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Items: 23


GvmR - A Novel LysR-Type Transcriptional Regulator Involved in Virulence and Primary and Secondary Metabolism of Burkholderia pseudomallei.

Duong LT, Schwarz S, Gross H, Breitbach K, Hochgräfe F, Mostertz J, Eske-Pogodda K, Wagner GE, Steinmetz I, Kohler C.

Front Microbiol. 2018 May 16;9:935. doi: 10.3389/fmicb.2018.00935. eCollection 2018.


Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.

Bartel A, Göhler A, Hopf V, Breitbach K.

PLoS One. 2017 Jul 7;12(7):e0180203. doi: 10.1371/journal.pone.0180203. eCollection 2017.


NADPH Oxidase Contributes to Resistance against Aggregatibacter actinomycetemcomitans-Induced Periodontitis in Mice.

Bast A, Kubis H, Holtfreter B, Ribback S, Martin H, Schreiner HC, Dominik MJ, Breitbach K, Dombrowski F, Kocher T, Steinmetz I.

Infect Immun. 2017 Jan 26;85(2). pii: e00849-16. doi: 10.1128/IAI.00849-16. Print 2017 Feb.


Bone marrow-derived macrophages from BALB/c and C57BL/6 mice fundamentally differ in their respiratory chain complex proteins, lysosomal enzymes and components of antioxidant stress systems.

Depke M, Breitbach K, Dinh Hoang Dang K, Brinkmann L, Salazar MG, Dhople VM, Bast A, Steil L, Schmidt F, Steinmetz I, Völker U.

J Proteomics. 2014 May 30;103:72-86. doi: 10.1016/j.jprot.2014.03.027. Epub 2014 Apr 1.


Caspase-1-dependent and -independent cell death pathways in Burkholderia pseudomallei infection of macrophages.

Bast A, Krause K, Schmidt IH, Pudla M, Brakopp S, Hopf V, Breitbach K, Steinmetz I.

PLoS Pathog. 2014 Mar 13;10(3):e1003986. doi: 10.1371/journal.ppat.1003986. eCollection 2014 Mar.


BPSS1504, a cluster 1 type VI secretion gene, is involved in intracellular survival and virulence of Burkholderia pseudomallei.

Hopf V, Göhler A, Eske-Pogodda K, Bast A, Steinmetz I, Breitbach K.

Infect Immun. 2014 May;82(5):2006-15. doi: 10.1128/IAI.01544-14. Epub 2014 Mar 4.


Glyburide reduces bacterial dissemination in a mouse model of melioidosis.

Koh GC, Weehuizen TA, Breitbach K, Krause K, de Jong HK, Kager LM, Hoogendijk AJ, Bast A, Peacock SJ, van der Poll T, Steinmetz I, Wiersinga WJ.

PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2500. doi: 10.1371/journal.pntd.0002500. eCollection 2013.


High prevalence of extended-spectrum-β-lactamase-producing Enterobacteriaceae in organic and conventional retail chicken meat, Germany.

Kola A, Kohler C, Pfeifer Y, Schwab F, Kühn K, Schulz K, Balau V, Breitbach K, Bast A, Witte W, Gastmeier P, Steinmetz I.

J Antimicrob Chemother. 2012 Nov;67(11):2631-4. doi: 10.1093/jac/dks295. Epub 2012 Aug 6.


Defense Mechanisms of Hepatocytes Against Burkholderia pseudomallei.

Bast A, Schmidt IH, Brauner P, Brix B, Breitbach K, Steinmetz I.

Front Microbiol. 2012 Jan 10;2:277. doi: 10.3389/fmicb.2011.00277. eCollection 2011.


A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei.

Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I.

Microbiology. 2011 Sep;157(Pt 9):2629-38. doi: 10.1099/mic.0.049163-0. Epub 2011 Jun 16.


PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2.

Erttmann SF, Bast A, Seidel J, Breitbach K, Walther R, Steinmetz I.

Free Radic Biol Med. 2011 Aug 1;51(3):626-40. doi: 10.1016/j.freeradbiomed.2011.05.022. Epub 2011 May 27.


NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model.

Köhler J, Breitbach K, Renner C, Heitsch AK, Bast A, van Rooijen N, Vogelgesang S, Steinmetz I.

Microbes Infect. 2011 Oct;13(11):914-22. doi: 10.1016/j.micinf.2011.05.004. Epub 2011 May 27.


Distinct roles for nitric oxide in resistant C57BL/6 and susceptible BALB/c mice to control Burkholderia pseudomallei infection.

Breitbach K, Wongprompitak P, Steinmetz I.

BMC Immunol. 2011 Mar 16;12:20. doi: 10.1186/1471-2172-12-20.


Caspase-1 mediates resistance in murine melioidosis.

Breitbach K, Sun GW, Köhler J, Eske K, Wongprompitak P, Tan G, Liu Y, Gan YH, Steinmetz I.

Infect Immun. 2009 Apr;77(4):1589-95. doi: 10.1128/IAI.01257-08. Epub 2009 Jan 29.


Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle.

Breitbach K, Köhler J, Steinmetz I.

Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S89-94. doi: 10.1016/S0035-9203(08)70022-1.


Clinical and microbiological features of melioidosis in northern Vietnam.

Phuong DM, Trung TT, Breitbach K, Tuan NQ, Nübel U, Flunker G, Khang DD, Quang NX, Steinmetz I.

Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S30-6. doi: 10.1016/S0035-9203(08)70009-9.


Generation of murine bone marrow derived macrophages in a standardised serum-free cell culture system.

Eske K, Breitbach K, Köhler J, Wongprompitak P, Steinmetz I.

J Immunol Methods. 2009 Mar 15;342(1-2):13-9. doi: 10.1016/j.jim.2008.11.011. Epub 2009 Jan 6.


Detrimental role of CC chemokine receptor 4 in murine polymicrobial sepsis.

Traeger T, Kessler W, Assfalg V, Cziupka K, Koerner P, Dassow C, Breitbach K, Mikulcak M, Steinmetz I, Pfeffer K, Heidecke CD, Maier S.

Infect Immun. 2008 Nov;76(11):5285-93. doi: 10.1128/IAI.00310-08. Epub 2008 Sep 2.


Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice.

Breitbach K, Klocke S, Tschernig T, van Rooijen N, Baumann U, Steinmetz I.

Infect Immun. 2006 Nov;74(11):6300-9. Epub 2006 Sep 25.


Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence.

Pilatz S, Breitbach K, Hein N, Fehlhaber B, Schulze J, Brenneke B, Eberl L, Steinmetz I.

Infect Immun. 2006 Jun;74(6):3576-86.


In vitro and in vivo evaluation of WK-X-34, a novel inhibitor of P-glycoprotein and BCRP, using radio imaging techniques.

Jekerle V, Klinkhammer W, Scollard DA, Breitbach K, Reilly RM, Piquette-Miller M, Wiese M.

Int J Cancer. 2006 Jul 15;119(2):414-22.


Actin-based motility of Burkholderia pseudomallei involves the Arp 2/3 complex, but not N-WASP and Ena/VASP proteins.

Breitbach K, Rottner K, Klocke S, Rohde M, Jenzora A, Wehland J, Steinmetz I.

Cell Microbiol. 2003 Jun;5(6):385-93.


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