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Effect of phytase on intestinal phytate breakdown, plasma inositol concentrations and glucose transporter type 4 abundance in muscle membranes of weanling pigs.

Lu H, Kühn I, Bedford MR, Whitfield H, Brearley C, Adeola O, Ajuwon KM.

J Anim Sci. 2019 Jul 10. pii: skz234. doi: 10.1093/jas/skz234. [Epub ahead of print]


Lab-scale preparation and QC of phytase assay substrate from rice bran.

Madsen CK, Brearley CA, Brinch-Pedersen H.

Anal Biochem. 2019 Aug 1;578:7-12. doi: 10.1016/j.ab.2019.04.021. Epub 2019 May 2.


Manipulation of plasma myo-inositol in broiler chickens: effect on growth performance, dietary energy, nutrient availability, and hepatic function.

Pirgozliev V, Brearley CA, Rose SP, Mansbridge SC.

Poult Sci. 2019 Jan 1;98(1):260-268. doi: 10.3382/ps/pey341.


A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase.

Whitfield H, Gilmartin M, Baker K, Riley AM, Godage HY, Potter BVL, Hemmings AM, Brearley CA.

J Med Chem. 2018 Oct 11;61(19):8838-8846. doi: 10.1021/acs.jmedchem.8b01022. Epub 2018 Sep 19.


Exogenous phytase and xylanase exhibit opposing effects on real-time gizzard pH in broiler chickens.

Lee SA, Dunne J, Febery E, Brearley CA, Mottram T, Bedford MR.

Br Poult Sci. 2018 Oct;59(5):568-578. doi: 10.1080/00071668.2018.1496403. Epub 2018 Aug 2. Erratum in: Br Poult Sci. 2018 Dec;59(6):703.


Simple synthesis of 32P-labelled inositol hexakisphosphates for study of phosphate transformations.

Whitfield H, Riley AM, Diogenous S, Godage HY, Potter BVL, Brearley CA.

Plant Soil. 2018 Jun;427(1-2):149-161. doi: 10.1007/s11104-017-3315-9. Epub 2017 Jun 27.


Arabidopsis inositol phosphate kinases IPK1 and ITPK1 constitute a metabolic pathway in maintaining phosphate homeostasis.

Kuo HF, Hsu YY, Lin WC, Chen KY, Munnik T, Brearley CA, Chiou TJ.

Plant J. 2018 May 19. doi: 10.1111/tpj.13974. [Epub ahead of print]


The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.

Franco-Echevarría E, Sanz-Aparicio J, Brearley CA, González-Rubio JM, González B.

J Biol Chem. 2017 Jun 23;292(25):10534-10548. doi: 10.1074/jbc.M117.780395. Epub 2017 Apr 27.


Land-use influences phosphatase gene microdiversity in soils.

Neal AL, Rossmann M, Brearley C, Akkari E, Guyomar C, Clark IM, Allen E, Hirsch PR.

Environ Microbiol. 2017 Jul;19(7):2740-2753. doi: 10.1111/1462-2920.13778. Epub 2017 May 30.


Assessment of iron bioavailability from different bread making processes using an in vitro intestinal cell model.

Rodriguez-Ramiro I, Brearley CA, Bruggraber SF, Perfecto A, Shewry P, Fairweather-Tait S.

Food Chem. 2017 Aug 1;228:91-98. doi: 10.1016/j.foodchem.2017.01.130. Epub 2017 Jan 28.


Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach.

Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ.

BMJ Open. 2015 Jan 28;5(1):e005750. doi: 10.1136/bmjopen-2014-005750.


Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics.

Stentz R, Horn N, Cross K, Salt L, Brearley C, Livermore DM, Carding SR.

J Antimicrob Chemother. 2015 Mar;70(3):701-9. doi: 10.1093/jac/dku466. Epub 2014 Nov 27.


A bacterial homolog of a eukaryotic inositol phosphate signaling enzyme mediates cross-kingdom dialog in the mammalian gut.

Stentz R, Osborne S, Horn N, Li AW, Hautefort I, Bongaerts R, Rouyer M, Bailey P, Shears SB, Hemmings AM, Brearley CA, Carding SR.

Cell Rep. 2014 Feb 27;6(4):646-56. doi: 10.1016/j.celrep.2014.01.021. Epub 2014 Feb 13.


Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.

Baños-Sanz JI, Sanz-Aparicio J, Whitfield H, Hamilton C, Brearley CA, González B.

J Biol Chem. 2012 Aug 24;287(35):29237-49. doi: 10.1074/jbc.M112.363671. Epub 2012 Jun 28.


Effects of fou8/fry1 mutation on sulfur metabolism: is decreased internal sulfate the trigger of sulfate starvation response?

Lee BR, Huseby S, Koprivova A, Chételat A, Wirtz M, Mugford ST, Navid E, Brearley C, Saha S, Mithen R, Hell R, Farmer EE, Kopriva S.

PLoS One. 2012;7(6):e39425. doi: 10.1371/journal.pone.0039425. Epub 2012 Jun 18.


Expression, purification, crystallization and preliminary X-ray diffraction analysis of the apo form of InsP5 2-K from Arabidopsis thaliana.

Baños-Sanz JI, Sanz-Aparicio J, Brearley CA, González B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):701-4. doi: 10.1107/S1744309112017307. Epub 2012 May 23.


Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover.

Hanke DE, Parmar PN, Caddick SE, Green P, Brearley CA.

Biochem J. 2012 Jun 15;444(3):601-9. doi: 10.1042/BJ20111811.


Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis.

Estavillo GM, Crisp PA, Pornsiriwong W, Wirtz M, Collinge D, Carrie C, Giraud E, Whelan J, David P, Javot H, Brearley C, Hell R, Marin E, Pogson BJ.

Plant Cell. 2011 Nov;23(11):3992-4012. doi: 10.1105/tpc.111.091033. Epub 2011 Nov 29.


A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus.

Seipke RF, Barke J, Brearley C, Hill L, Yu DW, Goss RJ, Hutchings MI.

PLoS One. 2011;6(8):e22028. doi: 10.1371/journal.pone.0022028. Epub 2011 Aug 3.


A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity.

Panzeri D, Cassani E, Doria E, Tagliabue G, Forti L, Campion B, Bollini R, Brearley CA, Pilu R, Nielsen E, Sparvoli F.

New Phytol. 2011 Jul;191(1):70-83. doi: 10.1111/j.1469-8137.2011.03666.x. Epub 2011 Mar 11.


Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition.

González B, Baños-Sanz JI, Villate M, Brearley CA, Sanz-Aparicio J.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9608-13. doi: 10.1073/pnas.0912979107. Epub 2010 May 7.


Jasmonate and phytochrome A signaling in Arabidopsis wound and shade responses are integrated through JAZ1 stability.

Robson F, Okamoto H, Patrick E, Harris SR, Wasternack C, Brearley C, Turner JG.

Plant Cell. 2010 Apr;22(4):1143-60. doi: 10.1105/tpc.109.067728. Epub 2010 Apr 30.


Cloning and biochemical characterization of a novel carbendazim (methyl-1H-benzimidazol-2-ylcarbamate)-hydrolyzing esterase from the newly isolated Nocardioides sp. strain SG-4G and its potential for use in enzymatic bioremediation.

Pandey G, Dorrian SJ, Russell RJ, Brearley C, Kotsonis S, Oakeshott JG.

Appl Environ Microbiol. 2010 May;76(9):2940-5. doi: 10.1128/AEM.02990-09. Epub 2010 Mar 12.


Intrinsic GTPase activity of a bacterial twin-arginine translocation proofreading chaperone induced by domain swapping.

Guymer D, Maillard J, Agacan MF, Brearley CA, Sargent F.

FEBS J. 2010 Jan;277(2):511-25. doi: 10.1111/j.1742-4658.2009.07507.x.


Crystallization and preliminary X-ray diffraction analysis of inositol 1,3,4,5,6-pentakisphosphate kinase from Arabidopsis thaliana.

Baños-Sanz JI, Villate M, Sanz-Aparicio J, Brearley CA, González B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):102-6. doi: 10.1107/S1744309109051057. Epub 2009 Dec 25.


Molecular dissection of bacterial acrylate catabolism--unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production.

Todd JD, Curson AR, Nikolaidou-Katsaraidou N, Brearley CA, Watmough NJ, Chan Y, Page PC, Sun L, Johnston AW.

Environ Microbiol. 2010 Feb;12(2):327-43. doi: 10.1111/j.1462-2920.2009.02071.x. Epub 2009 Oct 5.


The Arabidopsis ATP-binding cassette protein AtMRP5/AtABCC5 is a high affinity inositol hexakisphosphate transporter involved in guard cell signaling and phytate storage.

Nagy R, Grob H, Weder B, Green P, Klein M, Frelet-Barrand A, Schjoerring JK, Brearley C, Martinoia E.

J Biol Chem. 2009 Nov 27;284(48):33614-22. doi: 10.1074/jbc.M109.030247. Epub 2009 Sep 21.


Sorting out PtdIns(4,5)P2 and clathrin-coated vesicles in plants.

Brearley C.

Biochem J. 2008 Nov 1;415(3):e1-3. doi: 10.1042/BJ20081830.


Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves.

Tedman-Jones JD, Lei R, Jay F, Fabro G, Li X, Reiter WD, Brearley C, Jones JD.

Plant J. 2008 Dec;56(5):691-703. doi: 10.1111/j.1365-313X.2008.03636.x. Epub 2008 Jul 23.


A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens.

Murphy AM, Otto B, Brearley CA, Carr JP, Hanke DE.

Plant J. 2008 Nov;56(4):638-52. doi: 10.1111/j.1365-313X.2008.03629.x. Epub 2008 Jul 16.


A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities.

Caddick SE, Harrison CJ, Stavridou I, Mitchell JL, Hemmings AM, Brearley CA.

FEBS Lett. 2008 May 28;582(12):1731-7. doi: 10.1016/j.febslet.2008.04.034. Epub 2008 Apr 28.


Molecular genetic analysis of a dimethylsulfoniopropionate lyase that liberates the climate-changing gas dimethylsulfide in several marine alpha-proteobacteria and Rhodobacter sphaeroides.

Curson AR, Rogers R, Todd JD, Brearley CA, Johnston AW.

Environ Microbiol. 2008 Mar;10(3):757-67. doi: 10.1111/j.1462-2920.2007.01499.x. Erratum in: Environ Microbiol. 2008 Apr;10(4):1099.


Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis.

Sweetman D, Stavridou I, Johnson S, Green P, Caddick SE, Brearley CA.

FEBS Lett. 2007 Sep 4;581(22):4165-71. Epub 2007 Jul 30.


A lysine accumulation phenotype of ScIpk2Delta mutant yeast is rescued by Solanum tuberosum inositol phosphate multikinase.

Caddick SE, Harrison CJ, Stavridou I, Johnson S, Brearley CA.

Biochem J. 2007 May 1;403(3):381-9.


Characterization of myo-inositol hexakisphosphate deposits from larval Echinococcus granulosus.

Casaravilla C, Brearley C, Soulé S, Fontana C, Veiga N, Bessio MI, Ferreira F, Kremer C, Díaz A.

FEBS J. 2006 Jul;273(14):3192-203. Epub 2006 Jun 19.


At5PTase13 modulates cotyledon vein development through regulating auxin homeostasis.

Lin WH, Wang Y, Mueller-Roeber B, Brearley CA, Xu ZH, Xue HW.

Plant Physiol. 2005 Dec;139(4):1677-91. Epub 2005 Nov 18.


Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).

Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA.

Biochem J. 2006 Feb 15;394(Pt 1):95-103.


A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets.

Fung CY, Brearley CA, Farndale RW, Mahaut-Smith MP.

Thromb Haemost. 2005 Jul;94(1):37-40.


A role of Arabidopsis inositol polyphosphate kinase, AtIPK2alpha, in pollen germination and root growth.

Xu J, Brearley CA, Lin WH, Wang Y, Ye R, Mueller-Roeber B, Xu ZH, Xue HW.

Plant Physiol. 2005 Jan;137(1):94-103. Epub 2004 Dec 23.


AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression.

Gómez-Merino FC, Brearley CA, Ornatowska M, Abdel-Haliem ME, Zanor MI, Mueller-Roeber B.

J Biol Chem. 2004 Feb 27;279(9):8230-41. Epub 2003 Dec 9.


Inositol hexakisphosphate mobilizes an endomembrane store of calcium in guard cells.

Lemtiri-Chlieh F, MacRobbie EA, Webb AA, Manison NF, Brownlee C, Skepper JN, Chen J, Prestwich GD, Brearley CA.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10091-5. Epub 2003 Aug 11.


Platelet shape change evoked by selective activation of P2X1 purinoceptors with alpha,beta-methylene ATP.

Rolf MG, Brearley CA, Mahaut-Smith MP.

Thromb Haemost. 2001 Feb;85(2):303-8.


Inositol hexakisphosphate is a physiological signal regulating the K+-inward rectifying conductance in guard cells.

Lemtiri-Chlieh F, MacRobbie EA, Brearley CA.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8687-92.

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