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Items: 1 to 50 of 210

1.

Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.

Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, Swanson S, Catlow J, Witkin JM, Zwart R, Sher E, Choong KC, Wall TM, Schober D, Felder CC, Kato AS, Bredt DS, Nisenbaum ES.

J Pharmacol Exp Ther. 2019 Jun;369(3):345-363. doi: 10.1124/jpet.118.250126. Epub 2019 Mar 25.

PMID:
30910921
2.

α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.

Gu S, Matta JA, Davini WB, Dawe GB, Lord B, Bredt DS.

Cell Rep. 2019 Jan 22;26(4):866-874.e3. doi: 10.1016/j.celrep.2018.12.103.

3.

Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins.

Maher MP, Matta JA, Gu S, Seierstad M, Bredt DS.

Neuron. 2017 Dec 6;96(5):989-1001. doi: 10.1016/j.neuron.2017.10.001. Review.

4.

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.

Matta JA, Gu S, Davini WB, Lord B, Siuda ER, Harrington AW, Bredt DS.

Cell Rep. 2017 Apr 25;19(4):688-696. doi: 10.1016/j.celrep.2017.04.008.

5.

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.

Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, Fitzjohn SM, Pasqui F, Wang H, Qian Y, Sher E, Zwart R, Wafford KA, Rasmussen K, Ornstein PL, Isaac JT, Nisenbaum ES, Bredt DS, Witkin JM.

Nat Med. 2016 Dec;22(12):1496-1501. doi: 10.1038/nm.4221. Epub 2016 Nov 7.

PMID:
27820603
6.

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.

Gu S, Matta JA, Lord B, Harrington AW, Sutton SW, Davini WB, Bredt DS.

Neuron. 2016 Mar 2;89(5):948-55. doi: 10.1016/j.neuron.2016.01.018. Epub 2016 Feb 11.

7.

Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission.

Erlenhardt N, Yu H, Abiraman K, Yamasaki T, Wadiche JI, Tomita S, Bredt DS.

Cell Rep. 2016 Feb 2;14(4):782-794. doi: 10.1016/j.celrep.2015.12.078. Epub 2016 Jan 14.

8.

Translating depression biomarkers for improved targeted therapies.

Bredt DS, Furey ML, Chen G, Lovenberg T, Drevets WC, Manji HK.

Neurosci Biobehav Rev. 2015 Dec;59:1-15. doi: 10.1016/j.neubiorev.2015.09.013. Epub 2015 Oct 1. Review.

PMID:
26432926
9.

Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses.

Yudowski GA, Olsen O, Adesnik H, Marek KW, Bredt DS.

PLoS One. 2013;8(1):e53965. doi: 10.1371/journal.pone.0053965. Epub 2013 Jan 16.

10.
11.

AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform.

Gill MB, Kato AS, Wang H, Bredt DS.

Eur J Neurosci. 2012 Jan;35(2):182-94. doi: 10.1111/j.1460-9568.2011.07948.x. Epub 2011 Dec 30.

PMID:
22211840
12.

PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.

Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S.

Nat Neurosci. 2011 Oct 16;14(11):1410-2. doi: 10.1038/nn.2952.

13.

Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology.

Gill MB, Kato AS, Roberts MF, Yu H, Wang H, Tomita S, Bredt DS.

J Neurosci. 2011 May 4;31(18):6928-38. doi: 10.1523/JNEUROSCI.6271-10.2011.

14.

MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis.

Ivanova S, Gregorc U, Vidergar N, Javier R, Bredt DS, Vandenabeele P, Pardo J, Simon MM, Turk V, Banks L, Turk B.

Cell Death Dis. 2011 Jan 20;2:e116. doi: 10.1038/cddis.2010.92.

15.

Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.

Schober DA, Gill MB, Yu H, Gernert DL, Jeffries MW, Ornstein PL, Kato AS, Felder CC, Bredt DS.

J Biol Chem. 2011 Apr 15;286(15):13134-42. doi: 10.1074/jbc.M110.212522. Epub 2011 Feb 22.

16.

Protein Palmitoylation by DHHC Protein Family.

Fukata Y, Bredt DS, Fukata M.

In: Kittler JT, Moss SJ, editors. The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Boca Raton (FL): CRC Press/Taylor & Francis; 2006. Chapter 5.

17.

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS.

Neuron. 2010 Dec 22;68(6):1082-96. doi: 10.1016/j.neuron.2010.11.026.

18.

An emerging role for TARPs in neuropsychiatric disorders.

Gill MB, Bredt DS.

Neuropsychopharmacology. 2011 Jan;36(1):362-3. doi: 10.1038/npp.2010.149. No abstract available.

19.

TARPs differentially decorate AMPA receptors to specify neuropharmacology.

Kato AS, Gill MB, Yu H, Nisenbaum ES, Bredt DS.

Trends Neurosci. 2010 May;33(5):241-8. doi: 10.1016/j.tins.2010.02.004. Epub 2010 Mar 8. Review.

PMID:
20219255
20.

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95.

Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M.

J Cell Biol. 2009 Jul 13;186(1):147-60. doi: 10.1083/jcb.200903101.

21.

AMPA receptor subunit-specific regulation by a distinct family of type II TARPs.

Kato AS, Siuda ER, Nisenbaum ES, Bredt DS.

Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.

22.

Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.

Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A.

J Neurosci. 2008 Sep 3;28(36):8897-907. doi: 10.1523/JNEUROSCI.2171-08.2008.

23.

TARP redundancy is critical for maintaining AMPA receptor function.

Menuz K, O'Brien JL, Karmizadegan S, Bredt DS, Nicoll RA.

J Neurosci. 2008 Aug 27;28(35):8740-6. doi: 10.1523/JNEUROSCI.1319-08.2008.

24.

Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.

Ogawa Y, Horresh I, Trimmer JS, Bredt DS, Peles E, Rasband MN.

J Neurosci. 2008 May 28;28(22):5731-9. doi: 10.1523/JNEUROSCI.4431-07.2008.

25.

MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.

Srinivasan K, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK.

Development. 2008 May;135(10):1781-90. doi: 10.1242/dev.013847. Epub 2008 Apr 9.

26.

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.

Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G.

J Biol Chem. 2008 Apr 11;283(15):10048-57. doi: 10.1074/jbc.M708151200. Epub 2008 Jan 31.

27.

Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.

Zhao Y, Chen YQ, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G.

J Biol Chem. 2008 Mar 28;283(13):8258-65. doi: 10.1074/jbc.M710422200. Epub 2008 Jan 14.

28.

AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity.

Tomita S, Byrd RK, Rouach N, Bellone C, Venegas A, O'Brien JL, Kim KS, Olsen O, Nicoll RA, Bredt DS.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18784-8. Epub 2007 Nov 13.

29.

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.

Olsen O, Funke L, Long JF, Fukata M, Kazuta T, Trinidad JC, Moore KA, Misawa H, Welling PA, Burlingame AL, Zhang M, Bredt DS.

J Cell Biol. 2007 Oct 8;179(1):151-64.

30.

TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.

Milstein AD, Zhou W, Karimzadegan S, Bredt DS, Nicoll RA.

Neuron. 2007 Sep 20;55(6):905-18.

31.

Pharmacological regulation of ion channels by auxiliary subunits.

Kato AS, Bredt DS.

Curr Opin Drug Discov Devel. 2007 Sep;10(5):565-72. Review.

PMID:
17786855
32.

New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors.

Kato AS, Zhou W, Milstein AD, Knierman MD, Siuda ER, Dotzlaf JE, Yu H, Hale JE, Nisenbaum ES, Nicoll RA, Bredt DS.

J Neurosci. 2007 May 2;27(18):4969-77.

33.

The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a.

Reese ML, Dakoji S, Bredt DS, Dötsch V.

Nat Struct Mol Biol. 2007 Feb;14(2):155-63. Epub 2007 Jan 14.

PMID:
17220895
34.

Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

Elias GM, Funke L, Stein V, Grant SG, Bredt DS, Nicoll RA.

Neuron. 2006 Oct 19;52(2):307-20. Erratum in: Neuron. 2007 Feb 1;53(3):465.

35.

Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.

Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M.

Science. 2006 Sep 22;313(5794):1792-5.

36.

Stargazin interacts functionally with the AMPA receptor glutamate-binding module.

Tomita S, Shenoy A, Fukata Y, Nicoll RA, Bredt DS.

Neuropharmacology. 2007 Jan;52(1):87-91. Epub 2006 Aug 21. Review.

PMID:
16919685
37.

Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase.

Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC.

J Cell Biol. 2006 Jul 31;174(3):369-77. Epub 2006 Jul 24.

38.

Stargazin controls the pharmacology of AMPA receptor potentiators.

Tomita S, Sekiguchi M, Wada K, Nicoll RA, Bredt DS.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10064-7. Epub 2006 Jun 19.

39.

Auxiliary subunits assist AMPA-type glutamate receptors.

Nicoll RA, Tomita S, Bredt DS.

Science. 2006 Mar 3;311(5765):1253-6. Review.

PMID:
16513974
40.

Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex.

Olsen O, Moore KA, Nicoll RA, Bredt DS.

Curr Opin Cell Biol. 2006 Apr;18(2):223-7. Epub 2006 Feb 28. Review.

PMID:
16504495
41.

TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity.

Rouach N, Byrd K, Petralia RS, Elias GM, Adesnik H, Tomita S, Karimzadegan S, Kealey C, Bredt DS, Nicoll RA.

Nat Neurosci. 2005 Nov;8(11):1525-33. Epub 2005 Oct 9.

PMID:
16222232
42.

Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.

Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS.

J Cell Biol. 2005 Sep 26;170(7):1127-34.

43.

Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.

Funke L, Dakoji S, Bredt DS.

Annu Rev Biochem. 2005;74:219-45. Review.

PMID:
15952887
44.

Molecular constituents of neuronal AMPA receptors.

Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS.

J Cell Biol. 2005 May 9;169(3):399-404.

45.

Stargazin modulates AMPA receptor gating and trafficking by distinct domains.

Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS.

Nature. 2005 Jun 23;435(7045):1052-8. Epub 2005 Apr 27.

46.

Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.

Kato A, Rouach N, Nicoll RA, Bredt DS.

Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5600-5. Epub 2005 Apr 4.

47.
48.

Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.

Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS.

Neuron. 2005 Jan 20;45(2):269-77.

49.

Stargazin is an AMPA receptor auxiliary subunit.

Vandenberghe W, Nicoll RA, Bredt DS.

Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):485-90. Epub 2005 Jan 3.

50.

Identification of PSD-95 palmitoylating enzymes.

Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS.

Neuron. 2004 Dec 16;44(6):987-96.

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