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Items: 1 to 50 of 422

1.

High levels of AAV vector integration into CRISPR-induced DNA breaks.

Hanlon KS, Kleinstiver BP, Garcia SP, Zaborowski MP, Volak A, Spirig SE, Muller A, Sousa AA, Tsai SQ, Bengtsson NE, Lööv C, Ingelsson M, Chamberlain JS, Corey DP, Aryee MJ, Joung JK, Breakefield XO, Maguire CA, György B.

Nat Commun. 2019 Sep 30;10(1):4439. doi: 10.1038/s41467-019-12449-2.

2.

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.

Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous BA, Breakefield XO.

Mol Ther Methods Clin Dev. 2019 Aug 16;15:18-26. doi: 10.1016/j.omtm.2019.08.003. eCollection 2019 Dec 13.

3.

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21.

Abels ER, Maas SLN, Nieland L, Wei Z, Cheah PS, Tai E, Kolsteeg CJ, Dusoswa SA, Ting DT, Hickman S, El Khoury J, Krichevsky AM, Broekman MLD, Breakefield XO.

Cell Rep. 2019 Sep 17;28(12):3105-3119.e7. doi: 10.1016/j.celrep.2019.08.036.

4.

Glioma EVs Contribute to Immune Privilege in the Brain.

Abels ER, Broekman MLD, Breakefield XO, Maas SLN.

Trends Cancer. 2019 Jul;5(7):393-396. doi: 10.1016/j.trecan.2019.05.006. Epub 2019 Jun 4.

PMID:
31311653
5.

Advances in therapeutic applications of extracellular vesicles.

Wiklander OPB, Brennan MÁ, Lötvall J, Breakefield XO, El Andaloussi S.

Sci Transl Med. 2019 May 15;11(492). pii: eaav8521. doi: 10.1126/scitranslmed.aav8521. Review.

PMID:
31092696
6.

Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation.

Srinivasan S, Yeri A, Cheah PS, Chung A, Danielson K, De Hoff P, Filant J, Laurent CD, Laurent LD, Magee R, Moeller C, Murthy VL, Nejad P, Paul A, Rigoutsos I, Rodosthenous R, Shah RV, Simonson B, To C, Wong D, Yan IK, Zhang X, Balaj L, Breakefield XO, Daaboul G, Gandhi R, Lapidus J, Londin E, Patel T, Raffai RL, Sood AK, Alexander RP, Das S, Laurent LC.

Cell. 2019 Apr 4;177(2):446-462.e16. doi: 10.1016/j.cell.2019.03.024.

PMID:
30951671
7.

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.

Das S; Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC.

Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023. Review.

PMID:
30951667
8.

Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours.

Ricklefs FL, Maire CL, Reimer R, Dührsen L, Kolbe K, Holz M, Schneider E, Rissiek A, Babayan A, Hille C, Pantel K, Krasemann S, Glatzel M, Heiland DH, Flitsch J, Martens T, Schmidt NO, Peine S, Breakefield XO, Lawler S, Chiocca EA, Fehse B, Giebel B, Görgens A, Westphal M, Lamszus K.

J Extracell Vesicles. 2019 Mar 21;8(1):1588555. doi: 10.1080/20013078.2019.1588555. eCollection 2019.

9.

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.

Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO.

Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003.

10.

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD.

Neuron. 2018 Dec 19;100(6):1527-1532. doi: 10.1016/j.neuron.2018.11.043. No abstract available.

PMID:
30571943
11.

Characterization of single microvesicles in plasma from glioblastoma patients.

Fraser K, Jo A, Giedt J, Vinegoni C, Yang KS, Peruzzi P, Chiocca EA, Breakefield XO, Lee H, Weissleder R.

Neuro Oncol. 2019 May 6;21(5):606-615. doi: 10.1093/neuonc/noy187.

PMID:
30561734
12.

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells.

Gustafsson G, Lööv C, Persson E, Lázaro DF, Takeda S, Bergström J, Erlandsson A, Sehlin D, Balaj L, György B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M.

Cell Mol Neurobiol. 2018 Nov;38(8):1539-1550. doi: 10.1007/s10571-018-0622-5. Epub 2018 Oct 4.

13.

Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies.

Antoury L, Hu N, Balaj L, Das S, Georghiou S, Darras B, Clark T, Breakefield XO, Wheeler TM.

Nat Commun. 2018 Sep 25;9(1):3906. doi: 10.1038/s41467-018-06206-0.

14.

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

Eimer WA, Vijaya Kumar DK, Navalpur Shanmugam NK, Rodriguez AS, Mitchell T, Washicosky KJ, György B, Breakefield XO, Tanzi RE, Moir RD.

Neuron. 2018 Jul 11;99(1):56-63.e3. doi: 10.1016/j.neuron.2018.06.030. Erratum in: Neuron. 2018 Dec 19;100(6):1527-1532.

15.

Multidimensional communication in the microenvirons of glioblastoma.

Broekman ML, Maas SLN, Abels ER, Mempel TR, Krichevsky AM, Breakefield XO.

Nat Rev Neurol. 2018 Aug;14(8):482-495. doi: 10.1038/s41582-018-0025-8. Review.

16.

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M.

Mol Ther Nucleic Acids. 2018 Jun 1;11:429-440. doi: 10.1016/j.omtn.2018.03.007. Epub 2018 Mar 16.

17.

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA.

Sci Adv. 2018 Mar 7;4(3):eaar2766. doi: 10.1126/sciadv.aar2766. eCollection 2018 Mar.

18.

Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly.

Aneichyk T, Hendriks WT, Yadav R, Shin D, Gao D, Vaine CA, Collins RL, Domingo A, Currall B, Stortchevoi A, Multhaupt-Buell T, Penney EB, Cruz L, Dhakal J, Brand H, Hanscom C, Antolik C, Dy M, Ragavendran A, Underwood J, Cantsilieris S, Munson KM, Eichler EE, Acuña P, Go C, Jamora RDG, Rosales RL, Church DM, Williams SR, Garcia S, Klein C, Müller U, Wilhelmsen KC, Timmers HTM, Sapir Y, Wainger BJ, Henderson D, Ito N, Weisenfeld N, Jaffe D, Sharma N, Breakefield XO, Ozelius LJ, Bragg DC, Talkowski ME.

Cell. 2018 Feb 22;172(5):897-909.e21. doi: 10.1016/j.cell.2018.02.011.

19.

Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.

György B, Cruz L, Yellen D, Aufiero M, Alland I, Zhang X, Ericsson M, Fraefel C, Li YC, Takeda S, Hyman BT, Breakefield XO.

Sci Rep. 2018 Feb 2;8(1):2324. doi: 10.1038/s41598-018-19865-2.

20.

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles.

Reátegui E, van der Vos KE, Lai CP, Zeinali M, Atai NA, Aldikacti B, Floyd FP Jr, H Khankhel A, Thapar V, Hochberg FH, Sequist LV, Nahed BV, S Carter B, Toner M, Balaj L, T Ting D, Breakefield XO, Stott SL.

Nat Commun. 2018 Jan 12;9(1):175. doi: 10.1038/s41467-017-02261-1.

21.

Multiplexed Profiling of Single Extracellular Vesicles.

Lee K, Fraser K, Ghaddar B, Yang K, Kim E, Balaj L, Chiocca EA, Breakefield XO, Lee H, Weissleder R.

ACS Nano. 2018 Jan 23;12(1):494-503. doi: 10.1021/acsnano.7b07060. Epub 2018 Jan 4.

22.

Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1.

Bragg DC, Mangkalaphiban K, Vaine CA, Kulkarni NJ, Shin D, Yadav R, Dhakal J, Ton ML, Cheng A, Russo CT, Ang M, Acuña P, Go C, Franceour TN, Multhaupt-Buell T, Ito N, Müller U, Hendriks WT, Breakefield XO, Sharma N, Ozelius LJ.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11020-E11028. doi: 10.1073/pnas.1712526114. Epub 2017 Dec 11.

23.

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Wei Z, Batagov AO, Schinelli S, Wang J, Wang Y, El Fatimy R, Rabinovsky R, Balaj L, Chen CC, Hochberg F, Carter B, Breakefield XO, Krichevsky AM.

Nat Commun. 2017 Oct 26;8(1):1145. doi: 10.1038/s41467-017-01196-x.

24.

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.

György B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP, Maguire CA.

Mol Ther. 2017 Feb 1;25(2):379-391. doi: 10.1016/j.ymthe.2016.12.010. Epub 2017 Jan 9.

25.

Extracellular Vesicles: Unique Intercellular Delivery Vehicles.

Maas SLN, Breakefield XO, Weaver AM.

Trends Cell Biol. 2017 Mar;27(3):172-188. doi: 10.1016/j.tcb.2016.11.003. Epub 2016 Dec 13. Review.

26.

Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells.

Soares VY, Atai NA, Fujita T, Dilwali S, Sivaraman S, Landegger LD, Hochberg FH, Oliveira CA, Bahmad F, Breakefield XO, Stankovic KM.

Neuro Oncol. 2016 Nov;18(11):1498-1507. Epub 2016 May 18.

27.

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake.

Abels ER, Breakefield XO.

Cell Mol Neurobiol. 2016 Apr;36(3):301-12. doi: 10.1007/s10571-016-0366-z. Epub 2016 Apr 6. Review.

28.

Extracellular vesicles and intercellular communication within the nervous system.

Zappulli V, Friis KP, Fitzpatrick Z, Maguire CA, Breakefield XO.

J Clin Invest. 2016 Apr 1;126(4):1198-207. doi: 10.1172/JCI81134. Epub 2016 Apr 1. Review.

29.

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.

Hall J, Prabhakar S, Balaj L, Lai CP, Cerione RA, Breakefield XO.

Cell Mol Neurobiol. 2016 Apr;36(3):417-27. doi: 10.1007/s10571-015-0309-0. Epub 2016 Mar 26. Review.

30.

Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity.

Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A.

Cancer Res. 2016 May 15;76(10):2876-81. doi: 10.1158/0008-5472.CAN-15-3432. Epub 2016 Mar 24.

31.

α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.

Lööv C, Scherzer CR, Hyman BT, Breakefield XO, Ingelsson M.

Cell Mol Neurobiol. 2016 Apr;36(3):437-48. doi: 10.1007/s10571-015-0317-0. Epub 2016 Mar 18. Review.

PMID:
26993503
32.

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions.

Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ.

Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.

33.

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study.

Zaborowski MP, Balaj L, Breakefield XO, Lai CP.

Bioscience. 2015 Aug 1;65(8):783-797. Epub 2015 Jun 26.

34.

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture.

Zhang X, Abels ER, Redzic JS, Margulis J, Finkbeiner S, Breakefield XO.

Cell Mol Neurobiol. 2016 Apr;36(3):459-70. doi: 10.1007/s10571-016-0350-7. Epub 2016 Mar 7.

35.

Viral vectors for therapy of neurologic diseases.

Choudhury SR, Hudry E, Maguire CA, Sena-Esteves M, Breakefield XO, Grandi P.

Neuropharmacology. 2017 Jul 1;120:63-80. doi: 10.1016/j.neuropharm.2016.02.013. Epub 2016 Feb 21. Review.

36.

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells.

Ito N, Hendriks WT, Dhakal J, Vaine CA, Liu C, Shin D, Shin K, Wakabayashi-Ito N, Dy M, Multhaupt-Buell T, Sharma N, Breakefield XO, Bragg DC.

Dis Model Mech. 2016 Apr;9(4):451-62. doi: 10.1242/dmm.022590. Epub 2016 Jan 14.

37.

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain.

van der Vos KE, Abels ER, Zhang X, Lai C, Carrizosa E, Oakley D, Prabhakar S, Mardini O, Crommentuijn MH, Skog J, Krichevsky AM, Stemmer-Rachamimov A, Mempel TR, El Khoury J, Hickman SE, Breakefield XO.

Neuro Oncol. 2016 Jan;18(1):58-69. doi: 10.1093/neuonc/nov244. Epub 2015 Oct 3.

38.

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.

Prabhakar S, Zhang X, Goto J, Han S, Lai C, Bronson R, Sena-Esteves M, Ramesh V, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.

Neurobiol Dis. 2015 Oct;82:22-31. doi: 10.1016/j.nbd.2015.04.018. Epub 2015 May 24.

39.

Heparin affinity purification of extracellular vesicles.

Balaj L, Atai NA, Chen W, Mu D, Tannous BA, Breakefield XO, Skog J, Maguire CA.

Sci Rep. 2015 May 19;5:10266. doi: 10.1038/srep10266.

40.

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.

Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO.

Nat Commun. 2015 May 13;6:7029. doi: 10.1038/ncomms8029.

41.

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H, Weissleder R.

Nat Commun. 2015 May 11;6:6999. doi: 10.1038/ncomms7999.

42.

Mutant human torsinA, responsible for early-onset dystonia, dominantly suppresses GTPCH expression, dopamine levels and locomotion in Drosophila melanogaster.

Wakabayashi-Ito N, Ajjuri RR, Henderson BW, Doherty OM, Breakefield XO, O'Donnell JM, Ito N.

Biol Open. 2015 Apr 17;4(5):585-95. doi: 10.1242/bio.201411080.

43.

Adenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy.

Gong Y, Mu D, Prabhakar S, Moser A, Musolino P, Ren J, Breakefield XO, Maguire CA, Eichler FS.

Mol Ther. 2015 May;23(5):824-834. doi: 10.1038/mt.2015.6. Epub 2015 Jan 16.

44.

Emerging roles of extracellular vesicles in the nervous system.

Rajendran L, Bali J, Barr MM, Court FA, Krämer-Albers EM, Picou F, Raposo G, van der Vos KE, van Niel G, Wang J, Breakefield XO.

J Neurosci. 2014 Nov 12;34(46):15482-9. doi: 10.1523/JNEUROSCI.3258-14.2014. Review.

45.

Therapeutic applications of extracellular vesicles: clinical promise and open questions.

György B, Hung ME, Breakefield XO, Leonard JN.

Annu Rev Pharmacol Toxicol. 2015;55:439-464. doi: 10.1146/annurev-pharmtox-010814-124630. Epub 2014 Oct 3. Review.

46.

New methods for investigation of neuronal migration in embryonic brain explants.

Nery FC, da Hora CC, Yaqub U, Zhang X, McCarthy DM, Bhide PG, Irimia D, Breakefield XO.

J Neurosci Methods. 2015 Jan 15;239:80-4. doi: 10.1016/j.jneumeth.2014.09.028. Epub 2014 Oct 5.

47.

Update from the 2013 International Neurofibromatosis Conference.

Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Kalamarides M, McClatchey AI, Messiaen L, Morrison H, Parkinson DB, Stemmer-Rachamimov AO, Van Raamsdonk CD, Riccardi VM, Rosser T, Schindeler A, Smith MJ, Stevenson DA, Ullrich NJ, van der Vaart T, Weiss B, Widemann BC, Zhu Y, Bakker AC, Lloyd AC.

Am J Med Genet A. 2014 Dec;164A(12):2969-78. doi: 10.1002/ajmg.a.36754. Epub 2014 Sep 24. No abstract available.

48.

Gene therapy for the nervous system: challenges and new strategies.

Maguire CA, Ramirez SH, Merkel SF, Sena-Esteves M, Breakefield XO.

Neurotherapeutics. 2014 Oct;11(4):817-39. doi: 10.1007/s13311-014-0299-5. Review.

49.

Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1A.

Hettich J, Ryan SD, de Souza ON, Saraiva Macedo Timmers LF, Tsai S, Atai NA, da Hora CC, Zhang X, Kothary R, Snapp E, Ericsson M, Grundmann K, Breakefield XO, Nery FC.

Hum Mutat. 2014 Sep;35(9):1101-13. doi: 10.1002/humu.22602. Epub 2014 Jul 17.

50.

Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.

Nery FC, Atai NA, da Hora CC, Kim EY, Hettich J, Mempel TR, Breakefield XO, Irimia D.

J Neurosci Methods. 2014 Jul 30;232:181-188. doi: 10.1016/j.jneumeth.2014.05.027. Epub 2014 May 29.

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