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Items: 24

1.

XLF and H2AX function in series to promote replication fork stability.

Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP.

J Cell Biol. 2019 Jul 1;218(7):2113-2123. doi: 10.1083/jcb.201808134. Epub 2019 May 23.

PMID:
31123184
2.

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP.

Mol Cell. 2018 Jul 19;71(2):332-342.e8. doi: 10.1016/j.molcel.2018.06.018. Epub 2018 Jul 12.

3.

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining.

Bredemeyer AL, Edwards BS, Haynes MK, Morales AJ, Wang Y, Ursu O, Waller A, Sklar LA, Sleckman BP.

SLAS Discov. 2018 Aug;23(7):624-633. doi: 10.1177/2472555217746324. Epub 2017 Dec 12.

4.

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.

Hung PJ, Chen BR, George R, Liberman C, Morales AJ, Colon-Ortiz P, Tyler JK, Sleckman BP, Bredemeyer AL.

Cell Cycle. 2017 Feb;16(3):286-295. doi: 10.1080/15384101.2016.1253640. Epub 2016 Nov 10.

5.

DNA damage responses: beyond double-strand break repair.

Bredemeyer AL, Sleckman BP.

Curr Biol. 2015 Jan 5;25(1):R45-6. doi: 10.1016/j.cub.2014.11.024.

6.

HCoDES reveals chromosomal DNA end structures with single-nucleotide resolution.

Dorsett Y, Zhou Y, Tubbs AT, Chen BR, Purman C, Lee BS, George R, Bredemeyer AL, Zhao JY, Sodergen E, Weinstock GM, Han ND, Reyes A, Oltz EM, Dorsett D, Misulovin Z, Payton JE, Sleckman BP.

Mol Cell. 2014 Dec 18;56(6):808-18. doi: 10.1016/j.molcel.2014.10.024. Epub 2014 Nov 26.

7.

KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.

Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP.

Mol Cell Biol. 2014 Aug;34(15):2811-21. doi: 10.1128/MCB.00441-14. Epub 2014 May 19.

8.

β-Catenin induces T-cell transformation by promoting genomic instability.

Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26.

9.

Recurrent hemizygous deletions in cancers may optimize proliferative potential.

Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ.

Science. 2012 Jul 6;337(6090):104-9. doi: 10.1126/science.1219580. Epub 2012 May 24.

10.

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.

Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 Nov 4.

11.

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex.

Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I.

Nat Immunol. 2010 Mar;11(3):207-15. doi: 10.1038/ni.1839. Epub 2010 Jan 17.

12.

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.

Yin B, Savic V, Juntilla MM, Bredemeyer AL, Yang-Iott KS, Helmink BA, Koretzky GA, Sleckman BP, Bassing CH.

J Exp Med. 2009 Nov 23;206(12):2625-39. doi: 10.1084/jem.20091320. Epub 2009 Nov 2.

13.

Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.

Mahowald GK, Baron JM, Mahowald MA, Kulkarni S, Bredemeyer AL, Bassing CH, Sleckman BP.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18339-44. doi: 10.1073/pnas.0902545106. Epub 2009 Oct 9.

14.

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.

Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJ.

Genes Dev. 2009 Oct 15;23(20):2415-25. doi: 10.1101/gad.1832309. Epub 2009 Sep 30.

15.

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH.

Mol Cell. 2009 May 15;34(3):298-310. doi: 10.1016/j.molcel.2009.04.012.

16.

Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.

Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8641-6. doi: 10.1073/pnas.0812255106. Epub 2009 May 7.

17.

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP.

J Exp Med. 2009 Mar 16;206(3):669-79. doi: 10.1084/jem.20081326. Epub 2009 Feb 16.

18.

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.

Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP.

Nature. 2008 Dec 11;456(7223):819-23. doi: 10.1038/nature07392. Epub 2008 Oct 12.

19.

Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.

Bredemeyer AL, Huang CY, Walker LM, Bassing CH, Sleckman BP.

J Immunol. 2008 Aug 15;181(4):2620-5.

20.

Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse.

Huang CY, Bredemeyer AL, Walker LM, Bassing CH, Sleckman BP.

Eur J Immunol. 2008 Feb;38(2):342-9. doi: 10.1002/eji.200737972.

21.

SWI-SNF: promoter of accessibility.

Bredemeyer AL, Sleckman BP.

Nat Immunol. 2007 Aug;8(8):795-6. No abstract available.

PMID:
17641658
22.

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A.

Cell. 2007 Jul 13;130(1):63-75. Epub 2007 Jun 28.

23.

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

Bredemeyer AL, Sharma GG, Huang CY, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH, Sleckman BP.

Nature. 2006 Jul 27;442(7101):466-70. Epub 2006 Jun 14.

PMID:
16799570
24.

Proteasome activator PA200 is required for normal spermatogenesis.

Khor B, Bredemeyer AL, Huang CY, Turnbull IR, Evans R, Maggi LB Jr, White JM, Walker LM, Carnes K, Hess RA, Sleckman BP.

Mol Cell Biol. 2006 Apr;26(8):2999-3007.

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