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Items: 1 to 50 of 82

1.

In vitro and in vivo testing of a novel local nicardipine delivery system to the brain: a preclinical study.

Bayerl SH, Ghori A, Nieminen-Kelhä M, Adage T, Breitenbach J, Vajkoczy P, Prinz V.

J Neurosurg. 2019 Jan 25:1-8. doi: 10.3171/2018.9.JNS173085. [Epub ahead of print]

PMID:
30684943
2.

Genetic modification of the carotenoid pathway in the red yeast Xanthophyllomyces dendrorhous: Engineering of a high-yield zeaxanthin strain.

Breitenbach J, Pollmann H, Sandmann G.

J Biotechnol. 2019 Jan 10;289:112-117. doi: 10.1016/j.jbiotec.2018.11.019. Epub 2018 Nov 26.

PMID:
30496776
3.

Low-dose calcipotriol can elicit wound closure, anti-microbial, and anti-neoplastic effects in epidermolysis bullosa keratinocytes.

Guttmann-Gruber C, Tockner B, Scharler C, Hüttner C, Common JE, Tay ASL, Denil SLIJ, Klausegger A, Trost A, Breitenbach J, Schnitzhofer P, Hofbauer P, Wolkersdorfer M, Diem A, Laimer M, Strunk D, Bauer JW, Reichelt J, Lang R, Piñón Hofbauer J.

Sci Rep. 2018 Sep 7;8(1):13430. doi: 10.1038/s41598-018-31823-6.

4.

An ex vivo RNA trans-splicing strategy to correct human generalized severe epidermolysis bullosa simplex.

Peking P, Breitenbach JS, Ablinger M, Muss WH, Poetschke FJ, Kocher T, Koller U, Hainzl S, Kitzmueller S, Bauer JW, Reichelt J, Lettner T, Wally V.

Br J Dermatol. 2019 Jan;180(1):141-148. doi: 10.1111/bjd.17075. Epub 2018 Oct 7.

5.

Combinatorial Biosynthesis of Novel Multi-Hydroxy Carotenoids in the Red Yeast Xanthophyllomyces dendrorhous.

Pollmann H, Breitenbach J, Wolff H, Bode HB, Sandmann G.

J Fungi (Basel). 2017 Feb 22;3(1). pii: E9. doi: 10.3390/jof3010009.

6.

Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years.

Knebel C, Lenze U, Pohlig F, Lenze F, Harrasser N, Suren C, Breitenbach J, Rechl H, von Eisenhart-Rothe R, Mühlhofer HML.

BMC Cancer. 2017 Jun 12;17(1):410. doi: 10.1186/s12885-017-3398-y.

7.

Development of Xanthophyllomyces dendrorhous as a production system for the colorless carotene phytoene.

Pollmann H, Breitenbach J, Sandmann G.

J Biotechnol. 2017 Apr 10;247:34-41. doi: 10.1016/j.jbiotec.2017.02.027. Epub 2017 Mar 3.

PMID:
28263769
8.

A Novel Genistein Prodrug: Design, Synthesis and Bioactivity on Mouse RAW264.7 Macrophages.

Kloesch B, Loebsch S, Breitenbach J, Goldhahn K, Handler N, Schreppel P, Erker T.

Nat Prod Commun. 2016 Oct;11(10):1437-1440.

PMID:
30549594
9.

Control of light-dependent keto carotenoid biosynthesis in Nostoc 7120 by the transcription factor NtcA.

Sandmann G, Mautz J, Breitenbach J.

Z Naturforsch C. 2016 Sep 1;71(9-10):303-311. doi: 10.1515/znc-2016-0117.

PMID:
27564697
10.

Engineering of the carotenoid pathway in Xanthophyllomyces dendrorhous leading to the synthesis of zeaxanthin.

Pollmann H, Breitenbach J, Sandmann G.

Appl Microbiol Biotechnol. 2017 Jan;101(1):103-111. doi: 10.1007/s00253-016-7769-0. Epub 2016 Aug 16.

PMID:
27527661
11.

Engineered maize as a source of astaxanthin: processing and application as fish feed.

Breitenbach J, Nogueira M, Farré G, Zhu C, Capell T, Christou P, Fleck G, Focken U, Fraser PD, Sandmann G.

Transgenic Res. 2016 Dec;25(6):785-793. Epub 2016 Aug 12.

PMID:
27520497
12.

A comparative study of three signaling forms of the orange carotenoid protein.

Maksimov EG, Moldenhauer M, Shirshin EA, Parshina EA, Sluchanko NN, Klementiev KE, Tsoraev GV, Tavraz NN, Willoweit M, Schmitt FJ, Breitenbach J, Sandmann G, Paschenko VZ, Friedrich T, Rubin AB.

Photosynth Res. 2016 Dec;130(1-3):389-401. Epub 2016 May 9.

PMID:
27161566
13.

European Bluetongue Serotype 8: Disease Threat Assessment for U.S. Sheep.

Drolet BS, Reister-Hendricks LM, Podell BK, Breitenbach JE, McVey DS, van Rijn PA, Bowen RA.

Vector Borne Zoonotic Dis. 2016 Jun;16(6):400-7. doi: 10.1089/vbz.2015.1924. Epub 2016 Apr 25.

PMID:
27111674
14.

Metabolic engineering of astaxanthin biosynthesis in maize endosperm and characterization of a prototype high oil hybrid.

Farré G, Perez-Fons L, Decourcelle M, Breitenbach J, Hem S, Zhu C, Capell T, Christou P, Fraser PD, Sandmann G.

Transgenic Res. 2016 Aug;25(4):477-89. doi: 10.1007/s11248-016-9943-7. Epub 2016 Mar 1.

PMID:
26931320
15.

Identification of genes coding for functional zeaxanthin epoxidases in the diatom Phaeodactylum tricornutum.

Eilers U, Dietzel L, Breitenbach J, Büchel C, Sandmann G.

J Plant Physiol. 2016 Mar 15;192:64-70. doi: 10.1016/j.jplph.2016.01.006. Epub 2016 Jan 25.

PMID:
26851888
16.

Pseudosyndactyly - an inflammatory and fibrotic wound healing disorder in recessive dystrophic epidermolysis bullosa.

Breitenbach J, Gruber C, Klausegger A, Trost A, Bogner B, Reitsamer H, Bauer JW.

J Dtsch Dermatol Ges. 2015 Dec;13(12):1257-66. doi: 10.1111/ddg.12839.

PMID:
26612796
17.

Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging.

Breitenbach JS, Rinnerthaler M, Trost A, Weber M, Klausegger A, Gruber C, Bruckner D, Reitsamer HA, Bauer JW, Breitenbach M.

Aging (Albany NY). 2015 Jun;7(6):389-411.

18.

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Gentry BG, Phan Q, Hall ED, Breitenbach JM, Borysko KZ, Kamil JP, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2015 Jan;59(1):226-32. doi: 10.1128/AAC.03686-14. Epub 2014 Oct 27.

19.

Pediatric mass-casualty education: experiential learning through university-sponsored disaster simulation.

Austin EN, Bastepe-Gray SE, Nelson HW, Breitenbach J, Ogle KT, Durry A, Green SD, Crabtree LA, Haluska M.

J Emerg Nurs. 2014 Sep;40(5):428-33. doi: 10.1016/j.jen.2014.05.015. No abstract available.

PMID:
25194652
20.

Multiple transformation with the crtYB gene of the limiting enzyme increased carotenoid synthesis and generated novel derivatives in Xanthophyllomyces dendrorhous.

Ledetzky N, Osawa A, Iki K, Pollmann H, Gassel S, Breitenbach J, Shindo K, Sandmann G.

Arch Biochem Biophys. 2014 Mar 1;545:141-7. doi: 10.1016/j.abb.2014.01.014. Epub 2014 Jan 30.

PMID:
24486200
21.

A novel carotenoid, 4-keto-α-carotene, as an unexpected by-product during genetic engineering of carotenogenesis in rice callus.

Breitenbach J, Bai C, Rivera SM, Canela R, Capell T, Christou P, Zhu C, Sandmann G.

Phytochemistry. 2014 Feb;98:85-91. doi: 10.1016/j.phytochem.2013.12.008. Epub 2014 Jan 3.

PMID:
24393458
22.

Genetic engineering of the complete carotenoid pathway towards enhanced astaxanthin formation in Xanthophyllomyces dendrorhous starting from a high-yield mutant.

Gassel S, Breitenbach J, Sandmann G.

Appl Microbiol Biotechnol. 2014 Jan;98(1):345-50. doi: 10.1007/s00253-013-5358-z. Epub 2013 Nov 17.

PMID:
24241897
23.

Contribution of two ζ-carotene desaturases to the poly-cis desaturation pathway in the cyanobacterium Nostoc PCC 7120.

Breitenbach J, Bruns M, Sandmann G.

Arch Microbiol. 2013 Jul;195(7):491-8. doi: 10.1007/s00203-013-0899-1. Epub 2013 May 22.

PMID:
23695436
24.

Baculovirus replication induces the expression of heat shock proteins in vivo and in vitro.

Breitenbach JE, Popham HJ.

Arch Virol. 2013 Jul;158(7):1517-22. doi: 10.1007/s00705-013-1640-8. Epub 2013 Feb 27.

PMID:
23443933
25.

Gut Transcription in Helicoverpa zea is Dynamically Altered in Response to Baculovirus Infection.

Noland JE, Breitenbach JE, Popham HJ, Hum-Musser SM, Vogel H, Musser RO.

Insects. 2013 Sep 23;4(3):506-20. doi: 10.3390/insects4030506.

26.

Catalytic properties and reaction mechanism of the CrtO carotenoid ketolase from the cyanobacterium Synechocystis sp. PCC 6803.

Breitenbach J, Gerjets T, Sandmann G.

Arch Biochem Biophys. 2013 Jan 15;529(2):86-91. doi: 10.1016/j.abb.2012.11.003. Epub 2012 Dec 5.

PMID:
23220023
27.

Determination and analysis of the genome sequence of Spodoptera littoralis multiple nucleopolyhedrovirus.

Breitenbach JE, El-Sheikh el-SA, Harrison RL, Rowley DL, Sparks ME, Gundersen-Rindal DE, Popham HJ.

Virus Res. 2013 Jan;171(1):194-208. doi: 10.1016/j.virusres.2012.11.016. Epub 2012 Dec 5.

PMID:
23219924
28.

Biosynthesis of fucoxanthin and diadinoxanthin and function of initial pathway genes in Phaeodactylum tricornutum.

Dambek M, Eilers U, Breitenbach J, Steiger S, Büchel C, Sandmann G.

J Exp Bot. 2012 Sep;63(15):5607-12. doi: 10.1093/jxb/ers211. Epub 2012 Aug 9.

29.

Genetic variation and virulence of Autographa californica multiple nucleopolyhedrovirus and Trichoplusia ni single nucleopolyhedrovirus isolates.

Harrison RL, Popham HJ, Breitenbach JE, Rowley DL.

J Invertebr Pathol. 2012 May;110(1):33-47. doi: 10.1016/j.jip.2012.02.002. Epub 2012 Feb 14.

PMID:
22349146
30.

Carotenoid synthesis and phytoene synthase activity during mating of Blakeslea trispora.

Breitenbach J, Fraser PD, Sandmann G.

Phytochemistry. 2012 Apr;76:40-5. doi: 10.1016/j.phytochem.2011.12.017. Epub 2012 Jan 24.

PMID:
22281381
31.

Baculovirus induced transcripts in hemocytes from the larvae of Heliothis virescens.

Breitenbach JE, Shelby KS, Popham HJ.

Viruses. 2011 Nov;3(11):2047-64. doi: 10.3390/v3112047. Epub 2011 Oct 28. Review.

32.

Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.

Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE.

J Med Chem. 2011 Aug 25;54(16):5680-93. doi: 10.1021/jm2001426. Epub 2011 Aug 3.

33.

Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.

Peterson LW, Kim JS, Kijek P, Mitchell S, Hilfinger J, Breitenbach J, Borysko K, Drach JC, Kashemirov BA, McKenna CE.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4045-9. doi: 10.1016/j.bmcl.2011.04.126. Epub 2011 May 3.

34.

The UL4 protein of equine herpesvirus 1 is not essential for replication or pathogenesis and inhibits gene expression controlled by viral and heterologous promoters.

Charvat RA, Breitenbach JE, Ahn B, Zhang Y, O'Callaghan DJ.

Virology. 2011 Apr 10;412(2):366-77. doi: 10.1016/j.virol.2011.01.025. Epub 2011 Feb 15.

35.

Engineering of geranylgeranyl pyrophosphate synthase levels and physiological conditions for enhanced carotenoid and astaxanthin synthesis in Xanthophyllomyces dendrorhous.

Breitenbach J, Visser H, Verdoes JC, van Ooyen AJ, Sandmann G.

Biotechnol Lett. 2011 Apr;33(4):755-61. doi: 10.1007/s10529-010-0495-2. Epub 2010 Dec 17.

PMID:
21165672
36.

Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation.

Li Q, Farre G, Naqvi S, Breitenbach J, Sanahuja G, Bai C, Sandmann G, Capell T, Christou P, Zhu C.

Transgenic Res. 2010 Dec;19(6):1053-68. doi: 10.1007/s11248-010-9381-x. Epub 2010 Mar 11.

PMID:
20221689
37.

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways.

Naqvi S, Zhu C, Farre G, Ramessar K, Bassie L, Breitenbach J, Perez Conesa D, Ros G, Sandmann G, Capell T, Christou P.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7762-7. doi: 10.1073/pnas.0901412106. Epub 2009 Apr 27.

38.

Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium.

Strobel I, Breitenbach J, Scheckhuber CQ, Osiewacz HD, Sandmann G.

Curr Genet. 2009 Apr;55(2):175-84. doi: 10.1007/s00294-009-0235-0. Epub 2009 Mar 10.

PMID:
19277665
39.

Design and synthesis of vidarabine prodrugs as antiviral agents.

Shen W, Kim JS, Kish PE, Zhang J, Mitchell S, Gentry BG, Breitenbach JM, Drach JC, Hilfinger J.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):792-6. doi: 10.1016/j.bmcl.2008.12.031. Epub 2008 Dec 10.

40.

The IR4 auxiliary regulatory protein expands the in vitro host range of equine herpesvirus 1 and is essential for pathogenesis in the murine model.

Breitenbach JE, Ebner PD, O'Callaghan DJ.

Virology. 2009 Jan 20;383(2):188-94. doi: 10.1016/j.virol.2008.10.017. Epub 2008 Nov 13.

41.

Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize.

Zhu C, Naqvi S, Breitenbach J, Sandmann G, Christou P, Capell T.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18232-7. doi: 10.1073/pnas.0809737105. Epub 2008 Nov 14.

42.

Ethanol effects on drug release from Verapamil Meltrex, an innovative melt extruded formulation.

Roth W, Setnik B, Zietsch M, Burst A, Breitenbach J, Sellers E, Brennan D.

Int J Pharm. 2009 Feb 23;368(1-2):72-5. doi: 10.1016/j.ijpharm.2008.09.052. Epub 2008 Oct 15.

PMID:
18992310
43.

Structure, function and biosynthesis of carotenoids in the moderately halophilic bacterium Halobacillus halophilus.

Köcher S, Breitenbach J, Müller V, Sandmann G.

Arch Microbiol. 2009 Feb;191(2):95-104. doi: 10.1007/s00203-008-0431-1. Epub 2008 Sep 27.

PMID:
18820900
44.

Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity.

Eriksson U, Peterson LW, Kashemirov BA, Hilfinger JM, Drach JC, Borysko KZ, Breitenbach JM, Kim JS, Mitchell S, Kijek P, McKenna CE.

Mol Pharm. 2008 Jul-Aug;5(4):598-609. doi: 10.1021/mp8000099. Epub 2008 May 16.

45.

The predictive value of the sacral base pressure test in detecting specific types of sacroiliac dysfunction.

Mitchell TD, Urli KE, Breitenbach J, Yelverton C.

J Chiropr Med. 2007 Jun;6(2):45-55. doi: 10.1016/j.jcme.2007.04.003.

46.
47.

The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect.

Klein CE, Chiu YL, Awni W, Zhu T, Heuser RS, Doan T, Breitenbach J, Morris JB, Brun SC, Hanna GJ.

J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):401-10.

PMID:
17224848
48.

Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir.

Eriksson U, Hilfinger JM, Kim JS, Mitchell S, Kijek P, Borysko KZ, Breitenbach JM, Drach JC, Kashemirov BA, McKenna CE.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):583-6. Epub 2006 Nov 10.

49.

Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase.

Ojima K, Breitenbach J, Visser H, Setoguchi Y, Tabata K, Hoshino T, van den Berg J, Sandmann G.

Mol Genet Genomics. 2006 Feb;275(2):148-58. Epub 2006 Jan 17.

PMID:
16416328
50.

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL.

J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. Epub 2005 May 18.

PMID:
15901797

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