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MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury.

Hassanpour Golakani M, Mohammad MG, Li H, Gamble J, Breit SN, Ruitenberg MJ, Brown DA.

J Neurotrauma. 2019 Dec 15;36(24):3410-3421. doi: 10.1089/neu.2019.6421. Epub 2019 Aug 1.


GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.

Tsai VW, Zhang HP, Manandhar R, Schofield P, Christ D, Lee-Ng KKM, Lebhar H, Marquis CP, Husaini Y, Brown DA, Breit SN.

Int J Obes (Lond). 2019 Dec;43(12):2370-2380. doi: 10.1038/s41366-019-0365-5. Epub 2019 May 31.


Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes.

Tsai VW, Brown DA, Breit SN.

Curr Opin Support Palliat Care. 2018 Dec;12(4):404-409. doi: 10.1097/SPC.0000000000000384. Review.


The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.

Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN.

Cell Metab. 2018 Sep 4;28(3):353-368. doi: 10.1016/j.cmet.2018.07.018. Review.


A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood.

Jiang J, Thalamuthu A, Ho JE, Mahajan A, Ek WE, Brown DA, Breit SN, Wang TJ, Gyllensten U, Chen MH, Enroth S, Januzzi JL Jr, Lind L, Armstrong NJ, Kwok JB, Schofield PR, Wen W, Trollor JN, Johansson Å, Morris AP, Vasan RS, Sachdev PS, Mather KA.

Front Genet. 2018 Mar 23;9:97. doi: 10.3389/fgene.2018.00097. eCollection 2018.


Targeting Obesity and Cachexia: Identification of the GFRAL Receptor-MIC-1/GDF15 Pathway.

Breit SN, Tsai VW, Brown DA.

Trends Mol Med. 2017 Dec;23(12):1065-1067. doi: 10.1016/j.molmed.2017.10.005. Epub 2017 Nov 9.


Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.

Tsai VW, Zhang HP, Manandhar R, Lee-Ng KKM, Lebhar H, Marquis CP, Husaini Y, Sainsbury A, Brown DA, Breit SN.

Int J Obes (Lond). 2018 Mar;42(3):561-571. doi: 10.1038/ijo.2017.258. Epub 2017 Dec 5.


Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia.

Danta M, Barber DA, Zhang HP, Lee-Ng M, Baumgart SWL, Tsai VWW, Husaini Y, Saxena M, Marquis CP, Errington W, Kerr S, Breit SN, Brown DA.

Aliment Pharmacol Ther. 2017 Aug;46(3):347-354. doi: 10.1111/apt.14156. Epub 2017 Jun 1.


First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15.

Low JK, Ambikairajah A, Shang K, Brown DA, Tsai VW, Breit SN, Karl T.

PLoS One. 2017 Jan 12;12(1):e0168416. doi: 10.1371/journal.pone.0168416. eCollection 2017.


Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15.

Borner T, Arnold M, Ruud J, Breit SN, Langhans W, Lutz TA, Blomqvist A, Riediger T.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):417-427. doi: 10.1002/jcsm.12169. Epub 2016 Dec 26.


Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study.

Hare JE, Goodchild SC, Breit SN, Curmi PM, Brown LJ.

Biochemistry. 2016 Jul 12;55(27):3825-33. doi: 10.1021/acs.biochem.6b00080. Epub 2016 Jun 29.


CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.

Salao K, Jiang L, Li H, Tsai VW, Husaini Y, Curmi PM, Brown LJ, Brown DA, Breit SN.

Biol Open. 2016 May 15;5(5):620-30. doi: 10.1242/bio.018119.


Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15.

Tsai VW, Lin S, Brown DA, Salis A, Breit SN.

Int J Obes (Lond). 2016 Feb;40(2):193-7. doi: 10.1038/ijo.2015.242. Epub 2015 Dec 1. Review.


Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay.

Sasson SC, McGill K, Wienholt L, Carr A, Brown DA, Kelleher AD, Breit SN, Sewell WA.

Pathology. 2015 Oct;47(6):564-9. doi: 10.1097/PAT.0000000000000316.


An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals.

Jiang J, Trollor JN, Brown DA, Crawford JD, Thalamuthu A, Smith E, Breit SN, Liu T, Brodaty H, Baune BT, Sachdev PS, Wen W.

Psychoneuroendocrinology. 2015 Dec;62:80-8. doi: 10.1016/j.psyneuen.2015.07.610. Epub 2015 Jul 29.


Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

Tsai VW, Macia L, Feinle-Bisset C, Manandhar R, Astrup A, Raben A, Lorenzen JK, Schmidt PT, Wiklund F, Pedersen NL, Campbell L, Kriketos A, Xu A, Pengcheng Z, Jia W, Curmi PM, Angstmann CN, Lee-Ng KK, Zhang HP, Marquis CP, Husaini Y, Beglinger C, Lin S, Herzog H, Brown DA, Sainsbury A, Breit SN.

PLoS One. 2015 Jul 24;10(7):e0133362. doi: 10.1371/journal.pone.0133362. eCollection 2015.


The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.

Jiang J, Wen W, Brown DA, Crawford J, Thalamuthu A, Smith E, Breit SN, Liu T, Zhu W, Brodaty H, Baune BT, Trollor JN, Sachdev PS.

PLoS One. 2015 Apr 13;10(4):e0123399. doi: 10.1371/journal.pone.0123399. eCollection 2015.


MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma.

Fisher OM, Levert-Mignon AJ, Lord SJ, Lee-Ng KK, Botelho NK, Falkenback D, Thomas ML, Bobryshev YV, Whiteman DC, Brown DA, Breit SN, Lord RV.

Br J Cancer. 2015 Apr 14;112(8):1384-91. doi: 10.1038/bjc.2015.100. Epub 2015 Mar 17.


Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer.

Mahon KL, Lin HM, Castillo L, Lee BY, Lee-Ng M, Chatfield MD, Chiam K, Breit SN, Brown DA, Molloy MP, Marx GM, Pavlakis N, Boyer MJ, Stockler MR, Daly RJ, Henshall SM, Horvath LG.

Br J Cancer. 2015 Apr 14;112(8):1340-8. doi: 10.1038/bjc.2015.74. Epub 2015 Mar 31.


Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice.

Husaini Y, Lockwood GP, Nguyen TV, Tsai VW, Mohammad MG, Russell PJ, Brown DA, Breit SN.

PLoS One. 2015 Feb 19;10(2):e0115189. doi: 10.1371/journal.pone.0115189. eCollection 2015.


The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

Tsai VW, Manandhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Marquis CP, Jiang L, Husaini Y, Lin S, Sainsbury A, Sawchenko PE, Brown DA, Breit SN.

PLoS One. 2014 Jun 27;9(6):e100370. doi: 10.1371/journal.pone.0100370. eCollection 2014.


Immune cell trafficking from the brain maintains CNS immune tolerance.

Mohammad MG, Tsai VW, Ruitenberg MJ, Hassanpour M, Li H, Hart PH, Breit SN, Sawchenko PE, Brown DA.

J Clin Invest. 2014 Mar;124(3):1228-41. doi: 10.1172/JCI71544. Epub 2014 Feb 24.


Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical properties.

Averaimo S, Abeti R, Savalli N, Brown LJ, Curmi PM, Breit SN, Mazzanti M.

PLoS One. 2013 Sep 18;8(9):e74523. doi: 10.1371/journal.pone.0074523. eCollection 2013.


Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney Memory and Aging Study.

Fuchs T, Trollor JN, Crawford J, Brown DA, Baune BT, Samaras K, Campbell L, Breit SN, Brodaty H, Sachdev P, Smith E.

Aging Cell. 2013 Oct;12(5):882-9. doi: 10.1111/acel.12116. Epub 2013 Jul 19.


CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: a smoking gun?

Jiang L, Phang JM, Yu J, Harrop SJ, Sokolova AV, Duff AP, Wilk KE, Alkhamici H, Breit SN, Valenzuela SM, Brown LJ, Curmi PM.

Biochim Biophys Acta. 2014 Feb;1838(2):643-57. doi: 10.1016/j.bbamem.2013.05.025. Epub 2013 Jun 1. Review.


TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

Tsai VW, Macia L, Johnen H, Kuffner T, Manadhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Wu L, Marquis CP, Jiang L, Husaini Y, Lin S, Herzog H, Brown DA, Sainsbury A, Breit SN.

PLoS One. 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28.


Dendritic cells and multiple sclerosis: disease, tolerance and therapy.

Mohammad MG, Hassanpour M, Tsai VW, Li H, Ruitenberg MJ, Booth DW, Serrats J, Hart PH, Symonds GP, Sawchenko PE, Breit SN, Brown DA.

Int J Mol Sci. 2012 Dec 27;14(1):547-62. doi: 10.3390/ijms14010547. Review.


Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

Jiang L, Salao K, Li H, Rybicka JM, Yates RM, Luo XW, Shi XX, Kuffner T, Tsai VW, Husaini Y, Wu L, Brown DA, Grewal T, Brown LJ, Curmi PM, Breit SN.

J Cell Sci. 2012 Nov 15;125(Pt 22):5479-88. doi: 10.1242/jcs.110072. Epub 2012 Sep 6.


Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

Husaini Y, Qiu MR, Lockwood GP, Luo XW, Shang P, Kuffner T, Tsai VW, Jiang L, Russell PJ, Brown DA, Breit SN.

PLoS One. 2012;7(8):e43833. doi: 10.1371/journal.pone.0043833. Epub 2012 Aug 27.


Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.

Tsai VW, Husaini Y, Manandhar R, Lee-Ng KK, Zhang HP, Harriott K, Jiang L, Lin S, Sainsbury A, Brown DA, Breit SN.

J Cachexia Sarcopenia Muscle. 2012 Dec;3(4):239-43. doi: 10.1007/s13539-012-0082-6. Epub 2012 Aug 31.


Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.

Macia L, Tsai VW, Nguyen AD, Johnen H, Kuffner T, Shi YC, Lin S, Herzog H, Brown DA, Breit SN, Sainsbury A.

PLoS One. 2012;7(4):e34868. doi: 10.1371/journal.pone.0034868. Epub 2012 Apr 13.


Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis.

Johnen H, Kuffner T, Brown DA, Wu BJ, Stocker R, Breit SN.

Cardiovasc Pathol. 2012 Nov-Dec;21(6):499-505. doi: 10.1016/j.carpath.2012.02.003. Epub 2012 Mar 2.


Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer?

Brown DA, Hance KW, Rogers CJ, Sansbury LB, Albert PS, Murphy G, Laiyemo AO, Wang Z, Cross AJ, Schatzkin A, Danta M, Srasuebkul P, Amin J, Law M, Breit SN, Lanza E.

Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):337-46. doi: 10.1158/1055-9965.EPI-11-0786. Epub 2011 Dec 5.


CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease.

Tsai VW, Mohammad MG, Tolhurst O, Breit SN, Sawchenko PE, Brown DA.

J Neurosci. 2011 Nov 30;31(48):17612-21. doi: 10.1523/JNEUROSCI.3449-11.2011.


Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction.

Goodchild SC, Angstmann CN, Breit SN, Curmi PM, Brown LJ.

Biochemistry. 2011 Dec 20;50(50):10887-97. doi: 10.1021/bi2012564. Epub 2011 Nov 18.


Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

Breit SN, Carrero JJ, Tsai VW, Yagoutifam N, Luo W, Kuffner T, Bauskin AR, Wu L, Jiang L, Barany P, Heimburger O, Murikami MA, Apple FS, Marquis CP, Macia L, Lin S, Sainsbury A, Herzog H, Law M, Stenvinkel P, Brown DA.

Nephrol Dial Transplant. 2012 Jan;27(1):70-5. doi: 10.1093/ndt/gfr575. Epub 2011 Sep 22.


The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

Breit SN, Johnen H, Cook AD, Tsai VW, Mohammad MG, Kuffner T, Zhang HP, Marquis CP, Jiang L, Lockwood G, Lee-Ng M, Husaini Y, Wu L, Hamilton JA, Brown DA.

Growth Factors. 2011 Oct;29(5):187-95. doi: 10.3109/08977194.2011.607137. Epub 2011 Aug 11.


Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4.

Mynott AV, Harrop SJ, Brown LJ, Breit SN, Kobe B, Curmi PM.

FEBS J. 2011 May;278(10):1662-75. doi: 10.1111/j.1742-4658.2011.08086.x. Epub 2011 Mar 30.


Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality.

Wiklund FE, Bennet AM, Magnusson PK, Eriksson UK, Lindmark F, Wu L, Yaghoutyfam N, Marquis CP, Stattin P, Pedersen NL, Adami HO, Grönberg H, Breit SN, Brown DA.

Aging Cell. 2010 Dec;9(6):1057-64. doi: 10.1111/j.1474-9726.2010.00629.x. Epub 2010 Oct 21.


GDF-15 contributes to proliferation and immune escape of malignant gliomas.

Roth P, Junker M, Tritschler I, Mittelbronn M, Dombrowski Y, Breit SN, Tabatabai G, Wick W, Weller M, Wischhusen J.

Clin Cancer Res. 2010 Aug 1;16(15):3851-9. doi: 10.1158/1078-0432.CCR-10-0705. Epub 2010 Jun 9.


Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction.

Goodchild SC, Howell MW, Littler DR, Mandyam RA, Sale KL, Mazzanti M, Breit SN, Curmi PM, Brown LJ.

Biochemistry. 2010 Jun 29;49(25):5278-89. doi: 10.1021/bi100111c.


The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.

Bauskin AR, Jiang L, Luo XW, Wu L, Brown DA, Breit SN.

J Interferon Cytokine Res. 2010 Jun;30(6):389-97. doi: 10.1089/jir.2009.0052.


Structure of human CLIC3 at 2 A resolution.

Littler DR, Brown LJ, Breit SN, Perrakis A, Curmi PM.

Proteins. 2010 May 1;78(6):1594-600. doi: 10.1002/prot.22675. No abstract available.


Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.

Skipworth RJ, Deans DA, Tan BH, Sangster K, Paterson-Brown S, Brown DA, Hunter M, Breit SN, Ross JA, Fearon KC.

Br J Cancer. 2010 Feb 16;102(4):665-72. doi: 10.1038/sj.bjc.6605532. Epub 2010 Jan 26.


The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?

Littler DR, Harrop SJ, Goodchild SC, Phang JM, Mynott AV, Jiang L, Valenzuela SM, Mazzanti M, Brown LJ, Breit SN, Curmi PM.

FEBS Lett. 2010 May 17;584(10):2093-101. doi: 10.1016/j.febslet.2010.01.027. Epub 2010 Jan 19. Review.


Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Qiu MR, Jiang L, Matthaei KI, Schoenwaelder SM, Kuffner T, Mangin P, Joseph JE, Low J, Connor D, Valenzuela SM, Curmi PM, Brown LJ, Mahaut-Smith M, Jackson SP, Breit SN.

Genesis. 2010 Feb;48(2):127-36. doi: 10.1002/dvg.20590. Erratum in: Genesis. 2010 May;48(5):351.


Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer.

Brown DA, Lindmark F, Stattin P, Bälter K, Adami HO, Zheng SL, Xu J, Isaacs WB, Grönberg H, Breit SN, Wiklund FE.

Clin Cancer Res. 2009 Nov 1;15(21):6658-64. doi: 10.1158/1078-0432.CCR-08-3126. Epub 2009 Oct 20.


Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling.

Zhao L, Lee BY, Brown DA, Molloy MP, Marx GM, Pavlakis N, Boyer MJ, Stockler MR, Kaplan W, Breit SN, Sutherland RL, Henshall SM, Horvath LG.

Cancer Res. 2009 Oct 1;69(19):7696-703. doi: 10.1158/0008-5472.CAN-08-4901. Epub 2009 Sep 22.


High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40).

Zaunders JJ, Munier ML, Seddiki N, Pett S, Ip S, Bailey M, Xu Y, Brown K, Dyer WB, Kim M, de Rose R, Kent SJ, Jiang L, Breit SN, Emery S, Cunningham AL, Cooper DA, Kelleher AD.

J Immunol. 2009 Aug 15;183(4):2827-36. doi: 10.4049/jimmunol.0803548. Epub 2009 Jul 27.


Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome.

Shnaper S, Desbaillets I, Brown DA, Murat A, Migliavacca E, Schluep M, Ostermann S, Hamou MF, Stupp R, Breit SN, de Tribolet N, Hegi ME.

Int J Cancer. 2009 Dec 1;125(11):2624-30. doi: 10.1002/ijc.24639.

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