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Items: 34

1.

Analysis of Yeast Killer Toxin K1 Precursor Processing via Site-Directed Mutagenesis: Implications for Toxicity and Immunity.

Gier S, Schmitt MJ, Breinig F.

mSphere. 2020 Feb 12;5(1). pii: e00979-19. doi: 10.1128/mSphere.00979-19.

2.

Yeast Viral Killer Toxin K1 Induces Specific Host Cell Adaptions via Intrinsic Selection Pressure.

Gier S, Simon M, Gasparoni G, Khalifa S, Schulz MH, Schmitt MJ, Breinig F.

Appl Environ Microbiol. 2020 Feb 3;86(4). pii: e02446-19. doi: 10.1128/AEM.02446-19. Print 2020 Feb 3.

PMID:
31811035
3.

Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae.

Kiefer R, Jurisic M, Dahlem C, Koch M, Schmitt MJ, Kiemer AK, Schneider M, Breinig F.

Biotechnol Bioeng. 2020 Mar;117(3):776-788. doi: 10.1002/bit.27226. Epub 2019 Nov 28.

PMID:
31736060
4.

Substitution of cysteines in the yeast viral killer toxin K1 precursor reveals novel insights in heterodimer formation and immunity.

Gier S, Lermen M, Schmitt MJ, Breinig F.

Sci Rep. 2019 Sep 11;9(1):13127. doi: 10.1038/s41598-019-49621-z.

5.

Transcriptome Kinetics of Saccharomyces cerevisiae in Response to Viral Killer Toxin K1.

Gier S, Simon M, Nordström K, Khalifa S, Schulz MH, Schmitt MJ, Breinig F.

Front Microbiol. 2019 May 16;10:1102. doi: 10.3389/fmicb.2019.01102. eCollection 2019.

6.

Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.

Humaidan D, Breinig F, Helms V.

PLoS One. 2018 Dec 4;13(12):e0208515. doi: 10.1371/journal.pone.0208515. eCollection 2018.

7.

Maturation and cytokine pattern of human dendritic cells in response to different yeasts.

Bazan SB, Walch-Rückheim B, Schmitt MJ, Breinig F.

Med Microbiol Immunol. 2018 Feb;207(1):75-81. doi: 10.1007/s00430-017-0528-8. Epub 2017 Nov 21.

PMID:
29164392
9.

Primary T cells for mRNA-mediated immunotoxin delivery.

Eggers R, Philippi A, Altmeyer MO, Breinig F, Schmitt MJ.

Gene Ther. 2018 Jan;25(1):47-53. doi: 10.1038/gt.2017.87. Epub 2017 Sep 22.

PMID:
28937681
10.

Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype.

Seif M, Hoppstädter J, Breinig F, Kiemer AK.

Eur J Pharm Biopharm. 2017 Aug;117:1-13. doi: 10.1016/j.ejpb.2017.03.008. Epub 2017 Mar 18.

PMID:
28323110
11.

H/KDEL receptors mediate host cell intoxication by a viral A/B toxin in yeast.

Becker B, Blum A, Gießelmann E, Dausend J, Rammo D, Müller NC, Tschacksch E, Steimer M, Spindler J, Becherer U, Rettig J, Breinig F, Schmitt MJ.

Sci Rep. 2016 Aug 5;6:31105. doi: 10.1038/srep31105.

12.

Yeast (Saccharomyces cerevisiae) Polarizes Both M-CSF- and GM-CSF-Differentiated Macrophages Toward an M1-Like Phenotype.

Seif M, Philippi A, Breinig F, Kiemer AK, Hoppstädter J.

Inflammation. 2016 Oct;39(5):1690-703. doi: 10.1007/s10753-016-0404-5.

PMID:
27422006
13.

Surface-modified yeast cells: A novel eukaryotic carrier for oral application.

Kenngott EE, Kiefer R, Schneider-Daum N, Hamann A, Schneider M, Schmitt MJ, Breinig F.

J Control Release. 2016 Feb 28;224:1-7. doi: 10.1016/j.jconrel.2015.12.054. Epub 2016 Jan 5.

PMID:
26763373
14.

Coexpression of human perforin improves yeast-mediated delivery of DNA and mRNA to mammalian antigen-presenting cells.

Walch-Rückheim B, Kiefer R, Geginat G, Schmitt MJ, Breinig F.

Gene Ther. 2016 Jan;23(1):103-7. doi: 10.1038/gt.2015.77. Epub 2015 Aug 20.

PMID:
26289665
15.

Schizosaccharomyces pombe: a novel transport vehicle of functional DNA and mRNA into mammalian antigen-presenting cells.

Walch-Rückheim B, Schmitt MJ, Breinig F.

Vaccine. 2014 Oct 21;32(46):6029-33. doi: 10.1016/j.vaccine.2014.09.011. Epub 2014 Sep 17.

PMID:
25239486
16.

Heat treatment improves antigen-specific T cell activation after protein delivery by several but not all yeast genera.

Bazan SB, Breinig T, Schmitt MJ, Breinig F.

Vaccine. 2014 May 7;32(22):2591-8. doi: 10.1016/j.vaccine.2014.03.043. Epub 2014 Mar 24.

PMID:
24674665
17.

mRNA delivery to human dendritic cells by recombinant yeast and activation of antigen-specific memory T cells.

Breinig F, Breinig T, Schmitt MJ.

Methods Mol Biol. 2013;969:163-84. doi: 10.1007/978-1-62703-260-5_11. Review.

PMID:
23296934
18.

Human yeast-specific CD8 T lymphocytes show a nonclassical effector molecule profile.

Breinig T, Scheller N, Glombitza B, Breinig F, Meyerhans A.

Med Microbiol Immunol. 2012 May;201(2):127-36. doi: 10.1007/s00430-011-0213-2. Epub 2011 Sep 25.

PMID:
21947167
19.

Delivery of functional DNA and messenger RNA to mammalian phagocytic cells by recombinant yeast.

Walch B, Breinig T, Schmitt MJ, Breinig F.

Gene Ther. 2012 Mar;19(3):237-45. doi: 10.1038/gt.2011.121. Epub 2011 Aug 25.

PMID:
21866176
20.

Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes.

Bazan SB, Geginat G, Breinig T, Schmitt MJ, Breinig F.

Vaccine. 2011 Oct 19;29(45):8165-73. doi: 10.1016/j.vaccine.2011.07.141. Epub 2011 Aug 19.

PMID:
21856351
21.

Yeast-based protein delivery to mammalian phagocytic cells is increased by coexpression of bacterial listeriolysin.

Walch B, Breinig T, Geginat G, Schmitt MJ, Breinig F.

Microbes Infect. 2011 Oct;13(11):908-13. doi: 10.1016/j.micinf.2011.05.006. Epub 2011 May 27.

PMID:
21652018
22.

RNA-directed DNA methylation and plant development require an IWR1-type transcription factor.

Kanno T, Bucher E, Daxinger L, Huettel B, Kreil DP, Breinig F, Lind M, Schmitt MJ, Simon SA, Gurazada SG, Meyers BC, Lorkovic ZJ, Matzke AJ, Matzke M.

EMBO Rep. 2010 Jan;11(1):65-71. doi: 10.1038/embor.2009.246. Epub 2009 Dec 11.

23.

Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD.

Heiligenstein S, Eisfeld K, Sendzik T, Jimenéz-Becker N, Breinig F, Schmitt MJ.

EMBO J. 2006 Oct 18;25(20):4717-27. Epub 2006 Sep 28.

24.

Cell surface expression of bacterial esterase A by Saccharomyces cerevisiae and its enhancement by constitutive activation of the cellular unfolded protein response.

Breinig F, Diehl B, Rau S, Zimmer C, Schwab H, Schmitt MJ.

Appl Environ Microbiol. 2006 Nov;72(11):7140-7. Epub 2006 Sep 15.

25.

Dissecting toxin immunity in virus-infected killer yeast uncovers an intrinsic strategy of self-protection.

Breinig F, Sendzik T, Eisfeld K, Schmitt MJ.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3810-5. Epub 2006 Feb 27.

26.

Yeast viral killer toxins: lethality and self-protection.

Schmitt MJ, Breinig F.

Nat Rev Microbiol. 2006 Mar;4(3):212-21. Review.

PMID:
16489348
27.

Yeast Kre1p is GPI-anchored and involved in both cell wall assembly and architecture.

Breinig F, Schleinkofer K, Schmitt MJ.

Microbiology. 2004 Oct;150(Pt 10):3209-18.

PMID:
15470101
28.
29.

Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans.

Heintel T, Breinig F, Schmitt MJ, Meyerhans A.

FEMS Immunol Med Microbiol. 2003 Dec 5;39(3):279-86.

30.

Specific activation of CMV-primed human T lymphocytes by cytomegalovirus pp65 expressed in fission yeast.

Breinig F, Heintel T, Schumacher A, Meyerhans A, Schmitt MJ.

FEMS Immunol Med Microbiol. 2003 Oct 15;38(3):231-9.

31.

The viral killer system in yeast: from molecular biology to application.

Schmitt MJ, Breinig F.

FEMS Microbiol Rev. 2002 Aug;26(3):257-76. Review.

32.

Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae.

Riffer F, Eisfeld K, Breinig F, Schmitt MJ.

Microbiology. 2002 May;148(Pt 5):1317-28.

PMID:
11988505
33.

Spacer-elongated cell wall fusion proteins improve cell surface expression in the yeast Saccharomyces cerevisiae.

Breinig F, Schmitt MJ.

Appl Microbiol Biotechnol. 2002 Apr;58(5):637-44. Epub 2002 Feb 12.

PMID:
11956747
34.

Kre1p, the plasma membrane receptor for the yeast K1 viral toxin.

Breinig F, Tipper DJ, Schmitt MJ.

Cell. 2002 Feb 8;108(3):395-405.

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