMID:
14623314
29.

Calcium sensing receptor activation by a calcimimetic suggests a link between cooperativity and intracellular calcium oscillations.

Miedlich S, Gama L, Breitwieser GE.

J Biol Chem. 2002 Dec 20;277(51):49691-9. Epub 2002 Oct 23.

30.
31.

Generation of epitope-tagged proteins by inverse polymerase chain reaction mutagenesis.

Gama L, Breitwieser GE.

Methods Mol Biol. 2002;182:77-83. No abstract available.

PMID:
11768979
32.

Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons.

Gama L, Wilt SG, Breitwieser GE.

J Biol Chem. 2001 Oct 19;276(42):39053-9. Epub 2001 Aug 6.

33.

Calcium-sensing receptor activation induces intracellular calcium oscillations.

Breitwieser GE, Gama L.

Am J Physiol Cell Physiol. 2001 Jun;280(6):C1412-21.

34.

Generation of epitope-tagged proteins by inverse PCR mutagenesis.

Gama L, Breitwieser GE.

Biotechniques. 1999 May;26(5):814-6. No abstract available.

36.

Activation of Na+,K+,Cl- cotransport in squid giant axon by extracellular ions: evidence for ordered binding.

Altamirano AA, Breitwieser GE, Russell JM.

Biochim Biophys Acta. 1999 Jan 12;1416(1-2):195-207.

38.

Ca2+-sensing receptors in intestinal epithelium.

Gama L, Baxendale-Cox LM, Breitwieser GE.

Am J Physiol. 1997 Oct;273(4):C1168-75. doi: 10.1152/ajpcell.1997.273.4.C1168.

PMID:
9357760
39.

Colonic epithelium-enriched protein A4 is a proteolipid that exhibits ion channel characteristics.

Breitwieser GE, McLenithan JC, Cortese JF, Shields JM, Oliva MM, Majewski JL, Machamer CE, Yang VW.

Am J Physiol. 1997 Mar;272(3 Pt 1):C957-65.

PMID:
9124532
40.
41.

Mechanisms of K+ channel regulation.

Breitwieser GE.

J Membr Biol. 1996 Jul;152(1):1-11. Review. No abstract available.

PMID:
8660412
42.

Elevated [Cl-]i, and [Na+]i inhibit Na+, K+, Cl- cotransport by different mechanisms in squid giant axons.

Breitwieser GE, Altamirano AA, Russell JM.

J Gen Physiol. 1996 Feb;107(2):261-70.

43.

Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation.

Mjaatvedt AE, Cabin DE, Cole SE, Long LJ, Breitwieser GE, Reeves RH.

Genome Res. 1995 Dec;5(5):453-63.

44.

Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport.

Altamirano AA, Breitwieser GE, Russell JM.

Am J Physiol. 1995 Oct;269(4 Pt 1):C878-83.

PMID:
7485456
45.

Protein kinase-independent inhibition of muscarinic K+ channels by staurosporine.

Lo CF, Breitwieser GE.

Am J Physiol. 1994 Apr;266(4 Pt 1):C1128-32.

PMID:
8178960
46.

Leukotriene C4 modulation of muscarinic K+ current activation in bullfrog atrial myocytes.

Scherer RW, Lo CF, Breitwieser GE.

J Gen Physiol. 1993 Jul;102(1):125-41.

47.
48.

G protein-mediated ion channel activation.

Breitwieser GE.

Hypertension. 1991 May;17(5):684-92. Review.

PMID:
1708743
49.
50.

Osmotic stimulation of Na(+)-K(+)-Cl- cotransport in squid giant axon is [Cl-]i dependent.

Breitwieser GE, Altamirano AA, Russell JM.

Am J Physiol. 1990 Apr;258(4 Pt 1):C749-53.

PMID:
2333955

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