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Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface.

Tsoutsoulopoulos A, Gohlsch K, Möhle N, Breit A, Hoffmann S, Krischenowski O, Mückter H, Gudermann T, Thiermann H, Aufderheide M, Steinritz D.

J Vis Exp. 2020 Feb 23;(156). doi: 10.3791/60572.


Exposure of 19 substances to lung A549 cells at the air liquid interface or under submerged conditions reveals high correlation between cytotoxicity in vitro and CLP classifications for acute lung toxicity.

Gohlsch K, Mückter H, Steinritz D, Aufderheide M, Hoffmann S, Gudermann T, Breit A.

Toxicol Lett. 2019 Nov;316:119-126. doi: 10.1016/j.toxlet.2019.09.014. Epub 2019 Sep 17.


Validation of the CULTEX® Radial Flow System for the assessment of the acute inhalation toxicity of airborne particles.

Tsoutsoulopoulos A, Gohlsch K, Möhle N, Breit A, Hoffmann S, Krischenowski O, Mückter H, Gudermann T, Thiermann H, Aufderheide M, Steinritz D.

Toxicol In Vitro. 2019 Aug;58:245-255. doi: 10.1016/j.tiv.2019.03.020. Epub 2019 Mar 16.


TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival.

Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E, Gudermann T, Chubanov V.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4706-4715. doi: 10.1073/pnas.1810633116. Epub 2019 Feb 15.


Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3β signaling.

Breit A, Miek L, Schredelseker J, Geibel M, Merrow M, Gudermann T.

J Biol Chem. 2018 Nov 2;293(44):17278-17290. doi: 10.1074/jbc.RA118.004429. Epub 2018 Sep 14.


Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.

Schweitzer MK, Wilting F, Sedej S, Dreizehnter L, Dupper NJ, Tian Q, Moretti A, My I, Kwon O, Priori SG, Laugwitz KL, Storch U, Lipp P, Breit A, Mederos Y Schnitzler M, Gudermann T, Schredelseker J.

JACC Basic Transl Sci. 2017 Dec;2(6):737-747. doi: 10.1016/j.jacbts.2017.06.008. Epub 2017 Nov 8.


Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression.

Glas E, Mückter H, Gudermann T, Breit A.

Sci Rep. 2016 Sep 9;6:32776. doi: 10.1038/srep32776.


Endogenous 5-HT2C Receptors Phosphorylate the cAMP Response Element Binding Protein via Protein Kinase C-Promoted Activation of Extracellular-Regulated Kinases-1/2 in Hypothalamic mHypoA-2/10 Cells.

Lauffer L, Glas E, Gudermann T, Breit A.

J Pharmacol Exp Ther. 2016 Jul;358(1):39-49. doi: 10.1124/jpet.116.232397. Epub 2016 Apr 26.


Glucose Enhances Basal or Melanocortin-Induced cAMP-Response Element Activity in Hypothalamic Cells.

Breit A, Wicht K, Boekhoff I, Glas E, Lauffer L, Mückter H, Gudermann T.

Mol Endocrinol. 2016 Jul;30(7):748-62. doi: 10.1210/me.2016-1001. Epub 2016 May 4.


The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.

Borth H, Weber N, Meyer D, Wartenberg A, Arlt E, Zierler S, Breit A, Wennemuth G, Gudermann T, Boekhoff I.

J Cell Physiol. 2016 May;231(5):1114-29. doi: 10.1002/jcp.25209. Epub 2015 Nov 16.


Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.

Breit A, Besik V, Solinski HJ, Muehlich S, Glas E, Yarwood SJ, Gudermann T.

Mol Endocrinol. 2015 Mar;29(3):445-59. doi: 10.1210/me.2014-1300. Epub 2015 Jan 13.


RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

Weber N, Vieweg L, Henze F, Oprisoreanu AM, Solinski HJ, Breit A, Fecher-Trost C, Schalkowsky P, Wilhelm B, Wennemuth G, Schoch S, Gudermann T, Boekhoff I.

J Mol Cell Biol. 2014 Oct;6(5):434-7. doi: 10.1093/jmcb/mju037. Epub 2014 Sep 19. No abstract available.


Pharmacology and signaling of MAS-related G protein-coupled receptors.

Solinski HJ, Gudermann T, Breit A.

Pharmacol Rev. 2014 Jul;66(3):570-97. doi: 10.1124/pr.113.008425. Review.


Adducin is required for desmosomal cohesion in keratinocytes.

Rötzer V, Breit A, Waschke J, Spindler V.

J Biol Chem. 2014 May 23;289(21):14925-40. doi: 10.1074/jbc.M113.527127. Epub 2014 Apr 7.


Wnt5a/β-catenin signaling drives calcium-induced differentiation of human primary keratinocytes.

Popp T, Steinritz D, Breit A, Deppe J, Egea V, Schmidt A, Gudermann T, Weber C, Ries C.

J Invest Dermatol. 2014 Aug;134(8):2183-2191. doi: 10.1038/jid.2014.149. Epub 2014 Mar 21.


NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I.

Mol Biol Cell. 2014 Mar;25(6):948-64. doi: 10.1091/mbc.E13-09-0523. Epub 2014 Jan 22.


Optical control of TRPV1 channels.

Stein M, Breit A, Fehrentz T, Gudermann T, Trauner D.

Angew Chem Int Ed Engl. 2013 Sep 9;52(37):9845-8. doi: 10.1002/anie.201302530. Epub 2013 Jul 19. No abstract available.


TSH induces metallothionein 1 in thyrocytes via Gq/11- and PKC-dependent signaling.

Bäck CM, Stohr S, Schäfer EA, Biebermann H, Boekhoff I, Breit A, Gudermann T, Büch TR.

J Mol Endocrinol. 2013 Jun 4;51(1):79-90. doi: 10.1530/JME-12-0200. Print 2013.


Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line.

Solinski HJ, Petermann F, Rothe K, Boekhoff I, Gudermann T, Breit A.

PLoS One. 2013;8(3):e58756. doi: 10.1371/journal.pone.0058756. Epub 2013 Mar 7.


Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.

Solinski HJ, Zierler S, Gudermann T, Breit A.

J Biol Chem. 2012 Nov 30;287(49):40956-71. doi: 10.1074/jbc.M112.408617. Epub 2012 Oct 16.


Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.

Rothe K, Solinski HJ, Boekhoff I, Gudermann T, Breit A.

J Pharmacol Exp Ther. 2012 Jul;342(1):41-52. doi: 10.1124/jpet.112.192757. Epub 2012 Mar 27.


Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.

Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, Marschall S, de Angelis MH, Boehm U, Meyerhof W, Gudermann T, Boekhoff I.

PLoS One. 2012;7(2):e32354. doi: 10.1371/journal.pone.0032354. Epub 2012 Feb 29.


Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells.

Damm E, Buech TR, Gudermann T, Breit A.

Mol Endocrinol. 2012 Apr;26(4):643-54. doi: 10.1210/me.2011-1218. Epub 2012 Feb 23.


The "acrosomal synapse": Subcellular organization by lipid rafts and scaffolding proteins exhibits high similarities in neurons and mammalian spermatozoa.

Zitranski N, Borth H, Ackermann F, Meyer D, Vieweg L, Breit A, Gudermann T, Boekhoff I.

Commun Integr Biol. 2010 Nov;3(6):513-21. doi: 10.4161/cib.3.6.13137. Epub 2010 Nov 1.


Alternative G protein coupling and biased agonism: new insights into melanocortin-4 receptor signalling.

Breit A, Büch TR, Boekhoff I, Solinski HJ, Damm E, Gudermann T.

Mol Cell Endocrinol. 2011 Jan 15;331(2):232-40. doi: 10.1016/j.mce.2010.07.007. Epub 2010 Jul 30. Review.


Sensory neuron-specific MAS-related gene-X1 receptors resist agonist-promoted endocytosis.

Solinski HJ, Boekhoff I, Bouvier M, Gudermann T, Breit A.

Mol Pharmacol. 2010 Aug;78(2):249-59. doi: 10.1124/mol.110.063867. Epub 2010 Apr 27.


Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.

Büch TR, Heling D, Damm E, Gudermann T, Breit A.

J Biol Chem. 2009 Sep 25;284(39):26411-20. doi: 10.1074/jbc.M109.039339. Epub 2009 Jul 31.


Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction.

Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, Gollasch M, Gudermann T.

EMBO J. 2008 Dec 3;27(23):3092-103. doi: 10.1038/emboj.2008.233. Epub 2008 Nov 6.


Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction.

Pontier SM, Percherancier Y, Galandrin S, Breit A, Galés C, Bouvier M.

J Biol Chem. 2008 Sep 5;283(36):24659-72. doi: 10.1074/jbc.M800778200. Epub 2008 Jun 19.


G13-dependent activation of MAPK by thyrotropin.

Büch TR, Biebermann H, Kalwa H, Pinkenburg O, Hager D, Barth H, Aktories K, Breit A, Gudermann T.

J Biol Chem. 2008 Jul 18;283(29):20330-41. doi: 10.1074/jbc.M800211200. Epub 2008 Apr 29.


A conformational contribution of the luteinizing hormone-receptor ectodomain to receptor activation.

Nurwakagari P, Breit A, Hess C, Salman-Livny H, Ben-Menahem D, Gudermann T.

J Mol Endocrinol. 2007 Feb;38(1-2):259-75.


The natural inverse agonist agouti-related protein induces arrestin-mediated endocytosis of melanocortin-3 and -4 receptors.

Breit A, Wolff K, Kalwa H, Jarry H, Büch T, Gudermann T.

J Biol Chem. 2006 Dec 8;281(49):37447-56. Epub 2006 Oct 14.


Real-time monitoring of receptor and G-protein interactions in living cells.

Galés C, Rebois RV, Hogue M, Trieu P, Breit A, Hébert TE, Bouvier M.

Nat Methods. 2005 Mar;2(3):177-84. Epub 2005 Feb 17.


Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin.

Schroeder C, Breit A, Böning H, Dedio J, Gera L, Stewart J, Müller-Esterl W.

Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1924-32. Epub 2003 Feb 6.


Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis.

Terrillon S, Durroux T, Mouillac B, Breit A, Ayoub MA, Taulan M, Jockers R, Barberis C, Bouvier M.

Mol Endocrinol. 2003 Apr;17(4):677-91. Epub 2002 Dec 23.


Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer.

Mercier JF, Salahpour A, Angers S, Breit A, Bouvier M.

J Biol Chem. 2002 Nov 22;277(47):44925-31. Epub 2002 Sep 19.


Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.

Lavoie C, Mercier JF, Salahpour A, Umapathy D, Breit A, Villeneuve LR, Zhu WZ, Xiao RP, Lakatta EG, Bouvier M, Hébert TE.

J Biol Chem. 2002 Sep 20;277(38):35402-10. Epub 2002 Jul 24.


Coupling of endothelin receptors to the ERK/MAP kinase pathway. Roles of palmitoylation and G(alpha)q.

Cramer H, Schmenger K, Heinrich K, Horstmeyer A, Böning H, Breit A, Piiper A, Lundstrom K, Müller-Esterl W, Schroeder C.

Eur J Biochem. 2001 Oct;268(20):5449-59.


Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I.

J Biol Chem. 2001 Nov 2;276(44):40431-40. Epub 2001 Aug 21.


[Experiences with an over 8-year MR and 15-year CT cooperation from general practice of the Passau clinic].

Breit A, Braitinger S, Kett H, Genzel H.

Rontgenpraxis. 1995 Mar;48(3):65-71. German. No abstract available.


Delayed myelination in children with West syndrome: an MRI-study.

Schropp C, Staudt M, Staudt F, Bise K, Obletter N, Breit A, Weinmann HM.

Neuropediatrics. 1994 Jun;25(3):116-20.


MRI assessment of myelination: an age standardization.

Staudt M, Schropp C, Staudt F, Obletter N, Bise K, Breit A, Weinmann HM.

Pediatr Radiol. 1994;24(2):122-7.


[CT and MRI in tumors of the mouth and oropharynx--comparison of methods with reference to fast and ultra-fast MR pulse sequences].

Held P, Langnickel R, Breit A.

Laryngorhinootologie. 1993 Nov;72(11):521-31. German.


Myelination of the brain in MRI: a staging system.

Staudt M, Schropp C, Staudt F, Obletter N, Bise K, Breit A.

Pediatr Radiol. 1993;23(3):169-76.


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