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Items: 1 to 50 of 109

1.

PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling.

Egners A, Rezaei M, Kuzmanov A, Poitz DM, Streichert D, Müller-Reichert T, Wielockx B, Breier G.

Cancers (Basel). 2018 Dec 6;10(12). pii: E496. doi: 10.3390/cancers10120496.

2.

Heparanase and Thrombin: Common Signalling Pathways in Melanoma Cells?

Breier G.

Thromb Haemost. 2018 Oct;118(10):1688-1689. doi: 10.1055/s-0038-1673329. Epub 2018 Oct 1. No abstract available.

PMID:
30273953
3.

Hematopoietic hypoxia-inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis.

Korovina I, Neuwirth A, Sprott D, Weber S, Sardar Pasha SPB, Gercken B, Breier G, El-Armouche A, Deussen A, Karl MO, Wielockx B, Chavakis T, Klotzsche-von Ameln A.

FASEB J. 2019 Feb;33(2):1758-1770. doi: 10.1096/fj.201800430R. Epub 2018 Aug 29.

PMID:
30156910
4.

The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions.

Rezaei M, Cao J, Friedrich K, Kemper B, Brendel O, Grosser M, Adrian M, Baretton G, Breier G, Schnittler HJ.

Histochem Cell Biol. 2018 Jan;149(1):15-30. doi: 10.1007/s00418-017-1619-8. Epub 2017 Nov 15.

PMID:
29143117
5.

Angiogenesis in metabolic-vascular disease.

Breier G, Chavakis T, Hirsch E.

Thromb Haemost. 2017 Jun 27;117(7):1289-1295. doi: 10.1160/TH17-05-0325. Epub 2017 Jun 8. Review.

PMID:
28594427
6.

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

Van Welden S, De Vos M, Wielockx B, Tavernier SJ, Dullaers M, Neyt S, Descamps B, Devisscher L, Devriese S, Van den Bossche L, Holvoet T, Baeyens A, Correale C, D'Alessio S, Vanhove C, De Vos F, Verhasselt B, Breier G, Lambrecht BN, Janssens S, Carmeliet P, Danese S, Elewaut D, Laukens D, Hindryckx P.

J Pathol. 2017 Mar;241(4):547-558. doi: 10.1002/path.4861. Epub 2017 Jan 27.

PMID:
27981571
7.

Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation.

García-Martín R, Alexaki VI, Qin N, Rubín de Celis MF, Economopoulou M, Ziogas A, Gercken B, Kotlabova K, Phieler J, Ehrhart-Bornstein M, Bornstein SR, Eisenhofer G, Breier G, Blüher M, Hampe J, El-Armouche A, Chatzigeorgiou A, Chung KJ, Chavakis T.

Mol Cell Biol. 2015 Nov 16;36(3):376-93. doi: 10.1128/MCB.00430-15. Print 2016 Feb 1.

8.

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, Stürzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ.

Gastroenterology. 2015 Jul;149(1):177-189.e10. doi: 10.1053/j.gastro.2015.03.016. Epub 2015 Mar 19.

PMID:
25797700
9.

Receptor tyrosine kinase inhibitors: Are they real tumor killers?

Gaumann AK, Kiefer F, Alfer J, Lang SA, Geissler EK, Breier G.

Int J Cancer. 2016 Feb 1;138(3):540-54. doi: 10.1002/ijc.29499. Epub 2015 Mar 11. Review.

10.

The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®).

Gaumann AK, Drexler HC, Lang SA, Stoeltzing O, Diermeier-Daucher S, Buchdunger E, Wood J, Bold G, Breier G.

Int J Oncol. 2014 Dec;45(6):2267-77. doi: 10.3892/ijo.2014.2683. Epub 2014 Sep 29.

11.

Endothelial cadherins in cancer.

Breier G, Grosser M, Rezaei M.

Cell Tissue Res. 2014 Mar;355(3):523-7. doi: 10.1007/s00441-014-1851-7. Epub 2014 Mar 12. Review.

PMID:
24619142
12.

PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.

Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G.

Mol Cancer Res. 2013 Nov;11(11):1337-48. doi: 10.1158/1541-7786.MCR-13-0201. Epub 2013 Sep 18.

13.

Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development.

Hermann A, Loewenbrück KF, Boldt Ä, Fiedler C, Maisel M, Kalucka J, Schwarz J, Breier G, Storch A.

Neurosci Lett. 2013 Oct 11;553:142-7. doi: 10.1016/j.neulet.2013.08.031. Epub 2013 Aug 29.

PMID:
23994060
14.

Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice.

Kalucka J, Ettinger A, Franke K, Mamlouk S, Singh RP, Farhat K, Muschter A, Olbrich S, Breier G, Katschinski DM, Huttner W, Weidemann A, Wielockx B.

Mol Cell Biol. 2013 Sep;33(17):3426-38. doi: 10.1128/MCB.00609-13. Epub 2013 Jun 24.

15.

A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity.

Corcoran A, Kunze R, Harney SC, Breier G, Marti HH, O'Connor JJ.

Hippocampus. 2013 Oct;23(10):861-72. doi: 10.1002/hipo.22142. Epub 2013 Jun 6.

PMID:
23674383
16.

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.

Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B.

Blood. 2013 Jun 27;121(26):5158-66. doi: 10.1182/blood-2012-12-471185. Epub 2013 May 10.

PMID:
23667053
17.

Stress-stimulated volitional coping competencies and depression in multiple sclerosis.

Nielsen-Prohl J, Saliger J, Güldenberg V, Breier G, Karbe H.

J Psychosom Res. 2013 Mar;74(3):221-6. doi: 10.1016/j.jpsychores.2012.11.003. Epub 2012 Nov 22.

PMID:
23438712
18.

Spatial regulation of VEGF receptor endocytosis in angiogenesis.

Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH.

Nat Cell Biol. 2013 Mar;15(3):249-60. doi: 10.1038/ncb2679. Epub 2013 Jan 27.

19.

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.

Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20.

20.

Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression.

Rezaei M, Friedrich K, Wielockx B, Kuzmanov A, Kettelhake A, Labelle M, Schnittler H, Baretton G, Breier G.

Breast Cancer Res. 2012 Dec 6;14(6):R154. doi: 10.1186/bcr3367.

21.

Identification of a clonally expanding haematopoietic compartment in bone marrow.

Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH.

EMBO J. 2013 Jan 23;32(2):219-30. doi: 10.1038/emboj.2012.308. Epub 2012 Nov 27.

22.

Prognostic and predictive value of circulating tumor cell analysis in colorectal cancer patients.

de Albuquerque A, Kubisch I, Stölzel U, Ernst D, Boese-Landgraf J, Breier G, Stamminger G, Fersis N, Kaul S.

J Transl Med. 2012 Nov 13;10:222. doi: 10.1186/1479-5876-10-222.

23.

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.

Kunze R, Zhou W, Veltkamp R, Wielockx B, Breier G, Marti HH.

Stroke. 2012 Oct;43(10):2748-56. Epub 2012 Aug 28.

PMID:
22933585
24.

Development of a molecular multimarker assay for the analysis of circulating tumor cells in adenocarcinoma patients.

de Albuquerque A, Kubisch I, Ernst D, Breier G, Stamminger G, Fersis N, Stölzel U, Boese-Landgraf J, Eichler A, Kaul S.

Clin Lab. 2012;58(5-6):373-84.

PMID:
22783565
25.

Propanolol and angiogenesis inhibition in hereditary haemorrhagic telangiectasia.

Breier G.

Thromb Haemost. 2012 Jul;108(1):1-2. doi: 10.1160/TH12-05-0312. Epub 2012 May 25. No abstract available.

PMID:
22628061
26.

Multimarker Analysis of Circulating Tumor Cells in Peripheral Blood of Metastatic Breast Cancer Patients: A Step Forward in Personalized Medicine.

de Albuquerque A, Kaul S, Breier G, Krabisch P, Fersis N.

Breast Care (Basel). 2012 Feb;7(1):7-12. Epub 2012 Feb 21.

27.

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation.

Klotzsche-von Ameln A, Muschter A, Heimesaat MM, Breier G, Wielockx B.

Cancer Biol Ther. 2012 Feb 15;13(4):216-23. doi: 10.4161/cbt.13.4.18830.

PMID:
22354010
28.

Multimarker gene analysis of circulating tumor cells in pancreatic cancer patients: a feasibility study.

de Albuquerque A, Kubisch I, Breier G, Stamminger G, Fersis N, Eichler A, Kaul S, Stölzel U.

Oncology. 2012;82(1):3-10. doi: 10.1159/000335479. Epub 2012 Jan 20.

PMID:
22270149
29.

Mechanoinduction of lymph vessel expansion.

Planas-Paz L, Strilić B, Goedecke A, Breier G, Fässler R, Lammert E.

EMBO J. 2012 Feb 15;31(4):788-804. doi: 10.1038/emboj.2011.456. Epub 2011 Dec 13.

30.

Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.

Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G.

Int J Cancer. 2012 Sep 1;131(5):E603-13. doi: 10.1002/ijc.27360. Epub 2012 Jan 3.

31.

Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ.

Klotzsche-von Ameln A, Muschter A, Mamlouk S, Kalucka J, Prade I, Franke K, Rezaei M, Poitz DM, Breier G, Wielockx B.

Cancer Res. 2011 May 1;71(9):3306-16. doi: 10.1158/0008-5472.CAN-10-3838. Epub 2011 Mar 24.

32.

Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.

Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A.

J Biol Chem. 2011 Apr 1;286(13):11185-94. doi: 10.1074/jbc.M110.186809. Epub 2011 Jan 26.

33.

Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models.

Mente C, Prade I, Brusch L, Breier G, Deutsch A.

J Math Biol. 2011 Jul;63(1):173-200. doi: 10.1007/s00285-010-0366-4. Epub 2010 Oct 1.

PMID:
20886214
34.

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis.

Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8350-5. doi: 10.1073/pnas.0903541106. Epub 2009 May 5.

35.

Tracking adult neovascularization during ischemia and inflammation using Vegfr2-LacZ reporter mice.

Heidenreich R, Murayama T, Silver M, Essl C, Asahara T, Rocken M, Breier G.

J Vasc Res. 2008;45(5):437-44. doi: 10.1159/000126106. Epub 2008 Apr 16.

PMID:
18418002
36.

Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.

Ahlbrecht K, Schmitz J, Seay U, Schwarz C, Mittnacht-Kraus R, Gaumann A, Haberberger RV, Herold S, Breier G, Grimminger F, Seeger W, Voswinckel R.

Am J Respir Cell Mol Biol. 2008 Aug;39(2):163-70. doi: 10.1165/rcmb.2007-0231OC. Epub 2008 Mar 6.

PMID:
18323533
37.

Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling.

Labelle M, Schnittler HJ, Aust DE, Friedrich K, Baretton G, Vestweber D, Breier G.

Cancer Res. 2008 Mar 1;68(5):1388-97. doi: 10.1158/0008-5472.CAN-07-2706.

38.

HIF in vascular development and tumour angiogenesis.

Breier G, Licht AH, Nicolaus A, Klotzsche A, Wielockx B, Kirsnerova Z.

Novartis Found Symp. 2007;283:126-33; discussion 133-8, 238-41.

PMID:
18300418
39.

Judah Folkman.

Augustin HG, Breier G.

Thromb Haemost. 2008 Feb;99(2):250. No abstract available.

PMID:
18278170
40.

A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature.

Vervoort VS, Lu M, Valencia F, Lesperance J, Breier G, Oshima R, Pasquale EB.

Transgenic Res. 2008 Jun;17(3):403-15. Epub 2007 Nov 20.

PMID:
18027100
41.

Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors.

Li X, Edholm D, Lanner F, Breier G, Farnebo F, Dimberg A, Claesson-Welsh L.

Stem Cells. 2007 Dec;25(12):2987-95. Epub 2007 Aug 16.

42.

Simultaneous blockade of VEGFR-1 and VEGFR-2 activation is necessary to efficiently inhibit experimental melanoma growth and metastasis formation.

Gille J, Heidenreich R, Pinter A, Schmitz J, Boehme B, Hicklin DJ, Henschler R, Breier G.

Int J Cancer. 2007 May 1;120(9):1899-908.

43.

Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis.

Kidszun A, Schneider D, Erb D, Hertl G, Schmidt V, Eckhard M, Preissner KT, Breier G, Bretzel RG, Linn T.

Cell Transplant. 2006;15(6):489-97.

PMID:
17121160
44.

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

Diez H, Fischer A, Winkler A, Hu CJ, Hatzopoulos AK, Breier G, Gessler M.

Exp Cell Res. 2007 Jan 1;313(1):1-9. Epub 2006 Sep 19.

PMID:
17045587
45.

[Autocrine stimulation of receptor-tyrosine kinases (RTK) in human tumor cell lines in vitro: therapeutic implications].

Gaumann A, Groot M, Drexler HC, Breier G.

Verh Dtsch Ges Pathol. 2003;87:232-9. German.

PMID:
16888917
46.
47.

Continuous endothelial cell activation increases angiogenesis: evidence for the direct role of endothelium linking angiogenesis and inflammation.

Rajashekhar G, Willuweit A, Patterson CE, Sun P, Hilbig A, Breier G, Helisch A, Clauss M.

J Vasc Res. 2006;43(2):193-204. Epub 2006 Jan 12.

PMID:
16410682
48.

Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.

Mitola S, Brenchio B, Piccinini M, Tertoolen L, Zammataro L, Breier G, Rinaudo MT, den Hertog J, Arese M, Bussolino F.

Circ Res. 2006 Jan 6;98(1):45-54. Epub 2005 Dec 8.

PMID:
16339483
49.

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

Licht AH, Müller-Holtkamp F, Flamme I, Breier G.

Blood. 2006 Jan 15;107(2):584-90. Epub 2005 Sep 27.

PMID:
16189264
50.

Lymphangiogenesis in regenerating tissue: is VEGF-C sufficient?

Breier G.

Circ Res. 2005 Jun 10;96(11):1132-4. No abstract available.

PMID:
15947252

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