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Items: 31

1.

An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes.

Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y.

Chem Biol Interact. 2019 Aug 1;308:179-184. doi: 10.1016/j.cbi.2019.05.016. Epub 2019 May 14.

PMID:
31100280
2.

Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease.

Meden A, Knez D, Jukič M, Brazzolotto X, Gršič M, Pišlar A, Zahirović A, Kos J, Nachon F, Svete J, Gobec S, Grošelj U.

Chem Commun (Camb). 2019 Mar 26;55(26):3765-3768. doi: 10.1039/c9cc01330j.

PMID:
30864579
3.

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K.

Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27.

PMID:
30851693
4.

Purification of recombinant human butyrylcholinesterase on Hupresin®.

Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Dec 1;1102-1103:109-115. doi: 10.1016/j.jchromb.2018.10.026. Epub 2018 Oct 25.

PMID:
30384187
5.

X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates.

Touvrey C, Courageux C, Guillon V, Terreux R, Nachon F, Brazzolotto X.

Toxicology. 2019 Jan 1;411:15-23. doi: 10.1016/j.tox.2018.10.015. Epub 2018 Oct 22.

PMID:
30359675
6.

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.

Knez D, Coquelle N, Pišlar A, Žakelj S, Jukič M, Sova M, Mravljak J, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.

Eur J Med Chem. 2018 Aug 5;156:598-617. doi: 10.1016/j.ejmech.2018.07.033. Epub 2018 Jul 19.

PMID:
30031971
7.

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.

Košak U, Brus B, Knez D, Žakelj S, Trontelj J, Pišlar A, Šink R, Jukič M, Živin M, Podkowa A, Nachon F, Brazzolotto X, Stojan J, Kos J, Coquelle N, Sałat K, Colletier JP, Gobec S.

J Med Chem. 2018 Jan 11;61(1):119-139. doi: 10.1021/acs.jmedchem.7b01086. Epub 2017 Dec 22.

PMID:
29227101
8.

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

Rosenberry TL, Brazzolotto X, Macdonald IR, Wandhammer M, Trovaslet-Leroy M, Darvesh S, Nachon F.

Molecules. 2017 Nov 29;22(12). pii: E2098. doi: 10.3390/molecules22122098.

9.

Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development.

Brazzolotto X, Igert A, Guillon V, Santoni G, Nachon F.

Molecules. 2017 Oct 27;22(11). pii: E1828. doi: 10.3390/molecules22111828.

10.

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

Košak U, Brus B, Knez D, Šink R, Žakelj S, Trontelj J, Pišlar A, Šlenc J, Gobec M, Živin M, Tratnjek L, Perše M, Sałat K, Podkowa A, Filipek B, Nachon F, Brazzolotto X, Więckowska A, Malawska B, Stojan J, Raščan IM, Kos J, Coquelle N, Colletier JP, Gobec S.

Sci Rep. 2016 Dec 21;6:39495. doi: 10.1038/srep39495.

11.

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.

Košak U, Knez D, Coquelle N, Brus B, Pišlar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.

Bioorg Med Chem. 2017 Jan 15;25(2):633-645. doi: 10.1016/j.bmc.2016.11.032. Epub 2016 Nov 19.

PMID:
27908752
12.

Structural analysis of point mutations at the Vaccinia virus A20/D4 interface.

Contesto-Richefeu C, Tarbouriech N, Brazzolotto X, Burmeister WP, Peyrefitte CN, Iseni F.

Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):687-91. doi: 10.1107/S2053230X16011778. Epub 2016 Aug 9.

13.

Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.

Dighe SN, Deora GS, De la Mora E, Nachon F, Chan S, Parat MO, Brazzolotto X, Ross BP.

J Med Chem. 2016 Aug 25;59(16):7683-9. doi: 10.1021/acs.jmedchem.6b00356. Epub 2016 Jul 26.

PMID:
27405689
14.

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.

Knez D, Brus B, Coquelle N, Sosič I, Šink R, Brazzolotto X, Mravljak J, Colletier JP, Gobec S.

Bioorg Med Chem. 2015 Aug 1;23(15):4442-52. doi: 10.1016/j.bmc.2015.06.010. Epub 2015 Jun 14.

PMID:
26116179
15.

Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.

Brazzolotto X, Pierrel F, Pelosi L.

Biochem J. 2014 May 15;460(1):79-89. doi: 10.1042/BJ20140107.

PMID:
24624902
16.

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain.

Contesto-Richefeu C, Tarbouriech N, Brazzolotto X, Betzi S, Morelli X, Burmeister WP, Iseni F.

PLoS Pathog. 2014 Mar 6;10(3):e1003978. doi: 10.1371/journal.ppat.1003978. eCollection 2014 Mar.

17.

An EPR/HYSCORE, Mössbauer, and resonance Raman study of the hydrogenase maturation enzyme HydF: a model for N-coordination to [4Fe-4S] clusters.

Berggren G, Garcia-Serres R, Brazzolotto X, Clemancey M, Gambarelli S, Atta M, Latour JM, Hernández HL, Subramanian S, Johnson MK, Fontecave M.

J Biol Inorg Chem. 2014 Jan;19(1):75-84. doi: 10.1007/s00775-013-1062-9. Epub 2013 Nov 17.

18.

Progress in the development of enzyme-based nerve agent bioscavengers.

Nachon F, Brazzolotto X, Trovaslet M, Masson P.

Chem Biol Interact. 2013 Dec 5;206(3):536-44. doi: 10.1016/j.cbi.2013.06.012. Epub 2013 Jun 26. Review.

PMID:
23811386
19.

Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: implication of the PKA pathway.

Conti A, Sueur C, Lupo J, Brazzolotto X, Burmeister WP, Manet E, Gruffat H, Morand P, Boyer V.

Eur J Cell Biol. 2013 Mar;92(3):105-11. doi: 10.1016/j.ejcb.2012.12.001. Epub 2013 Feb 8.

PMID:
23395486
20.

Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.

Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F.

FEBS J. 2012 Aug;279(16):2905-16. doi: 10.1111/j.1742-4658.2012.08672.x. Epub 2012 Jul 12.

21.

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.

Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041. Epub 2011 Jun 12.

PMID:
21683774
22.

A micromolar O-sulfated thiohydroximate inhibitor bound to plant myrosinase.

Besle A, Brazzolotto X, Tatibouët A, Cerniauskaite D, Gallienne E, Rollin P, Burmeister WP.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Feb 1;66(Pt 2):152-5. doi: 10.1107/S1744309109052865. Epub 2010 Jan 27.

23.

The Saccharomyces cerevisiae ADP/ATP carrier-iso 1 cytochrome c fusion protein: one-step purification and functional analysis in vitro.

Rey M, Brazzolotto X, Clémençon B, Afchain A, Brandolin G, Pelosi L.

Biochimie. 2007 Sep;89(9):1070-9. Epub 2007 Apr 10.

PMID:
17524547
24.

Crystallization and preliminary X-ray diffraction data for the aconitase form of human iron-regulatory protein 1.

Dupuy J, Darnault C, Brazzolotto X, Kühn LC, Moulis JM, Volbeda A, Fontecilla-Camps JC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):482-5. Epub 2005 Apr 9.

25.

The [Fe-Fe]-hydrogenase maturation protein HydF from Thermotoga maritima is a GTPase with an iron-sulfur cluster.

Brazzolotto X, Rubach JK, Gaillard J, Gambarelli S, Atta M, Fontecave M.

J Biol Chem. 2006 Jan 13;281(2):769-74. Epub 2005 Nov 8.

26.

Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima.

Rubach JK, Brazzolotto X, Gaillard J, Fontecave M.

FEBS Lett. 2005 Sep 12;579(22):5055-60.

27.

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute T, Brazzolotto X, Berger UV, Land W, Ollivierre-Wilson H, Grinberg A, Love P, Rouault TA.

EMBO J. 2004 Jan 28;23(2):386-95. Epub 2004 Jan 15.

28.

Peroxynitrite and nitric oxide differently target the iron-sulfur cluster and amino acid residues of human iron regulatory protein 1.

Soum E, Brazzolotto X, Goussias C, Bouton C, Moulis JM, Mattioli TA, Drapier JC.

Biochemistry. 2003 Jul 1;42(25):7648-54.

PMID:
12820873
29.

Interactions between doxorubicin and the human iron regulatory system.

Brazzolotto X, Andriollo M, Guiraud P, Favier A, Moulis JM.

Biochim Biophys Acta. 2003 Feb 17;1593(2-3):209-18.

30.

Structural changes associated with switching activities of human iron regulatory protein 1.

Brazzolotto X, Timmins P, Dupont Y, Moulis JM.

J Biol Chem. 2002 Apr 5;277(14):11995-2000. Epub 2002 Jan 25.

31.

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