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Items: 20


Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6.

Acosta Lopez MJ, Trevisson E, Canton M, Vazquez-Fonseca L, Morbidoni V, Baschiera E, Frasson C, Pelosi L, Rascalou B, Desbats MA, Alcázar-Fabra M, Ríos JJ, Sánchez-García A, Basso G, Navas P, Pierrel F, Brea-Calvo G, Salviati L.

Oxid Med Cell Longev. 2019 Jul 10;2019:3904905. doi: 10.1155/2019/3904905. eCollection 2019.


Clinical whole-exome sequencing reveals a common pathogenic variant in patients with CoQ10 deficiency: An underdiagnosed cause of mitochondriopathy.

Ling TK, Law CY, Yan KW, Fong NC, Wong KC, Lee KL, Chu WC, Brea-Calvo G, Lam CW.

Clin Chim Acta. 2019 Jul 17;497:88-94. doi: 10.1016/j.cca.2019.07.016. [Epub ahead of print]


Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.

Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C.

Cell Metab. 2018 Nov 6;28(5):764-775.e5. doi: 10.1016/j.cmet.2018.07.012. Epub 2018 Aug 16.


Clinical syndromes associated with Coenzyme Q10 deficiency.

Alcázar-Fabra M, Trevisson E, Brea-Calvo G.

Essays Biochem. 2018 Jul 20;62(3):377-398. doi: 10.1042/EBC20170107. Print 2018 Jul 20. Review.


Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.

Navas-Enamorado I, Bernier M, Brea-Calvo G, de Cabo R.

Ageing Res Rev. 2017 Aug;37:39-52. doi: 10.1016/j.arr.2017.04.005. Epub 2017 May 6. Review. No abstract available.


Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders.

Yubero D, Montero R, Martín MA, Montoya J, Ribes A, Grazina M, Trevisson E, Rodriguez-Aguilera JC, Hargreaves IP, Salviati L, Navas P, Artuch R; CoQ deficiency study group, Jou C, Jimenez-Mallebrera C, Nascimento A, Pérez-Dueñas B, Ortez C, Ramos F, Colomer J, O'Callaghan M, Pineda M, García-Cazorla A, Espinós C, Ruiz A, Macaya A, Marcé-Grau A, Garcia-Villoria J, Arias A, Emperador S, Ruiz-Pesini E, Lopez-Gallardo E, Neergheen V, Simões M, Diogo L, Blázquez A, González-Quintana A, Delmiro A, Domínguez-González C, Arenas J, García-Silva MT, Martín E, Quijada P, Hernández-Laín A, Morán M, Rivas Infante E, Ávila Polo R, Paradas Lópe C, Bautista Lorite J, Martínez Fernández EM, Cortés AB, Sánchez-Cuesta A, Cascajo MV, Alcázar M, Brea-Calvo G.

Mitochondrion. 2016 Sep;30:51-8. doi: 10.1016/j.mito.2016.06.007. Epub 2016 Jun 30.


Coenzyme Q biosynthesis and its role in the respiratory chain structure.

Alcázar-Fabra M, Navas P, Brea-Calvo G.

Biochim Biophys Acta. 2016 Aug;1857(8):1073-1078. doi: 10.1016/j.bbabio.2016.03.010. Epub 2016 Mar 10. Review.


COQ4 mutations cause a broad spectrum of mitochondrial disorders associated with CoQ10 deficiency.

Brea-Calvo G, Haack TB, Karall D, Ohtake A, Invernizzi F, Carrozzo R, Kremer L, Dusi S, Fauth C, Scholl-Bürgi S, Graf E, Ahting U, Resta N, Laforgia N, Verrigni D, Okazaki Y, Kohda M, Martinelli D, Freisinger P, Strom TM, Meitinger T, Lamperti C, Lacson A, Navas P, Mayr JA, Bertini E, Murayama K, Zeviani M, Prokisch H, Ghezzi D.

Am J Hum Genet. 2015 Feb 5;96(2):309-17. doi: 10.1016/j.ajhg.2014.12.023.


MPV17L2 is required for ribosome assembly in mitochondria.

Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A.

Nucleic Acids Res. 2014 Jul;42(13):8500-15. doi: 10.1093/nar/gku513. Epub 2014 Jun 19.


Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis.

Johnson MA, Vidoni S, Durigon R, Pearce SF, Rorbach J, He J, Brea-Calvo G, Minczuk M, Reyes A, Holt IJ, Spinazzola A.

PLoS One. 2014 Apr 9;9(4):e93597. doi: 10.1371/journal.pone.0093597. eCollection 2014.


A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.

Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ.

PLoS One. 2013 May 13;8(5):e62340. doi: 10.1371/journal.pone.0062340. Print 2013.


Alternative translation initiation augments the human mitochondrial proteome.

Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ.

Nucleic Acids Res. 2013 Feb 1;41(4):2354-69. doi: 10.1093/nar/gks1347. Epub 2012 Dec 28.


Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis.

Brea-Calvo G, Siendones E, Sánchez-Alcázar JA, de Cabo R, Navas P.

PLoS One. 2009;4(4):e5301. doi: 10.1371/journal.pone.0005301. Epub 2009 Apr 23.


The apoptotic microtubule network preserves plasma membrane integrity during the execution phase of apoptosis.

Sánchez-Alcázar JA, Rodríguez-Hernández A, Cordero MD, Fernández-Ayala DJ, Brea-Calvo G, Garcia K, Navas P.

Apoptosis. 2007 Jul;12(7):1195-208.


Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation.

Artuch R, Brea-Calvo G, Briones P, Aracil A, Galván M, Espinós C, Corral J, Volpini V, Ribes A, Andreu AL, Palau F, Sánchez-Alcázar JA, Navas P, Pineda M.

J Neurol Sci. 2006 Jul 15;246(1-2):153-8. Epub 2006 May 3.


Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines.

Brea-Calvo G, Rodríguez-Hernández A, Fernández-Ayala DJ, Navas P, Sánchez-Alcázar JA.

Free Radic Biol Med. 2006 Apr 15;40(8):1293-302. Epub 2005 Dec 13.


Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis.

Rodríguez-Hernández A, Brea-Calvo G, Fernández-Ayala DJ, Cordero M, Navas P, Sánchez-Alcázar JA.

Apoptosis. 2006 Jan;11(1):131-9. Erratum in: Apoptosis. 2006 Mar;11(3):453.


Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system.

Fernández-Ayala DJ, Brea-Calvo G, López-Lluch G, Navas P.

Biochim Biophys Acta. 2005 Jul 30;1713(2):129-37.


Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression.

Sánchez-Alcázar JA, Bradbury DA, Brea-Calvo G, Navas P, Knox AJ.

Apoptosis. 2003 Dec;8(6):639-47.


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