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Items: 19

1.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

Subkhangulova A, Malik AR, Hermey G, Popp O, Dittmar G, Rathjen T, Poy MN, Stumpf A, Beed PS, Schmitz D, Breiderhoff T, Willnow TE.

EMBO Rep. 2018 Apr;19(4). pii: e44810. doi: 10.15252/embr.201744810. Epub 2018 Feb 12.

2.

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria.

Breiderhoff T, Himmerkus N, Drewell H, Plain A, Günzel D, Mutig K, Willnow TE, Müller D, Bleich M.

Kidney Int. 2018 Mar;93(3):580-588. doi: 10.1016/j.kint.2017.08.029. Epub 2017 Nov 10.

PMID:
29129401
3.

Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage.

Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, Schuster J, Fatima A, Asif M, Sher M, Mäbert K, Fromm A, Baig SM, Günzel D, Dahl N.

PLoS Genet. 2017 Jul 7;13(7):e1006897. doi: 10.1371/journal.pgen.1006897. eCollection 2017 Jul.

4.

Claudin Loss-of-Function Disrupts Tight Junctions and Impairs Amelogenesis.

Bardet C, Ribes S, Wu Y, Diallo MT, Salmon B, Breiderhoff T, Houillier P, Müller D, Chaussain C.

Front Physiol. 2017 May 24;8:326. doi: 10.3389/fphys.2017.00326. eCollection 2017.

5.

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.

Milatz S, Himmerkus N, Wulfmeyer VC, Drewell H, Mutig K, Hou J, Breiderhoff T, Müller D, Fromm M, Bleich M, Günzel D.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E219-E227. doi: 10.1073/pnas.1611684114. Epub 2016 Dec 27.

6.

One gene, two paracellular ion channels-claudin-10 in the kidney.

Milatz S, Breiderhoff T.

Pflugers Arch. 2017 Jan;469(1):115-121. doi: 10.1007/s00424-016-1921-7. Epub 2016 Dec 10. Review.

PMID:
27942952
7.

Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.

Giménez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M, Kostantin E, Diercks T, Pey AL, Ereño-Orbea J, Martínez-Chantar ML, Khalaf-Nazzal R, Claverie-Martin F, Müller D, Tremblay ML, Martínez-Cruz LA.

J Biol Chem. 2017 Jan 20;292(3):786-801. doi: 10.1074/jbc.M116.759944. Epub 2016 Nov 29.

8.

Role of Sortilin in Models of Autoimmune Neuroinflammation.

Reuter E, Weber J, Paterka M, Ploen R, Breiderhoff T, van Horssen J, Willnow TE, Siffrin V, Zipp F.

J Immunol. 2015 Dec 15;195(12):5762-9. doi: 10.4049/jimmunol.1403156. Epub 2015 Nov 13.

9.

Claudin-16 Deficiency Impairs Tight Junction Function in Ameloblasts, Leading to Abnormal Enamel Formation.

Bardet C, Courson F, Wu Y, Khaddam M, Salmon B, Ribes S, Thumfart J, Yamaguti PM, Rochefort GY, Figueres ML, Breiderhoff T, Garcia-Castaño A, Vallée B, Le Denmat D, Baroukh B, Guilbert T, Schmitt A, Massé JM, Bazin D, Lorenz G, Morawietz M, Hou J, Carvalho-Lobato P, Manzanares MC, Fricain JC, Talmud D, Demontis R, Neves F, Zenaty D, Berdal A, Kiesow A, Petzold M, Menashi S, Linglart A, Acevedo AC, Vargas-Poussou R, Müller D, Houillier P, Chaussain C.

J Bone Miner Res. 2016 Mar;31(3):498-513. doi: 10.1002/jbmr.2726. Epub 2015 Oct 20.

10.

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.

Breiderhoff T, Christiansen GB, Pallesen LT, Vaegter C, Nykjaer A, Holm MM, Glerup S, Willnow TE.

PLoS One. 2013 Sep 19;8(9):e75006. doi: 10.1371/journal.pone.0075006. eCollection 2013.

11.

The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A.

Immunity. 2012 Nov 16;37(5):854-66. doi: 10.1016/j.immuni.2012.07.012. Epub 2012 Oct 16.

12.

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.

Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6. doi: 10.1073/pnas.1203834109. Epub 2012 Aug 13. Erratum in: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15072.

13.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Kjolby M, Andersen OM, Breiderhoff T, Fjorback AW, Pedersen KM, Madsen P, Jansen P, Heeren J, Willnow TE, Nykjaer A.

Cell Metab. 2010 Sep 8;12(3):213-23. doi: 10.1016/j.cmet.2010.08.006.

14.

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.

Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D.

Am J Physiol Renal Physiol. 2010 May;298(5):F1152-61. doi: 10.1152/ajprenal.00499.2009. Epub 2010 Feb 10.

15.

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A.

Nat Neurosci. 2007 Nov;10(11):1449-57. Epub 2007 Oct 14.

PMID:
17934455
16.

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.

Petersen HH, Andreassen TK, Breiderhoff T, Bräsen JH, Schulz H, Gross V, Gröne HJ, Nykjaer A, Willnow TE.

Mol Cell Biol. 2006 Oct;26(19):7236-45.

17.

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13461-6. Epub 2005 Sep 7.

18.

Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.

Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA, Bösl MR, Ruether K, Jahn H, Draguhn A, Jahn R, Jentsch TJ.

Neuron. 2001 Jan;29(1):185-96.

19.

Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.

Friedrich T, Breiderhoff T, Jentsch TJ.

J Biol Chem. 1999 Jan 8;274(2):896-902.

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