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Items: 1 to 50 of 217

1.

Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.

Brautigan DL, Shenolikar S.

Annu Rev Biochem. 2018 Jun 20;87:921-964. doi: 10.1146/annurev-biochem-062917-012332.

PMID:
29925267
2.

Modulation of GSK3β autoinhibition by Thr-7 and Thr-8.

Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z.

FEBS Lett. 2018 Feb;592(4):537-546. doi: 10.1002/1873-3468.12990. Epub 2018 Feb 8.

PMID:
29377106
3.

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.

McClinch K, Avelar RA, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky DB, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D, Zaware N, Gong Y, Brautigan DL, Plymate SR, Sprenger CCT, Oh WK, Levine AC, Kirschenbaum A, Sfakianos JP, Sears R, DiFeo A, Ioannou Y, Ohlmeyer M, Narla G, Galsky MD.

Cancer Res. 2018 Apr 15;78(8):2065-2080. doi: 10.1158/0008-5472.CAN-17-0123. Epub 2018 Jan 22.

PMID:
29358171
4.

The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization.

Wilkins LR, Stone JR, Mata J, Hawrylack A, Kubicka E, Brautigan DL.

J Vasc Interv Radiol. 2017 Oct;28(10):1467-1471. doi: 10.1016/j.jvir.2017.04.005.

PMID:
28941521
5.

Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Ziembik MA, Bender TP, Larner JM, Brautigan DL.

Biochem Soc Trans. 2017 Jun 15;45(3):693-701. doi: 10.1042/BST20160169. Review.

6.

Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.

Sarkar S, Brautigan DL, Larner JM.

Mol Cancer Res. 2017 Aug;15(8):1063-1072. doi: 10.1158/1541-7786.MCR-17-0062. Epub 2017 May 23.

PMID:
28536143
7.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G.

J Clin Invest. 2017 Jun 1;127(6):2081-2090. doi: 10.1172/JCI89548. Epub 2017 May 15.

8.

Lysolecithin as feed additive enhances collagen expression and villus length in the jejunum of broiler chickens.

Brautigan DL, Li R, Kubicka E, Turner SD, Garcia JS, Weintraut ML, Wong EA.

Poult Sci. 2017 Aug 1;96(8):2889-2898. doi: 10.3382/ps/pex078.

PMID:
28444343
9.

The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.

Biswas K, Sarkar S, Du K, Brautigan DL, Abbas T, Larner JM.

Mol Cancer Res. 2017 Jun;15(6):651-659. doi: 10.1158/1541-7786.MCR-16-0466. Epub 2017 Feb 23.

10.

Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.

Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S244-S262. doi: 10.1074/mcp.O116.063487. Epub 2017 Feb 7.

11.

Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma.

Wilkins LR, Brautigan DL, Wu H, Yarmohammadi H, Kubicka E, Serbulea V, Leitinger N, Liu W, Haaga JR.

Cardiovasc Intervent Radiol. 2017 Mar;40(3):430-437. doi: 10.1007/s00270-016-1515-y. Epub 2016 Nov 21.

12.

Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.

Farinha CM, Swiatecka-Urban A, Brautigan DL, Jordan P.

Front Chem. 2016 Jan 20;4:1. doi: 10.3389/fchem.2016.00001. eCollection 2016. Review.

13.

Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin.

Li R, Turner SD, Brautigan DL.

Biochem Biophys Rep. 2015 Aug 21;4:52-58. doi: 10.1016/j.bbrep.2015.08.012. eCollection 2015 Dec.

14.

RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.

Griner EM, Dancik GM, Costello JC, Owens C, Guin S, Edwards MG, Brautigan DL, Theodorescu D.

Mol Cancer Res. 2015 Mar;13(3):483-92. doi: 10.1158/1541-7786.MCR-14-0420. Epub 2014 Dec 16.

15.

Discovery and characterization of small molecules that target the GTPase Ral.

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D.

Nature. 2014 Nov 20;515(7527):443-7. doi: 10.1038/nature13713. Epub 2014 Sep 14.

16.

Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53.

Hall EH, Liu Y, Xiao A, Shock L, Brautigan DL, Mayo MW, Adusumilli PS, Jones DR.

PLoS One. 2014 Apr 24;9(4):e95869. doi: 10.1371/journal.pone.0095869. eCollection 2014.

17.

LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.

Luz S, Cihil KM, Brautigan DL, Amaral MD, Farinha CM, Swiatecka-Urban A.

J Biol Chem. 2014 May 23;289(21):15080-93. doi: 10.1074/jbc.M114.563742. Epub 2014 Apr 11.

18.

T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.

Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J.

Mol Cancer Res. 2014 Mar;12(3):348-58. doi: 10.1158/1541-7786.MCR-13-0485. Epub 2013 Dec 20.

19.

Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions.

Ohama T, Wang L, Griner EM, Brautigan DL.

BMC Cell Biol. 2013 Sep 25;14:42. doi: 10.1186/1471-2121-14-42.

20.

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.

Martín-Montalvo A, González-Mariscal I, Pomares-Viciana T, Padilla-López S, Ballesteros M, Vazquez-Fonseca L, Gandolfo P, Brautigan DL, Navas P, Santos-Ocaña C.

J Biol Chem. 2013 Sep 27;288(39):28126-37. doi: 10.1074/jbc.M113.474494. Epub 2013 Aug 12.

21.

Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47).

Slingluff CL Jr, Petroni GR, Molhoek KR, Brautigan DL, Chianese-Bullock KA, Shada AL, Smolkin ME, Olson WC, Gaucher A, Chase CM, Grosh WW, Weiss GR, Wagenseller AG, Olszanski AJ, Martin L, Shea SM, Erdag G, Ram P, Gershenwald JE, Weber MJ.

Clin Cancer Res. 2013 Jul 1;19(13):3611-20. doi: 10.1158/1078-0432.CCR-12-3919. Epub 2013 Apr 25.

22.

Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.

Korrodi-Gregório L, Ferreira M, Vintém AP, Wu W, Muller T, Marcus K, Vijayaraghavan S, Brautigan DL, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF.

BMC Cell Biol. 2013 Mar 18;14:15. doi: 10.1186/1471-2121-14-15.

23.
24.

Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.

Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J.

Biochem Pharmacol. 2013 Apr 1;85(7):888-97. doi: 10.1016/j.bcp.2012.12.017. Epub 2013 Jan 1.

PMID:
23287412
25.

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells.

Sarkar S, Brautigan DL, Parsons SJ, Larner JM.

Oncogene. 2014 Jan 2;33(1):26-33. doi: 10.1038/onc.2012.561. Epub 2012 Dec 17.

26.

Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.

Holy M, Brautigan DL.

Toxins (Basel). 2012 Oct;4(10):940-54. doi: 10.3390/toxins4100940. Epub 2012 Oct 22.

27.

Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling.

Eto M, Brautigan DL.

IUBMB Life. 2012 Sep;64(9):732-9. doi: 10.1002/iub.1067. Epub 2012 Jul 20. Review.

28.

Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.

Brautigan DL.

FEBS J. 2013 Jan;280(2):324-45. doi: 10.1111/j.1742-4658.2012.08609.x. Epub 2012 May 21. Review.

29.

PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity.

Griner EM, Churchill ME, Brautigan DL, Theodorescu D.

Oncogene. 2013 Feb 21;32(8):1010-7. doi: 10.1038/onc.2012.124. Epub 2012 Apr 2.

30.

PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.

Hosing AS, Valerie NC, Dziegielewski J, Brautigan DL, Larner JM.

J Biol Chem. 2012 Mar 16;287(12):9230-9. doi: 10.1074/jbc.M111.333708. Epub 2012 Feb 1.

31.
32.

Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.

Martín-Montalvo A, González-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C.

Biochem J. 2011 Nov 15;440(1):107-14. doi: 10.1042/BJ20101422.

PMID:
21812761
33.

Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1.

Hall EH, Gurel V, Dahlberg AE, McMichael J, Brautigan DL.

Cell Signal. 2011 Dec;23(12):1972-7. doi: 10.1016/j.cellsig.2011.07.007. Epub 2011 Jul 20.

34.

Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.

Sami F, Smet-Nocca C, Khan M, Landrieu I, Lippens G, Brautigan DL.

Biochemistry. 2011 Aug 2;50(30):6567-78. doi: 10.1021/bi200553e. Epub 2011 Jul 8.

35.

Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R.

Molhoek KR, Shada AL, Smolkin M, Chowbina S, Papin J, Brautigan DL, Slingluff CL Jr.

Melanoma Res. 2011 Aug;21(4):274-84. doi: 10.1097/CMR.0b013e328343a1d6.

36.

VEGFR-2 expression in human melanoma: revised assessment.

Molhoek KR, Erdag G, Rasamny JK, Murphy C, Deacon D, Patterson JW, Slingluff CL Jr, Brautigan DL.

Int J Cancer. 2011 Dec 15;129(12):2807-15. doi: 10.1002/ijc.25963. Epub 2011 May 5.

37.

Mitotic phosphorylation activates hepatoma-derived growth factor as a mitogen.

Everett AD, Yang J, Rahman M, Dulloor P, Brautigan DL.

BMC Cell Biol. 2011 Apr 13;12:15. doi: 10.1186/1471-2121-12-15.

38.

Phosphorylation of RalB is important for bladder cancer cell growth and metastasis.

Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D.

Cancer Res. 2010 Nov 1;70(21):8760-9. doi: 10.1158/0008-5472.CAN-10-0952. Epub 2010 Oct 12.

39.

D-chiro-inositol glycans in insulin signaling and insulin resistance.

Larner J, Brautigan DL, Thorner MO.

Mol Med. 2010 Nov-Dec;16(11-12):543-52. doi: 10.2119/molmed.2010.00107. Epub 2010 Aug 27. Review.

40.

Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.

Hall EH, Balsbaugh JL, Rose KL, Shabanowitz J, Hunt DF, Brautigan DL.

Mol Cell Proteomics. 2010 Dec;9(12):2853-63. doi: 10.1074/mcp.M110.003665. Epub 2010 Aug 26.

41.

Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.

Ohama T, Brautigan DL.

J Biol Chem. 2010 Mar 19;285(12):8711-8. doi: 10.1074/jbc.M109.099788. Epub 2010 Jan 25.

42.

Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha.

Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR.

Bioorg Med Chem. 2010 Feb;18(3):1103-10. doi: 10.1016/j.bmc.2009.12.056. Epub 2010 Jan 4.

43.
44.

Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.

Guergnon J, Derewenda U, Edelson JR, Brautigan DL.

BMC Biochem. 2009 Oct 16;10:24. doi: 10.1186/1471-2091-10-24.

45.

Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.

Hall EH, Daugherty AE, Choi CK, Horwitz AF, Brautigan DL.

J Biol Chem. 2009 Dec 11;284(50):34713-22. doi: 10.1074/jbc.M109.059592. Epub 2009 Oct 13.

46.

Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.

Morales-Johansson H, Puria R, Brautigan DL, Cardenas ME.

PLoS One. 2009 Jul 21;4(7):e6331. doi: 10.1371/journal.pone.0006331.

47.

Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.

Mi J, Dziegielewski J, Bolesta E, Brautigan DL, Larner JM.

PLoS One. 2009;4(2):e4395. doi: 10.1371/journal.pone.0004395. Epub 2009 Feb 9.

48.

PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

Mi J, Bolesta E, Brautigan DL, Larner JM.

Mol Cancer Ther. 2009 Jan;8(1):135-40. doi: 10.1158/1535-7163.MCT-08-0457.

49.

Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.

Wang W, Brautigan DL.

BMC Cell Biol. 2008 Nov 26;9:62. doi: 10.1186/1471-2121-9-62.

50.

Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2.

Molhoek KR, McSkimming CC, Olson WC, Brautigan DL, Slingluff CL Jr.

Cancer Immunol Immunother. 2009 Jun;58(6):867-76. doi: 10.1007/s00262-008-0602-6. Epub 2008 Oct 8.

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